ES2072193A1 - Nuevos derivados del1-fenilmetil bencimidazol piperacinas. - Google Patents
Nuevos derivados del1-fenilmetil bencimidazol piperacinas.Info
- Publication number
- ES2072193A1 ES2072193A1 ES09301104A ES9301104A ES2072193A1 ES 2072193 A1 ES2072193 A1 ES 2072193A1 ES 09301104 A ES09301104 A ES 09301104A ES 9301104 A ES9301104 A ES 9301104A ES 2072193 A1 ES2072193 A1 ES 2072193A1
- Authority
- ES
- Spain
- Prior art keywords
- phenylmethyl
- new
- piperazine derivatives
- benzimidazole
- benzimidazole piperazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE DESCRIBEN NUEVOS DERIVADOS DE 1-FENILMETIL BENCIMIDAZOL PIPERACINAS DE FORMULA GENERAL: *FIG* EN DONDE R1 Y R2 PUEDEN SER UN ATOMO DE HIDROGENO, UN ATOMO DE HALOGENO, UN GRUPO ALQUILO DE CADENA CORTA, UN GRUPO NITRO, Y UN GRUPO HIDROXI, ASI COMO DE SUS SALES DE ADICION CON ACIDOS FARMACEUTICAMENTE ACEPTABLES. ESTOS COMPUESTOS PRESENTAN ACTIVIDAD FARMACOLOGICA COMO ANTAGONISTAS DE LOS RECEPTORES 5HT3 DE LA SEROTONINA.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09301104A ES2072193B1 (es) | 1993-05-21 | 1993-05-21 | Nuevos derivados del1-fenilmetil bencimidazol piperacinas. |
DE69426372T DE69426372T2 (de) | 1993-05-21 | 1994-05-19 | Neue 1-Phenylmethyl-benzimidazol-piperazinderivate |
EP94500089A EP0628549B1 (en) | 1993-05-21 | 1994-05-19 | New 1-phenylmethyl benzimidazole piperazine derivatives |
AT94500089T ATE197952T1 (de) | 1993-05-21 | 1994-05-19 | Neue 1-phenylmethyl-benzimidazol- piperazinderivate |
US08/589,651 US5672604A (en) | 1993-05-21 | 1996-01-22 | 1-phenylmethyl benzimidazole piperazine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09301104A ES2072193B1 (es) | 1993-05-21 | 1993-05-21 | Nuevos derivados del1-fenilmetil bencimidazol piperacinas. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2072193A1 true ES2072193A1 (es) | 1995-07-01 |
ES2072193B1 ES2072193B1 (es) | 1996-02-16 |
Family
ID=8281908
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09301104A Expired - Fee Related ES2072193B1 (es) | 1993-05-21 | 1993-05-21 | Nuevos derivados del1-fenilmetil bencimidazol piperacinas. |
Country Status (5)
Country | Link |
---|---|
US (1) | US5672604A (es) |
EP (1) | EP0628549B1 (es) |
AT (1) | ATE197952T1 (es) |
DE (1) | DE69426372T2 (es) |
ES (1) | ES2072193B1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2731707B1 (fr) * | 1995-03-13 | 1997-04-30 | Synthelabo | Derives de benzimidazole, leur preparation et leur application en therapeutique |
JP2000507579A (ja) * | 1996-04-03 | 2000-06-20 | メルク エンド カンパニー インコーポレーテッド | ファルネシル―タンパク質トランスフェラーゼ阻害剤 |
US6136807A (en) * | 1998-11-10 | 2000-10-24 | 3M Innovative Properties Company | Composition for the transdermal delivery of lerisetron |
ES2154605B1 (es) * | 1999-09-14 | 2001-11-16 | Univ Madrid Complutense | Nuevos derivados mixtos de bencimidazol-arilpiperazina con afinidad por los receptores serotoninergicos 5-ht1a y 5-ht3 |
US10501421B1 (en) | 2017-01-27 | 2019-12-10 | Vanderbilt University | Substituted benzimidazoles as modulators of Ras signaling |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4093726A (en) * | 1976-12-02 | 1978-06-06 | Abbott Laboratories | N-(2-benzimidazolyl)-piperazines |
EP0079545A1 (en) * | 1981-11-06 | 1983-05-25 | Kanebo, Ltd. | Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same |
WO1991018904A1 (en) * | 1990-05-30 | 1991-12-12 | American Home Products Corporation | Substituted arylsulfonamides and benzamides |
WO1992006977A1 (fr) * | 1990-10-17 | 1992-04-30 | Laboratoire Theramex S.A. | NOUVEAUX DERIVES p-SUBSTITUES DE PHENYL 4-OXYBUTANE AMINE, LEURS PROCEDES DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES EN RENFERMANT |
ES2038532A1 (es) * | 1991-05-10 | 1993-07-16 | Espanola Prod Quimicos | Procedimiento de preparacion de nuevos derivados de 2-piperacinilbecimidazol. |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4941198A (es) * | 1972-09-11 | 1974-04-17 | ||
JPS50126682A (es) * | 1974-03-25 | 1975-10-04 | ||
US5248672A (en) * | 1990-11-01 | 1993-09-28 | The Regents Of The University Of Michigan | Polysubstituted benzimidazole nucleosides as antiviral agents |
US5106857A (en) * | 1991-05-09 | 1992-04-21 | A. H. Robins Company, Incorporated | N-(1-methyl-3-pyrrolidinyl)-1-(phenylmethyl)-1H-benzimidazol-2-amine and analogs as antiarrhythmic and muscle relaxing agents |
US5256665A (en) * | 1991-05-10 | 1993-10-26 | Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. | Process for preparing new 2-piperazinylbenzimidazole |
-
1993
- 1993-05-21 ES ES09301104A patent/ES2072193B1/es not_active Expired - Fee Related
-
1994
- 1994-05-19 AT AT94500089T patent/ATE197952T1/de not_active IP Right Cessation
- 1994-05-19 DE DE69426372T patent/DE69426372T2/de not_active Expired - Fee Related
- 1994-05-19 EP EP94500089A patent/EP0628549B1/en not_active Expired - Lifetime
-
1996
- 1996-01-22 US US08/589,651 patent/US5672604A/en not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4093726A (en) * | 1976-12-02 | 1978-06-06 | Abbott Laboratories | N-(2-benzimidazolyl)-piperazines |
EP0079545A1 (en) * | 1981-11-06 | 1983-05-25 | Kanebo, Ltd. | Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same |
WO1991018904A1 (en) * | 1990-05-30 | 1991-12-12 | American Home Products Corporation | Substituted arylsulfonamides and benzamides |
WO1992006977A1 (fr) * | 1990-10-17 | 1992-04-30 | Laboratoire Theramex S.A. | NOUVEAUX DERIVES p-SUBSTITUES DE PHENYL 4-OXYBUTANE AMINE, LEURS PROCEDES DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES EN RENFERMANT |
ES2038532A1 (es) * | 1991-05-10 | 1993-07-16 | Espanola Prod Quimicos | Procedimiento de preparacion de nuevos derivados de 2-piperacinilbecimidazol. |
Also Published As
Publication number | Publication date |
---|---|
ATE197952T1 (de) | 2000-12-15 |
ES2072193B1 (es) | 1996-02-16 |
DE69426372T2 (de) | 2001-05-10 |
US5672604A (en) | 1997-09-30 |
EP0628549A1 (en) | 1994-12-14 |
EP0628549B1 (en) | 2000-12-06 |
DE69426372D1 (de) | 2001-01-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
GC2A | Exploitation certificate registered application with search report |
Effective date: 19990628 |
|
FD1A | Patent lapsed |
Effective date: 20010522 |