BR0208384A - Sìntese enantiosseletiva de compostos intermediários de azetidinona - Google Patents
Sìntese enantiosseletiva de compostos intermediários de azetidinonaInfo
- Publication number
- BR0208384A BR0208384A BR0208384-1A BR0208384A BR0208384A BR 0208384 A BR0208384 A BR 0208384A BR 0208384 A BR0208384 A BR 0208384A BR 0208384 A BR0208384 A BR 0208384A
- Authority
- BR
- Brazil
- Prior art keywords
- intermediate compounds
- enantioselective synthesis
- azetidinone intermediate
- compound
- formula
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- MNFORVFSTILPAW-UHFFFAOYSA-N azetidin-2-one Chemical compound O=C1CCN1 MNFORVFSTILPAW-UHFFFAOYSA-N 0.000 title 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 239000003529 anticholesteremic agent Substances 0.000 abstract 1
- -1 azide compounds Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
"SìNTESE ENANTIOSSELETIVA DE COMPOSTOS INTERMEDIáRIOS DE AZETIDINONA". Este pedido de patente refere-se a um processo para preparar um composto da Fórmula I Fórmula I Este composto é um intermediário usado para produzir compostos que são úteis como agentes hipocolesterolêmicos no tratamento e prevenção de aterosclerose.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27928801P | 2001-03-28 | 2001-03-28 | |
PCT/US2002/009123 WO2002079174A2 (en) | 2001-03-28 | 2002-03-25 | Enantioselective synthesis of azetidinone intermediate compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
BR0208384A true BR0208384A (pt) | 2004-06-15 |
BRPI0208384B1 BRPI0208384B1 (pt) | 2016-05-31 |
Family
ID=23068350
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0208384A BRPI0208384B1 (pt) | 2001-03-28 | 2002-03-25 | síntese enantiosseletiva de compostos intermediários de azetidinona |
Country Status (29)
Country | Link |
---|---|
US (1) | US6627757B2 (pt) |
EP (1) | EP1373230B1 (pt) |
JP (1) | JP4145663B2 (pt) |
KR (1) | KR100590342B1 (pt) |
CN (1) | CN1275949C (pt) |
AT (1) | ATE305459T1 (pt) |
AU (1) | AU2002258605B2 (pt) |
BG (1) | BG66189B1 (pt) |
BR (1) | BRPI0208384B1 (pt) |
CA (1) | CA2442219C (pt) |
CZ (1) | CZ304929B6 (pt) |
DE (1) | DE60206365T2 (pt) |
DK (1) | DK1373230T3 (pt) |
EA (1) | EA006898B1 (pt) |
EE (1) | EE05453B1 (pt) |
ES (1) | ES2245733T3 (pt) |
HK (1) | HK1057546A1 (pt) |
HR (1) | HRP20030760B1 (pt) |
HU (1) | HU230229B1 (pt) |
IL (2) | IL157552A0 (pt) |
MX (1) | MXPA03008803A (pt) |
NZ (1) | NZ527852A (pt) |
PL (1) | PL205952B1 (pt) |
RS (1) | RS50386B (pt) |
SI (1) | SI1373230T1 (pt) |
SK (1) | SK287408B6 (pt) |
UA (1) | UA75644C2 (pt) |
WO (1) | WO2002079174A2 (pt) |
ZA (1) | ZA200306612B (pt) |
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GB0215579D0 (en) | 2002-07-05 | 2002-08-14 | Astrazeneca Ab | Chemical compounds |
US20040132058A1 (en) | 2002-07-19 | 2004-07-08 | Schering Corporation | NPC1L1 (NPC3) and methods of use thereof |
US7135556B2 (en) | 2002-07-19 | 2006-11-14 | Schering Corporation | NPC1L1 (NPC3) and methods of use thereof |
