BR0215452A - Highly sensitive protein tyrosine phosphatase (ptpase) test using 6,8-difluoro-4-methyl-umbeliferylphosphate - Google Patents
Highly sensitive protein tyrosine phosphatase (ptpase) test using 6,8-difluoro-4-methyl-umbeliferylphosphateInfo
- Publication number
- BR0215452A BR0215452A BR0215452-8A BR0215452A BR0215452A BR 0215452 A BR0215452 A BR 0215452A BR 0215452 A BR0215452 A BR 0215452A BR 0215452 A BR0215452 A BR 0215452A
- Authority
- BR
- Brazil
- Prior art keywords
- protein tyrosine
- ptpase
- difluoro
- methyl
- test
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"TESTE DE PROTEìNA TIROSINA-FOSFATASE (PTPase) ALTAMENTE SENSITIVO COM O EMPREGO DE 6,8-DIFLúOR4-METIL-UMBELIFERILFOSFATO". A invenção descreve um processo para a comprovação de uma proteína-tirosina fosfatase em material biológico com o emprego de 6,8-diflúor -4-metilumbeliferilfosfato (DiFMUP)."HIGH SENSITIVE PROTEIN TYROSINE PHOSPHASE (PTPase) TEST WITH EMPLOYMENT OF 6,8-DIFLUOR4-METHYL-UMBELIFERYPHOSPHATE". The invention describes a process for testing a protein tyrosine phosphatase in biological material employing 6,8-difluoro-4-methylumbelliferyl phosphate (DiFMUP).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2002100173 DE10200173A1 (en) | 2002-01-04 | 2002-01-04 | Detecting activity of protein-tyrosine phosphatase by detecting hydrolysis of 6,8-difluoro-4-methylumbelliferyl phosphate, useful for identifying modulators of the enzyme that can be used to treat diabetes |
DE2002136329 DE10236329A1 (en) | 2002-08-08 | 2002-08-08 | Detecting activity of protein-tyrosine phosphatase by detecting hydrolysis of 6,8-difluoro-4-methylumbelliferyl phosphate, useful for identifying modulators of the enzyme that can be used to treat diabetes |
EP0201475 | 2002-12-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0215452A true BR0215452A (en) | 2004-11-23 |
Family
ID=26010898
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0215452-8A BR0215452A (en) | 2002-01-04 | 2002-12-24 | Highly sensitive protein tyrosine phosphatase (ptpase) test using 6,8-difluoro-4-methyl-umbeliferylphosphate |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP1466009A2 (en) |
JP (1) | JP2005512600A (en) |
KR (1) | KR20040073539A (en) |
CN (1) | CN1612939A (en) |
AU (1) | AU2002361217A1 (en) |
BR (1) | BR0215452A (en) |
CA (1) | CA2471601A1 (en) |
IL (1) | IL162832A0 (en) |
MX (1) | MXPA04006361A (en) |
NO (1) | NO20043244L (en) |
RU (1) | RU2004123794A (en) |
WO (1) | WO2003056029A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100350045C (en) * | 2003-08-21 | 2007-11-21 | 北京农业生物技术研究中心 | Corn tyrosin protein phosphatase gene and its coding protein and use |
US8008035B2 (en) | 2007-01-25 | 2011-08-30 | Roche Diagnostics Operations, Inc. | Enhancement of vanadium-containing phosphatase inhibitors |
EP1949894B1 (en) * | 2007-01-25 | 2016-06-29 | Roche Diagnostics GmbH | Enhancement of vanadium-containing phosphatase inhibitors by polyols |
CN113155787A (en) * | 2020-12-29 | 2021-07-23 | 武汉合研生物医药科技有限公司 | Activity detection method of mutant enzyme SHP 2E 76K |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2331056A1 (en) * | 1998-05-12 | 1999-12-02 | Wyeth | 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia |
-
2002
- 2002-12-24 AU AU2002361217A patent/AU2002361217A1/en not_active Abandoned
- 2002-12-24 RU RU2004123794/15A patent/RU2004123794A/en not_active Application Discontinuation
- 2002-12-24 BR BR0215452-8A patent/BR0215452A/en not_active Application Discontinuation
- 2002-12-24 CN CNA028266668A patent/CN1612939A/en active Pending
- 2002-12-24 EP EP02796734A patent/EP1466009A2/en not_active Withdrawn
- 2002-12-24 KR KR10-2004-7010451A patent/KR20040073539A/en not_active Application Discontinuation
- 2002-12-24 CA CA002471601A patent/CA2471601A1/en not_active Abandoned
- 2002-12-24 IL IL16283202A patent/IL162832A0/en unknown
- 2002-12-24 WO PCT/EP2002/014755 patent/WO2003056029A2/en not_active Application Discontinuation
- 2002-12-24 MX MXPA04006361A patent/MXPA04006361A/en not_active Application Discontinuation
- 2002-12-24 JP JP2003556546A patent/JP2005512600A/en not_active Withdrawn
-
2004
- 2004-08-02 NO NO20043244A patent/NO20043244L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2005512600A (en) | 2005-05-12 |
AU2002361217A1 (en) | 2003-07-15 |
CN1612939A (en) | 2005-05-04 |
KR20040073539A (en) | 2004-08-19 |
CA2471601A1 (en) | 2003-07-10 |
WO2003056029A2 (en) | 2003-07-10 |
WO2003056029A3 (en) | 2004-04-01 |
MXPA04006361A (en) | 2004-10-04 |
EP1466009A2 (en) | 2004-10-13 |
NO20043244L (en) | 2004-08-02 |
RU2004123794A (en) | 2005-04-20 |
IL162832A0 (en) | 2005-11-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |