BR0315113A - Processo enantioseletivo para a preparação de ambos enantiÈmeros de 10,11-diidro-10-hidróxi-5h-dibenz[b,f]azepina-5-carbox amida e suas formas de cristal - Google Patents
Processo enantioseletivo para a preparação de ambos enantiÈmeros de 10,11-diidro-10-hidróxi-5h-dibenz[b,f]azepina-5-carbox amida e suas formas de cristalInfo
- Publication number
- BR0315113A BR0315113A BR0315113-1A BR0315113A BR0315113A BR 0315113 A BR0315113 A BR 0315113A BR 0315113 A BR0315113 A BR 0315113A BR 0315113 A BR0315113 A BR 0315113A
- Authority
- BR
- Brazil
- Prior art keywords
- dibenz
- crystal forms
- azepine
- hydroxy
- dihydro
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- BMPDWHIDQYTSHX-UHFFFAOYSA-N licarbazepine Chemical class C1C(O)C2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 BMPDWHIDQYTSHX-UHFFFAOYSA-N 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- JRKDKWDSUYBIQB-UHFFFAOYSA-N 7,8-dihydrobenzo[b][1]benzazepin-5-one Chemical compound O=C1C=C2CCC=CC2=NC2=CC=CC=C12 JRKDKWDSUYBIQB-UHFFFAOYSA-N 0.000 abstract 1
- 241001139947 Mida Species 0.000 abstract 1
- UVGSRARLWOYTNE-UHFFFAOYSA-N OC1=C2C=CC=CC2=NC2=CCCCC2=C1 Chemical class OC1=C2C=CC=CC2=NC2=CCCCC2=C1 UVGSRARLWOYTNE-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
- 229910052759 nickel Inorganic materials 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229910052703 rhodium Inorganic materials 0.000 abstract 1
- 229910052707 ruthenium Inorganic materials 0.000 abstract 1
- 238000009901 transfer hydrogenation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0046—Ruthenium compounds
- C07F15/0053—Ruthenium compounds without a metal-carbon linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
"PROCESSO ENANTIOSSELETIVO PARA A PREPARAçãO DE AMBOS ENANTIÈMEROS DE 10,11-DIIDRO-10-HIDRóXI5H-DIBENZ[b,f]AZEPINA-5-CARBOXA MIDA E SUAS FORMAS DE CRISTAL". A invenção refere-se a um novo processo para a fabricação de 10-hidróxi-diidrodibenz[b,f]azepinas enantiopuras substituídas onde cada um de R^ 1^ e R^ 2^, independentemente, é hidrogênio, halogênio, amino ou nitro; e cada um de R^ 3^ e R^ 4^, independentemente, são hidrogênio ou C~ 1-6~ alquila; através de hidrogenação de transferência de 10-oxo diidro dibenz[b,f]azepinas; e a novos catalisadores de fórmulas III<39>a e III<39>b onde M é Ru, Rh, IV, Fe, Co ou Ni; L~ 1~ é hidrogênio; L~ 2~ representa um resíduo arila ou aril alifático; e os outros radicais tendo os significados como aqui definidos; e a novas formas de cristais de ambos enantiómeros de 10,11-diidro-10hidróxi-5H-dibenz[b,f]azepina-5-carboxamida, obteníveis através de novos processos, sua utilização, na produção de preparações farmacêuticas, novas preparações farmacêuticas compreendendo estas novas formas de cristal e/ou o uso destas novas formas de cristal no tratamento de distúrbios como epilepsia, ou na produção de formulações farmacêuticas que são apropriadas para este tratamento.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0223224.7A GB0223224D0 (en) | 2002-10-07 | 2002-10-07 | Organic compounds |
| PCT/EP2003/011034 WO2004031155A1 (en) | 2002-10-07 | 2003-10-06 | ENANTIOSELECTIVE PROCESS FOR THE PREPARATION OF BOTH ENANTIOMERS OF 10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ [b,f]AZEPINE-5-CARBOXAMIDE AND NEW CRYSTAL FORMS THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0315113A true BR0315113A (pt) | 2005-08-23 |
Family
ID=9945425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0315113-1A BR0315113A (pt) | 2002-10-07 | 2003-10-06 | Processo enantioseletivo para a preparação de ambos enantiÈmeros de 10,11-diidro-10-hidróxi-5h-dibenz[b,f]azepina-5-carbox amida e suas formas de cristal |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20060142566A1 (pt) |
| EP (1) | EP1551808A1 (pt) |
| JP (1) | JP2006504710A (pt) |
| KR (1) | KR20050071549A (pt) |
| CN (2) | CN101062932A (pt) |
| AR (1) | AR041544A1 (pt) |
| AU (1) | AU2003276055B2 (pt) |
| BR (1) | BR0315113A (pt) |
| CA (1) | CA2501237A1 (pt) |
| EC (1) | ECSP055738A (pt) |
| GB (1) | GB0223224D0 (pt) |
| HK (1) | HK1079790A1 (pt) |
| MX (1) | MXPA05003737A (pt) |
| NO (1) | NO20052244L (pt) |
| PE (1) | PE20040686A1 (pt) |
| PL (1) | PL376379A1 (pt) |
| RU (1) | RU2005114350A (pt) |
| TW (1) | TW200413324A (pt) |
| WO (1) | WO2004031155A1 (pt) |
| ZA (1) | ZA200502561B (pt) |
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| GB0303615D0 (en) * | 2003-02-17 | 2003-03-19 | Novartis Ag | Use of organic compounds |
| GB0425320D0 (en) | 2004-11-17 | 2004-12-22 | Johnson Matthey Plc | Diamines |
| US20060252745A1 (en) | 2005-05-06 | 2006-11-09 | Almeida Jose L D | Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use |
| GB0515690D0 (en) | 2005-07-29 | 2005-09-07 | Portela & Ca Sa | Asymmetric catalytic reduction |
| GB2437078A (en) * | 2006-04-11 | 2007-10-17 | Portela & Ca Sa | 10-Acyloxy-5H-dibenzo[b,f]azepine-5-carboxamides & their asymmetric hydrogenation to the chiral 10,11-dihydro derivatives |
| JP5172124B2 (ja) * | 2006-09-29 | 2013-03-27 | 関東化学株式会社 | ２位に置換基を有する光学活性キヌクリジノール類の製造方法 |
| GB0700773D0 (en) | 2007-01-15 | 2007-02-21 | Portela & Ca Sa | Drug therapies |
| WO2011045648A2 (en) * | 2009-10-12 | 2011-04-21 | Matrix Laboratories Limited | Process for preparing (s)-(-)-10-acetoxy-10,11-dihydro-5h-dibenz[b,f]azepine-5-carboxamide and its esters thereof |
| EP2383261B1 (en) | 2010-04-23 | 2013-09-04 | Euticals GmbH | Process for the asymmetric hydrogenation of ketones |
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| ES2687678T3 (es) | 2011-03-08 | 2018-10-26 | Jubilant Life Sciences Limited | Procedimiento para la preparación de (S)-(+)-10,11-dihidro-10-hidroxi-5H-dibenzo[b,f]azepina-5-carboxamida y ésteres de la misma mediante reducción enantioselectiva de 10,11-dihidro-10-oxo-5H-dibenzo[b,f]azepina-5-carboxamida |
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| CN107033079B (zh) * | 2016-10-17 | 2020-07-28 | 扬子江药业集团北京海燕药业有限公司 | 醋酸艾司利卡西平的制备方法 |
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Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT101732B (pt) * | 1995-06-30 | 1997-12-31 | Portela & Ca Sa | Novas di-hidrodibenzo<b,f>azepinas substituidas processo para a sua preparacao composicoes farmaceuticas que as contem e utilizacao dos novos compostos na preparacao de composicoes farmaceuticas empregues em doencas do sistema nervoso |
| IL146952A0 (en) * | 1999-06-15 | 2002-08-14 | Rhodia Chimie Sa | Sulphonylamides and carboxamides and their use in asymmmetical catalysis |
| HUP0303154A3 (en) * | 2001-02-12 | 2009-08-28 | Teva Pharma | New crystal forms of oxcarbazepine and processes for their preparation |
-
2002
- 2002-10-07 GB GBGB0223224.7A patent/GB0223224D0/en not_active Ceased
-
2003
- 2003-10-06 CA CA002501237A patent/CA2501237A1/en not_active Abandoned
- 2003-10-06 KR KR1020057005920A patent/KR20050071549A/ko not_active Application Discontinuation
- 2003-10-06 CN CNA2007101126346A patent/CN101062932A/zh active Pending
- 2003-10-06 US US10/530,617 patent/US20060142566A1/en not_active Abandoned
- 2003-10-06 RU RU2005114350/04A patent/RU2005114350A/ru not_active Application Discontinuation
- 2003-10-06 AU AU2003276055A patent/AU2003276055B2/en not_active Expired - Fee Related
- 2003-10-06 JP JP2004540788A patent/JP2006504710A/ja active Pending
- 2003-10-06 BR BR0315113-1A patent/BR0315113A/pt not_active IP Right Cessation
- 2003-10-06 EP EP03798930A patent/EP1551808A1/en not_active Withdrawn
- 2003-10-06 WO PCT/EP2003/011034 patent/WO2004031155A1/en active Application Filing
- 2003-10-06 MX MXPA05003737A patent/MXPA05003737A/es not_active Application Discontinuation
- 2003-10-06 CN CNA2003801013117A patent/CN1703404A/zh active Pending
- 2003-10-06 PL PL03376379A patent/PL376379A1/xx unknown
- 2003-10-07 PE PE2003001022A patent/PE20040686A1/es not_active Application Discontinuation
- 2003-10-07 TW TW092127799A patent/TW200413324A/zh unknown
- 2003-10-07 AR ARP030103648A patent/AR041544A1/es not_active Application Discontinuation
-
2005
- 2005-03-30 ZA ZA200502561A patent/ZA200502561B/en unknown
- 2005-04-06 EC EC2005005738A patent/ECSP055738A/es unknown
- 2005-05-06 NO NO20052244A patent/NO20052244L/no not_active Application Discontinuation
- 2005-12-30 HK HK05112208.8A patent/HK1079790A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101062932A (zh) | 2007-10-31 |
| NO20052244D0 (no) | 2005-05-06 |
| RU2005114350A (ru) | 2006-01-20 |
| JP2006504710A (ja) | 2006-02-09 |
| AU2003276055B2 (en) | 2008-01-03 |
| GB0223224D0 (en) | 2002-11-13 |
| AU2003276055A1 (en) | 2004-04-23 |
| MXPA05003737A (es) | 2005-06-17 |
| AR041544A1 (es) | 2005-05-18 |
| NO20052244L (no) | 2005-07-07 |
| KR20050071549A (ko) | 2005-07-07 |
| PE20040686A1 (es) | 2004-10-29 |
| TW200413324A (en) | 2004-08-01 |
| CA2501237A1 (en) | 2004-04-15 |
| HK1079790A1 (zh) | 2006-04-13 |
| ZA200502561B (en) | 2006-02-22 |
| PL376379A1 (en) | 2005-12-27 |
| EP1551808A1 (en) | 2005-07-13 |
| WO2004031155A1 (en) | 2004-04-15 |
| US20060142566A1 (en) | 2006-06-29 |
| ECSP055738A (es) | 2005-07-06 |
| CN1703404A (zh) | 2005-11-30 |
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