BR0311952A - Novos compostos úteis para o tratamento de obesidade, diabetes tipo ii e distúrbios do snc - Google Patents

Novos compostos úteis para o tratamento de obesidade, diabetes tipo ii e distúrbios do snc

Info

Publication number
BR0311952A
BR0311952A BR0311952-1A BR0311952A BR0311952A BR 0311952 A BR0311952 A BR 0311952A BR 0311952 A BR0311952 A BR 0311952A BR 0311952 A BR0311952 A BR 0311952A
Authority
BR
Brazil
Prior art keywords
diabetes
type
compounds useful
new compounds
treating obesity
Prior art date
Application number
BR0311952-1A
Other languages
English (en)
Inventor
Johansson
Gary
Jenmalm-Jensen
Annika
Beierlein
Katarina
Original Assignee
Biovitrum Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0201925A external-priority patent/SE0201925D0/xx
Priority claimed from SE0202181A external-priority patent/SE0202181D0/xx
Priority claimed from SE0202908A external-priority patent/SE0202908D0/xx
Priority claimed from SE0300357A external-priority patent/SE0300357D0/xx
Application filed by Biovitrum Ab filed Critical Biovitrum Ab
Publication of BR0311952A publication Critical patent/BR0311952A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"NOVOS COMPOSTOS úTEIS PARA O TRATAMENTO DE OBESIDADE, DIABETES TIPO II E DISTúRBIOS DO SNC". A presente invenção refere-se e compostos de fórmula geral (I) onde P é sulfona ou sulfonamida e A, B, W, X, Y e ^ R3^ são como definidos no relatório descritivo, a composições farmacêuticas compreendendo estes compostos, e ao uso dos compostos para a profilaxia e tratamento de condições médicas relativas à obesidade, diabetes do tipo II, e/ou distúrbios do SNC, para obter-se redução do peso corporal e do ganho de peso corporal.
BR0311952-1A 2002-06-20 2003-06-19 Novos compostos úteis para o tratamento de obesidade, diabetes tipo ii e distúrbios do snc BR0311952A (pt)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
SE0201925A SE0201925D0 (sv) 2002-06-20 2002-06-20 New compounds
SE0202181A SE0202181D0 (sv) 2002-07-11 2002-07-11 New compounds
US40612002P 2002-08-26 2002-08-26
SE0202908A SE0202908D0 (sv) 2002-10-01 2002-10-01 New compounds
US43401002P 2002-12-17 2002-12-17
SE0300357A SE0300357D0 (sv) 2003-02-10 2003-02-10 New compounds
US46470103P 2003-04-23 2003-04-23
PCT/SE2003/001061 WO2004000828A1 (en) 2002-06-20 2003-06-19 New compounds useful for the treatment of obesity, type ii diabetes and cns disorders

Publications (1)

Publication Number Publication Date
BR0311952A true BR0311952A (pt) 2005-04-19

Family

ID=30004107

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0311952-1A BR0311952A (pt) 2002-06-20 2003-06-19 Novos compostos úteis para o tratamento de obesidade, diabetes tipo ii e distúrbios do snc

Country Status (13)

Country Link
EP (1) EP1513828A1 (pt)
CN (1) CN1662521A (pt)
AU (1) AU2003243091A1 (pt)
BR (1) BR0311952A (pt)
CA (1) CA2486989A1 (pt)
EA (2) EA011581B1 (pt)
IL (1) IL165051A0 (pt)
MX (1) MXPA04012914A (pt)
NO (1) NO20050294L (pt)
NZ (3) NZ536600A (pt)
RS (1) RS111204A (pt)
SG (1) SG156524A1 (pt)
WO (1) WO2004000828A1 (pt)

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JP4455064B2 (ja) 2002-03-27 2010-04-21 グラクソ グループ リミテッド キノリン誘導体および５−ｈｔ６リガンドとしてのその使用
SE0301446D0 (sv) 2003-05-16 2003-05-16 Astrazeneca Ab New Compounds
TWI328009B (en) 2003-05-21 2010-08-01 Glaxo Group Ltd Quinoline derivatives as phosphodiesterase inhibitors
ATE313532T1 (de) 2003-07-22 2006-01-15 Arena Pharm Inc Diaryl- und arylheteroarylharnstoffderivate als modulatoren des 5-ht2a-serotoninrezeptors, die sich zur prophylaxe und behandlung von damit im zusammenhang stehenden erkrankungen eignen
SE0302760D0 (sv) * 2003-10-20 2003-10-20 Biovitrum Ab New compounds
SE0303480D0 (sv) 2003-12-19 2003-12-19 Biovitrum Ab Benzofuranes
KR20060127886A (ko) * 2003-12-19 2006-12-13 바이오비트럼 에이비 5-ｈｔ6 수용체-관련 장애의 예방 및 치료에 사용될 수있는, 신규한 벤조퓨란 유도체
GB0407025D0 (en) * 2004-03-29 2004-04-28 Glaxo Group Ltd Novel compounds
US7745436B2 (en) * 2004-04-13 2010-06-29 Synta Pharmaceuticals Corporation Disalt inhibitors of IL-12 production
WO2006062481A1 (en) * 2004-12-09 2006-06-15 Biovitrum Ab New benzofuran derivatives and their use in the treatment of obesity, type ii diabetes and cns disorders .
AR054044A1 (es) * 2005-05-23 2007-05-30 Astrazeneca Ab Derivados de cromano y tetrahidronaftaleno como moduladores del receptor 5 - ht6; intermediarios en su preparacion; composiciones farmaceuticas que los contienen y su empelo en la fabricacion de medicamentos para el tratamiento de enfermedades del snc y de la obesidad.
US7582767B2 (en) * 2005-06-17 2009-09-01 Biovitrum Ab (Publ.) Substituted sulphonamide compound and uses thereof
US20090221644A1 (en) * 2005-06-30 2009-09-03 Stuart Edward Bradley Gpcr Agonists
AU2006302179C1 (en) 2005-10-07 2013-06-20 Exelixis, Inc. N- (3-amino-quinoxalin-2-yl) -sulfonamide derivatives and their use as phosphatidylinositol 3-kinase inhibitors
BRPI0618206A2 (pt) 2005-11-03 2011-08-23 Hoffmann La Roche arilsulfonil cromanos como inibidores de 5-ht6, bem como composição farmacêutica, uso e processo para produção dos mesmos
AR058705A1 (es) 2005-12-23 2008-02-20 Astrazeneca Ab Compuestos de bencimidazol como inhibidores del receptor vaniloide 1 (vr1)
AU2007263084A1 (en) 2006-06-20 2007-12-27 F. Hoffmann-La Roche Ag Tetralin and indane derivatives and uses thereof
CA2654822A1 (en) 2006-06-20 2007-12-27 F. Hoffmann-La Roche Ag Arylsulfonyl naphthalene derivatives and uses thereof
EP2076489A1 (en) 2006-06-20 2009-07-08 F. Hoffmann-Roche AG Arylsulfonamidyl tetralin derivatives and uses thereof
TWI433839B (zh) 2006-08-11 2014-04-11 Neomed Inst 新穎的苯并咪唑衍生物290
WO2009074607A1 (en) 2007-12-12 2009-06-18 Glaxo Group Limited Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline
WO2009123714A2 (en) 2008-04-02 2009-10-08 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
US7888662B2 (en) 2008-06-20 2011-02-15 Varian Semiconductor Equipment Associates, Inc. Ion source cleaning method and apparatus
WO2010062321A1 (en) 2008-10-28 2010-06-03 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto
AR082889A1 (es) * 2011-05-09 2013-01-16 Forma Therapeutics Inc Compuestos y composiciones para la inhibicion de nampt
WO2015090233A1 (en) 2013-12-20 2015-06-25 Sunshine Lake Pharma Co., Ltd. Aromatic heterocyclic compounds and their application in pharmaceuticals
WO2016201373A1 (en) 2015-06-12 2016-12-15 Axovant Sciences Ltd. Diaryl and arylheteroaryl urea derivatives useful for the prophylaxis and treatment of rem sleep behavior disorder
CN108472285A (zh) 2015-07-15 2018-08-31 阿速万科学有限责任公司 用于预防和治疗与神经退行性疾病相关联的幻觉的二芳基和芳基杂芳基脲衍生物
US20190119236A1 (en) 2016-02-23 2019-04-25 Portola Pharmaceuticals, Inc. Compounds for binding proprotein convertase subtilisin/kexin type 9 (pcsk9)

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US4808595A (en) * 1986-12-24 1989-02-28 Merck & Co., Inc. Furopyridine sulfonamides and their opthalmological compositions
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AU1542201A (en) * 1999-11-05 2001-05-14 Nps Allelix Corp. Compounds having 5-HT6 receptor antagonist activity
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WO2001096336A2 (en) * 2000-06-14 2001-12-20 Warner-Lambert Company 6,5-fused bicyclic heterocycles
EA006132B1 (ru) * 2000-10-20 2005-10-27 Биовитрум Аб 2-, 3-, 4- или 5-замещенные n-(1-(арил-, гетероарил- или арилалкил)сульфонил)индолы и их применение в терапии
NZ528450A (en) * 2001-05-11 2006-02-24 Biovitrum Ab Novel, arylsulfonamide compounds for the treatment of obesity, type II diabetes and CNS-disorders
JP4187642B2 (ja) * 2001-06-07 2008-11-26 エフ．ホフマン−ラ ロシュ アーゲー ５−ｈｔ６受容体親和性を有する新規インドール誘導体
EA008476B1 (ru) * 2001-06-11 2007-06-29 Биовитрум Аб Замещенные сульфонамиды, способ их получения и их применение в качестве лечебного средства для лечения расстройств цнс, ожирения и диабета типа ii

Also Published As

Publication number Publication date
IL165051A0 (en) 2005-12-18
CN1662521A (zh) 2005-08-31
EP1513828A1 (en) 2005-03-16
EA008835B1 (ru) 2007-08-31
EA011581B1 (ru) 2009-04-28
MXPA04012914A (es) 2005-03-31
SG156524A1 (en) 2009-11-26
CA2486989A1 (en) 2003-12-31
WO2004000828A1 (en) 2003-12-31
NO20050294L (no) 2005-02-04
NZ536600A (en) 2007-08-31
AU2003243091A1 (en) 2004-01-06
RS111204A (en) 2006-12-15
NZ552282A (en) 2008-07-31
EA200600975A1 (ru) 2006-10-27
EA200500054A1 (ru) 2005-06-30
NZ552283A (en) 2008-07-31

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: BIOVITRUM AB (PUBL) (SE)

Free format text: ALTERADO DE: BIOVITRUM AB

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA INT.CL: C07D 207/12, C07D 211/40, C07D 211/46, C07D 215/46, C07D 217/22, C07D 401/04, C07D 406/12, C07D 471/04, C07D 495/04, A61K 31/40, A61K 31/4025, A61K 31/4353, A61K 31/4465, A61K 31/4523, A61K 31/496, A61K 31/551, A61P 25/00, A61P 3/04, A61P 3/10, A61P 3/00, A61P 43/00

Ipc: C07D 401/04 (2011.01), C07D 495/04 (2011.01), C07D

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 8A. ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE A 8A ANUIDADE.