BR0215279A - Compostos antagonistas a2b seletivos da pirrolopirimidina, sua sìntese e uso - Google Patents
Compostos antagonistas a2b seletivos da pirrolopirimidina, sua sìntese e usoInfo
- Publication number
- BR0215279A BR0215279A BR0215279-7A BR0215279A BR0215279A BR 0215279 A BR0215279 A BR 0215279A BR 0215279 A BR0215279 A BR 0215279A BR 0215279 A BR0215279 A BR 0215279A
- Authority
- BR
- Brazil
- Prior art keywords
- nrarb
- substituted
- nrac
- alkyl
- substituent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
"COMPOSTOS ANTAGONISTAS A~ 2b~ SELETIVOS DA PIRROLOPIRIMIDINA, SUA SìNTESE E USO". Composto apresentando a estrutura onde R~ 1~ é uma alquila substituída ou não substituída, onde o substituinte é hidroxila, diidroxila, carboxila, C (=O) NR~ a~R~ b~, -NR~ a~R~ b~, NR~ a~C (=O) NR~ a~R~ b~, - NR~ a~C (=O) OR~ a~, OC (=O) NR~ a~ R~ b~ ou - NHC (=O) R~ a~; R~ 2~ é hidrogênio ou uma alquila substituída ou não substituída, onde o substituinte é hidroxila, diidroxila, carboxila, - C (=O) NR~ a~,R~ b~, -NR~ a~R~ b~, - NR~ a~C (=O) NR~ a~R~ b~, - NR~ a~C (=O) OR~ a~, - OC (=O) NR~ a~R~ b~ ou - NHC (=O) R~ a~, ou R~ 1~, R~ 2~ e N juntos formam um anel de piperazina substituído, anel de azetidina substituído ou um anel de pirrolidina substituído por (CH~ 2~)~ 2~OH ou - CH~ 2~C (=O)OH; R~ 3~ é uma fenila substituída ou não substituída ou um anel heteroarila com 5-6 membros, onde o substituinte é halogênio, hidroxila, ciano, alquila (C~ 1~-C~ 15~), alquoxila (C~ 1~-C~ 15~) ou NR~ a~R~ b~; R~ 4~ é hidrogênio ou alquila (C~ 1~-C~ 15~) , substituída ou não substituída; R~ 5~ é - (CH~ 2~)~ m~OR~ 6~, CHNOR~ 7~, -C(=O)NR~ 8~R~ 9~, - (CH~ 2~)~ m~C(=O)OR~ 10~, -(CH~ 2~)~ k~C(=O)NR~ 11~R~ 12~.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34344301P | 2001-12-20 | 2001-12-20 | |
| PCT/US2002/040890 WO2003053361A2 (en) | 2001-12-20 | 2002-12-20 | PYRROLOPYRIMIDINE A2b SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0215279A true BR0215279A (pt) | 2005-05-10 |
Family
ID=42828977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0215279-7A BR0215279A (pt) | 2001-12-20 | 2002-12-20 | Compostos antagonistas a2b seletivos da pirrolopirimidina, sua sìntese e uso |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1467995B1 (pt) |
| JP (1) | JP4607457B2 (pt) |
| KR (1) | KR100960827B1 (pt) |
| AT (1) | ATE468339T1 (pt) |
| AU (1) | AU2002366801B8 (pt) |
| BR (1) | BR0215279A (pt) |
| CA (1) | CA2470044C (pt) |
| DK (1) | DK1467995T3 (pt) |
| EA (1) | EA012926B1 (pt) |
| HK (1) | HK1070647A1 (pt) |
| MX (1) | MXPA04005861A (pt) |
| WO (1) | WO2003053361A2 (pt) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ508314A (en) | 1998-06-02 | 2004-03-26 | Osi Pharm Inc | Pyrrolo[2,3d]pyrimidine compositions and their use |
| US6680324B2 (en) | 2000-12-01 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
| ATE446298T1 (de) | 2001-11-30 | 2009-11-15 | Osi Pharm Inc | Verbindungen, die für adenosin a1 und a3 rezeptoren spezifisch sind, und deren anwendungen |
| AU2002366811B2 (en) | 2001-12-20 | 2009-01-15 | Osi Pharmaceuticals, Inc. | Pyrimidine A2B selective antagonist compounds, their synthesis and use |
| TW200403058A (en) * | 2002-04-19 | 2004-03-01 | Bristol Myers Squibb Co | Heterocyclo inhibitors of potassium channel function |
| EP1479680A1 (en) * | 2003-05-19 | 2004-11-24 | Aventis Pharma Deutschland GmbH | Azaindole derivatives as Factor Xa inhibitors |
| WO2005035807A1 (en) * | 2003-09-19 | 2005-04-21 | Sri International | Methods and apparatuses for producing metallic compositions via reduction of metal halides |
| WO2005037269A1 (ja) * | 2003-10-21 | 2005-04-28 | Dainippon Sumitomo Pharma Co., Ltd. | 新規ピペリジン誘導体 |
| GB0412467D0 (en) * | 2004-06-04 | 2004-07-07 | Astrazeneca Ab | Chemical compounds |
| GB0503646D0 (en) * | 2005-02-22 | 2005-03-30 | Novartis Ag | Organic compounds |
| CN102295636A (zh) | 2005-07-29 | 2011-12-28 | 弗·哈夫曼-拉罗切有限公司 | 吲哚-3-基-羰基-哌啶和哌嗪衍生物 |
