BR0314670A - Métodos e composições de compostos de triazina - Google Patents
Métodos e composições de compostos de triazinaInfo
- Publication number
- BR0314670A BR0314670A BR0314670-7A BR0314670A BR0314670A BR 0314670 A BR0314670 A BR 0314670A BR 0314670 A BR0314670 A BR 0314670A BR 0314670 A BR0314670 A BR 0314670A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- present
- compositions
- methods
- smooth muscle
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical group C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 102100036597 Basement membrane-specific heparan sulfate proteoglycan core protein Human genes 0.000 abstract 2
- 230000028709 inflammatory response Effects 0.000 abstract 2
- 230000035755 proliferation Effects 0.000 abstract 2
- 210000002460 smooth muscle Anatomy 0.000 abstract 2
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 108090000054 Syndecan-2 Proteins 0.000 abstract 1
- -1 TRIAZINE COMPOUNDS Chemical class 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 210000002889 endothelial cell Anatomy 0.000 abstract 1
- 108091005996 glycated proteins Proteins 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 230000004963 pathophysiological condition Effects 0.000 abstract 1
- 108010049224 perlecan Proteins 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Classifications
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
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Abstract
"MéTODOS E COMPOSIçõES DE COMPOSTOS DE TRIAZINA". A presente invenção relaciona-se aos métodos e às composições compreendendo os compostos que tratam as condições fisiopatológicas que surgem de respostas inflamatórias. Em particular, a presente invenção é dirigida aos compostos que inibem ou bloqueiam a indução produzida por proteína glicada da resposta inflamatória associada à sinalização em células endoteliais. A presente invenção relaciona-se aos compostos que inibem a proliferação do músculo liso. Em particular, a presente invenção é dirigida aos compostos que inibem a proliferação das células do músculo liso por modulação dos HSPGs, tais como o Perlecan. A presente invenção adicionalmente relaciona-se ao uso de compostos para tratar condições oclusivas vasculares, caracterizadas por proliferação do músculo liso, tais como a reestenose e a aterosclerose.
Applications Claiming Priority (3)
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US25338802A | 2002-09-23 | 2002-09-23 | |
US10/390,485 US7173032B2 (en) | 2001-09-21 | 2003-03-17 | Methods and compositions of novel triazine compounds |
PCT/US2003/009356 WO2004026844A1 (en) | 2002-09-23 | 2003-03-26 | Methods and compositions of novel triazine compounds |
Publications (1)
Publication Number | Publication Date |
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BR0314670A true BR0314670A (pt) | 2005-08-09 |
Family
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Family Applications (1)
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BR0314670-7A BR0314670A (pt) | 2002-09-23 | 2003-03-26 | Métodos e composições de compostos de triazina |
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US (3) | US7173032B2 (pt) |
EP (1) | EP1560817A4 (pt) |
JP (2) | JP2006511476A (pt) |
AU (1) | AU2003231975A1 (pt) |
BR (1) | BR0314670A (pt) |
CA (1) | CA2499964A1 (pt) |
RU (1) | RU2005108351A (pt) |
