BR0315666A - Dna de a34 e a33 do tipo 3, proteìnas, seus anticorpos e métodos de tratamento usando os mesmos - Google Patents
Dna de a34 e a33 do tipo 3, proteìnas, seus anticorpos e métodos de tratamento usando os mesmosInfo
- Publication number
- BR0315666A BR0315666A BR0315666-4A BR0315666A BR0315666A BR 0315666 A BR0315666 A BR 0315666A BR 0315666 A BR0315666 A BR 0315666A BR 0315666 A BR0315666 A BR 0315666A
- Authority
- BR
- Brazil
- Prior art keywords
- type
- antibodies
- same
- dna
- proteins
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 201000011510 cancer Diseases 0.000 abstract 2
- 238000001514 detection method Methods 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Abstract
"DNA DE A34 E A33 DO TIPO 3, PROTEìNAS, SEUS ANTICORPOS E MéTODOS DE TRATAMENTO USANDO OS MESMOS". Moléculas de polinucleotídeo e moléculas de polipeptídeo A34 e A33 do tipo 3 são descritas, bem como anticorpos para as moléculas de polipeptídeo A34 e A33 do tipo 3. São também descritos métodos de detecção de cânceres expressando esses polipeptídeos e métodos e kits para diagnóstico dos ditos cânceres e métodos de inibição dos efeitos de um câncer em um paciente.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42028502P | 2002-10-23 | 2002-10-23 | |
US60/420,285 | 2002-10-23 | ||
PCT/US2003/033707 WO2004037999A2 (en) | 2002-10-23 | 2003-10-23 | A34 and a33-like 3 dna, proteins, antibodies thereto and methods of treatment using same |
Publications (3)
Publication Number | Publication Date |
---|---|
BR0315666A true BR0315666A (pt) | 2005-08-30 |
BRPI0315666B1 BRPI0315666B1 (pt) | 2019-04-30 |
BRPI0315666B8 BRPI0315666B8 (pt) | 2021-05-25 |
Family
ID=32176548
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0315666A BRPI0315666B8 (pt) | 2002-10-23 | 2003-10-23 | dna de a34 e a33 do tipo 3, proteínas, seus anticorpos e métodos de tratamento usando os mesmos |
Country Status (6)
Country | Link |
---|---|
US (3) | US7521543B2 (pt) |
EP (1) | EP1565482B1 (pt) |
JP (1) | JP2006512910A (pt) |
AU (1) | AU2003284891A1 (pt) |
BR (1) | BRPI0315666B8 (pt) |
WO (1) | WO2004037999A2 (pt) |
Families Citing this family (60)
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AU2005325801A1 (en) | 2005-01-31 | 2006-08-03 | Ablynx N.V. | Method for generating variable domain sequences of heavy chain antibodies |
EP1888640B1 (en) | 2005-05-18 | 2012-03-14 | Ablynx N.V. | Improved nanobodies against tumor necrosis factor-alpha |
PL3415535T3 (pl) | 2005-05-20 | 2021-06-14 | Ablynx N.V. | Ulepszone Nanociała TM do leczenia zaburzeń, w których pośredniczy agregacja |
WO2008074840A2 (en) | 2006-12-19 | 2008-06-26 | Ablynx N.V. | Amino acid sequences directed against a metalloproteinase from the adam family and polypeptides comprising the same for the treatment of adam-related diseases and disorders |
EP2557090A3 (en) | 2006-12-19 | 2013-05-29 | Ablynx N.V. | Amino acid sequences directed against GPCRs and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders |
PT2190469E (pt) * | 2007-09-04 | 2015-06-25 | Compugen Ltd | Polipéptidos e polinucleótidos, e utilizações dos mesmos como um alvo de fármacos para produzir fármacos e agentes biológicos |
