BR0317005A - Processo para a preparação de compostos ativos opticamente puros - Google Patents

Processo para a preparação de compostos ativos opticamente puros

Info

Publication number
BR0317005A
BR0317005A BR0317005-5A BR0317005A BR0317005A BR 0317005 A BR0317005 A BR 0317005A BR 0317005 A BR0317005 A BR 0317005A BR 0317005 A BR0317005 A BR 0317005A
Authority
BR
Brazil
Prior art keywords
optically pure
preparation
active compounds
pure active
chiral
Prior art date
Application number
BR0317005-5A
Other languages
English (en)
Inventor
Bernhard Kohl
Bernd Mueller
Ralf Stefffen Weingart
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of BR0317005A publication Critical patent/BR0317005A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrrole Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE COMPOSTOS ATIVOS OPTICAMENTE PUROS". A presente invenção refere-se a um novo processo para a preparação de PPI opticamente puro, possuindo uma estrutura de sulfinila, utilizando um complexo quiral de zircónio ou um complexo quiral de háfnio.
BR0317005-5A 2002-12-06 2003-12-03 Processo para a preparação de compostos ativos opticamente puros BR0317005A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02027273 2002-12-06
DE10340255 2003-08-29
PCT/EP2003/013605 WO2004052882A1 (en) 2002-12-06 2003-12-03 Process for preparing optically pure active compounds

Publications (1)

Publication Number Publication Date
BR0317005A true BR0317005A (pt) 2005-10-25

Family

ID=32509784

Family Applications (2)

Application Number Title Priority Date Filing Date
BR0317005-5A BR0317005A (pt) 2002-12-06 2003-12-03 Processo para a preparação de compostos ativos opticamente puros
BRPI0310118A BRPI0310118B1 (pt) 2002-12-06 2003-12-03 processo para a preparação de inibidores de bomba de próton (ppi) opticamente puro possuindo uma estrutura de sulfinila

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI0310118A BRPI0310118B1 (pt) 2002-12-06 2003-12-03 processo para a preparação de inibidores de bomba de próton (ppi) opticamente puro possuindo uma estrutura de sulfinila

Country Status (28)

