BR0206363A - Utilização de deerivados de 2-amino-4-heteroariletiltiazolina como inibidores de no-sintase indutìvel - Google Patents

Utilização de deerivados de 2-amino-4-heteroariletiltiazolina como inibidores de no-sintase indutìvel

Info

Publication number
BR0206363A
BR0206363A BR0206363-8A BR0206363A BR0206363A BR 0206363 A BR0206363 A BR 0206363A BR 0206363 A BR0206363 A BR 0206363A BR 0206363 A BR0206363 A BR 0206363A
Authority
BR
Brazil
Prior art keywords
amino
heteroarylethylthiazoline
synthase
deerivates
inducibly
Prior art date
Application number
BR0206363-8A
Other languages
English (en)
Inventor
Eric Bacque
Antony Bigot
Jean-Christophe Carry
Serge Mignani
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0114509A external-priority patent/FR2832151B1/fr
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of BR0206363A publication Critical patent/BR0206363A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"UTILIZAçãO DE DERIVADOS DE 2-AMINO-4-HETEROARILETILTIAZOLINA COMO INIBIDORES DE NO-SINTASE INDUTìVEL". A presente invenção refere-se à utilização de derivados 2-amino-4-heteroariletil-tiazolina de fórmula (I) na qual Het representa um radical tienila, pirimidila, piridila ou tiazol ou seus sais farmaceuticamente aceitáveis como inibidores de NO-sintase indutível.
BR0206363-8A 2001-11-09 2002-11-07 Utilização de deerivados de 2-amino-4-heteroariletiltiazolina como inibidores de no-sintase indutìvel BR0206363A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0114509A FR2832151B1 (fr) 2001-11-09 2001-11-09 Utilisation de derives de 2-amino-4-heteroarylethyl-thiazoline comme inhibiteurs de no-synthase inductible
US35297702P 2002-01-30 2002-01-30
PCT/FR2002/003809 WO2003040142A1 (fr) 2001-11-09 2002-11-07 Derives de 2-amino-4-heteroarylethyl thiazoline et leur utilisation comme inhibiteurs de no-synthase inductible

Publications (1)

Publication Number Publication Date
BR0206363A true BR0206363A (pt) 2003-12-23

Family

ID=26213259

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0206363-8A BR0206363A (pt) 2001-11-09 2002-11-07 Utilização de deerivados de 2-amino-4-heteroariletiltiazolina como inibidores de no-sintase indutìvel

Country Status (19)

Country Link
US (1) US6872740B2 (pt)
EP (1) EP1446402B1 (pt)
JP (1) JP4365681B2 (pt)
AT (1) ATE308541T1 (pt)
AU (1) AU2002358874B2 (pt)
BR (1) BR0206363A (pt)
CA (1) CA2465691C (pt)
DE (1) DE60207104T2 (pt)
DK (1) DK1446402T3 (pt)
ES (1) ES2250731T3 (pt)
HR (1) HRP20040401A2 (pt)
HU (1) HUP0402038A2 (pt)
IL (2) IL161842A0 (pt)
MA (1) MA27077A1 (pt)
MX (1) MXPA04003766A (pt)
NO (1) NO20033130L (pt)
PL (1) PL370322A1 (pt)
RU (1) RU2004117525A (pt)
WO (1) WO2003040142A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL161841A0 (en) * 2001-11-09 2005-11-20 Aventis Pharma Sa 2-Amino-thiazoline derivatives and their use as inhibitors of inducible no-synthase
US8173642B2 (en) * 2005-10-25 2012-05-08 Shionogi & Co., Ltd. Aminodihydrothiazine derivatives
JP5383484B2 (ja) 2007-04-24 2014-01-08 塩野義製薬株式会社 環式基で置換されたアミノジヒドロチアジン誘導体
EP2151435A4 (en) 2007-04-24 2011-09-14 Shionogi & Co PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE
CN102119161B (zh) 2008-06-13 2015-07-08 盐野义制药株式会社 具有β分泌酶抑制作用的含硫杂环衍生物
JPWO2010047372A1 (ja) 2008-10-22 2012-03-22 塩野義製薬株式会社 Ｂａｃｅ１阻害活性を有する２−アミノピリミジン−４−オンおよび２−アミノピリジン誘導体
CN102834384A (zh) 2009-12-11 2012-12-19 盐野义制药株式会社 *嗪衍生物
EP2634188A4 (en) 2010-10-29 2014-05-07 Shionogi & Co FUSIONED AMINODIHYDROPYRIMIDINE DERIVATIVE
JP5816630B2 (ja) 2010-10-29 2015-11-18 塩野義製薬株式会社 ナフチリジン誘導体
US8883779B2 (en) 2011-04-26 2014-11-11 Shinogi & Co., Ltd. Oxazine derivatives and a pharmaceutical composition for inhibiting BACE1 containing them
WO2014065434A1 (en) 2012-10-24 2014-05-01 Shionogi & Co., Ltd. Dihydrooxazine or oxazepine derivatives having bace1 inhibitory activity
CN113456623A (zh) 2014-10-24 2021-10-01 韩国海洋研究院 用于预防或治疗神经变性疾病的含有Ramalin的组合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1095710A (zh) * 1992-11-27 1994-11-30 惠尔康基金会集团公司 酶抑制剂
WO1995011231A1 (en) * 1993-10-21 1995-04-27 G. D. Searle & Co. Amidino derivatives useful as nitric oxide synthase inhibitors
WO1996014842A1 (en) * 1994-11-15 1996-05-23 Merck & Co., Inc. Substituted heterocycles as inhibitors of nitric oxide synthase
FR2810037B1 (fr) * 2000-06-09 2004-04-23 Aventis Pharma Sa Utilisation de derives de 2-aminothiazoline comme inhibiteurs de no-synthase inductible

Also Published As

Publication number Publication date
IL161842A (en) 2010-12-30
CA2465691C (fr) 2011-07-19
DK1446402T3 (da) 2006-03-06
ES2250731T3 (es) 2006-04-16
NO20033130D0 (no) 2003-07-08
DE60207104D1 (de) 2005-12-08
RU2004117525A (ru) 2005-04-20
MXPA04003766A (es) 2004-07-29
ATE308541T1 (de) 2005-11-15
MA27077A1 (fr) 2004-12-20
HRP20040401A2 (en) 2004-10-31
JP4365681B2 (ja) 2009-11-18
JP2005509651A (ja) 2005-04-14
EP1446402B1 (fr) 2005-11-02
NO20033130L (no) 2003-08-27
DE60207104T2 (de) 2006-07-13
PL370322A1 (en) 2005-05-16
CA2465691A1 (fr) 2003-05-15
US20030225140A1 (en) 2003-12-04
AU2002358874B2 (en) 2007-09-06
IL161842A0 (en) 2005-11-20
HUP0402038A2 (hu) 2005-01-28
EP1446402A1 (fr) 2004-08-18
US6872740B2 (en) 2005-03-29
WO2003040142A1 (fr) 2003-05-15

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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