BR0306208A - Compostos de dibenzilamina e seu uso farmacêutico - Google Patents

Compostos de dibenzilamina e seu uso farmacêutico

Info

Publication number
BR0306208A
BR0306208A BR0306208-2A BR0306208A BR0306208A BR 0306208 A BR0306208 A BR 0306208A BR 0306208 A BR0306208 A BR 0306208A BR 0306208 A BR0306208 A BR 0306208A
Authority
BR
Brazil
Prior art keywords
dibenzylamine
pharmaceutical use
alkyl group
hydrogen atom
compounds
Prior art date
Application number
BR0306208-2A
Other languages
English (en)
Inventor
Kimiya Maeda
Hironobu Nagamori
Hiroshi Nakamura
Hisashi Shinkai
Yasunori Suzuki
Daisuke Takahashi
Toshio Taniguchi
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of BR0306208A publication Critical patent/BR0306208A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C07D257/06—Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/48—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Abstract

"COMPOSTOS DE DIBENZILAMINA E SEU USO FARMACêUTICO". Um composto de dibenzilamina representado pela fórmula (1) em que R^ 1^ e R^ 2^ são, cada um, um grupo C~ 1-6~ alquila opcionalmente substituído por átomos de halógeno e outros; R^ 3^, R^ 4^ e R^ 5^ são cada um átomo de hidrogênio, um átomo de halógeno e outros, ou R^ 3^ e R^ 4^ podem formar, juntos com os átomos de carbono ligados a eles, um anel homocíclico ou heterocíclico opcionalmente tendo substituinte(s); A é -N(R^ 7^)(R^ 8^) e outros; anel B é um grupo arila ou um resíduo heterocíclico; R^ 6^ é um átomo de hidrogênio, um átomo de halógeno, um grupo nitro, um grupo C~ 1-6~ alquila e outros; n é um número inteiro de 1 a 3, um pró-medicamento deste e um sal farmaceuticamente aceitável deste apresentam atividade inibidora de CETP seletiva e potente, e, portanto, eles podem ser fornecidos como agentes terapêuticos ou profilácticos para hiperlipidemia ou arteriosclerose e outros.
BR0306208-2A 2002-08-30 2003-08-29 Compostos de dibenzilamina e seu uso farmacêutico BR0306208A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2002255604 2002-08-30
JP2003107161 2003-04-10
PCT/JP2003/011041 WO2004020393A1 (ja) 2002-08-30 2003-08-29 ジベンジルアミン化合物及びその医薬用途

Publications (1)

Publication Number Publication Date
BR0306208A true BR0306208A (pt) 2004-10-13

Family

ID=31980551

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0306208-2A BR0306208A (pt) 2002-08-30 2003-08-29 Compostos de dibenzilamina e seu uso farmacêutico

Country Status (25)

