BR0111116A - Imitadores de trombopoietina - Google Patents
Imitadores de trombopoietinaInfo
- Publication number
- BR0111116A BR0111116A BR0111116-7A BR0111116A BR0111116A BR 0111116 A BR0111116 A BR 0111116A BR 0111116 A BR0111116 A BR 0111116A BR 0111116 A BR0111116 A BR 0111116A
- Authority
- BR
- Brazil
- Prior art keywords
- designed
- imitators
- thrombopoietin
- mammal
- thrombopoethine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
- C07D231/46—Oxygen atom in position 3 or 5 and nitrogen atom in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
- C07D231/46—Oxygen atom in position 3 or 5 and nitrogen atom in position 4
- C07D231/48—Oxygen atom in position 3 or 5 and nitrogen atom in position 4 with hydrocarbon radicals attached to said nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pyridine Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Information Transfer Systems (AREA)
- Vehicle Body Suspensions (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Hard Magnetic Materials (AREA)
Abstract
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20708400P | 2000-05-25 | 2000-05-25 | |
US22892900P | 2000-08-30 | 2000-08-30 | |
PCT/US2001/016863 WO2001089457A2 (en) | 2000-05-25 | 2001-05-24 | Thrombopoietin mimetics |
Publications (3)
Publication Number | Publication Date |
---|---|
BR0111116A true BR0111116A (pt) | 2003-04-08 |
BR0111116B1 BR0111116B1 (pt) | 2013-10-08 |
BRPI0111116B8 BRPI0111116B8 (pt) | 2021-05-25 |
Family
ID=26901947
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0111116A BRPI0111116B8 (pt) | 2000-05-25 | 2001-05-24 | imitadores de trombopoietina |
Country Status (30)
Country | Link |
---|---|
US (9) | US7160870B2 (pt) |
EP (3) | EP1864981B8 (pt) |
JP (2) | JP3813875B2 (pt) |
KR (2) | KR100798568B1 (pt) |
CN (4) | CN101343250B (pt) |
AR (2) | AR030696A1 (pt) |
AT (2) | ATE445606T1 (pt) |
AU (2) | AU2001274938C1 (pt) |
BE (1) | BE2010C018I2 (pt) |
BR (1) | BRPI0111116B8 (pt) |
CA (1) | CA2411468C (pt) |
CY (4) | CY2010012I2 (pt) |
CZ (1) | CZ303176B6 (pt) |
DE (4) | DE60140224D1 (pt) |
DK (3) | DK1889838T3 (pt) |
ES (3) | ES2328179T3 (pt) |
FR (1) | FR10C0034I2 (pt) |
HK (4) | HK1113057A1 (pt) |
HU (3) | HU227476B1 (pt) |
IL (5) | IL152988A0 (pt) |
LU (1) | LU91681I2 (pt) |
MX (1) | MXPA02011621A (pt) |
MY (1) | MY136707A (pt) |
NO (3) | NO324246B1 (pt) |
NZ (2) | NZ522474A (pt) |
PL (2) | PL218617B1 (pt) |
PT (3) | PT1864981E (pt) |
SI (3) | SI1864981T1 (pt) |
TW (1) | TWI305207B (pt) |
WO (1) | WO2001089457A2 (pt) |
Families Citing this family (107)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ20023018A3 (cs) | 2000-03-08 | 2003-01-15 | Metabasis Therapeutics, Inc. | Nové inhibitory fruktóza-1,6-bisfosfatázy obsahující arylovou skupinu |
CY2010012I2 (el) * | 2000-05-25 | 2020-05-29 | Novartis Ag | Μιμητικα θρομβοποιητινης |
US20110212054A1 (en) * | 2000-05-25 | 2011-09-01 | Glaxosmithkline Llc. | Thrombopoietin mimetics |
WO2002085343A1 (en) * | 2001-03-01 | 2002-10-31 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
US7659409B2 (en) | 2002-03-19 | 2010-02-09 | Mitsubishi Chemical Corporation | 3-Hydroxy-3-(2-thienyl) propionamides and production method thereof, and production method of 3-amino-1-(2-thienyl)-1-propanols using the same |
TWI280128B (en) * | 2002-05-22 | 2007-05-01 | Smithkline Beecham Corp | 3'-[(2Z)-[1-(3,4- dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid bis-(monoethanolamine) |
