BR0212107A - Análogos da ciclopropil e da ciclobutil epotilona - Google Patents
Análogos da ciclopropil e da ciclobutil epotilonaInfo
- Publication number
- BR0212107A BR0212107A BR0212107-7A BR0212107A BR0212107A BR 0212107 A BR0212107 A BR 0212107A BR 0212107 A BR0212107 A BR 0212107A BR 0212107 A BR0212107 A BR 0212107A
- Authority
- BR
- Brazil
- Prior art keywords
- cyclopropyl
- cyclobutyl
- epothilone analogues
- compounds
- cyclobutyl epothilone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Silicon Polymers (AREA)
Abstract
"ANáLOGOS DA CICLOPROPIL E DA CICLOBUTIL EPOTILONA". A presente invenção refere-se a cis- e trans-12,13-ciclopropil e 12,13-ciclobutil epotilonas da fórmula I até IV em que Ar é um radical representado pela estrutura a seguir: e os outros radicais e símbolos possuem os significados que são definidos aqui; à síntese química e à avaliação biológica dos mesmos; ao seu uso no tratamento de doenças neoplásticas e às preparações farmacêuticas contendo tais compostos. Os compostos descritos aqui são potentes promotores da polimerização da tubulina e agentes citotóxicos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31469801P | 2001-08-23 | 2001-08-23 | |
PCT/EP2002/009407 WO2003018002A2 (en) | 2001-08-23 | 2002-08-22 | Cyclopropyl and cyclobutyl epothilone analogs |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0212107A true BR0212107A (pt) | 2004-08-24 |
Family
ID=23221047
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0212107-7A BR0212107A (pt) | 2001-08-23 | 2002-08-22 | Análogos da ciclopropil e da ciclobutil epotilona |
Country Status (13)
Country | Link |
---|---|
US (1) | US7358266B2 (pt) |
EP (2) | EP1420780B1 (pt) |
JP (2) | JP4176015B2 (pt) |
CN (1) | CN100536841C (pt) |
AT (1) | ATE409473T1 (pt) |
AU (1) | AU2002331171A1 (pt) |
BR (1) | BR0212107A (pt) |
CA (1) | CA2456280A1 (pt) |
DE (1) | DE60229143D1 (pt) |
ES (1) | ES2315399T3 (pt) |
HK (1) | HK1066464A1 (pt) |
PT (1) | PT1420780E (pt) |
WO (1) | WO2003018002A2 (pt) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999001124A1 (en) * | 1996-12-03 | 1999-01-14 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
US6867305B2 (en) | 1996-12-03 | 2005-03-15 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
ATE409473T1 (de) * | 2001-08-23 | 2008-10-15 | Novartis Pharma Gmbh | Cyclopropyl und cyclobutyl epothilon analoge |
AU2003266961A1 (en) * | 2002-08-02 | 2004-02-25 | Novartis Ag | Epothilone derivatives |
PT1767535E (pt) * | 2002-08-23 | 2010-02-24 | Sloan Kettering Inst Cancer | Síntese de epotilonas, respectivos intermediários, análogos e suas utilizações |
US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US7384964B2 (en) * | 2002-08-23 | 2008-06-10 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
US20050171167A1 (en) | 2003-11-04 | 2005-08-04 | Haby Thomas A. | Process and formulation containing epothilones and analogs thereof |
GB0405898D0 (en) * | 2004-03-16 | 2004-04-21 | Novartis Ag | Organic compounds |
AU2006336468B2 (en) | 2005-02-11 | 2012-04-12 | University Of Southern California | Method of expressing proteins with disulfide bridges |
US8003801B2 (en) * | 2005-11-22 | 2011-08-23 | The Scripps Research Institute | Chemical synthesis of a highly potent epothilone |
US8008256B2 (en) * | 2006-05-01 | 2011-08-30 | University Of Southern California | Combination therapy for treatment of cancer |
JP5115729B2 (ja) * | 2008-06-20 | 2013-01-09 | 信越化学工業株式会社 | トリアルキルシリル基で保護されたアセト酢酸エステル基含有有機ケイ素化合物及びその製造方法 |