AU2013204943A1 (en) * | 2007-09-04 | 2013-05-16 | Compugen Ltd. | Polypeptides and polynucleotides related to fxyd3, and uses thereof as a drug target for producing drugs and biologics |
PL2769729T3 (pl) | 2007-09-04 | 2019-09-30 | Compugen Ltd. | Polipeptydy i polinukleotydy i ich zastosowanie jako cel dla leków do wytwarzania leków i środków biologicznych |
EP2205249B1 (en) | 2007-09-28 | 2018-11-07 | Intrexon Corporation | Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof |
WO2009068630A1 (en) | 2007-11-27 | 2009-06-04 | Ablynx N.V. | Immunoglobulin constructs |
US20110091462A1 (en) | 2008-03-05 | 2011-04-21 | Ablynx N.V. | Novel antigen binding dimer-complexes, methods of making and uses thereof |
WO2009124931A2 (en) | 2008-04-07 | 2009-10-15 | Ablynx Nv | Amino acid sequences directed against the notch pathways and uses thereof |
AU2009237662A1 (en) | 2008-04-17 | 2009-10-22 | Ablynx N.V. | Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same |
WO2010100135A1 (en) | 2009-03-05 | 2010-09-10 | Ablynx N.V. | Novel antigen binding dimer-complexes, methods of making/avoiding and uses thereof |
US8748581B2 (en) | 2009-04-10 | 2014-06-10 | Ablynx N.V. | Anti-IL-6R polypeptides and pharmaceutical compositions thereof |
SG176095A1 (en) | 2009-06-05 | 2011-12-29 | Ablynx Nv | Monovalent, bivalent and trivalent anti human respiratory syncytial virus (hrsv) nanobody constructs for the prevention and/or treatment of respiratory tract infections |
WO2011040978A2 (en) | 2009-10-02 | 2011-04-07 | Ludwig Institute For Cancer Research Ltd. | Immunodominant mhc dr52b restricted ny-eso-1 epitopes, mhc class ii monomers and multimers, and uses thereof |
WO2011045079A1 (en) | 2009-10-15 | 2011-04-21 | Intercell Ag | Hepatitis b virus specific human antibodies |
EP2507262A1 (en) | 2009-11-30 | 2012-10-10 | Ablynx N.V. | Improved amino acid sequences directed against human respiratory syncytial virus (hrsv) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections |
JP2013518853A (ja) | 2010-02-05 | 2013-05-23 | アブリンクス エン.ヴェー. | 血清アルブミンと結合することが可能なペプチド並びにこれを含む化合物、構築物及びポリペプチド |
US10745467B2 (en) | 2010-03-26 | 2020-08-18 | The Trustees Of Dartmouth College | VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders |
EP2552947A4 (en) | 2010-03-26 | 2013-11-13 | Dartmouth College | VISTA REGULATORY T CELL MEDIATOR PROTEIN, VISTA BINDING ACTIVE SUBSTANCES AND USE THEREOF |
US20150231215A1 (en) | 2012-06-22 | 2015-08-20 | Randolph J. Noelle | VISTA Antagonist and Methods of Use |
EP2638068B1 (en) | 2010-11-08 | 2018-12-26 | Novartis AG | Cxcr2 binding polypeptides |
US8197471B1 (en) | 2011-02-14 | 2012-06-12 | Samuel Harry Tersigni | Core-excited nanoparticles and methods of their use in the diagnosis and treatment of disease |
US9255595B2 (en) * | 2011-04-29 | 2016-02-09 | Bae Systems Information And Electronic Systems Integration Inc. | Optical dome bezel |
JP2014525736A (ja) | 2011-06-23 | 2014-10-02 | アブリンクス エン.ヴェー. | IgEに対する免疫グロブリン単一可変ドメイン |
WO2013001517A1 (en) | 2011-06-30 | 2013-01-03 | Compugen Ltd. | Polypeptides and uses thereof for treatment of autoimmune disorders and infection |