AU2003248630A1 (en) * | 2002-06-06 | 2003-12-22 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
EP1552828A4 (en) | 2002-08-14 | 2007-01-24 | Nissan Chemical Ind Ltd | THROMBOPOIETIN RECEPTOR ACTIVATOR AND METHOD OF PRODUCTION |
TWI324593B (en) | 2002-10-09 | 2010-05-11 | Nissan Chemical Ind Ltd | Pyrazolone compounds and thrombopoietin receptor activator |
US20100004302A1 (en) * | 2003-04-29 | 2010-01-07 | Connie Erickson-Miller | Methods for Treating Degenerative Diseases/Injuries |
US20090298179A1 (en) * | 2003-04-29 | 2009-12-03 | Connie Erickson-Miller | Methods For Treating Degenerative Diseases/Injuries |
US20090143453A1 (en) * | 2003-04-29 | 2009-06-04 | Connie Erickson-Miller | Methods for treating degenerative diseases/injuries |
WO2004096154A2 (en) * | 2003-04-29 | 2004-11-11 | Smithkline Beecham Corporation | Methods for treating degenerative diseases/injuries |
US20090048318A1 (en) * | 2003-04-29 | 2009-02-19 | Connie Erickson-Miller | Methods for treating degenerative diseases/injuries |
US7753958B2 (en) * | 2003-08-05 | 2010-07-13 | Gordon Charles R | Expandable intervertebral implant |
SE0302486D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
TW200526638A (en) * | 2003-10-22 | 2005-08-16 | Smithkline Beecham Corp | 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline |
WO2005118551A2 (en) * | 2004-05-28 | 2005-12-15 | Ligand Pharmaceuticals Inc. | Thrombopoietin activity modulating compounds and methods |
WO2006034474A2 (en) * | 2004-09-23 | 2006-03-30 | Reddy Us Therapeutics, Inc. | Novel pyridine compounds, process for their preparation and compositions containing them |
BRPI0516883A (pt) * | 2004-10-25 | 2008-09-23 | Ligand Pharm Inc | compostos e métodos para modulação da atividade de trombopoietina |
NZ555466A (en) | 2004-12-08 | 2010-08-27 | Nissan Chemical Ind Ltd | 3-ethylidenehydrazino substituted heterocyclic compounds as thrombopoietin receptor activators |
WO2006064957A1 (ja) | 2004-12-14 | 2006-06-22 | Nissan Chemical Industries, Ltd. | アミド化合物及びトロンボポエチンレセプター活性化剤 |
PE20070083A1 (es) | 2005-06-08 | 2007-01-27 | Smithkline Beecham Corp | (5z)-5-(6-quinoxalinilmetilideno)-2-[(2,6-diclorofenil)amino]-1,3-tiazol-4(5h)-ona |
TWI368617B (en) | 2005-07-15 | 2012-07-21 | Nissan Chemical Ind Ltd | Thiophene compounds and thrombopoietin receptor activators |
TWI330184B (en) | 2005-07-20 | 2010-09-11 | Nissan Chemical Ind Ltd | Pyrazole compounds and thrombopoietin receptor activators |
JP2009511603A (ja) * | 2005-10-13 | 2009-03-19 | スミスクライン・ビーチャム・コーポレイション | 貯蔵中の血小板の有効性を維持する方法 |
US8026368B2 (en) | 2005-11-07 | 2011-09-27 | Nissan Chemical Industries, Ltd. | Hydrazide compounds and thrombopoietin receptor activators |
JP5157900B2 (ja) | 2006-06-07 | 2013-03-06 | 日産化学工業株式会社 | 含窒素ヘテロ環化合物及びトロンボポエチンレセプター活性化剤 |
JP2010511631A (ja) * | 2006-12-01 | 2010-04-15 | ステイテジックス・インコーポレイテッド | トロンボポエチン擬態物 |
UY30915A1 (es) * | 2007-02-16 | 2008-09-02 | Smithkline Beecham Corp | Método de tratamiento de canceres |
US20110160130A1 (en) * | 2007-02-16 | 2011-06-30 | Connie Erickson-Miller | Cancer treatment method |
US20110129550A1 (en) * | 2007-02-16 | 2011-06-02 | Connie Erickson-Miller | Cancer treatment method |
JP2010525072A (ja) * | 2007-04-24 | 2010-07-22 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | Tpo模倣薬としてのヒドロキシ−1−アゾ−誘導体の新規な製造方法 |
ECSP077628A (es) | 2007-05-03 | 2008-12-30 | Smithkline Beechman Corp | Nueva composición farmacéutica |
CA2709224C (en) * | 2007-10-09 | 2015-06-23 | The Trustees Of The University Of Pennsylvania | Thrombopoietin receptor agonist (tpora) kills acute human myeloid leukemia cells |
CN101481352A (zh) | 2008-01-10 | 2009-07-15 | 上海恒瑞医药有限公司 | 双环取代吡唑酮偶氮类衍生物、其制备方法及其在医药上的应用 |
WO2009131951A2 (en) | 2008-04-21 | 2009-10-29 | Institute For Oneworld Health | Compounds, compositions and methods comprising isoxazole derivatives |
WO2009131957A2 (en) | 2008-04-21 | 2009-10-29 | Institute For Oneworld Health | Compounds, compositions and methods comprising oxadiazole derivatives |
WO2009151862A1 (en) * | 2008-05-15 | 2009-12-17 | Smithkline Beecham Corporation | Method of treatment |
EP2348858A4 (en) * | 2008-10-16 | 2013-06-12 | Glaxosmithkline Llc | PROCESS FOR THE TREATMENT OF THROMBOCYTOPENIA |
PE20100362A1 (es) | 2008-10-30 | 2010-05-27 | Irm Llc | Derivados de purina que expanden las celulas madre hematopoyeticas |
KR20140138349A (ko) | 2009-04-01 | 2014-12-03 | 플리바 흐르바츠카 디.오.오. | 엘트롬보팩 및 엘트롬보팩 염의 다형체 및 이의 제조 방법 |
US8343976B2 (en) | 2009-04-20 | 2013-01-01 | Institute For Oneworld Health | Compounds, compositions and methods comprising pyrazole derivatives |
US8476249B2 (en) | 2009-05-07 | 2013-07-02 | Glaxosmithkline Llc | Method of treating thrombocytopenia |
EP2427053A4 (en) * | 2009-05-07 | 2012-12-05 | Glaxosmithkline Llc | METHOD FOR TREATING THROMBOCYTOPENIA |
US8680150B2 (en) * | 2009-05-28 | 2014-03-25 | Ligand Pharmaceuticals, Inc. | Small molecule hematopoietic growth factor mimetic compounds that activate hematopoietic growth factor receptors |
CN102458120A (zh) * | 2009-05-29 | 2012-05-16 | 葛兰素史密斯克莱有限责任公司 | 给药血小板生成素激动剂化合物的方法 |
CN101921232A (zh) * | 2009-06-11 | 2010-12-22 | 上海恒瑞医药有限公司 | 双环取代吡唑酮偶氮类衍生物的盐,其制备方法及其在医药上的应用 |
MX2012006281A (es) | 2009-12-01 | 2012-06-28 | Basf Se | Sistema de resina de extrusion por estirado basada en poliuretano. |
CN101805291A (zh) * | 2010-04-26 | 2010-08-18 | 西北大学 | 1-(4-异丙苯基)-3-甲基-5-吡唑啉酮及其制备方法和应用 |
EP2611436A1 (en) | 2010-09-01 | 2013-07-10 | Novartis AG | Combination of hdac inhibitors with thrombocytopenia drugs |
WO2012102937A2 (en) | 2011-01-25 | 2012-08-02 | Irm Llc | Compounds that expand hematopoietic stem cells |
WO2012121958A2 (en) * | 2011-03-08 | 2012-09-13 | Glaxosmithkline Llc | Combination |
WO2012121957A1 (en) * | 2011-03-08 | 2012-09-13 | Glaxosmithkline Llc | Combination |
US20120309796A1 (en) | 2011-06-06 | 2012-12-06 | Fariborz Firooznia | Benzocycloheptene acetic acids |
JP2014523741A (ja) * | 2011-07-06 | 2014-09-18 | セレラント セラピューティクス インコーポレイテッド | 血小板産生のための巨核球前駆細胞 |
HUE034802T2 (en) * | 2011-08-30 | 2018-02-28 | Chdi Foundation Inc | Kinurenin-3-monooxygenase inhibitors, pharmaceutical preparations and methods of use |
WO2013072921A2 (en) | 2011-09-13 | 2013-05-23 | Glenmark Generics Limited | Process for preparation of substituted 3'-hydrazino-biphenyl-3-carboxylic acid compounds |
WO2013049605A1 (en) | 2011-09-28 | 2013-04-04 | Assia Chemical Industries Ltd. | Processes for the preparation of an intermediate in the synthesis of eltrombopag |
US9303024B2 (en) | 2011-10-11 | 2016-04-05 | Dana-Farber Cancer Institute, Inc. | Pyrazol-3-ones that activate pro-apoptotic BAX |
JP6072058B2 (ja) | 2011-11-14 | 2017-02-01 | リガンド・ファーマシューティカルズ・インコーポレイテッド | 顆粒球コロニー刺激因子受容体と結合する方法および組成物 |