Country Link
US (2) US7332514B2 (pt)
EP (2) EP1829858A3 (pt)
KR (1) KR100634195B1 (pt)
CN (1) CN1289467C (pt)
AT (1) ATE353870T1 (pt)
AU (1) AU2003261826B2 (pt)
BR (1) BR0306208A (pt)
CA (1) CA2464846C (pt)
CY (1) CY1106425T1 (pt)
CZ (1) CZ2004627A3 (pt)
DE (1) DE60311821T2 (pt)
DK (1) DK1533292T3 (pt)
ES (1) ES2277142T3 (pt)
HK (1) HK1077567A1 (pt)
IL (2) IL161559A0 (pt)
MX (1) MXPA04005350A (pt)
NO (1) NO328886B1 (pt)
NZ (1) NZ532494A (pt)
PT (1) PT1533292E (pt)
RU (1) RU2293078C2 (pt)
SI (1) SI1533292T1 (pt)
SK (1) SK2332004A3 (pt)
TR (1) TR200401413T1 (pt)
WO (1) WO2004020393A1 (pt)
ZA (1) ZA200403137B (pt)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060293266A1 (en) * 2000-05-10 2006-12-28 The Trustees Of Columbia Phosphodiesterase 4D in the ryanodine receptor complex protects against heart failure
US7393652B2 (en) * 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
US8022058B2 (en) 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US20040229781A1 (en) * 2000-05-10 2004-11-18 Marks Andrew Robert Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias
US20040048780A1 (en) * 2000-05-10 2004-03-11 The Trustees Of Columbia University In The City Of New York Method for treating and preventing cardiac arrhythmia
US6489125B1 (en) * 2000-05-10 2002-12-03 The Trustees Of Columbia University In The City Of New York Methods for identifying chemical compounds that inhibit dissociation of FKBP12.6 binding protein from type 2 ryanodine receptor
US7718644B2 (en) * 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US7879840B2 (en) * 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
ATE353870T1 (de) * 2002-08-30 2007-03-15 Japan Tobacco Inc Dibenzylaminverbindung und deren medizinische verwendung
US7544678B2 (en) * 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
SG146695A1 (en) * 2003-09-26 2008-10-30 Japan Tobacco Inc Method of inhibiting remnant lipoprotein production
AU2008201550B2 (en) * 2003-09-26 2011-02-10 Japan Tobacco Inc. Method of inhibiting remnant lipoprotein production
SI1670768T1 (sl) 2003-10-08 2010-01-29 Lilly Co Eli Spojine in metode za zdravljenje dislipidemije
US8710045B2 (en) * 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
JP4587685B2 (ja) * 2004-03-23 2010-11-24 セントラル硝子株式会社 ３−ホルミル−５−トリフルオロメチルベンゾニトリル誘導体とその製造方法
WO2005097806A1 (en) * 2004-03-26 2005-10-20 Eli Lilly And Company Compounds and methods for treating dyslipidemia
CN1942428A (zh) * 2004-04-13 2007-04-04 默克公司 Cetp抑制剂
US20080269284A1 (en) 2004-06-24 2008-10-30 Eli Lilly And Company Compounds and Methods for Treating Dyslipidemia
CN1993323B (zh) 2004-08-05 2011-04-20 霍夫曼-拉罗奇有限公司 吲哚，吲唑或二氢吲哚衍生物
US8604055B2 (en) 2004-12-31 2013-12-10 Dr. Reddy's Laboratories Ltd. Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
US9040558B2 (en) 2004-12-31 2015-05-26 Dr. Reddy's Laboratories Ltd. Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
EP2548894A1 (en) 2005-02-03 2013-01-23 Bend Research, Inc. Pharmaceutical compositions with enhanced performance
WO2006098394A1 (ja) * 2005-03-14 2006-09-21 Japan Tobacco Inc. 脂質吸収抑制方法および脂質吸収抑制剤
US7704990B2 (en) * 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US20100167986A1 (en) * 2005-09-30 2010-07-01 Amjad Ali Cholesteryl Ester Transfer Protein Inhibitors
CA2625988A1 (en) * 2005-10-19 2007-04-26 Merck & Co., Inc. Cetp inhibitors
PE20110019A1 (es) * 2005-12-22 2011-01-27 Takeda Pharmaceutical Composicion farmaceutica que contiene un sensibilizante de insulina y un secretagogo de insulina
CN101448397B (zh) * 2005-12-28 2013-04-24 雷迪博士实验室有限公司 选择性的苄胺衍生物和其作为胆固醇酯转运蛋白抑制剂的应用
WO2007073934A1 (en) * 2005-12-29 2007-07-05 Novartis Ag Pyridinyl amine derivatives as inhibitors of cholesteryl ester transfer protein (cetp)
UY30117A1 (es) * 2006-01-31 2007-06-29 Tanabe Seiyaku Co Compuesto amina trisustituido
UY30118A1 (es) * 2006-01-31 2007-06-29 Tanabe Seiyaku Co Compueto amina trisustituido
US7572823B2 (en) 2006-02-07 2009-08-11 Hoffmann-La Roche Inc. Heteroaryl carboxamide compounds
CA2641451C (en) 2006-02-09 2012-10-02 Merck & Co., Inc. Polymer formulations of cetp inhibitors
US7919506B2 (en) * 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
US8383660B2 (en) * 2006-03-10 2013-02-26 Pfizer Inc. Dibenzyl amine compounds and derivatives
TW200808731A (en) 2006-03-30 2008-02-16 Tanabe Seiyaku Co A process for preparing tetrahydroquinoline derivatives
GB0609268D0 (en) * 2006-05-10 2006-06-21 Novartis Ag Organic compounds
CA2650954C (en) 2006-05-10 2014-02-11 Novartis Ag Bicyclic derivatives as cetp inhibitors
RU2008148600A (ru) * 2006-05-11 2010-06-20 Новартис АГ (CH) Производные бензиламина в качестве ингибиторов сетр
EP2049493B1 (en) 2006-07-31 2012-03-21 Cadila Healthcare Limited Compounds suitable as modulators of hdl
KR100821688B1 (ko) 2006-08-10 2008-04-11 (주)유케이케미팜 암로디핀 라셈화물의 입체이성질체의 분리방법과 그의친수성 약물 및 그의 제조방법
US7750019B2 (en) 2006-08-11 2010-07-06 Kowa Company, Ltd. Pyrimidine compound having benzyl(pyridylmethyl)amine structure and medicament comprising the same
US7790737B2 (en) 2007-03-13 2010-09-07 Kowa Company, Ltd. Substituted pyrimidine compounds and their utility as CETP inhibitors
CN101679309B (zh) * 2007-04-13 2012-02-29 兴和株式会社 具有二苄胺结构的新型嘧啶化合物和含有该化合物的药物
JP4846769B2 (ja) * 2007-07-30 2011-12-28 田辺三菱製薬株式会社 医薬組成物
JP4834699B2 (ja) * 2007-07-30 2011-12-14 田辺三菱製薬株式会社 医薬組成物
JP5319457B2 (ja) * 2008-08-25 2013-10-16 興和株式会社 新規なジベンジルアミン構造を有するピリミジン化合物及びこれを含有する医薬
CN102300839B (zh) * 2008-11-28 2014-12-10 兴和株式会社 反式-{4-[(烷基氨基)甲基]环己基}乙酸酯的制备方法
AR077208A1 (es) * 2009-06-30 2011-08-10 Lilly Co Eli Derivados del acido trans-4-[[(5s)-5-[[[3,5-bis(trifluorometil) fenil] metil] (2-metil-2h-tetrazol-5-il) amino) -2,3,4,5-tetrahidro-7,9-dimetil-1h-1-benzazepin-1-il) metil)-ciclohexancarboxilico y sus formas cristalinas, composiciones farmaceuticas que los comprenden, su uso para preparar un medicam
PT2729142T (pt) * 2011-07-08 2018-10-01 Novartis Ag Método de tratamento de aterosclerose em sujeitos com nível elevado de triglicéridos
WO2013024358A2 (en) 2011-08-18 2013-02-21 Dr. Reddy's Laboratories Ltd. Substituted heterocyclic amine compounds as cholestryl ester-transfer protein (cetp) inhibitors
EP2760864B1 (en) 2011-09-27 2018-01-24 Dr. Reddy's Laboratories Ltd. 5-BENZYLAMINOMETHYL-6-AMINOPYRAZOLO[3,4-b]PYRIDINE DERIVATIVES AS CHOLESTERYL ESTER-TRANSFER PROTEIN (CETP) INHIBITORS USEFUL FOR THE TREATMENT OF ATHEROSCLEROSIS
US9682942B2 (en) 2013-05-31 2017-06-20 Kowa Company, Ltd. Form of pyrimidine compound having dibenzylamine structure
ES2901114T3 (es) 2014-08-29 2022-03-21 Tes Pharma S R L Inhibidores de ácido alfa-amino-beta-carboximucónico semialdehído descarboxilasa
CA3032229A1 (en) 2016-07-27 2018-02-01 Hartis-Pharma Sa Therapeutic combinations to treat red blood cell disorders

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3576830A (en) * 1966-08-12 1971-04-27 Sumitomo Chemical Co Amides containing sulfur
US4064125A (en) * 1976-10-29 1977-12-20 E. R. Squibb And Sons, Inc. Substituted amides having antiinflammatory activity
US4623662A (en) * 1985-05-23 1986-11-18 American Cyanamid Company Antiatherosclerotic ureas and thioureas
US4473579A (en) * 1982-01-26 1984-09-25 American Cyanamid Company Antiatherosclerotic tetrasubstituted ureas and thioureas
US5446207A (en) 1993-09-01 1995-08-29 Harbor Branch Oceanographic Institution, Inc. Anti-dyslipidemic agents
MX9605196A (es) 1994-04-29 1997-12-31 Sanofi Winthrop Inc Halometilamidas como inhibidores de la proteasa il-1b.
EP0784612A1 (en) 1994-10-04 1997-07-23 Fujisawa Pharmaceutical Co., Ltd. Urea derivatives and their use as acat-inhibitors
US5834514A (en) * 1995-05-30 1998-11-10 Vertex Pharmaceuticals, Incorporated Halomethyl amides as IL-1β protease inhibitors
GB9526560D0 (en) 1995-12-27 1996-02-28 Bayer Ag Use of 2-Amino-Heterocycles
AR008789A1 (es) 1996-07-31 2000-02-23 Bayer Corp Piridinas y bifenilos substituidos
AU738134B2 (en) * 1997-10-02 2001-09-06 Sankyo Company Limited Amidocarboxylic acid derivatives
JP2002505318A (ja) * 1998-03-05 2002-02-19 アゴーロン・ファーマシューティカルズ・インコーポレイテッド 非ペプチドＧｎＲＨ因子
SE9802209D0 (sv) 1998-06-22 1998-06-22 Astra Pharma Inc Novel compounds
US6197786B1 (en) 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
US6147090A (en) 1998-09-17 2000-11-14 Pfizer Inc. 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines
AU6161099A (en) * 1998-09-25 2000-04-17 Monsanto Company Substituted n-aliphatic-n-aromatic (tertiary)-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
AU6160899A (en) 1998-09-25 2000-04-17 Monsanto Company (r)-chiral halogenated 1-substitutedamino-(n+1)-alkanols useful for inhibiting cholesteryl ester transfer protein activity
AU4537900A (en) 1999-05-17 2000-12-05 Agouron Pharmaceuticals, Inc. Glucagon antagonists/inverse agonists
UA73307C2 (uk) 1999-08-05 2005-07-15 Куміаі Кемікал Індастрі Ко., Лтд. Похідна карбамату і фунгіцид сільськогосподарського/садівницького призначення
CO5271716A1 (es) 1999-11-30 2003-04-30 Pfizer Prod Inc Cristales de 4- carboxamino 1,2,3,4-tetrahidroquinolina 2- sustituida
JP4290648B2 (ja) * 2002-07-03 2009-07-08 エフ．ホフマン−ラ ロシュ アーゲー オキサゾール誘導体及びインスリン感作物質としてのそれらの使用
ATE353870T1 (de) * 2002-08-30 2007-03-15 Japan Tobacco Inc Dibenzylaminverbindung und deren medizinische verwendung