BR112014018481A2 (pt) | 2012-02-01 | 2017-07-04 | Compugen Ltd | anticorpo monoclonal ou policlonal ou um fragmento de ligação a antígeno do mesmo, polinucleotídeo, anticorpo monoclonal, vetor, hibridoma, anticorpo, hibridoma 5166-2 e/ou 5166-9, anticorpo ou fragmento de ligação a antígeno, composição farmacêutica, uso do anticorpo ou fragmento de ligação a anticorpo, método para tratar câncer, método para diagnosticar câncer em um indivíduo, anticorpo, método, composição ou uso |
US9328174B2 (en) | 2012-05-09 | 2016-05-03 | Novartis Ag | Chemokine receptor binding polypeptides |
US9890215B2 (en) | 2012-06-22 | 2018-02-13 | King's College London | Vista modulators for diagnosis and treatment of cancer |
AU2013312211B2 (en) | 2012-09-07 | 2018-03-29 | King's College London | VISTA modulators for diagnosis and treatment of cancer |
WO2014087010A1 (en) | 2012-12-07 | 2014-06-12 | Ablynx N.V. | IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE |
NL1040254C2 (en) | 2013-05-17 | 2014-11-24 | Ablynx Nv | Stable formulations of immunoglobulin single variable domains and uses thereof. |
US11014987B2 (en) | 2013-12-24 | 2021-05-25 | Janssen Pharmaceutics Nv | Anti-vista antibodies and fragments, uses thereof, and methods of identifying same |
WO2015097536A2 (en) | 2013-12-24 | 2015-07-02 | Janssen Pharmaceutical Nv | Anti-vista antibodies and fragments |
AU2015274504B2 (en) | 2014-06-11 | 2021-02-04 | Kathy A. Green | Use of VISTA agonists and antagonists to suppress or enhance humoral immunity |
NL2013007B1 (en) | 2014-06-16 | 2016-07-05 | Ablynx Nv | Methods of treating TTP with immunoglobulin single variable domains and uses thereof. |
NL2013661B1 (en) | 2014-10-21 | 2016-10-05 | Ablynx Nv | KV1.3 Binding immunoglobulins. |
AU2015357463B2 (en) * | 2014-12-05 | 2021-10-07 | Immunext, Inc. | Identification of VSIG8 as the putative vista receptor and its use thereof to produce vista/VSIG8 modulators |
CA2975078A1 (en) | 2015-01-27 | 2016-08-04 | Lava Therapeutics B.V. | Single domain antibodies targeting cd1d |
BR112017027870A2 (pt) | 2015-06-24 | 2018-08-28 | Janssen Pharmaceutica Nv | anticorpos e fragmentos anti-vista |
RU2018122255A (ru) | 2015-11-27 | 2019-12-19 | Аблинкс Нв | Полипептиды, ингибирующие cd40l |
US10899836B2 (en) | 2016-02-12 | 2021-01-26 | Janssen Pharmaceutica Nv | Method of identifying anti-VISTA antibodies |
CA3020848A1 (en) | 2016-04-15 | 2017-10-19 | Janssen Pharmaceuticals, Inc. | Anti-human vista antibodies and use thereof |
EP3512880A1 (en) | 2016-09-15 | 2019-07-24 | Ablynx NV | Immunoglobulin single variable domains directed against macrophage migration inhibitory factor |
CA3043515A1 (en) | 2016-11-16 | 2018-05-24 | Ablynx Nv | T cell recruiting polypeptides capable of binding cd123 and tcr alpha/beta |
CA3064469A1 (en) | 2017-06-02 | 2018-12-06 | Merck Patent Gmbh | Mmp13 binding immunoglobulins |
MX2019014397A (es) | 2017-06-02 | 2020-02-10 | Merck Patent Gmbh | Polipeptidos que enlazan adamts5, mmp13 y agrecano. |
EP3630818A1 (en) | 2017-06-02 | 2020-04-08 | Ablynx NV | Aggrecan binding immunoglobulins |
MX2019014400A (es) | 2017-06-02 | 2020-02-10 | Merck Patent Gmbh | Inmunoglobulinas que se unen a adamts. |
JP2021512947A (ja) | 2018-02-06 | 2021-05-20 | アブリンクス・エヌ・フェー | Ttpの初回エピソードを免疫グロブリン単一可変ドメインで処置する方法 |