WO (1) | WO2004026844A1 (pt) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9522217B2 (en) | 2000-03-15 | 2016-12-20 | Orbusneich Medical, Inc. | Medical device with coating for capturing genetically-altered cells and methods for using same |
US8088060B2 (en) | 2000-03-15 | 2012-01-03 | Orbusneich Medical, Inc. | Progenitor endothelial cell capturing with a drug eluting implantable medical device |
US7273712B2 (en) * | 2000-12-29 | 2007-09-25 | Reddy Us Therapeutics, Inc. | Methods and compositions for detecting compounds that modulate inflammatory responses |
US7112587B2 (en) * | 2001-09-21 | 2006-09-26 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
US7169785B2 (en) * | 2001-09-21 | 2007-01-30 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
US7163943B2 (en) * | 2001-09-21 | 2007-01-16 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
US7173032B2 (en) * | 2001-09-21 | 2007-02-06 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
US7307079B2 (en) * | 2002-05-30 | 2007-12-11 | Solvay Pharmaceuticals, B.V. | 1,3,5-Triazine derivatives as ligands for human adenosine-A3 receptors |
US20040167132A1 (en) * | 2003-01-16 | 2004-08-26 | Geetha Shankar | Methods of treating conditions associted with an Edg-2 receptor |
UY28213A1 (es) * | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos. |
US7335770B2 (en) * | 2004-03-24 | 2008-02-26 | Reddy U5 Therapeutics, Inc. | Triazine compounds and their analogs, compositions, and methods |
US7862835B2 (en) * | 2004-10-27 | 2011-01-04 | Boston Scientific Scimed, Inc. | Method of manufacturing a medical device having a porous coating thereon |
ITMI20050222A1 (it) * | 2005-02-15 | 2006-08-16 | Milano Politecnico | Lipidi cationici per la trasfezione di acidi nucleici |
US20090012148A1 (en) * | 2005-11-01 | 2009-01-08 | Maxfield Frederick R | Reducing cellular cholesterol levels and/or treating or preventing phospholipidosis |
US11098345B2 (en) * | 2006-06-05 | 2021-08-24 | California Institute Of Technology | Methods for detecting target analytes |
US11001881B2 (en) * | 2006-08-24 | 2021-05-11 | California Institute Of Technology | Methods for detecting analytes |
US8637436B2 (en) | 2006-08-24 | 2014-01-28 | California Institute Of Technology | Integrated semiconductor bioarray |
US11525156B2 (en) | 2006-07-28 | 2022-12-13 | California Institute Of Technology | Multiplex Q-PCR arrays |
WO2008014485A2 (en) | 2006-07-28 | 2008-01-31 | California Institute Of Technology | Multiplex q-pcr arrays |
WO2008016547A2 (en) | 2006-07-31 | 2008-02-07 | Praecis Pharmaceuticals Incorporated | Aurora kinase inhibitors from an encoded small molecule library |
JP2009545598A (ja) * | 2006-08-01 | 2009-12-24 | プリーシス・ファーマシューティカルズ・インコーポレイテッド | P38キナーゼ阻害剤 |
US11560588B2 (en) | 2006-08-24 | 2023-01-24 | California Institute Of Technology | Multiplex Q-PCR arrays |
US20080275049A1 (en) * | 2007-05-04 | 2008-11-06 | Reddy Us Therapeutics, Inc. | Methods and Compositions for Upregulation of GATA Activity |
KR20120026610A (ko) * | 2009-06-08 | 2012-03-19 | 아브락시스 바이오사이언스, 엘엘씨 | 트리아진 유도체와 이들의 치료적 용도 |
CN103003264B (zh) | 2010-05-21 | 2014-08-06 | 切米利亚股份公司 | 嘧啶衍生物 |
KR20120011667A (ko) * | 2010-07-29 | 2012-02-08 | 광주과학기술원 | 당뇨병 치료제의 스크리닝 방법 |
US9107983B2 (en) | 2010-10-27 | 2015-08-18 | Warsaw Orthopedic, Inc. | Osteoconductive matrices comprising statins |
US8877221B2 (en) | 2010-10-27 | 2014-11-04 | Warsaw Orthopedic, Inc. | Osteoconductive matrices comprising calcium phosphate particles and statins and methods of using the same |
WO2012054978A1 (en) * | 2010-10-27 | 2012-05-03 | Ludwig Institute For Cancer Research Limited | Novel anti-cancer agents |
JP5886411B2 (ja) | 2011-03-24 | 2016-03-16 | ノビガ・リサーチ・エービーNoviga Research AB | 新規のピリミジン誘導体 |
WO2012170417A2 (en) | 2011-06-06 | 2012-12-13 | Warsaw Orthopedic, Inc. | Methods and compositions to enhance bone growth comprising a statin |
WO2013047411A1 (ja) * | 2011-09-29 | 2013-04-04 | 富士フイルム株式会社 | 新規なトリアジン誘導体、紫外線吸収剤 |
US20150038511A1 (en) | 2012-08-09 | 2015-02-05 | Celgene Corporation | Treatment of immune-related and inflammatory diseases |
PL2882441T3 (pl) | 2012-08-09 | 2020-09-21 | Celgene Corporation | Leczenie chorób immunologicznych i zapalnych |
US9119606B2 (en) | 2013-01-21 | 2015-09-01 | Ethicon, Inc. | Sealant delivery device for anastomotic stapler |
JP2017522270A (ja) | 2014-05-19 | 2017-08-10 | セルジーン コーポレイション | 全身性エリテマトーデスの治療のための3−(4−((4−(モルホリノメチル−ベンジル)オキシ)−1−オキソイソインドリン−2−イル)ピペリジン−2,6−ジオン |
TWI602951B (zh) * | 2014-08-13 | 2017-10-21 | 日本派克乃成股份有限公司 | 補給劑、表面處理金屬材料及其製造方法 |
WO2016070241A1 (en) * | 2014-11-03 | 2016-05-12 | Ctxt Pty Ltd | Triazine compounds, compositions and synthesis |
US9708647B2 (en) | 2015-03-23 | 2017-07-18 | Insilixa, Inc. | Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays |
US9499861B1 (en) | 2015-09-10 | 2016-11-22 | Insilixa, Inc. | Methods and systems for multiplex quantitative nucleic acid amplification |
WO2017155858A1 (en) | 2016-03-07 | 2017-09-14 | Insilixa, Inc. | Nucleic acid sequence identification using solid-phase cyclic single base extension |
AU2018240172C1 (en) | 2017-03-20 | 2019-10-24 | Novo Nordisk Health Care Ag | Pyrrolopyrrole compositions as pyruvate kinase (PKR) activators |
US10675274B2 (en) | 2018-09-19 | 2020-06-09 | Forma Therapeutics, Inc. | Activating pyruvate kinase R |
CN113226356A (zh) | 2018-09-19 | 2021-08-06 | 福马治疗股份有限公司 | 活化丙酮酸激酶r |
WO2020141439A1 (en) * | 2018-12-31 | 2020-07-09 | Integral Biosciences Private Limited | Heterocyclic compounds as mutant idh inhibitors |
JP2022525322A (ja) | 2019-03-14 | 2022-05-12 | インシリクサ, インコーポレイテッド | 時間ゲート蛍光ベースの検出のための方法およびシステム |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3290305A (en) * | 1963-02-05 | 1966-12-06 | Goldschmidt Ag Th | Chloro-s-triazinyl-aminoacids |
BE726948A (pt) * | 1968-04-10 | 1969-07-01 | ||
US3867383A (en) * | 1971-03-29 | 1975-02-18 | Ciba Geigy Corp | Monoanthranilatoanilino-s-triazines |
DE3206398A1 (de) * | 1982-02-23 | 1983-09-01 | Basf Ag, 6700 Ludwigshafen | S-triazinderivate und ihre verwendung als lichtschutzmittel |
GB8808071D0 (en) * | 1988-04-07 | 1988-05-11 | Shell Int Research | Triazine herbicides |
DE69007092T2 (de) * | 1989-09-09 | 1994-07-21 | Sandoz Ag | Synthetische polyamide und deren salze. |
IT1255729B (it) * | 1992-05-19 | 1995-11-15 | Giuseppe Raspanti | Derivati di s-triazina come agenti fotostabilizzanti |
DE19531084A1 (de) | 1995-08-24 | 1997-02-27 | Hoechst Schering Agrevo Gmbh | 2,4-Diamino-1,3,5-triazine, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
GB9519197D0 (en) * | 1995-09-20 | 1995-11-22 | Affinity Chromatography Ltd | Novel affinity ligands and their use |
US6117996A (en) * | 1995-09-20 | 2000-09-12 | Novo Nordisk A/S | Triazine based ligands and use thereof |
IT1283295B1 (it) | 1996-03-22 | 1998-04-16 | 3V Sigma Spa | Filtri solari |
US5801224A (en) * | 1996-04-26 | 1998-09-01 | Board Of Trustees Operating Michigan State University | Bulk reactive extrusion polymerization process producing aliphatic ester polymer compositions |
DE19641693A1 (de) * | 1996-10-10 | 1998-04-16 | Bayer Ag | Substituierte 2-Amino-4-alkylamino-1,3,5-triazine |
US5759525A (en) * | 1996-12-26 | 1998-06-02 | 3V Inc. | Concentrated solutions of a 1,3,5-triazine derivative sunscreen and their use for the preparation of cosmetic compositions |
GB9726695D0 (en) | 1997-12-17 | 1998-02-18 | Smithkline Beecham Plc | Novel compounds |
JPH11158073A (ja) * | 1997-09-26 | 1999-06-15 | Takeda Chem Ind Ltd | アデノシンa3拮抗剤 |
JP3518300B2 (ja) * | 1997-11-17 | 2004-04-12 | 東洋インキ製造株式会社 | 顔料分散剤、及びそれを含有する顔料組成物 |
US6123763A (en) * | 1997-12-22 | 2000-09-26 | Toyo Ink Mfg. Co., Ltd. | Pigment dispersing agent and pigment composition containing the same |
ATE239012T1 (de) | 1997-12-12 | 2003-05-15 | Abbott Lab | Triazin angiogenese-inhibitoren |
JP2002509140A (ja) | 1998-01-13 | 2002-03-26 | アナディーズ・ファーマスーティカルズ,インコーポレイテッド | トリアジン抗ウイルス化合物 |
EP0945447A1 (en) * | 1998-03-27 | 1999-09-29 | Janssen Pharmaceutica N.V. | Trisubstituted 1,3,5-triazine derivatives for treatment of HIV infections |
WO2000043369A1 (en) * | 1999-01-22 | 2000-07-27 | Elan Pharmaceuticals, Inc. | Compounds which inhibit leukocyte adhesion mediated by vla-4 |
US6262053B1 (en) * | 1999-06-23 | 2001-07-17 | Parker Hughes Institute | Melamine derivatives as potent anti-cancer agents |
DE60003583T2 (de) | 1999-11-29 | 2004-05-13 | Aventis Pharma S.A. | Arylaminderivate und ihre verwendung als antitelomerasemittel |
US6645964B1 (en) | 1999-11-29 | 2003-11-11 | Aventis Pharma S.A. | Chemical derivatives and their application as antitelomerase agent |
US20020065270A1 (en) * | 1999-12-28 | 2002-05-30 | Moriarty Kevin Joseph | N-heterocyclic inhibitors of TNF-alpha expression |
JP4794793B2 (ja) | 1999-12-28 | 2011-10-19 | ファーマコペイア, インコーポレイテッド | N−ヘテロ環TNF−α発現阻害剤 |
US6491617B1 (en) * | 1999-12-30 | 2002-12-10 | St. Jude Medical, Inc. | Medical devices that resist restenosis |
FR2819255B1 (fr) * | 2001-01-09 | 2003-02-28 | Aventis Pharma Sa | Derives chimiques et leur application comme agent antitelomerase |
CO5380035A1 (es) * | 2001-03-23 | 2004-03-31 | Aventis Pharma Sa | Derivados quimicos y su aplicacion como agente antitelomerasa |
US7112587B2 (en) * | 2001-09-21 | 2006-09-26 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
JP2005511509A (ja) | 2001-09-21 | 2005-04-28 | レディ ユーエス セラピューティクス インコーポレイテッド | 新規トリアジン化合物の方法および組成物 |
US7163943B2 (en) * | 2001-09-21 | 2007-01-16 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
US7173032B2 (en) * | 2001-09-21 | 2007-02-06 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
US7132423B2 (en) * | 2001-09-21 | 2006-11-07 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
US7169785B2 (en) * | 2001-09-21 | 2007-01-30 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
CN1625410A (zh) * | 2002-02-05 | 2005-06-08 | 山之内制药株式会社 | 2,4,6-三氨基-1,3,5-三嗪衍生物 |
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WO2004026844A1 (en) | 2004-04-01 |
US7173032B2 (en) | 2007-02-06 |
JP2006188533A (ja) | 2006-07-20 |
EP1560817A1 (en) | 2005-08-10 |
JP2006511476A (ja) | 2006-04-06 |
EP1560817A4 (en) | 2011-05-11 |
CA2499964A1 (en) | 2004-04-01 |
US20070099874A1 (en) | 2007-05-03 |
US20070043051A1 (en) | 2007-02-22 |
RU2005108351A (ru) | 2006-02-27 |
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