CA2858069C (en) | 2011-12-08 | 2020-02-11 | Fred Hutchinson Cancer Research Center | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells |
AU2013212457B2 (en) | 2012-01-27 | 2017-02-16 | Universite De Montreal | Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells |
CN103360317B (zh) * | 2012-04-11 | 2016-12-14 | 齐鲁制药有限公司 | 双环取代吡唑酮偶氮类衍生物、其制备方法及用途 |
JP2015154715A (ja) * | 2012-05-22 | 2015-08-27 | 国立大学法人旭川医科大学 | ヒト単核球由来の新規血管再生細胞群及びその分化誘導法 |
US20140047572A1 (en) * | 2012-08-13 | 2014-02-13 | University Of Rochester | Thrombopoietin mimetics for the treatment of radiation or chemical induced bone marrow injury |
WO2014150252A1 (en) | 2013-03-15 | 2014-09-25 | Ligand Pharmaceuticals Incorporated | Methods of treatment associated with the granulocyte colony-stimulating factor receptor |
EP2799425A1 (en) | 2013-04-29 | 2014-11-05 | Esteve Química, S.A. | Preparation process of an agonist of the thrombopoietin receptor |
US9770437B2 (en) | 2013-09-02 | 2017-09-26 | Hetero Research Foundation | Compositions of eltrombopag |
ITMI20131782A1 (it) * | 2013-10-25 | 2015-04-26 | Dipharma Francis Srl | Procedimento per la preparazione di un agonista della trombopoietina |
CN104628647A (zh) * | 2013-11-12 | 2015-05-20 | 上海医药工业研究院 | 3-甲基-1-(3,4-二甲基苯基)-2-吡唑啉-5-酮的制备方法 |
CN104725318A (zh) * | 2013-12-20 | 2015-06-24 | 北京蓝贝望生物医药科技股份有限公司 | 一种爱曲伯帕的合成方法 |
WO2015111085A2 (en) | 2014-01-27 | 2015-07-30 | Cadila Healthcare Limited | Processes for the preparation of eltrombopag and pharmaceutically acceptable salts, solvates and intermediates thereof |
CN103819406B (zh) * | 2014-03-17 | 2015-04-08 | 苏州明锐医药科技有限公司 | 艾曲波帕的制备方法 |
WO2015161373A1 (en) | 2014-04-22 | 2015-10-29 | Université de Montréal | Compounds and use thereof in the expansion of hematopoietic stem cells and/or hematopoietic progenitor cells |
CN105085287A (zh) * | 2014-05-12 | 2015-11-25 | 上海医药工业研究院 | 3`-氨基-2`-羟基-[1,1`-联苯]-3-羧酸的制备方法 |
CN105085276A (zh) * | 2014-05-12 | 2015-11-25 | 上海医药工业研究院 | 艾曲波帕中间体及其制备方法和应用 |
KR20170026633A (ko) | 2014-07-17 | 2017-03-08 | 씨에이치디아이 파운데이션, 인코포레이티드 | Hiv-관련 장애의 치료 방법 및 치료용 조성물 |
US10336706B2 (en) | 2014-09-05 | 2019-07-02 | Hetero Research Foundation | Crystalline form of Eltrombopag free acid |
WO2016055935A1 (en) | 2014-10-06 | 2016-04-14 | Glaxosmithkline Intellectual Property (No.2) Limited | Combination of lysine-specific demethylase 1 inhibitor and thrombopoietin agonist |
WO2016068270A1 (ja) | 2014-10-31 | 2016-05-06 | 日産化学工業株式会社 | リガンド結合繊維及び当該繊維を用いた細胞培養基材 |
CN104829593B (zh) * | 2015-03-26 | 2017-08-25 | 苏州福来兹检测科技有限公司 | 一种用于检测溶液中金属离子含量的有机化合物及其应用 |
WO2017042839A1 (en) | 2015-09-08 | 2017-03-16 | Actavis Group Ptc Ehf. | Novel eltrombopag salt and preparation thereof |
MX2018012870A (es) | 2016-04-21 | 2019-03-28 | Basf Se | Metodo para la produccion de productos pultruidos a base de poliuretano. |
JP7104636B2 (ja) | 2016-06-27 | 2022-07-21 | ザ ジェネラル ホスピタル コーポレーション ドゥーイング ビジネス アズ マサチューセッツ ジェネラル ホスピタル | ミトコンドリア生物の活性化による血小板産生刺激 |
EP3592793A1 (en) | 2017-03-09 | 2020-01-15 | Basf Se | Polyurethane formulations for the production of composite elements |
CN107021928B (zh) * | 2017-04-01 | 2022-11-18 | 常州制药厂有限公司 | 艾曲波帕新的中间体及其制备方法和应用 |
EP3395331B1 (en) | 2017-04-26 | 2019-08-21 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Pharmaceutical tablet composition comprising eltrombopag olamine |
WO2019071111A1 (en) | 2017-10-06 | 2019-04-11 | Teva Pharmaceuticals Usa, Inc. | FORMS IN THE STRONG STATE OF ELTROMBOPAG CHOLINE |
EP3409272B1 (en) | 2018-03-07 | 2020-06-24 | Alfred E. Tiefenbacher (GmbH & Co. KG) | Pharmaceutical composition comprising eltrombopag olamine, reducing sugar, and polymeric binder |
CN110467531B (zh) * | 2018-05-09 | 2022-04-19 | 新发药业有限公司 | 一种3’-硝基-2’-羟基联苯-3-甲酸的制备方法 |
US11161821B2 (en) * | 2018-06-01 | 2021-11-02 | Aurobindo Pharma Ltd. | Process for the preparation of Eltrombopag olamine and its intermediates |
EP3604284B1 (en) | 2018-08-02 | 2020-11-11 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Crystalline eltrombopag monoethanolamine salt form d |
EP3604285B1 (en) | 2018-08-02 | 2020-06-17 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Highly stable crystalline form d1 of the eltrombopag monoethanolamine salt |
JP2022517211A (ja) * | 2019-01-08 | 2022-03-07 | 江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司 | 二環式置換ピラゾロンアゾ誘導体の投与レジメン |
US20220298116A1 (en) | 2019-07-04 | 2022-09-22 | F.l.S. - FABBRICA ITALIANA SINTETICI S.P.A | Process for the preparation of key intermediates for the synthesis of eltrombopag or salt thereof |
JP7083793B2 (ja) * | 2019-09-10 | 2022-06-13 | Jfeケミカル株式会社 | パラターフェニルテトラカルボン酸およびパラターフェニルテトラカルボン酸二無水物の製造方法 |
WO2021055820A1 (en) | 2019-09-20 | 2021-03-25 | Novartis Ag | 3'-[(2z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4h-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid and its salts formulation |
CN114341112A (zh) * | 2019-10-21 | 2022-04-12 | 广东东阳光药业有限公司 | 乙酰化艾曲波帕的新晶型及其制备方法 |
WO2021078077A1 (zh) * | 2019-10-21 | 2021-04-29 | 广东东阳光药业有限公司 | 乙酰化艾曲波帕的新晶型及其制备方法 |
WO2021110959A1 (en) | 2019-12-06 | 2021-06-10 | Synthon B.V. | Pharmaceutical composition comprising eltrombopag bis(monoethanolamine) |
EP4069203A1 (en) | 2019-12-06 | 2022-10-12 | Synthon B.V. | Pharmaceutical composition comprising eltrombopag bis(monoethanolamine) |
TR202014694A1 (tr) | 2020-09-16 | 2022-03-21 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Eltrombopag olami̇n i̇çeren bi̇r kati oral farmasöri̇k formülasyon |
WO2022201087A1 (en) | 2021-03-25 | 2022-09-29 | Novartis Ag | 3'-[(2z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4h-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid and its salts formulation |
CN113336704B (zh) * | 2021-06-11 | 2022-10-11 | 上海大学 | 丹参素衍生物及其制备方法和医药用途 |
CN114507186A (zh) * | 2021-12-02 | 2022-05-17 | 天津力生制药股份有限公司 | 一种艾曲波帕的制备方法 |
WO2023111187A1 (en) | 2021-12-15 | 2023-06-22 | Galenicum Health, S.L.U | Pharmaceutical compositions comprising eltrombopag |
Family Cites Families (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE193350C (pt) | ||||
US851444A (en) * | 1905-11-13 | 1907-04-23 | Agfa Ag | Amido-oxy-sulfonic acid of phenylnaphthimidazol and process of making same. |
GB779880A (en) | 1953-02-27 | 1957-07-24 | Ciba Ltd | Functional derivatives of azo-dyestuffs containing sulphonic acid groups and processfor making them |
US2809963A (en) * | 1954-10-26 | 1957-10-15 | Ciba Ltd | Azo-dyestuffs |
DE1046220B (de) * | 1956-04-21 | 1958-12-11 | Bayer Ag | Verfahren zur Herstellung von Monoazofarbstoffen und deren Metallkomplexverbindungen |
GB826207A (en) | 1956-07-23 | 1959-12-31 | Bayer Ag | ú´-ú´-dihydroxy-monoazo dyestuffs containing pyrrolidonyl residues and their metal complex compounds |