AR040588A1 (es) | 2002-07-26 | 2005-04-13 | Schering Corp | Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa |
EP1918000A2 (en) | 2003-11-05 | 2008-05-07 | Schering Corporation | Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions |
US7871998B2 (en) | 2003-12-23 | 2011-01-18 | Astrazeneca Ab | Diphenylazetidinone derivatives possessing cholesterol absorption inhibitory activity |
MXPA06008124A (es) * | 2004-01-16 | 2007-01-26 | Merck & Co Inc | Npc1l1 (npc3) y metodos para identificar ligandos del mismo. |
EP1807070A1 (en) * | 2004-09-29 | 2007-07-18 | Schering Corporation | Combinations of substituted azetidinones and cb1 antagonists |
NZ555320A (en) | 2004-12-03 | 2010-11-26 | Schering Corp | Substituted piperazines as CB1 antagonists |
US8308559B2 (en) * | 2007-05-07 | 2012-11-13 | Jay Chun | Paradise box gaming system |
TW200726746A (en) * | 2005-05-06 | 2007-07-16 | Microbia Inc | Processes for production of 4-biphenylylazetidin-2-ones |
BRPI0611531A2 (pt) * | 2005-05-09 | 2010-09-21 | Microbia Inc | agentes de acoplamento de benzenofosfonato de organometal e método de geração de ligação carbono-carbono |
KR20080017345A (ko) * | 2005-05-11 | 2008-02-26 | 마이크로비아 인코포레이티드 | 페놀성 4-비페닐일아제티딘-2-온의 제조방법 |
CN101222950A (zh) * | 2005-05-25 | 2008-07-16 | 迈克罗比亚公司 | 制备4-(联苯基)氮杂环丁-2-酮膦酸的方法 |
US7635705B2 (en) * | 2005-06-20 | 2009-12-22 | Schering Corporation | Heteroatom-linked substituted piperidines and derivatives thereof useful as histamine H3 antagonists |
SA06270191B1 (ar) | 2005-06-22 | 2010-03-29 | استرازينيكا ايه بي | مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم |
US20070259845A1 (en) * | 2005-09-08 | 2007-11-08 | Kansal Vinod K | Processes for the preparation of (3R,4S)-4-((4-benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-2-azetidinone, an intermediate for the synthesis of ezetimibe |
HU0501164D0 (en) * | 2005-12-20 | 2006-02-28 | Richter Gedeon Vegyeszet | New industrial process for the production of ezetimibe |
JP2009528266A (ja) | 2006-01-18 | 2009-08-06 | シェーリング コーポレイション | カンナビノイド受容体修飾因子 |
KR101074968B1 (ko) * | 2006-02-16 | 2011-10-18 | 고토부키 세이야쿠 가부시키가이샤 | 광학활성 알코올을 제조하는 방법 |
US7910698B2 (en) | 2006-02-24 | 2011-03-22 | Schering Corporation | NPC1L1 orthologues |
AR060623A1 (es) | 2006-04-27 | 2008-07-02 | Astrazeneca Ab | Compuestos derivados de 2-azetidinona y un metodo de preparacion |
WO2008030382A1 (en) * | 2006-09-05 | 2008-03-13 | Schering Corporation | Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis |
US20100197564A1 (en) * | 2007-04-19 | 2010-08-05 | Schering Corporation | Diaryl morpholines as cb1 modulators |
JP2010529148A (ja) * | 2007-06-07 | 2010-08-26 | テバ ファーマシューティカル インダストリーズ リミティド | エゼチミブ製造のための還元方法 |
EP2170847A2 (en) * | 2007-06-28 | 2010-04-07 | Intervet International BV | Substituted piperazines as cb1 antagonists |
EP2170846A2 (en) * | 2007-06-28 | 2010-04-07 | Intervet International BV | Substituted piperazines as cb1 antagonists |
WO2009032264A1 (en) * | 2007-08-30 | 2009-03-12 | Teva Pharmaceutical Industries Ltd. | Processes for preparing intermediates of ezetimibe by microbial reduction |