US8802394B2 (en) | 2008-11-13 | 2014-08-12 | Radu O. Minea | Method of expressing proteins with disulfide bridges with enhanced yields and activity |
CA2799202C (en) | 2010-05-18 | 2016-07-05 | Cerulean Pharma Inc. | Compositions and methods for treatment of autoimmune and other diseases |
CN115850224A (zh) * | 2022-07-22 | 2023-03-28 | 北京先通国际医药科技股份有限公司 | 一种修饰长链脂肪酸型pet试剂前体的合成方法及其用途 |
CN115141087B (zh) * | 2022-09-06 | 2023-03-24 | 北京先通国际医药科技股份有限公司 | Pet前体关键中间体的异构体的合成方法及其用途 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5969145A (en) * | 1996-08-30 | 1999-10-19 | Novartis Ag | Process for the production of epothilones and intermediate products within the process |
US6441186B1 (en) * | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
US6380394B1 (en) * | 1996-12-13 | 2002-04-30 | The Scripps Research Institute | Epothilone analogs |
US6399638B1 (en) * | 1998-04-21 | 2002-06-04 | Bristol-Myers Squibb Company | 12,13-modified epothilone derivatives |
DE19848306A1 (de) * | 1998-10-14 | 2000-04-20 | Schering Ag | Verfahren zur Herstellung von Epothilon B und Derivaten sowie Zwischenprodukte für dieses Verfahren |
EA200100833A1 (ru) * | 1999-02-11 | 2002-02-28 | Шеринг Акциенгезельшафт | Производные эпотилона, способ их получения и их применение в фармацевтике |
ATE409473T1 (de) * | 2001-08-23 | 2008-10-15 | Novartis Pharma Gmbh | Cyclopropyl und cyclobutyl epothilon analoge |
-
2002
- 2002-08-22 AT AT02767418T patent/ATE409473T1/de not_active IP Right Cessation
- 2002-08-22 ES ES02767418T patent/ES2315399T3/es not_active Expired - Lifetime
- 2002-08-22 BR BR0212107-7A patent/BR0212107A/pt not_active IP Right Cessation
- 2002-08-22 DE DE60229143T patent/DE60229143D1/de not_active Expired - Fee Related
- 2002-08-22 CA CA002456280A patent/CA2456280A1/en not_active Abandoned
- 2002-08-22 PT PT02767418T patent/PT1420780E/pt unknown
- 2002-08-22 AU AU2002331171A patent/AU2002331171A1/en not_active Abandoned
- 2002-08-22 WO PCT/EP2002/009407 patent/WO2003018002A2/en active IP Right Grant
- 2002-08-22 EP EP02767418A patent/EP1420780B1/en not_active Expired - Lifetime
- 2002-08-22 EP EP08165542A patent/EP2070534A3/en not_active Withdrawn
- 2002-08-22 CN CNB028164415A patent/CN100536841C/zh not_active Expired - Fee Related
- 2002-08-22 JP JP2003522522A patent/JP4176015B2/ja not_active Expired - Fee Related
- 2002-08-23 US US10/227,073 patent/US7358266B2/en not_active Expired - Fee Related
-
2004
- 2004-11-25 HK HK04109321.7A patent/HK1066464A1/xx not_active IP Right Cessation
-
2008
- 2008-07-15 JP JP2008183765A patent/JP2009007367A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2456280A1 (en) | 2003-03-06 |
DE60229143D1 (en) | 2008-11-13 |
JP4176015B2 (ja) | 2008-11-05 |
CN1545411A (zh) | 2004-11-10 |
AU2002331171A1 (en) | 2003-03-10 |
EP2070534A2 (en) | 2009-06-17 |
EP2070534A3 (en) | 2009-08-26 |
WO2003018002A2 (en) | 2003-03-06 |
JP2009007367A (ja) | 2009-01-15 |
EP1420780B1 (en) | 2008-10-01 |
WO2003018002A3 (en) | 2003-09-04 |
HK1066464A1 (en) | 2005-03-24 |
JP2005501107A (ja) | 2005-01-13 |
US20040039026A1 (en) | 2004-02-26 |
PT1420780E (pt) | 2008-12-29 |
ATE409473T1 (de) | 2008-10-15 |
ES2315399T3 (es) | 2009-04-01 |
EP1420780A2 (en) | 2004-05-26 |
US7358266B2 (en) | 2008-04-15 |
CN100536841C (zh) | 2009-09-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A E 9A A NUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2108 DE 31/05/2011. |