US2950273A (en) * | 1956-11-20 | 1960-08-23 | Agfa Ag | Process for the production of symmetrical and unsymmetrical azo compounds |
US3366619A (en) * | 1965-04-09 | 1968-01-30 | Interchem Corp | Disazo pyrazolone pigments |
US4435417A (en) * | 1981-02-20 | 1984-03-06 | Gruppo Lepetit S.P.A. | Antiinflammatory 3H-naphtho[1,2-d]imidazoles |
ES523609A0 (es) * | 1982-07-05 | 1985-03-01 | Erba Farmitalia | Procedimiento para preparar derivados n-imidazolilicos de compuestos biciclicos. |
FR2559483B1 (fr) * | 1984-02-10 | 1986-12-05 | Sandoz Sa | Composes heterocycliques contenant des groupes basiques et/ou cationiques, leur preparation et leur utilisation comme colorants |
FI91869C (fi) * | 1987-03-18 | 1994-08-25 | Tanabe Seiyaku Co | Menetelmä antidiabeettisena aineena käytettävien bensoksatsolijohdannaisten valmistamiseksi |
US4880788A (en) * | 1987-10-30 | 1989-11-14 | Baylor College Of Medicine | Method for preventing and treating thrombosis |
US5326776A (en) * | 1992-03-02 | 1994-07-05 | Abbott Laboratories | Angiotensin II receptor antagonists |
IL109570A0 (en) | 1993-05-17 | 1994-08-26 | Fujisawa Pharmaceutical Co | Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof |
EP0638617A1 (de) | 1993-08-13 | 1995-02-15 | Ciba-Geigy Ag | Pigmentsalze |
DE69412987T2 (de) * | 1993-12-28 | 1999-05-27 | Dainippon Printing Co Ltd | Thermische Übertragungsschicht |
SG47030A1 (en) * | 1994-01-03 | 1998-03-20 | Genentech Inc | Thrombopoietin |
WO1995021920A1 (en) | 1994-02-14 | 1995-08-17 | Zymogenetics, Inc. | Hematopoietic protein and materials and methods for making it |
US5482546A (en) * | 1994-03-30 | 1996-01-09 | Canon Kabushiki Kaisha | Dye, ink containing the same, and ink-jet recording method and instrument using the ink |
US5760038A (en) | 1995-02-06 | 1998-06-02 | Bristol-Myers Squibb Company | Substituted biphenyl sulfonamide endothelin antagonists |
US5746821A (en) | 1995-02-13 | 1998-05-05 | Engelhard Corporation | Pigment compositions |
EP2055712A1 (en) | 1995-06-07 | 2009-05-06 | Glaxo Group Limited | Peptides and compounds that bind to a thrombopoietin receptor |
US5622818A (en) * | 1995-11-29 | 1997-04-22 | Eastman Kodak Company | Color photographic elements containing yellow colored magenta dye forming masking couplers |
US5669967A (en) * | 1996-05-30 | 1997-09-23 | Engelhard Corporation | Pigment compositions |
US5932546A (en) * | 1996-10-04 | 1999-08-03 | Glaxo Wellcome Inc. | Peptides and compounds that bind to the thrombopoietin receptor |
SE9701398D0 (sv) | 1997-04-15 | 1997-04-15 | Astra Pharma Prod | Novel compounds |
GB9715830D0 (en) | 1997-07-25 | 1997-10-01 | Basf Ag | Reactive dyes containing piperazine |
WO1999011262A1 (en) | 1997-09-02 | 1999-03-11 | Roche Diagnostics Gmbh | Mpl-receptor ligands, process for their preparation, medicaments containing them and their use for the treatment and prevention of thrombocytopaenia and anaemia |
GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
EP1032387B1 (en) * | 1997-10-31 | 2007-03-07 | Smithkline Beecham Corporation | Novel metal complexes |
DE19851389A1 (de) * | 1998-11-07 | 2000-05-11 | Dystar Textilfarben Gmbh & Co | Gelbe Farbstoffmischungen von wasserlöslichen faserreaktiven Azofarbstoffen und ihre Verwendung |
GC0000177A (en) * | 1998-12-17 | 2006-03-29 | Smithkline Beecham | Thrombopoietin mimetics |
US6750342B1 (en) * | 1999-05-19 | 2004-06-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