US20090312302A1 (en) * | 2008-06-17 | 2009-12-17 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating nonalcoholic fatty liver disease-associated disorders |
SI2329014T1 (sl) | 2008-08-29 | 2015-01-30 | Codexis, Inc. | Polipeptidi ketoreduktaze za stereoselektivno produkcijo (4s)-3(5s)-5(4-fluorofenil)-5-hidroksipentanoil)-4-fenil-1,3-oksazolidin -2-ona |
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EP2566497B1 (en) | 2010-05-04 | 2015-07-29 | Codexis, Inc. | Biocatalysts for ezetimibe synthesis |
WO2012155932A1 (en) | 2011-05-17 | 2012-11-22 | Pharmathen S.A. | Improved process for the preparation of ezetimibe |
CN111518046B (zh) * | 2020-06-04 | 2022-04-15 | 中山奕安泰医药科技有限公司 | 依泽替米贝中间体及依泽替米贝的制备方法 |
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-
2002
- 2002-03-25 IL IL15755202A patent/IL157552A0/xx unknown
- 2002-03-25 EP EP02728561A patent/EP1373230B1/en not_active Expired - Lifetime
- 2002-03-25 WO PCT/US2002/009123 patent/WO2002079174A2/en active IP Right Grant
- 2002-03-25 KR KR1020037012486A patent/KR100590342B1/ko active IP Right Grant
- 2002-03-25 AT AT02728561T patent/ATE305459T1/de active
- 2002-03-25 BR BRPI0208384A patent/BRPI0208384B1/pt active IP Right Grant
- 2002-03-25 CN CNB028075374A patent/CN1275949C/zh not_active Expired - Lifetime
- 2002-03-25 RS YUP-748/03A patent/RS50386B/sr unknown
- 2002-03-25 AU AU2002258605A patent/AU2002258605B2/en not_active Expired
- 2002-03-25 UA UA2003109666A patent/UA75644C2/uk unknown
- 2002-03-25 PL PL363864A patent/PL205952B1/pl unknown
- 2002-03-25 US US10/105,710 patent/US6627757B2/en not_active Expired - Lifetime
- 2002-03-25 NZ NZ527852A patent/NZ527852A/en not_active IP Right Cessation
- 2002-03-25 EE EEP200300464A patent/EE05453B1/xx unknown
- 2002-03-25 EA EA200300970A patent/EA006898B1/ru not_active IP Right Cessation
- 2002-03-25 DK DK02728561T patent/DK1373230T3/da active
- 2002-03-25 CZ CZ2003-2610A patent/CZ304929B6/cs not_active IP Right Cessation
- 2002-03-25 DE DE60206365T patent/DE60206365T2/de not_active Expired - Lifetime
- 2002-03-25 MX MXPA03008803A patent/MXPA03008803A/es active IP Right Grant
- 2002-03-25 HU HU0303526A patent/HU230229B1/hu unknown
- 2002-03-25 ES ES02728561T patent/ES2245733T3/es not_active Expired - Lifetime
- 2002-03-25 JP JP2002577801A patent/JP4145663B2/ja not_active Expired - Lifetime
- 2002-03-25 SK SK1186-2003A patent/SK287408B6/sk unknown
- 2002-03-25 SI SI200230193T patent/SI1373230T1/sl unknown
- 2002-03-25 CA CA002442219A patent/CA2442219C/en not_active Expired - Lifetime
-
2003
- 2003-08-24 IL IL157552A patent/IL157552A/en unknown
- 2003-08-25 ZA ZA200306612A patent/ZA200306612B/en unknown
- 2003-09-09 BG BG108168A patent/BG66189B1/bg unknown
- 2003-09-19 HR HR20030760A patent/HRP20030760B1/xx not_active IP Right Cessation
-
2004
- 2004-01-07 HK HK04100111A patent/HK1057546A1/xx not_active IP Right Cessation
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