BR0309743A - Processo para a preparação de gama-butirolactamas e gama-aminoácidos altamente funcionalizados - Google Patents
Processo para a preparação de gama-butirolactamas e gama-aminoácidos altamente funcionalizadosInfo
- Publication number
- BR0309743A BR0309743A BR0309743-9A BR0309743A BR0309743A BR 0309743 A BR0309743 A BR 0309743A BR 0309743 A BR0309743 A BR 0309743A BR 0309743 A BR0309743 A BR 0309743A
- Authority
- BR
- Brazil
- Prior art keywords
- gamma
- butyrolactams
- preparation
- amino acids
- highly functionalized
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/18—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
"PROCESSO PARA A PREPARAçãO DE GAMA-BUTIROLACTAMAS E GAMA-AMINOáCIDOS ALTAMENTE FUNCIONALIZADOS". A presente invenção refere-se a um processo para a preparação de <sym>-butirolactamas e <sym>-aminoácidos altamente funcionalizados por aminação redutiva de ácido muco-hálico ou dos seus derivados, e descreve um processo para a preparação de pregabalina ou ácido 3-aminometil-5-metil-octanóico, análogos de GABA com atividade medicinal desejável (Fórmula I).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37699102P | 2002-04-30 | 2002-04-30 | |
PCT/IB2003/001646 WO2003093220A1 (en) | 2002-04-30 | 2003-04-17 | Process for preparing highly functionalized y-butyrolactams and y-amino acids |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0309743A true BR0309743A (pt) | 2005-02-09 |
Family
ID=29401429
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0309743-9A BR0309743A (pt) | 2002-04-30 | 2003-04-17 | Processo para a preparação de gama-butirolactamas e gama-aminoácidos altamente funcionalizados |
Country Status (15)
Country | Link |
---|---|
US (2) | US20030225149A1 (pt) |
EP (1) | EP1499583A1 (pt) |
JP (1) | JP2005523932A (pt) |
KR (1) | KR20040106415A (pt) |
CN (1) | CN1649827A (pt) |
AR (1) | AR039467A1 (pt) |
AU (1) | AU2003219425A1 (pt) |
BR (1) | BR0309743A (pt) |
CA (1) | CA2483830A1 (pt) |
IL (1) | IL164781A0 (pt) |
MX (1) | MXPA04010771A (pt) |
PL (1) | PL373296A1 (pt) |
RU (1) | RU2004131840A (pt) |
TW (1) | TW200400929A (pt) |
WO (1) | WO2003093220A1 (pt) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0934061T6 (en) | 1996-07-24 | 2015-01-26 | Warner Lambert Co | Isobutylgaba and its derivatives for the treatment of pain |
AU2005256945B2 (en) * | 2004-06-21 | 2008-11-13 | Upjohn Us 1 Llc | Preparation of pregabalin and related compounds |
SI1773902T1 (en) * | 2004-08-04 | 2018-04-30 | Foam Supplies, Inc. | Residue of reactivity and degradation of the catalyst in the polyurethane foam |
WO2006108151A1 (en) * | 2005-04-06 | 2006-10-12 | Teva Pharmaceutical Industries Ltd. | Crystalline forms of pregabalin |
US7488846B2 (en) * | 2005-04-11 | 2009-02-10 | Teva Pharmaceuical Industries Ltd. | Pregabalin free of lactam and a process for preparation thereof |
US20070066846A1 (en) * | 2005-04-11 | 2007-03-22 | Asher Maymon | Process for making (S)-Pregabalin |
MX2007000525A (es) * | 2005-05-10 | 2007-03-28 | Teva Pharma | Pregabalina libre de acido isobutilglutarico y un proceso para la preparacion de ella. |
KR20090019016A (ko) * | 2005-05-10 | 2009-02-24 | 테바 파마슈티컬 인더스트리즈 리미티드 | 3-카르바모일메틸-5-메틸 헥산산의 광학 분할 |
WO2006122258A1 (en) * | 2005-05-10 | 2006-11-16 | Teva Pharmaceutical Industries Ltd. | Method for the preparation of pregabalin and salts thereof |
CZ297970B6 (cs) * | 2005-08-10 | 2007-05-09 | Zentiva, A. S | Zpusob výroby (S)-3-(aminomethyl)-5-methyl-hexanové kyseliny (pregabalinu) |
US7446220B2 (en) * | 2005-09-19 | 2008-11-04 | Teva Pharmaceutical Industries Ltd. | Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid |
US20070259917A1 (en) * | 2006-04-24 | 2007-11-08 | Kansal Vinod K | Processes for the synthesis of 3-isobutylglutaric acid |
WO2007139933A2 (en) * | 2006-05-24 | 2007-12-06 | Teva Pharmaceutical Industries Ltd. | Processes for the preparation of r-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof |
EP2071032A3 (en) * | 2006-05-31 | 2009-07-08 | Teva Pharmaceutical Industries Ltd | The use of enzymatic resolution for the preparation of intermediates of pregabalin |
EP1912931A2 (en) * | 2006-05-31 | 2008-04-23 | Teva Pharmaceutical Industries Ltd. | Preparation of (s)-pregabalin-nitrile |
KR101036536B1 (ko) * | 2007-03-22 | 2011-05-24 | 테바 파마슈티컬 인더스트리즈 리미티드 | (s)-(+)-3-(아미노메틸)-5-메틸 헥산산의 합성 |
WO2008127646A2 (en) * | 2007-04-11 | 2008-10-23 | Dsm Ip Assets B.V. | Transaminase-based processes for preparation of pregabalin |
CN101688021B (zh) * | 2007-06-05 | 2013-01-02 | 阿克佐诺贝尔涂料责任有限公司 | 衍生自环氧化植物油的可辐射固化涂料组合物 |
US20090137842A1 (en) * | 2007-10-03 | 2009-05-28 | Vollerner Yuri | Pregabalin -4-eliminate, pregabalin 5-eliminate, their use as reference marker and standard, and method to produce pregabalin containing low levels thereof |
WO2009081208A1 (en) * | 2007-12-26 | 2009-07-02 | Generics [Uk] Limited | Processes to pregabalin |
SG176464A1 (en) | 2008-05-09 | 2011-12-29 | Agency Science Tech & Res | Diagnosis and treatment of kawasaki disease |
EP2297090A1 (en) * | 2008-06-23 | 2011-03-23 | Teva Pharmaceutical Industries Ltd. | Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester |
AU2010220406C1 (en) | 2009-03-05 | 2016-07-21 | Akzo Nobel Coatings International B.V. | Hydroxyl functional oil polyols and coating compositions prepared from hydroxyl functional oil polyols |
WO2011086565A1 (en) * | 2010-01-15 | 2011-07-21 | Lupin Limited | Method for preparation of enantiomerically enriched and/or racemic gamma-amino acids |
KR101963671B1 (ko) | 2010-12-28 | 2019-03-29 | 아크조노벨코팅스인터내셔널비.브이. | 금속에 사용하기 위한 방사선 경화성 코팅 조성물 |
GB201121317D0 (en) | 2011-12-09 | 2012-01-25 | Syngenta Ltd | Herbicidal compounds |
RU2605418C2 (ru) | 2011-12-21 | 2016-12-20 | Акцо Нобель Коатингс Интернэшнл Б.В. | Покрывные композиции на основе растворителей |
ES2629692T3 (es) | 2011-12-21 | 2017-08-14 | Akzo Nobel Coatings International B.V. | Composiciones de revestimiento basadas en agua |
CN105051022B (zh) * | 2013-03-27 | 2017-10-27 | 辉瑞爱尔兰制药公司 | 用于制备普瑞巴林的方法和中间体 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3935210A (en) | 1971-07-29 | 1976-01-27 | Sandoz, Inc. | Preparation of 1-aryl-4,5-dihalo-pyridazone-6 |
RU2140901C1 (ru) * | 1992-05-20 | 1999-11-10 | Нортвестерн Юниверсити | АНАЛОГИ γ-АМИНОМАСЛЯНОЙ КИСЛОТЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ, СПОСОБ ЛЕЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ |
DZ2770A1 (fr) | 1998-04-17 | 2003-12-01 | Lilly Co Eli | Procédé de préparation de 1h-indol-3 glyoxamides substituées en position 4. |
KR20010071778A (ko) | 1998-07-09 | 2001-07-31 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | 불면증의 치료를 위한 gaba 유사체의 용도 |
CZ300834B6 (cs) * | 1999-06-10 | 2009-08-19 | Warner-Lambert Company Llc | Mono- a disubstituované kyseliny 3-propyl-gamma-aminomáselné |
-
2003
- 2003-02-13 US US10/365,430 patent/US20030225149A1/en not_active Abandoned
- 2003-04-17 BR BR0309743-9A patent/BR0309743A/pt not_active IP Right Cessation
- 2003-04-17 KR KR10-2004-7017412A patent/KR20040106415A/ko not_active Application Discontinuation
- 2003-04-17 JP JP2004501360A patent/JP2005523932A/ja not_active Withdrawn
- 2003-04-17 RU RU2004131840/04A patent/RU2004131840A/ru not_active Application Discontinuation
- 2003-04-17 WO PCT/IB2003/001646 patent/WO2003093220A1/en not_active Application Discontinuation
- 2003-04-17 CN CNA038096412A patent/CN1649827A/zh active Pending
- 2003-04-17 AU AU2003219425A patent/AU2003219425A1/en not_active Abandoned
- 2003-04-17 EP EP03715236A patent/EP1499583A1/en not_active Withdrawn
- 2003-04-17 CA CA002483830A patent/CA2483830A1/en not_active Abandoned
- 2003-04-17 MX MXPA04010771A patent/MXPA04010771A/es not_active Application Discontinuation
- 2003-04-17 PL PL03373296A patent/PL373296A1/xx not_active Application Discontinuation
- 2003-04-23 US US10/421,350 patent/US6924377B2/en not_active Expired - Fee Related
- 2003-04-28 AR ARP030101461A patent/AR039467A1/es unknown
- 2003-04-29 TW TW092110024A patent/TW200400929A/zh unknown
-
2004
- 2004-10-21 IL IL16478104A patent/IL164781A0/xx unknown
Also Published As
Publication number | Publication date |
---|---|
AU2003219425A1 (en) | 2003-11-17 |
EP1499583A1 (en) | 2005-01-26 |
US6924377B2 (en) | 2005-08-02 |
JP2005523932A (ja) | 2005-08-11 |
US20030225149A1 (en) | 2003-12-04 |
CA2483830A1 (en) | 2003-11-13 |
US20030236415A1 (en) | 2003-12-25 |
PL373296A1 (en) | 2005-08-22 |
KR20040106415A (ko) | 2004-12-17 |
CN1649827A (zh) | 2005-08-03 |
TW200400929A (en) | 2004-01-16 |
IL164781A0 (en) | 2005-12-18 |
RU2004131840A (ru) | 2005-05-27 |
AR039467A1 (es) | 2005-02-23 |
WO2003093220A1 (en) | 2003-11-13 |
MXPA04010771A (es) | 2005-03-07 |
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Legal Events
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A E 7A ANUIDADES. |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2051 DE 27/04/2010. |
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B08J | Incorrect entry in the gazette republished [chapter 8.10 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 2105 DE 10/05/2011. TEXTO CORRETO: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2055 DE 25/05/2010. |