Country Link
US (1) US7452998B2 (pt)
EP (1) EP1578742B1 (pt)
JP (1) JP4612542B2 (pt)
KR (1) KR101062806B1 (pt)
CN (1) CN100482658C (pt)
AR (1) AR042277A1 (pt)
AU (1) AU2003289948B2 (pt)
BR (2) BR0317005A (pt)
CA (1) CA2507807C (pt)
CY (1) CY1114058T1 (pt)
DK (1) DK1578742T3 (pt)
EA (1) EA011771B1 (pt)
ES (1) ES2397380T3 (pt)
HK (1) HK1078864A1 (pt)
HR (1) HRP20050604B1 (pt)
IL (1) IL168456A (pt)
IS (1) IS2885B (pt)
ME (1) ME00563A (pt)
MX (1) MXPA05005762A (pt)
NO (1) NO330978B1 (pt)
NZ (1) NZ540815A (pt)
PL (1) PL375818A1 (pt)
PT (1) PT1578742E (pt)
RS (1) RS52667B (pt)
SI (1) SI1578742T1 (pt)
TW (1) TWI313268B (pt)
WO (1) WO2004052882A1 (pt)
ZA (1) ZA200503543B (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE556713T1 (de) 1999-01-13 2012-05-15 Bayer Healthcare Llc Omega-carboxyarylsubstituierte-diphenyl- harnstoffe als p38-kinasehemmer
BR0316702A (pt) * 2002-12-06 2005-10-18 Altana Pharma Ag xprocesso para preparação de (s)-pantoprazol
FR2848555B1 (fr) * 2002-12-16 2006-07-28 Negma Gild Enantiomere(-)du tenatoprazole et son application en therapeutique
WO2004056804A2 (en) * 2002-12-19 2004-07-08 Teva Pharmaceutical Industries Ltd. Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates
CA2528993A1 (en) * 2003-06-10 2004-12-23 Teva Pharmaceutical Industries Ltd. Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole
CN1960987A (zh) * 2004-06-02 2007-05-09 奥坦纳医药公司 制备吡啶－2－基甲基亚磺酰基－1h－苯并咪唑类化合物的方法
FR2871800B1 (fr) * 2004-06-17 2006-08-25 Sidem Pharma Sa Sa Sel de sodium monohydrate du s-tenatoprazole et application en therapeutique
NZ551970A (en) * 2004-06-24 2010-01-29 Astrazeneca Ab New process for the preparation of crystal modifications for use in the preparation of esomeprazole sodium salt
EP1801110A1 (en) 2005-12-22 2007-06-27 KRKA, tovarna zdravil, d.d., Novo mesto Esomeprazole arginine salt
US7579476B2 (en) * 2006-02-24 2009-08-25 Praktikatalyst Pharma, Llc Transition metal mediated oxidation of hetero atoms in organic molecules coordinated to transition metals
CA2660112A1 (en) 2006-08-08 2008-02-14 Jubilant Organosys Limited Process for producing sulphoxide compounds
JP5492417B2 (ja) 2006-10-13 2014-05-14 エーザイ・アール・アンド・ディー・マネジメント株式会社 胃酸分泌抑制作用を有するベンズイミダゾール化合物
US20080103169A1 (en) 2006-10-27 2008-05-01 The Curators Of The University Of Missouri Compositions comprising acid labile proton pump inhibiting agents, at least one other pharmaceutically active agent and methods of using same
MX2010010049A (es) * 2008-03-18 2010-10-04 Reddys Lab Ltd Dr Proceso y polimorfos de dexlansoprazol.
EP2143722A1 (en) 2008-07-09 2010-01-13 Lek Pharmaceuticals D.D. Process for preparation of esomeprazole sodium of high chemical purity and new forms of esomeprazole sodium
EP2264024A1 (en) 2008-10-14 2010-12-22 LEK Pharmaceuticals d.d. Process for the preparation of enantiomerically enriched proton pump inhibitors
US8071781B2 (en) 2008-11-11 2011-12-06 Syn-Tech Chem. & Pharm. Co., Ltd. Process for preparing rabeprazole sodium
US8680284B2 (en) 2010-02-12 2014-03-25 Esteve Quimica, S.A. Preparation process of the sodium salt of esomeprazole
CN103113351B (zh) * 2013-03-08 2015-01-21 苏州特瑞药业有限公司 一种光学纯手性亚砜类化合物的制备方法
CN103936714A (zh) * 2014-04-15 2014-07-23 北京华禧联合科技发展有限公司 一种埃索美拉唑镁的制备方法
WO2016104668A1 (ja) * 2014-12-26 2016-06-30 国立大学法人 東京大学 光学活性のプロトンポンプ阻害化合物の製造方法
CN105440018A (zh) * 2015-11-27 2016-03-30 福州闽海药业有限公司 一种锆催化的右旋兰索拉唑的不对称氧化合成方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
IL75400A (en) 1984-06-16 1988-10-31 Byk Gulden Lomberg Chem Fab Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
JPS6150978A (ja) 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
FI90544C (fi) 1986-11-13 1994-02-25 Eisai Co Ltd Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi
SE465514B (sv) 1990-02-19 1991-09-23 Curt Pettersson Foerfarande och anvaendning av ett separationsmedium vid separation av enantiomerer
DE4035455A1 (de) 1990-11-08 1992-05-14 Byk Gulden Lomberg Chem Fab Enantiomerentrennung
WO1994024867A1 (en) 1993-04-27 1994-11-10 Sepracor, Inc. Methods and compositions for treating gastric disorders using optically pure (-) pantoprazole
WO1994025028A1 (en) 1993-04-27 1994-11-10 Sepracor, Inc. Methods and compositions for treating gastric disorders using optically pure (+) pantoprazole
SE9301830D0 (sv) 1993-05-28 1993-05-28 Ab Astra New compounds
SE504459C2 (sv) * 1994-07-15 1997-02-17 Astra Ab Förfarande för framställning av substituerade sulfoxider
GB9423968D0 (en) 1994-11-28 1995-01-11 Astra Ab Resolution
GB9423970D0 (en) 1994-11-28 1995-01-11 Astra Ab Oxidation
HRP960232A2 (en) 1995-07-03 1998-02-28 Astra Ab A process for the optical purification of compounds
BR0316702A (pt) * 2002-12-06 2005-10-18 Altana Pharma Ag xprocesso para preparação de (s)-pantoprazol

Also Published As

Publication number Publication date
PT1578742E (pt) 2013-01-24
SI1578742T1 (sl) 2013-02-28
HRP20050604A2 (en) 2006-09-30
CN1717403A (zh) 2006-01-04
KR101062806B1 (ko) 2011-09-07
CA2507807A1 (en) 2004-06-24
WO2004052882A1 (en) 2004-06-24
EP1578742A1 (en) 2005-09-28
AU2003289948B2 (en) 2009-12-24
ZA200503543B (en) 2006-08-30
RS20050423A (en) 2007-04-10
MXPA05005762A (es) 2005-08-16
CN100482658C (zh) 2009-04-29
US7452998B2 (en) 2008-11-18
TWI313268B (en) 2009-08-11
HRP20050604B1 (hr) 2013-09-30
ES2397380T3 (es) 2013-03-06
IS7909A (is) 2005-06-23
IL168456A (en) 2012-02-29
DK1578742T3 (da) 2013-01-21
IS2885B (is) 2014-07-15
CY1114058T1 (el) 2016-07-27
NO20053099D0 (no) 2005-06-24
NO330978B1 (no) 2011-08-29
JP2006516261A (ja) 2006-06-29
NZ540815A (en) 2008-03-28
BRPI0310118B1 (pt) 2015-10-20
EA200500898A1 (ru) 2005-12-29
EP1578742B1 (en) 2012-10-17
AR042277A1 (es) 2005-06-15
RS52667B (en) 2013-06-28
JP4612542B2 (ja) 2011-01-12
NO20053099L (no) 2005-06-24
CA2507807C (en) 2013-10-22
ME00563A (en) 2011-12-20
US20050288334A1 (en) 2005-12-29
KR20050085224A (ko) 2005-08-29
TW200508219A (en) 2005-03-01
PL375818A1 (en) 2005-12-12
HK1078864A1 (en) 2006-03-24
AU2003289948A1 (en) 2004-06-30
EA011771B1 (ru) 2009-06-30

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