MXPA04006361A - Highly sensitive and continuous protein-tyrosine-phosphatase (ptpase) test using 6.8 difluoro-4-methyl-umbelliferylphosphate. - Google Patents

Highly sensitive and continuous protein-tyrosine-phosphatase (ptpase) test using 6.8 difluoro-4-methyl-umbelliferylphosphate.

Info

Publication number
MXPA04006361A
MXPA04006361A MXPA04006361A MXPA04006361A MXPA04006361A MX PA04006361 A MXPA04006361 A MX PA04006361A MX PA04006361 A MXPA04006361 A MX PA04006361A MX PA04006361 A MXPA04006361 A MX PA04006361A MX PA04006361 A MXPA04006361 A MX PA04006361A
Authority
MX
Mexico
Prior art keywords
difluoro
phosphatase
tyrosine
umbelliferylphosphate
ptpase
Prior art date
Application number
MXPA04006361A
Other languages
Spanish (es)
Inventor
Tennagels Norbert
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2002100173 external-priority patent/DE10200173A1/en
Priority claimed from DE2002136329 external-priority patent/DE10236329A1/en
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of MXPA04006361A publication Critical patent/MXPA04006361A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to a method for detecting a protein-tyrosine-phosphatase in biological material by using 6.8-difluoro-4-methylumbelliferylphosphate (DiFMUP).
MXPA04006361A 2002-01-04 2002-12-24 Highly sensitive and continuous protein-tyrosine-phosphatase (ptpase) test using 6.8 difluoro-4-methyl-umbelliferylphosphate. MXPA04006361A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE2002100173 DE10200173A1 (en) 2002-01-04 2002-01-04 Detecting activity of protein-tyrosine phosphatase by detecting hydrolysis of 6,8-difluoro-4-methylumbelliferyl phosphate, useful for identifying modulators of the enzyme that can be used to treat diabetes
DE2002136329 DE10236329A1 (en) 2002-08-08 2002-08-08 Detecting activity of protein-tyrosine phosphatase by detecting hydrolysis of 6,8-difluoro-4-methylumbelliferyl phosphate, useful for identifying modulators of the enzyme that can be used to treat diabetes
PCT/EP2002/014755 WO2003056029A2 (en) 2002-01-04 2002-12-24 Highly sensitive and continuous protein-tyrosine-phosphatase (ptpase) test using 6,8 difluoro-4-methyl-umbelliferylphosphate

Publications (1)

Publication Number Publication Date
MXPA04006361A true MXPA04006361A (en) 2004-10-04

Family

ID=26010898

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04006361A MXPA04006361A (en) 2002-01-04 2002-12-24 Highly sensitive and continuous protein-tyrosine-phosphatase (ptpase) test using 6.8 difluoro-4-methyl-umbelliferylphosphate.

Country Status (12)

Country Link
EP (1) EP1466009A2 (en)
JP (1) JP2005512600A (en)
KR (1) KR20040073539A (en)
CN (1) CN1612939A (en)
AU (1) AU2002361217A1 (en)
BR (1) BR0215452A (en)
CA (1) CA2471601A1 (en)
IL (1) IL162832A0 (en)
MX (1) MXPA04006361A (en)
NO (1) NO20043244L (en)
RU (1) RU2004123794A (en)
WO (1) WO2003056029A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100350045C (en) * 2003-08-21 2007-11-21 北京农业生物技术研究中心 Corn tyrosin protein phosphatase gene and its coding protein and use
US8008035B2 (en) 2007-01-25 2011-08-30 Roche Diagnostics Operations, Inc. Enhancement of vanadium-containing phosphatase inhibitors
EP1949894B1 (en) * 2007-01-25 2016-06-29 Roche Diagnostics GmbH Enhancement of vanadium-containing phosphatase inhibitors by polyols
CN113155787A (en) * 2020-12-29 2021-07-23 武汉合研生物医药科技有限公司 Activity detection method of mutant enzyme SHP 2E 76K

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2331056A1 (en) * 1998-05-12 1999-12-02 Wyeth 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia

Also Published As

Publication number Publication date
EP1466009A2 (en) 2004-10-13
CN1612939A (en) 2005-05-04
JP2005512600A (en) 2005-05-12
RU2004123794A (en) 2005-04-20
CA2471601A1 (en) 2003-07-10
WO2003056029A3 (en) 2004-04-01
KR20040073539A (en) 2004-08-19
BR0215452A (en) 2004-11-23
WO2003056029A2 (en) 2003-07-10
IL162832A0 (en) 2005-11-20
AU2002361217A1 (en) 2003-07-15
NO20043244L (en) 2004-08-02

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal