BR0212893A - Derivados de 4-pirimidona-3-substituìdo - Google Patents

Derivados de 4-pirimidona-3-substituìdo

Info

Publication number
BR0212893A
BR0212893A BR0212893-4A BR0212893A BR0212893A BR 0212893 A BR0212893 A BR 0212893A BR 0212893 A BR0212893 A BR 0212893A BR 0212893 A BR0212893 A BR 0212893A
Authority
BR
Brazil
Prior art keywords
ring
substituted
pyrimidone
group
atom
Prior art date
Application number
BR0212893-4A
Other languages
English (en)
Inventor
Fumiaki Uehara
Keiichi Aritomo
Aya Shoda
Shinsuke Hiki
Masahiro Okuyama
Yoshihiro Usui
Mitsuru Ooizumi
Kazutoshi Watanabe
Original Assignee
Mitsubishi Pharma Corp
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Pharma Corp, Sanofi Synthelabo filed Critical Mitsubishi Pharma Corp
Publication of BR0212893A publication Critical patent/BR0212893A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

"DERIVADOS DE 4-PIRIMIDONA-3-SUBSTITUìDO". Um derivado de pirimidona representado pela fórmula (I) ou seu sal ou seu solvato ou seu hidrato que possui atividade inibitória contra proteína tau de quinase 1: em que R^ 1^ representa um grupo de alkyl C~ 1~-C~ 12~ que pode ser substituído; R representa, por exemplo, um grupo representado pela fórmula (II) a seguir: em que R^ 2^ e R^ 3^ representam independentemente um átomo de hidrogênio ou um grupo de alkyl C~ 1~-C~ 8~; R~ 4~ representa um anel de benzeno que pode ser substituído, um anel de naftaleno que pode ser substituído um anel de indano que pode ser substituído, um anel de tetrahidronaftaleno que pode ser substituído ou um anel heterocíclico opcionalmente substituído que possui de 1 a 4 heteroátomos selecionados a partir do grupo que consiste em átomo de oxigênio, átomo de enxofre e átomo de nitrogênio e que possui de 5 a 10 átomos de constituição de anel no total;
BR0212893-4A 2001-09-21 2002-09-20 Derivados de 4-pirimidona-3-substituìdo BR0212893A (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2001331676 2001-09-21
JP2001331678 2001-09-21
JP2001331675 2001-09-21
JP2001331674 2001-09-21
PCT/JP2002/009684 WO2003027080A1 (en) 2001-09-21 2002-09-20 3-substituted-4-pyrimidone derivatives

Publications (1)

Publication Number Publication Date
BR0212893A true BR0212893A (pt) 2004-08-03

Family

ID=27482650

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0212893-4A BR0212893A (pt) 2001-09-21 2002-09-20 Derivados de 4-pirimidona-3-substituìdo

Country Status (24)

Country Link
US (1) US7572793B2 (pt)
EP (1) EP1427709B1 (pt)
JP (1) JP4368682B2 (pt)
KR (1) KR100754596B1 (pt)
CN (1) CN1319950C (pt)
AR (2) AR043700A1 (pt)
AT (1) ATE312827T1 (pt)
AU (1) AU2002337498B2 (pt)
BR (1) BR0212893A (pt)
CA (1) CA2460177C (pt)
CY (1) CY1105554T1 (pt)
DE (1) DE60208051T2 (pt)
DK (1) DK1427709T3 (pt)
EA (1) EA007224B1 (pt)
ES (1) ES2256540T3 (pt)
HK (1) HK1068608A1 (pt)
HU (1) HUP0401898A3 (pt)
IL (2) IL160701A0 (pt)
MX (1) MXPA04002661A (pt)
NO (1) NO326694B1 (pt)
NZ (1) NZ531637A (pt)
PL (1) PL368816A1 (pt)
TW (1) TWI303171B (pt)
WO (1) WO2003027080A1 (pt)

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Also Published As

Publication number Publication date
EP1427709A1 (en) 2004-06-16
CN1555367A (zh) 2004-12-15
NO20041604L (no) 2004-06-17
EP1427709B1 (en) 2005-12-14
JP2005510472A (ja) 2005-04-21
ES2256540T3 (es) 2006-07-16
CA2460177A1 (en) 2003-04-03
HUP0401898A3 (en) 2005-08-29
HK1068608A1 (en) 2005-04-29
CN1319950C (zh) 2007-06-06
NZ531637A (en) 2005-12-23
IL160701A (en) 2009-06-15
AU2002337498B2 (en) 2006-08-10
CA2460177C (en) 2010-03-23
DE60208051T2 (de) 2006-06-22
EA200400452A1 (ru) 2004-08-26
EA007224B1 (ru) 2006-08-25
AR036604A1 (es) 2004-09-22
KR20040054690A (ko) 2004-06-25
WO2003027080A1 (en) 2003-04-03
DK1427709T3 (da) 2006-04-03
JP4368682B2 (ja) 2009-11-18
TWI303171B (en) 2008-11-21
IL160701A0 (en) 2004-08-31
AR043700A1 (es) 2005-08-10
DE60208051D1 (de) 2006-01-19
US7572793B2 (en) 2009-08-11
MXPA04002661A (es) 2004-11-22
CY1105554T1 (el) 2010-07-28
ATE312827T1 (de) 2005-12-15
NO326694B1 (no) 2009-02-02
HUP0401898A2 (hu) 2004-12-28
PL368816A1 (en) 2005-04-04
US20050130967A1 (en) 2005-06-16
KR100754596B1 (ko) 2007-09-05

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