BR0211670A - Processos para a produção de compostos e compostos - Google Patents

Processos para a produção de compostos e compostos

Info

Publication number
BR0211670A
BR0211670A BR0211670-7A BR0211670A BR0211670A BR 0211670 A BR0211670 A BR 0211670A BR 0211670 A BR0211670 A BR 0211670A BR 0211670 A BR0211670 A BR 0211670A
Authority
BR
Brazil
Prior art keywords
compound
ring
optionally substituted
heterocyclic ring
production
Prior art date
Application number
BR0211670-7A
Other languages
English (en)
Inventor
Lee Terence Boulton
Robert James Crook
Alan John Pettman
Robert Walton
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BR0211670A publication Critical patent/BR0211670A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles

Abstract

"PROCESSOS PARA A PRODUçãO DE COMPOSTOS E COMPOSTOS". A presente invenção fornece um processo para a produção de um composto de fórmula (A) ou um de seus sais ou solvatos farmaceuticamente aceitáveis, em que R^ 1^ representa alcóxi C~ 1-4~ opcionalmente substituído por um ou mais átomos de flúor; R^ 2^ representa H ou alcóxi C~ 1-6~ opcionalmente substituído por um ou mais átomos de flúor; R^ 3^ representa um anel heterocíclico de 5 ou 6 membros que é opcionalmente substituído; R^ 4^ é um anel heterocíclico de 4, 5, 6 ou 7 membros que é opcionalmente fundido a um anel de benzeno ou um anel heterocíclico de 5 ou 6 membros, em que o sistema de anéis como um todo é opcionalmente substituído; o processo compreende a condensação de um composto de fórmula (B), em que R^ 1^ a R^ 3^ são conforme definidos acima; com um composto de fórmula (C), em que R^ 5^ e R^ 6^, tomados em conjunto com o átomo de N ao qual são ligados, representam um anel heterocíclico que contém N de 4, 5, 6 ou 7 membros, em que o anel é opcionalmente fundido a um anel de benzeno ou um anel heterocíclico de 5 ou 6 membros e o sistema de anéis, como um todo, é opcionalmente substituído.
BR0211670-7A 2001-08-01 2002-07-19 Processos para a produção de compostos e compostos BR0211670A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0118752.5A GB0118752D0 (en) 2001-08-01 2001-08-01 Process for the production of quinazolines
PCT/IB2002/002872 WO2003011829A1 (en) 2001-08-01 2002-07-19 Process for the production of quinazolines

Publications (1)

Publication Number Publication Date
BR0211670A true BR0211670A (pt) 2004-07-13

Family

ID=9919612

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0211670-7A BR0211670A (pt) 2001-08-01 2002-07-19 Processos para a produção de compostos e compostos

Country Status (27)

Country Link
US (1) US7026479B2 (pt)
EP (1) EP1412331B1 (pt)
JP (1) JP2005501054A (pt)
KR (1) KR20040019097A (pt)
CN (1) CN1533378A (pt)
AP (1) AP1299A (pt)
AR (1) AR036204A1 (pt)
AT (1) ATE323677T1 (pt)
BR (1) BR0211670A (pt)
CA (1) CA2451075A1 (pt)
CZ (1) CZ2004151A3 (pt)
DE (1) DE60210778T2 (pt)
DO (1) DOP2002000443A (pt)
EG (1) EG23204A (pt)
ES (1) ES2260457T3 (pt)
GB (1) GB0118752D0 (pt)
HN (1) HN2002000197A (pt)
HU (1) HUP0401573A3 (pt)
IL (1) IL158998A0 (pt)
MX (1) MXPA04000978A (pt)
PA (1) PA8550301A1 (pt)
PE (1) PE20030346A1 (pt)
PL (1) PL368520A1 (pt)
RU (1) RU2261861C1 (pt)
UY (1) UY27399A1 (pt)
WO (1) WO2003011829A1 (pt)
ZA (1) ZA200309043B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1521747B1 (en) * 2002-07-15 2018-09-05 Symphony Evolution, Inc. Receptor-type kinase modulators and methods of use
EP2210607B1 (en) 2003-09-26 2011-08-17 Exelixis Inc. N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide for the treatment of cancer
EP1746999B1 (en) * 2004-05-06 2011-11-16 Warner-Lambert Company LLC 4-phenylamino-quinazolin-6-yl-amides
EP2295439A1 (en) * 2006-08-04 2011-03-16 Merz Pharma GmbH & Co. KGaA Substituted pyrazolopyrimidines, a process for their preparation and their use as medicine
KR20200137052A (ko) 2009-01-16 2020-12-08 엑셀리시스, 인코포레이티드 암의 치료를 위한 ｎ-（４-｛〔６，７-비스（메틸옥시）퀴놀린-4-일〕옥시｝페닐）-ｎ＇-（４-플루오로페닐）사이클로프로판-1,1-디카르복사미드의 말산염 및 그 결정형
EP2408454A2 (en) 2009-03-18 2012-01-25 Resverlogix Corp. Novel anti-inflammatory agents
IN2012DN00352A (pt) * 2009-06-16 2015-08-21 Bikam Pharmaceuticals Inc
UA108618C2 (uk) 2009-08-07 2015-05-25 Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
US9353063B2 (en) 2011-11-30 2016-05-31 Bikam Pharmaceuticals, Inc. Opsin-binding ligands, compositions and methods of use
CA2888378C (en) * 2012-10-15 2015-09-22 Resverlogix Corp. Compounds useful in the synthesis of benzamide compounds
CN107530356A (zh) 2015-03-13 2018-01-02 雷斯韦洛吉克斯公司 用于治疗补体相关疾病之组合物及治疗方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8719378D0 (en) * 1987-08-15 1987-09-23 Pfizer Ltd Antiarrythmic agents
JP4101302B2 (ja) * 1997-01-09 2008-06-18 テルモ株式会社 新規アミド誘導体および合成中間体

Also Published As

Publication number Publication date
RU2004102692A (ru) 2005-07-10
ZA200309043B (en) 2004-11-22
WO2003011829A1 (en) 2003-02-13
ES2260457T3 (es) 2006-11-01
CA2451075A1 (en) 2003-02-13
EP1412331B1 (en) 2006-04-19
GB0118752D0 (en) 2001-09-26
CZ2004151A3 (cs) 2005-01-12
KR20040019097A (ko) 2004-03-04
HN2002000197A (es) 2003-02-27
DOP2002000443A (es) 2003-02-15
MXPA04000978A (es) 2004-04-20
US7026479B2 (en) 2006-04-11
PA8550301A1 (es) 2003-09-05
JP2005501054A (ja) 2005-01-13
DE60210778T2 (de) 2007-01-04
RU2261861C1 (ru) 2005-10-10
HUP0401573A3 (en) 2005-06-28
IL158998A0 (en) 2004-05-12
DE60210778D1 (de) 2006-05-24
UY27399A1 (es) 2003-02-28
HUP0401573A2 (hu) 2005-01-28
AP2002002602A0 (en) 2002-09-30
CN1533378A (zh) 2004-09-29
EP1412331A1 (en) 2004-04-28
AP1299A (en) 2004-09-06
EG23204A (en) 2004-07-31
ATE323677T1 (de) 2006-05-15
AR036204A1 (es) 2004-08-18
PL368520A1 (en) 2005-04-04
PE20030346A1 (es) 2003-04-05
US20030100753A1 (en) 2003-05-29

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A,7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2060 DE 29/06/2010.