| GB0519879D0 (en) | 2005-09-30 | 2005-11-09 | Astrazeneca Ab | Chemical process |
| GB0718434D0 (en) * | 2007-09-21 | 2007-10-31 | Vernalis R&D Ltd | New chemical compounds |
| GB0718432D0 (en) * | 2007-09-21 | 2007-10-31 | Vernalis R&D Ltd | New chemical compounds |
| CN102015712A (zh) | 2008-03-26 | 2011-04-13 | 阿德维纳斯治疗私人有限公司 | 作为腺苷受体拮抗剂的杂环化合物 |
| US8859566B2 (en) | 2009-03-13 | 2014-10-14 | Advinus Therapeutics Private Limited | Substituted fused pyrimidine compounds |
| US8324250B2 (en) | 2009-03-19 | 2012-12-04 | Hoffmann-La Roche Inc. | Piperidine derivatives as NK3 receptor antagonists |
| JP5843778B2 (ja) | 2009-11-09 | 2016-01-13 | アドヴィナス・セラピューティックス・リミテッド | 置換縮合ピリミジン化合物、その調製およびその使用 |
| JP5827998B2 (ja) | 2010-09-13 | 2015-12-02 | アドヴィナス・セラピューティックス・リミテッド | Ａ２ｂアデノシン受容体アンタゴニストのプロドラッグとしてのプリン化合物、これらの方法および薬剤の適用 |
| SG10201508715YA (en) * | 2010-10-25 | 2015-11-27 | G1 Therapeutics Inc | Cdk inhibitors |
| US20120115878A1 (en) * | 2010-11-10 | 2012-05-10 | John Vincent Calienni | Salt(s) of 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7h-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide and processes of making thereof |
| US9701689B2 (en) | 2012-11-30 | 2017-07-11 | Kyowa Hakko Kirin Co., Ltd. | Substituted pyridines and pyridazines as CCR10 receptor inhibitors |
| ES2659043T3 (es) * | 2013-10-07 | 2018-03-13 | Bayer Pharma Aktiengesellschaft | Tienouracil-carboxamidas cíclicas y su uso |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ508314A (en) * | 1998-06-02 | 2004-03-26 | Osi Pharm Inc | Pyrrolo[2,3d]pyrimidine compositions and their use |
| PT1246623E (pt) * | 1999-12-02 | 2006-12-29 | Osi Pharm Inc | Compostos específicos para o receptor de adenosina a1,a2a e a3 e as suas utilizações |
-
2002
- 2002-12-20 AT AT02805644T patent/ATE468339T1/de not_active IP Right Cessation
- 2002-12-20 EP EP02805644A patent/EP1467995B1/en not_active Expired - Lifetime
- 2002-12-20 CA CA2470044A patent/CA2470044C/en not_active Expired - Fee Related
- 2002-12-20 MX MXPA04005861A patent/MXPA04005861A/es active IP Right Grant
- 2002-12-20 DK DK02805644.8T patent/DK1467995T3/da active
- 2002-12-20 JP JP2003554121A patent/JP4607457B2/ja not_active Expired - Fee Related
- 2002-12-20 BR BR0215279-7A patent/BR0215279A/pt active Search and Examination
- 2002-12-20 EA EA200400829A patent/EA012926B1/ru not_active IP Right Cessation
- 2002-12-20 WO PCT/US2002/040890 patent/WO2003053361A2/en active Application Filing
- 2002-12-20 AU AU2002366801A patent/AU2002366801B8/en not_active Ceased
- 2002-12-20 KR KR1020047009796A patent/KR100960827B1/ko not_active IP Right Cessation
-
2005
- 2005-04-14 HK HK05103200.5A patent/HK1070647A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002366801B8 (en) | 2009-05-21 |
| AU2002366801A1 (en) | 2003-07-09 |
| CA2470044A1 (en) | 2003-07-03 |
| CA2470044C (en) | 2010-12-14 |
| EP1467995B1 (en) | 2010-05-19 |
| WO2003053361A2 (en) | 2003-07-03 |
| DK1467995T3 (da) | 2010-09-20 |
| EP1467995A4 (en) | 2005-12-07 |
| KR20040068966A (ko) | 2004-08-02 |
| AU2002366801B2 (en) | 2009-04-23 |
| EA200400829A1 (ru) | 2005-08-25 |
| JP2005525305A (ja) | 2005-08-25 |
| ATE468339T1 (de) | 2010-06-15 |
| JP4607457B2 (ja) | 2011-01-05 |
| MXPA04005861A (es) | 2004-10-29 |
| EA012926B1 (ru) | 2010-02-26 |
| EP1467995A2 (en) | 2004-10-20 |
| WO2003053361A3 (en) | 2003-12-24 |
| HK1070647A1 (en) | 2005-06-24 |
| KR100960827B1 (ko) | 2010-06-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B15K | Others concerning applications: alteration of classification |
Free format text: PARA.INT.CI.C07D 487/04, A61K 31/519, A61P 15/00 Ipc: C07D 487/04 (2011.01), A61K 31/519 (2011.01), A61P |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 11A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2259 DE 22/04/2014. |
|
| B07F | Notification of approval that there is no relation to art. 229 of lpi (pipeline patents) [chapter 7.6 patent gazette] |
Free format text: NOTIFICACAO DE NAO ANUENCIA RELACIONADA COM O ART. 229 DA LPI |