BR0201437A - Processo para preparar derivados de 9-desoxo-9a-aza-9a-homoeritromicina a 4"-substituìdos" - Google Patents

Processo para preparar derivados de 9-desoxo-9a-aza-9a-homoeritromicina a 4"-substituìdos"

Info

Publication number
BR0201437A
BR0201437A BR0201437-8A BRPI0201437A BR0201437A BR 0201437 A BR0201437 A BR 0201437A BR PI0201437 A BRPI0201437 A BR PI0201437A BR 0201437 A BR0201437 A BR 0201437A
Authority
BR
Brazil
Prior art keywords
preparing
aza
compounds
substituted
deoxo
Prior art date
Application number
BR0201437-8A
Other languages
English (en)
Inventor
Constantine Sklavounos
John Lloyd Tucker
Lulin Wei
Kerry Peter Mahon Jr
Philip Dietrich Hammen
Joanna Teresa Negri
Richard Shelton Lehner
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR0201437A publication Critical patent/BR0201437A/pt
Publication of BRPI0201437B1 publication Critical patent/BRPI0201437B1/pt
Publication of BRPI0201437B8 publication Critical patent/BRPI0201437B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

"PROCESSO PARA PREPARAR DERIVADOS DE 9-DESOXO-9A-AZA-9A-HOMOERITROMICINA A 4"-SUBSTITUìDOS". Esta invenção refere-se aos processos de preparação de compostos da fórmula 1. em que R 3 é definido como aqui, e de seus sais aceitáveis farmaceuticamente, bem como de intermediários úteis neste processo. Os composto da fórmula 1 são agentes antibacterianos que podem ser utilizados para o tratamento de várias infecções bacterianas e de protozoários. A invenção também refere-se a composições farmacêuticas contendo compostos preparados pelos processos da invenção e a métodos de tratamento de infecções bacterianas e de protozoários, pela administração de tais compostos.
BRPI0201437-8 2001-04-27 2002-04-26 processos para a preparação de derivados de 9-desoxo-9a-aza-9a-homoeritromicina a 4"-substituídos BRPI0201437B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28720301P 2001-04-27 2001-04-27
US60/287,203 2001-04-27

Publications (3)

Publication Number Publication Date
BR0201437A true BR0201437A (pt) 2003-06-10
BRPI0201437B1 BRPI0201437B1 (pt) 2017-11-28
BRPI0201437B8 BRPI0201437B8 (pt) 2021-05-25

Family

ID=23101880

Family Applications (2)

Application Number Title Priority Date Filing Date
BR0209241-7A BR0209241A (pt) 2001-04-27 2002-04-11 Processo para preparação de derivados de9-deoxo-9a-aza-9a-homoeritromicina a 4-substituida
BRPI0201437-8 BRPI0201437B8 (pt) 2001-04-27 2002-04-26 processos para a preparação de derivados de 9-desoxo-9a-aza-9a-homoeritromicina a 4"-substituídos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR0209241-7A BR0209241A (pt) 2001-04-27 2002-04-11 Processo para preparação de derivados de9-deoxo-9a-aza-9a-homoeritromicina a 4-substituida

Country Status (23)

Country Link
US (1) US6825327B2 (pt)
EP (2) EP1383780A1 (pt)
JP (3) JP4104463B2 (pt)
KR (1) KR100474225B1 (pt)
CN (4) CN100413879C (pt)
AR (1) AR035871A1 (pt)
AU (1) AU784362B2 (pt)
BR (2) BR0209241A (pt)
CA (2) CA2445306C (pt)
CZ (1) CZ303716B6 (pt)
DK (1) DK1253153T3 (pt)
ES (1) ES2608848T3 (pt)
HK (2) HK1050370A1 (pt)
HU (1) HU230717B1 (pt)
IL (3) IL158059A0 (pt)
MX (2) MXPA03009786A (pt)
PL (2) PL371766A1 (pt)
PT (1) PT1253153T (pt)
RU (2) RU2263117C2 (pt)
SG (1) SG100789A1 (pt)
WO (1) WO2002088158A1 (pt)
YU (1) YU29502A (pt)
ZA (2) ZA200203252B (pt)

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US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
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MX2007003378A (es) 2004-09-23 2007-05-10 Schering Plough Ltd Control de parasitos en animales mediante el uso de nuevos derivados de trifluorometansulfonanilida oxima eter.
WO2006055565A2 (en) 2004-11-19 2006-05-26 Schering-Plough Ltd. Control of parasites in animals by the use of parasiticidal 2-phenyl-3-(1h-pyrrol-2-yl) acrylonitrile derivatives
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US20070238700A1 (en) * 2006-04-10 2007-10-11 Winzenberg Kevin N N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
CA2672586A1 (en) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Water-soluble prodrugs of florfenicol and its analogs
US8044230B2 (en) * 2006-12-13 2011-10-25 Intervet Inc. Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
CN101743000A (zh) 2007-06-27 2010-06-16 杜邦公司 动物虫害控制方法
TWI401023B (zh) 2008-02-06 2013-07-11 Du Pont 中離子農藥
WO2010014566A2 (en) * 2008-07-30 2010-02-04 Intervet International B.V. Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol
WO2010086351A1 (en) * 2009-01-30 2010-08-05 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 3'-n-substituted 9-deoxo-9a-methyl-9a-aza-homoerythromycin having antimalarial activity
JP2013501063A (ja) 2009-08-05 2013-01-10 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー メソイオン性殺虫剤
AU2010279574A1 (en) 2009-08-05 2012-02-09 E. I. Du Pont De Nemours And Company Mesoionic pesticides
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
UA107804C2 (en) 2009-08-05 2015-02-25 Du Pont Mixtures of pesticides mezoionnyh
ES2566402T3 (es) 2010-05-27 2016-04-12 E. I. Du Pont De Nemours And Company Forma cristalina de 4-[5-[3-cloro-5-(trifluorometil)fenil]-4,5-dihidro-5-(trifluorometil)-3-isoxazolil]-N-[2-oxo-2-[(2,2,2-trifluoroetil)amino]etil]-1-naftalenocarboxamida
US20130102551A1 (en) * 2010-07-01 2013-04-25 Andreas Hotte Antibiotic compositions
US8940880B2 (en) * 2010-09-20 2015-01-27 Novartis Ag Process for the preparation of 9-deoxo-9a-homoerythromycin A, modified in the C-4″ of the cladinose ring by an epoxide group
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
CN102295672B (zh) * 2011-07-13 2014-06-04 武汉回盛生物科技有限公司 一种泰拉菌素的合成方法
CN102260306B (zh) * 2011-07-22 2012-07-18 山东鲁抗舍里乐药业有限公司 一种制备泰拉霉素的方法
EP2736915A1 (en) * 2011-07-27 2014-06-04 Farma GRS, d.o.o. New crystalline forms of tulathromycin
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
CN103965273B (zh) 2013-08-23 2016-05-25 普莱柯生物工程股份有限公司 一种大环内酯类化合物
CN103497227B (zh) * 2013-09-13 2015-09-30 青岛科技大学 一种泰拉菌素中间体的制备方法
CN108473524B (zh) * 2016-01-18 2021-11-02 浙江海正药业股份有限公司 一种泰拉霉素的制备方法及其中间体
CN106046077B (zh) * 2016-08-04 2019-07-26 湖北美天生物科技股份有限公司 一种泰拉霉素a的合成方法
CN106434797A (zh) * 2016-08-25 2017-02-22 艾美科健（中国）生物医药有限公司 一种酶法合成泰拉霉素的工艺
CN106939029B (zh) * 2017-04-28 2020-10-13 艾美科健（中国）生物医药有限公司 一种泰拉霉素的制备方法
CN107556351B (zh) * 2017-08-29 2019-10-18 博瑞生物医药（苏州）股份有限公司 一种泰拉菌素的制备方法
CN107400152B (zh) * 2017-08-29 2019-10-15 博瑞生物医药（苏州）股份有限公司 泰拉菌素草酸盐
CN109535210A (zh) * 2018-12-19 2019-03-29 江苏威凌生化科技有限公司 一种合成纯化泰拉霉素杂质e的方法
JP2022529315A (ja) 2019-04-18 2022-06-21 アズーラ オフサルミックス エルティーディー． 眼障害を処置するための化合物および方法
CN111072730B (zh) * 2019-12-16 2021-01-12 浙江国邦药业有限公司 一种泰拉霉素中间体盐的制备方法及应用
CN112225769A (zh) * 2020-09-21 2021-01-15 江苏威凌生化科技有限公司 一种合成纯化泰拉霉素杂质e的方法
CN113493483A (zh) * 2021-07-05 2021-10-12 上海应用技术大学 一种泰拉霉素的合成方法

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Also Published As

Publication number Publication date
PL371766A1 (en) 2005-06-27
PL213731B1 (pl) 2013-04-30
CA2383409C (en) 2007-01-02
PT1253153T (pt) 2016-12-29
AU3563002A (en) 2002-10-31
JP2007091754A (ja) 2007-04-12
CN1530370A (zh) 2004-09-22
BRPI0201437B8 (pt) 2021-05-25
JP4104463B2 (ja) 2008-06-18
RU2003131351A (ru) 2005-02-27
IL158059A0 (en) 2004-03-28
IL149226A0 (en) 2002-11-10
CN1295240C (zh) 2007-01-17
ZA200203252B (en) 2003-10-24
CN1297564C (zh) 2007-01-31
CN1503804A (zh) 2004-06-09
CZ20021417A3 (cs) 2003-05-14
CN1167708C (zh) 2004-09-22
ZA200307506B (en) 2005-01-26
DK1253153T3 (da) 2017-01-02
RU2233287C2 (ru) 2004-07-27
US6825327B2 (en) 2004-11-30
IL182418A0 (en) 2008-01-06
MXPA03009786A (es) 2004-01-29
US20030064939A1 (en) 2003-04-03
BR0209241A (pt) 2004-06-15
IL149226A (en) 2008-06-05
HU0201385D0 (pt) 2002-06-29
AR035871A1 (es) 2004-07-21
EP1253153A1 (en) 2002-10-30
WO2002088158A1 (en) 2002-11-07
CN100413879C (zh) 2008-08-27
HUP0201385A2 (hu) 2003-12-29
YU29502A (sh) 2005-03-15
ES2608848T3 (es) 2017-04-17
HK1065803A1 (en) 2005-03-04
JP2002326998A (ja) 2002-11-15
RU2263117C2 (ru) 2005-10-27
AU784362B2 (en) 2006-03-16
CA2445306C (en) 2008-02-12
JP2004528353A (ja) 2004-09-16
MXPA02004231A (es) 2002-11-13
KR20020083474A (ko) 2002-11-02
CZ303716B6 (cs) 2013-04-03
HK1050370A1 (en) 2003-06-20
CA2445306A1 (en) 2002-11-07
PL353633A1 (en) 2002-11-04
KR100474225B1 (ko) 2005-03-08
JP4100955B2 (ja) 2008-06-11
IL182418A (en) 2012-07-31
BRPI0201437B1 (pt) 2017-11-28
CA2383409A1 (en) 2002-10-27
SG100789A1 (en) 2003-12-26
EP1383780A1 (en) 2004-01-28
HU230717B1 (hu) 2017-11-28
CN1715289A (zh) 2006-01-04
CN1384108A (zh) 2002-12-11
EP1253153B1 (en) 2016-11-02

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B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
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