Also Published As

Publication number Publication date
PT1533292E (pt) 2007-05-31
NO20042584L (no) 2004-06-18
CA2464846A1 (en) 2004-03-11
IL161559A0 (en) 2004-09-27
MXPA04005350A (es) 2004-09-27
HK1077567A1 (en) 2006-04-13
US20050059810A1 (en) 2005-03-17
EP1829858A2 (en) 2007-09-05
CN1289467C (zh) 2006-12-13
EP1533292B1 (en) 2007-02-14
WO2004020393A1 (ja) 2004-03-11
CY1106425T1 (el) 2011-10-12
DK1533292T3 (da) 2007-06-04
CN1617850A (zh) 2005-05-18
KR20040075908A (ko) 2004-08-30
DE60311821D1 (de) 2007-03-29
CZ2004627A3 (cs) 2004-10-13
NZ532494A (en) 2006-03-31
AU2003261826A1 (en) 2004-03-19
RU2293078C2 (ru) 2007-02-10
EP1533292A1 (en) 2005-05-25
EP1533292A4 (en) 2005-11-02
ATE353870T1 (de) 2007-03-15
SK2332004A3 (en) 2004-12-01
KR100634195B1 (ko) 2006-10-16
US7807701B2 (en) 2010-10-05
CA2464846C (en) 2010-04-06
ZA200403137B (en) 2005-06-29
DE60311821T2 (de) 2007-10-31
ES2277142T3 (es) 2007-07-01
SI1533292T1 (sl) 2007-08-31
TR200401413T1 (tr) 2005-06-21
AU2003261826B2 (en) 2006-02-02
EP1829858A3 (en) 2007-10-03
US7332514B2 (en) 2008-02-19
IL161559A (en) 2009-12-24
NO328886B1 (no) 2010-06-07
RU2004119546A (ru) 2005-08-10
US20080146620A1 (en) 2008-06-19

Similar Documents

Publication Publication Date Title
BR0306208A (pt) Compostos de dibenzilamina e seu uso farmacêutico
CY1117132T1 (el) Παραγωγο θειαζολιου
AR035548A1 (es) Compuestos organicos
AR068413A2 (es) Derivados 8-amino, metodos de preparacion, composiciones farmaceuticas y su uso en terapia
BR0315405A (pt) Compostos inibidores da integrase tricìclica pré-organizados
BRPI0517343A (pt) derivados de betulina, preparação destes e uso dos mesmos
BRPI0615111B8 (pt) composto, composição farmacêutica, e, uso do composto
EP2017278A4 (en) DIHYDROPYRAZOLOPYRIMIDINONDERIVAT
DE60140456D1 (de) Aza heterocyclische derivate und ihre therapeutische verwendung
BRPI0213393B8 (pt) derivados de éter alquílico, ou um de seus sais, processo para produzir um derivado de éter alquílico, derivado de alquil-amida, ou um de seus sais, e, composição farmacêutica
BR0012697A (pt) Inibidores da diferenciação de th2
BR0010391A (pt) Composto, composição farmacêutica, método de preparação de um composto, e, uso de um composto
BRPI0413232B8 (pt) composto tendo atividade inibitória contra transportador dependente de sódio, composição farmacêutica compreendendo o composto, uso do composto na preparação de um medicamento e processo para a preparação do composto
DE69838662D1 (de) Morphinanderivate und ihre medizinische Anwendung
BRPI0408591A (pt) derivados de 6,7,8,9-tetrahidropirimido[1,2-a] pirimidin-4-ona 8-substituìda
MX2019004107A (es) Derivado heterociclico nitrogenado biciclico y composicion farmaceutica que lo contiene.
ATE194982T1 (de) Benzoxazepin-derivate als cholinesterase- inhibitoren
BRPI0414460A (pt) compostos derivados de carboxamida do tipo de amida, composição farmacêutica e respectivo uso
DE60000978D1 (de) 22r-hydroxycholesta-8,14-diene derivate zur hemmung der meiose
EP1211253A4 (en) DIHYDROBENZOFURAN TRICYCLIC DERIVATIVES, THEIR PREPARATION METHOD AND AGENTS
DE60144246D1 (de) Imidazolderivate, verfahren zu deren herstellung und deren verwendung
BRPI0414597A (pt) derivados de benzofurano do tipo carbamoìla
EP1496059A4 (en) CONDENSED BICYCLIC PYRIMIDINE DERIVATIVES
ES2072193A1 (es) Nuevos derivados del1-fenilmetil bencimidazol piperacinas.
HUP0201255A2 (hu) Új pirimidin-4-on-származékok, eljárás előállításukra, és az ezeket tartalmazó gyógyászati készítmények

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]