WO2020185069A1 (en) | 2019-03-08 | 2020-09-17 | Linxis B.V. | Internalizing binding molecules targeting receptors involved in cell proliferation or cell differentiation |
WO2020245663A1 (en) | 2019-06-01 | 2020-12-10 | Institut Pasteur | Nanobody-based ns1 assay for the specific diagnosis of acute zika virus infection |
EP4214235A1 (en) | 2020-09-16 | 2023-07-26 | LinXis B.V. | Internalizing binding molecules |
EP4019548A1 (en) | 2020-12-23 | 2022-06-29 | Vrije Universiteit Brussel | Anti lag3 vhhs and their use |
CN115433733A (zh) | 2021-06-04 | 2022-12-06 | 生物岛实验室 | 环状RNA Circ-ACE2翻译的多肽及其应用 |
WO2023068382A2 (en) | 2021-10-20 | 2023-04-27 | Takeda Pharmaceutical Company Limited | Compositions targeting bcma and methods of use thereof |
CN114369162B (zh) | 2021-12-28 | 2023-05-30 | 合肥天港免疫药物有限公司 | 抗体及其应用 |
WO2024023271A1 (en) | 2022-07-27 | 2024-02-01 | Ablynx Nv | Polypeptides binding to a specific epitope of the neonatal fc receptor |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5708157A (en) * | 1996-07-26 | 1998-01-13 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
US6312921B1 (en) | 1996-07-26 | 2001-11-06 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
WO1999060020A1 (en) | 1998-05-18 | 1999-11-25 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
EP1432804A2 (en) * | 2001-08-31 | 2004-06-30 | Diadexus, Inc. | Compositions and methods relating to ovary specific genes and proteins |
WO2003042661A2 (en) * | 2001-11-13 | 2003-05-22 | Protein Design Labs, Inc. | Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer |
-
2003
- 2003-10-23 BR BRPI0315666A patent/BRPI0315666B8/pt active IP Right Grant
- 2003-10-23 EP EP03779212.4A patent/EP1565482B1/en not_active Expired - Lifetime
- 2003-10-23 AU AU2003284891A patent/AU2003284891A1/en not_active Abandoned
- 2003-10-23 JP JP2004547109A patent/JP2006512910A/ja active Pending
- 2003-10-23 WO PCT/US2003/033707 patent/WO2004037999A2/en active Application Filing
- 2003-10-23 US US10/532,489 patent/US7521543B2/en not_active Expired - Lifetime
-
2009
- 2009-02-17 US US12/378,533 patent/US20090263394A1/en not_active Abandoned
-
2011
- 2011-09-15 US US13/233,086 patent/US8440807B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU2003284891A1 (en) | 2004-05-13 |
WO2004037999A3 (en) | 2005-06-30 |
EP1565482B1 (en) | 2014-04-30 |
US20120039892A1 (en) | 2012-02-16 |
US7521543B2 (en) | 2009-04-21 |
EP1565482A4 (en) | 2006-06-07 |
WO2004037999A2 (en) | 2004-05-06 |
BRPI0315666B1 (pt) | 2019-04-30 |
US20060292154A1 (en) | 2006-12-28 |
US20090263394A1 (en) | 2009-10-22 |
BRPI0315666B8 (pt) | 2021-05-25 |
AU2003284891A8 (en) | 2004-05-13 |
EP1565482A2 (en) | 2005-08-24 |
JP2006512910A (ja) | 2006-04-20 |
US8440807B2 (en) | 2013-05-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B07C | Technical examination (opinion): republication [chapter 7.3 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 30/04/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 30/04/2019, OBSERVADAS AS CONDICOES LEGAIS |
|
B25G | Requested change of headquarter approved |
Owner name: LUDWIG INSTITUTE FOR CANCER RESEARCH (US) |
|
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 23/10/2003 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |