BR0308441A - Proteìna variante de p4 de haemophilus influenzae não tipificável, composição imunogênica, molécula de nucleotìdeo isolada, célula hospedeira, e, métodos para induzir uma resposta imune em um ser humano contra h. influenzae não tipificável, e para produzir uma proteìna variante de p4 - Google Patents
Proteìna variante de p4 de haemophilus influenzae não tipificável, composição imunogênica, molécula de nucleotìdeo isolada, célula hospedeira, e, métodos para induzir uma resposta imune em um ser humano contra h. influenzae não tipificável, e para produzir uma proteìna variante de p4Info
- Publication number
- BR0308441A BR0308441A BR0308441-8A BR0308441A BR0308441A BR 0308441 A BR0308441 A BR 0308441A BR 0308441 A BR0308441 A BR 0308441A BR 0308441 A BR0308441 A BR 0308441A
- Authority
- BR
- Brazil
- Prior art keywords
- variant protein
- influenzae
- methods
- immunogenic composition
- typifiable
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 6
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 title abstract 4
- 230000002163 immunogen Effects 0.000 title abstract 3
- 241000606768 Haemophilus influenzae Species 0.000 title abstract 2
- 239000002773 nucleotide Substances 0.000 title abstract 2
- 229940047650 haemophilus influenzae Drugs 0.000 title 1
- 230000028993 immune response Effects 0.000 title 1
- 230000001939 inductive effect Effects 0.000 title 1
- 125000003729 nucleotide group Chemical group 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 241000606790 Haemophilus Species 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003380 propellant Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1242—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Pulmonology (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
"PROTEìNA VARIANTE DE P4 DE HAEMOPHILUS INFLUENZAE NãO TIPIFICáVEL, COMPOSIçãO IMUNOGêNICA, MOLéCULA DE NUCLEOTìDEO ISOLADA , CéLULA HOSPEDEIRA, E, MéTODOS PARA INDUZIR UMA RESPOSTA IMUNE EM UM SER HUMANO CONTRA H. INFLUENZAE NãO TIPIFICáVEL, E PAPA PRODUZIR UMA PROTEìNA VARIANTE DE P4". Uma proteina variante P4 que tem atividade enzimática reduzida e que induz anticorpo à proteina P4 do tipo selvagem e/ou tem boa atividade bacteriana contra H. influenzae não tipificável, é útil como um componente ativo em uma composição imunogênica para seres humanos. Os métodos de uso destas proteinas, e as composições contendo-as em combinação com antígenos adicionais, também são fornecidas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36468802P | 2002-03-15 | 2002-03-15 | |
PCT/US2003/007895 WO2003078453A1 (en) | 2002-03-15 | 2003-03-13 | Mutants of the p4 protein of nontypable haemophilus influenzae with reduced enzymatic activity |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0308441A true BR0308441A (pt) | 2005-01-18 |
Family
ID=28041949
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0308441-8A BR0308441A (pt) | 2002-03-15 | 2003-03-13 | Proteìna variante de p4 de haemophilus influenzae não tipificável, composição imunogênica, molécula de nucleotìdeo isolada, célula hospedeira, e, métodos para induzir uma resposta imune em um ser humano contra h. influenzae não tipificável, e para produzir uma proteìna variante de p4 |
Country Status (12)
Country | Link |
---|---|
US (2) | US7615229B2 (pt) |
EP (1) | EP1490395A4 (pt) |
JP (1) | JP2005532789A (pt) |
KR (1) | KR100981471B1 (pt) |
CN (1) | CN100593544C (pt) |
AU (1) | AU2003218162B2 (pt) |
BR (1) | BR0308441A (pt) |
CA (1) | CA2479118A1 (pt) |
IL (1) | IL163988A0 (pt) |
MX (1) | MXPA04008890A (pt) |
NZ (1) | NZ535754A (pt) |
WO (1) | WO2003078453A1 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2342890T3 (es) | 2003-12-23 | 2010-07-16 | Nationwide Children's Hospital, Inc. | Pili de tipo iv de la haemophilus influenzae. |
AU2012203017B2 (en) * | 2003-12-23 | 2014-10-09 | Nationwide Children's Hospital, Inc. | Haemophilus Influenzae Type IV Pili |
CN102716480B (zh) | 2005-04-08 | 2023-03-21 | 惠氏有限责任公司 | 多价肺炎球菌多糖-蛋白质缀合物组合物 |
US7709001B2 (en) | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
KR101408113B1 (ko) | 2005-06-27 | 2014-06-16 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 백신 제조 방법 |
JP4996934B2 (ja) * | 2007-02-05 | 2012-08-08 | 独立行政法人農業・食品産業技術総合研究機構 | 組換え型リゾチームの製造法 |
BR112013029024A2 (pt) * | 2011-05-11 | 2017-10-31 | Riesbeck Healthcare Sweden Ab | proteína f - uma nova adesina de haemophilus influenzae com propriedades de ligação à laminina e vitronectina |
CN113226361A (zh) * | 2018-10-15 | 2021-08-06 | 代表亚利桑那大学的亚利桑那校董会 | 疫苗多肽组合物及方法 |
WO2022056195A1 (en) * | 2020-09-10 | 2022-03-17 | The Rochester General Hospital | Haemophilus infuluenzae vaccine and methods of use |
Family Cites Families (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US518540A (en) * | 1894-04-17 | Electric-railway conduit | ||
US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
US4518526A (en) | 1982-12-22 | 1985-05-21 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4599197A (en) | 1982-12-22 | 1986-07-08 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4542104A (en) | 1983-04-06 | 1985-09-17 | The Board Of Trustees Of The Leland Stanford Jr. Univ. | Phycobiliprotein fluorescent conjugates |
US5078996A (en) | 1985-08-16 | 1992-01-07 | Immunex Corporation | Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor |
US4777127A (en) | 1985-09-30 | 1988-10-11 | Labsystems Oy | Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus |
US5091309A (en) | 1986-01-16 | 1992-02-25 | Washington University | Sindbis virus vectors |
US4734362A (en) | 1986-02-03 | 1988-03-29 | Cambridge Bioscience Corporation | Process for purifying recombinant proteins, and products thereof |
GB8702816D0 (en) | 1987-02-07 | 1987-03-11 | Al Sumidaie A M K | Obtaining retrovirus-containing fraction |
US5219740A (en) | 1987-02-13 | 1993-06-15 | Fred Hutchinson Cancer Research Center | Retroviral gene transfer into diploid fibroblasts for gene therapy |
US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
US5662896A (en) | 1988-03-21 | 1997-09-02 | Chiron Viagene, Inc. | Compositions and methods for cancer immunotherapy |
AP129A (en) | 1988-06-03 | 1991-04-17 | Smithkline Biologicals S A | Expression of retrovirus gag protein eukaryotic cells |
US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
US5217879A (en) | 1989-01-12 | 1993-06-08 | Washington University | Infectious Sindbis virus vectors |
JP2752788B2 (ja) | 1989-01-23 | 1998-05-18 | カイロン コーポレイション | 感染および過剰増殖障害の為の組換え療法 |
WO1990010458A1 (en) | 1989-03-09 | 1990-09-20 | Praxis Biologics, Inc. | Vaccines for nontypable haemophilus influenzae |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
US5185440A (en) | 1989-06-20 | 1993-02-09 | North Carolina State University | cDNA clone coding for Venezuelan equine encephalitis virus and attenuating mutations thereof |
EP0487587A1 (en) | 1989-08-18 | 1992-06-03 | Chiron Corporation | Recombinant retroviruses delivering vector constructs to target cells |
US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
GB8919607D0 (en) | 1989-08-30 | 1989-10-11 | Wellcome Found | Novel entities for cancer therapy |
US5272257A (en) | 1990-05-21 | 1993-12-21 | Coulter Corporation | Method of preferential labelling of a phycobiliprotein with an amine-reactive dye for use in a multiple color assay and product for such use |
SE9003978D0 (sv) | 1990-12-13 | 1990-12-13 | Henrik Garoff | Dna expressionssystem baserade paa ett virus replikon |
IL101715A (en) | 1991-05-02 | 2005-06-19 | Amgen Inc | Recombinant dna-derived cholera toxin subunit analogs |
CA2115742A1 (en) | 1991-08-20 | 1993-03-04 | Ronald G. Crystal | Adenovirus mediated transfer of genes to the gastrointestinal tract |
US5252479A (en) | 1991-11-08 | 1993-10-12 | Research Corporation Technologies, Inc. | Safe vector for gene therapy |
WO1993010218A1 (en) | 1991-11-14 | 1993-05-27 | The United States Government As Represented By The Secretary Of The Department Of Health And Human Services | Vectors including foreign genes and negative selective markers |
GB9125623D0 (en) | 1991-12-02 | 1992-01-29 | Dynal As | Cell modification |
IT1253009B (it) | 1991-12-31 | 1995-07-10 | Sclavo Ricerca S R L | Mutanti immunogenici detossificati della tossina colerica e della tossina lt, loro preparazione ed uso per la preparazione di vaccini |
FR2688514A1 (fr) | 1992-03-16 | 1993-09-17 | Centre Nat Rech Scient | Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant. |
EP0650370A4 (en) | 1992-06-08 | 1995-11-22 | Univ California | METHODS AND COMPOSITIONS TARGETED ON SPECIFIC TISSUES. |
EP0644946A4 (en) | 1992-06-10 | 1997-03-12 | Us Health | VECTOR PARTICLES RESISTANT TO HUMAN SERUM INACTIVATION. |
GB2269175A (en) | 1992-07-31 | 1994-02-02 | Imperial College | Retroviral vectors |
AU680459B2 (en) | 1992-12-03 | 1997-07-31 | Genzyme Corporation | Gene therapy for cystic fibrosis |
WO1994016737A1 (en) | 1993-01-26 | 1994-08-04 | Weiner David B | Compositions and methods for delivery of genetic material |
US5593972A (en) | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
JP3532566B2 (ja) | 1993-06-24 | 2004-05-31 | エル. グラハム,フランク | 遺伝子治療のためのアデノウイルスベクター |
WO1995007994A2 (en) | 1993-09-15 | 1995-03-23 | Viagene, Inc. | Recombinant alphavirus vectors |
DE69434594T2 (de) | 1993-10-25 | 2006-09-21 | Canji, Inc., San Diego | Rekombinante adenoviren-vektor und verfahren zur verwendung |
SE9401091D0 (sv) | 1994-03-31 | 1994-03-31 | Bioption Ab | Alphavirus cDNA vectors |
GB9406498D0 (en) | 1994-03-31 | 1994-05-25 | Smithkline Beecham Biolog | Novel compounds |
US5739118A (en) | 1994-04-01 | 1998-04-14 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
US5571515A (en) | 1994-04-18 | 1996-11-05 | The Wistar Institute Of Anatomy & Biology | Compositions and methods for use of IL-12 as an adjuvant |
US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US5837533A (en) | 1994-09-28 | 1998-11-17 | American Home Products Corporation | Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent |
US5698202A (en) | 1995-06-05 | 1997-12-16 | The Wistar Institute Of Anatomy & Biology | Replication-defective adenovirus human type 5 recombinant as a rabies vaccine carrier |
US6168918B1 (en) | 1996-01-31 | 2001-01-02 | American Home Products Corp. | Method of detecting foreign DNA integrated in eukaryotic chromosomes |
WO1998010087A1 (en) | 1996-09-06 | 1998-03-12 | Trustees Of The University Of Pennsylvania | Chimpanzee adenovirus vectors |
JP2001500015A (ja) | 1996-09-06 | 2001-01-09 | トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | T7ポリメラーゼを利用する組換えアデノ随伴ウイルスの誘導可能な製造方法 |
US6113918A (en) | 1997-05-08 | 2000-09-05 | Ribi Immunochem Research, Inc. | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
AU745805B2 (en) | 1997-10-28 | 2002-04-11 | Wyeth | Compositions and methods for delivery of genetic material |
DE69925113T2 (de) | 1998-03-13 | 2006-01-19 | Wyeth | Polynukleotidzusammensetzung, verfahren zu deren herstellung und verwendung |
DK1117435T3 (da) | 1998-09-30 | 2008-03-17 | Wyeth Corp | Muteret cholera-holotoxin som adjuvans |
AU768729B2 (en) | 1998-11-05 | 2004-01-08 | Trustees Of The University Of Pennsylvania, The | Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same |
EP1165842A4 (en) | 1999-03-16 | 2004-07-07 | Dana Farber Cancer Inst Inc | LENTIVIRAL VECTOR SYSTEMS FOR SCREENING LARGE QUANTITIES |
AU2001255575B2 (en) | 2000-04-28 | 2006-08-31 | The Trustees Of The University Of Pennsylvania | Recombinant aav vectors with aav5 capsids and aav5 vectors pseudotyped in heterologous capsids |
-
2003
- 2003-03-13 JP JP2003576457A patent/JP2005532789A/ja active Pending
- 2003-03-13 WO PCT/US2003/007895 patent/WO2003078453A1/en active Application Filing
- 2003-03-13 MX MXPA04008890A patent/MXPA04008890A/es active IP Right Grant
- 2003-03-13 US US10/507,786 patent/US7615229B2/en not_active Expired - Fee Related
- 2003-03-13 EP EP03714153A patent/EP1490395A4/en not_active Withdrawn
- 2003-03-13 BR BR0308441-8A patent/BR0308441A/pt not_active Application Discontinuation
- 2003-03-13 CA CA002479118A patent/CA2479118A1/en not_active Abandoned
- 2003-03-13 IL IL16398803A patent/IL163988A0/xx unknown
- 2003-03-13 CN CN03809166A patent/CN100593544C/zh not_active Expired - Fee Related
- 2003-03-13 NZ NZ535754A patent/NZ535754A/en not_active IP Right Cessation
- 2003-03-13 KR KR1020047014502A patent/KR100981471B1/ko not_active IP Right Cessation
- 2003-03-13 AU AU2003218162A patent/AU2003218162B2/en not_active Ceased
-
2008
- 2008-12-17 US US12/336,995 patent/US7666626B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US7615229B2 (en) | 2009-11-10 |
US20090148465A1 (en) | 2009-06-11 |
MXPA04008890A (es) | 2005-10-18 |
US20050249746A1 (en) | 2005-11-10 |
AU2003218162A1 (en) | 2003-09-29 |
KR20050016307A (ko) | 2005-02-21 |
US7666626B2 (en) | 2010-02-23 |
JP2005532789A (ja) | 2005-11-04 |
WO2003078453A1 (en) | 2003-09-25 |
EP1490395A1 (en) | 2004-12-29 |
EP1490395A4 (en) | 2006-06-21 |
IL163988A0 (en) | 2005-12-18 |
CA2479118A1 (en) | 2003-09-25 |
KR100981471B1 (ko) | 2010-09-10 |
NZ535754A (en) | 2007-01-26 |
AU2003218162B2 (en) | 2009-10-29 |
CN100593544C (zh) | 2010-03-10 |
CN1653084A (zh) | 2005-08-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0208874A (pt) | Proteìnas superficiais de streptococcus pyogenes | |
Mitchelhill et al. | Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase. | |
BR9712518A (pt) | Polipeptìdeo, molécula de dna, vetor de expressão, célula hospedeira, composição farmacêutica, vacina, proteìna de fusão, processo para detectar tuberculose em um paciente, e, kit diagnóstico | |
BR0015137A (pt) | Peptìdeos antigênicos de neisseria | |
ATE522541T1 (de) | Bakterielle adhäsine konformere | |
FR13C0040I2 (fr) | Vaccins polypeptidiques offrant une large protection contre des lignees de meningocoques hypervirulentes | |
TR200000115T2 (tr) | Tüberkülozun immünoterapi ve teşhisi için bileşikler ve bu bileşiklerin kullanımı için yöntemler. | |
DK1317537T3 (da) | Sammensætninger og fremgangsmåder med G-CSF analoger | |
BRPI0511118A (pt) | polipeptìdeos de haemophilus influenzae não transcritos | |
BRPI0410884A (pt) | composição de ração para uso em um animal de estimação, e, método para o controle de peso em um animal de estimação | |
BR0308441A (pt) | Proteìna variante de p4 de haemophilus influenzae não tipificável, composição imunogênica, molécula de nucleotìdeo isolada, célula hospedeira, e, métodos para induzir uma resposta imune em um ser humano contra h. influenzae não tipificável, e para produzir uma proteìna variante de p4 | |
BRPI0500311A (pt) | processo de preparação de uma composição de tratamento cosmético das matérias queratìnicas, composição de tratamento cosmético das matérias queratìnicas, processos de tratamento cosmético das matérias queratìnicas, dispositivo de condicionamento de uma composição cosmética e uso de uma composição | |
BR0114105A (pt) | Bactérias de acido lático capazes de reduzir uma tendência do indivìduo para desenvolver reações alérgicas | |
BR0314373A (pt) | Produto imunogênico estável para a indução de anticorpos contra uma ou várias proteìnas antigênicas em um indivìduo, composições farmacêutica, imunogênica e de vacina e processo de preparação de um produto imunogênico | |
DE69808743T2 (de) | Netrinrezeptoren | |
BRPI0407533A (pt) | proteìnas de fusão e muteìnas do interferon alfa com propriedades melhoradas | |
BR0208041A (pt) | Interferon beta modificado com imunogenicidade reduzida | |
BR9506272B8 (pt) | PROTEÍNA MUTANTE ISOLADA E PURIFICADA Hin47 DE Haemophilus influenzae, MOLÉCULA QUIMÉRICA, MOLÉCULA DE ÁCIDO NUCLÉICO, PLASMÍDEO RECOMBINANTE, CÉLULA E. coli TRANSFORMADA, COMPOSIÇÃO IMUNOGÊNICA, PROCESSO PARA DETERMINAR A PRESENÇA DE ANTICORPOS, ESPECIFICAMENTE REATIVOS COM A PROTEÍNA Hin47 NUMA AMOSTRA, PROCESSO PARA DETERMINAR A PRESENÇA DE PROTEÍNA Hin47 NUMA AMOSTRA E KIT DE DIAGNÓSTICO PARA DETERMINAR A PRESENÇA DE ANTICORPOS NUMA AMOSTRA ESPECIFICAMENTE REATIVA COM A PROTEÍNA Hin47. | |
DE60137347D1 (de) | Neuer immunogener komplex | |
BR9909097A (pt) | Molécula hìbrida de ácido nucleico, vetor de expressão, processos para preparação e para a produção de proteìna psaa lipidada recombinante, proteìna psaa lipidada isolada e purificada produzida recombinantemente, composição imunológica, processos para induzir uma resposta imunológica em um animal e para imunizar um hospedeiro contra infecção pneumocócica, e, composição imunogênica para administração intranasal a um hospedeiro | |
BRPI0706532A8 (pt) | mutantes de micobactéria seca2 | |
DK1276763T3 (da) | Anti-fryseproteiner, deres fremstilling og anvendelse | |
BR0302496A (pt) | Composições farmacêuticas com atividade antibiótica | |
BR0207014A (pt) | Antagonista de receptor de interleucina-1 modificada (il-1ra) com imunogenicidade reduzida. | |
TR200101141T2 (tr) | Antitümör etkiyi haiz antijenik proteini şifreleyen bir DNA'ya mahsus parçalar ihtiva eden farmasötik bileşim |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
B11T | Dismissal of application maintained [chapter 11.20 patent gazette] |