CN1376150A (zh) | 1999-07-26 | 2002-10-23 | 盐野义制药株式会社 | 具有血栓形成素受体拮抗作用的药物组合物 |
ES2256038T3 (es) | 1999-09-10 | 2006-07-16 | Smithkline Beecham Corporation | Mimeticos de trombopoyetina. |
US6552008B1 (en) * | 1999-09-24 | 2003-04-22 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
EP1228051A1 (en) | 1999-11-05 | 2002-08-07 | SmithKline Beecham Corporation | Semicarbazone derivatives and their use as thrombopoietin mimetics |
ES2160560T1 (es) | 1999-11-10 | 2001-11-16 | Curacyte Ag | Colorantes o,o'-dihidroxi-azoicos como constituyentes de medicamentos para el tratamiento de trombopenias. |
TWI284639B (en) | 2000-01-24 | 2007-08-01 | Shionogi & Co | A compound having thrombopoietin receptor agonistic effect |
AR030273A1 (es) * | 2000-03-10 | 2003-08-20 | Smithkline Beecham Corp | Compuestos de hidroxifenil urea sustituidos con sulfonamidas, composiciones farmaceuticas que los comprenden, y uso de los mismos en la fabricacion de medicamentos para tratar una enfermedad mediada por una quimioquina |
US6436915B1 (en) * | 2000-04-07 | 2002-08-20 | Kinetek Pharmaceuticals, Inc. | Pyrazole compounds |
US6214813B1 (en) * | 2000-04-07 | 2001-04-10 | Kinetek Pharmaceuticals, Inc. | Pyrazole compounds |
CY2010012I2 (el) * | 2000-05-25 | 2020-05-29 | Novartis Ag | Μιμητικα θρομβοποιητινης |
US6642265B1 (en) * | 2000-09-08 | 2003-11-04 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
US7241783B2 (en) | 2000-12-19 | 2007-07-10 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
DE60132488D1 (de) | 2000-12-21 | 2008-03-06 | Ligand Pharmaceuticals | Regulierte aktivierung von zellmembranrezeptoren durch metallchelatisierende agonisten |
US7169931B2 (en) | 2001-01-26 | 2007-01-30 | Shionogi & Co., Ltd. | Cyclic compounds exhibiting thrombopoietin receptor agonism |
CA2435143A1 (en) | 2001-01-26 | 2002-08-01 | Shionogi & Co., Ltd. | Halogen compounds having thrombopoietin receptor agonism |
WO2002085343A1 (en) | 2001-03-01 | 2002-10-31 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
JP3927001B2 (ja) | 2001-06-15 | 2007-06-06 | 三菱化学株式会社 | 色素セット、インクセット並びに記録方法 |
US6560161B1 (en) * | 2001-08-30 | 2003-05-06 | Micron Technology, Inc. | Synchronous flash memory command sequence |
US7875728B2 (en) | 2001-11-30 | 2011-01-25 | Valocor Therapeutics, Inc. | Hydrazonopyrazole derivatives and their use as therapeutics |
WO2003074550A2 (en) | 2002-03-01 | 2003-09-12 | Pintex Pharmaceuticals, Inc. | Pin1-modulating compounds and methods of use thereof |
TWI280128B (en) | 2002-05-22 | 2007-05-01 | Smithkline Beecham Corp | 3'-[(2Z)-[1-(3,4- dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid bis-(monoethanolamine) |
AU2003248630A1 (en) | 2002-06-06 | 2003-12-22 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
TWI324593B (en) * | 2002-10-09 | 2010-05-11 | Nissan Chemical Ind Ltd | Pyrazolone compounds and thrombopoietin receptor activator |
US20060084682A1 (en) | 2002-12-13 | 2006-04-20 | Heerding Dirk A | Thrombopoietin mimetics |
US20090298179A1 (en) * | 2003-04-29 | 2009-12-03 | Connie Erickson-Miller | Methods For Treating Degenerative Diseases/Injuries |
WO2004096154A2 (en) | 2003-04-29 | 2004-11-11 | Smithkline Beecham Corporation | Methods for treating degenerative diseases/injuries |
TW200526638A (en) * | 2003-10-22 | 2005-08-16 | Smithkline Beecham Corp | 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline |
WO2005118551A2 (en) * | 2004-05-28 | 2005-12-15 | Ligand Pharmaceuticals Inc. | Thrombopoietin activity modulating compounds and methods |
BRPI0516883A (pt) * | 2004-10-25 | 2008-09-23 | Ligand Pharm Inc | compostos e métodos para modulação da atividade de trombopoietina |
JP2009511603A (ja) * | 2005-10-13 | 2009-03-19 | スミスクライン・ビーチャム・コーポレイション | 貯蔵中の血小板の有効性を維持する方法 |
JP2010511631A (ja) * | 2006-12-01 | 2010-04-15 | ステイテジックス・インコーポレイテッド | トロンボポエチン擬態物 |
-
2000
- 2000-06-03 CY CY2010012C patent/CY2010012I2/el unknown
-
2001
- 2001-05-23 MY MYPI20012430A patent/MY136707A/en unknown
- 2001-05-23 AR ARP010102468A patent/AR030696A1/es active IP Right Grant
- 2001-05-23 TW TW090112317A patent/TWI305207B/zh active
- 2001-05-24 DK DK07112106.5T patent/DK1889838T3/da active
- 2001-05-24 EP EP07112105A patent/EP1864981B8/en not_active Expired - Lifetime
- 2001-05-24 HU HU0302257A patent/HU227476B1/hu active Protection Beyond IP Right Term
- 2001-05-24 US US10/296,688 patent/US7160870B2/en not_active Expired - Lifetime
- 2001-05-24 MX MXPA02011621A patent/MXPA02011621A/es active IP Right Grant
- 2001-05-24 CN CN200810129758XA patent/CN101343250B/zh not_active Expired - Fee Related
- 2001-05-24 DK DK01941599T patent/DK1294378T3/da active
- 2001-05-24 ES ES07112105T patent/ES2328179T3/es not_active Expired - Lifetime
- 2001-05-24 DK DK07112105T patent/DK1864981T3/da active
- 2001-05-24 KR KR1020027015869A patent/KR100798568B1/ko active Protection Beyond IP Right Term
- 2001-05-24 CN CN2008101297594A patent/CN101343251B/zh not_active Expired - Fee Related
- 2001-05-24 ES ES01941599T patent/ES2294000T3/es not_active Expired - Lifetime
- 2001-05-24 CN CNA2008101297607A patent/CN101342169A/zh active Pending
- 2001-05-24 PL PL393259A patent/PL218617B1/pl unknown
- 2001-05-24 NZ NZ522474A patent/NZ522474A/en not_active IP Right Cessation
- 2001-05-24 KR KR1020077018036A patent/KR100847172B1/ko active IP Right Review Request
- 2001-05-24 HU HU0800310A patent/HU230387B1/hu not_active IP Right Cessation
- 2001-05-24 DE DE60140224T patent/DE60140224D1/de not_active Expired - Lifetime
- 2001-05-24 AU AU2001274938A patent/AU2001274938C1/en active Active
- 2001-05-24 AT AT07112106T patent/ATE445606T1/de active
- 2001-05-24 PT PT07112105T patent/PT1864981E/pt unknown
- 2001-05-24 AU AU7493801A patent/AU7493801A/xx active Pending
- 2001-05-24 EP EP07112106A patent/EP1889838B1/en not_active Expired - Lifetime
- 2001-05-24 ES ES07112106T patent/ES2334843T3/es not_active Expired - Lifetime
- 2001-05-24 PT PT01941599T patent/PT1294378E/pt unknown
- 2001-05-24 SI SI200130938T patent/SI1864981T1/sl unknown
- 2001-05-24 HU HU0800710A patent/HU230487B1/hu not_active IP Right Cessation
- 2001-05-24 DE DE60130760T patent/DE60130760T2/de not_active Expired - Lifetime
- 2001-05-24 PT PT07112106T patent/PT1889838E/pt unknown
- 2001-05-24 SI SI200130955T patent/SI1889838T1/sl unknown
- 2001-05-24 CZ CZ20023852A patent/CZ303176B6/cs unknown
- 2001-05-24 PL PL359270A patent/PL216528B1/pl unknown
- 2001-05-24 CA CA002411468A patent/CA2411468C/en not_active Expired - Lifetime
- 2001-05-24 DE DE122010000037C patent/DE122010000037I1/de active Pending
- 2001-05-24 AT AT01941599T patent/ATE374772T1/de active
- 2001-05-24 WO PCT/US2001/016863 patent/WO2001089457A2/en active Application Filing
- 2001-05-24 DE DE60139354T patent/DE60139354D1/de not_active Expired - Lifetime
- 2001-05-24 IL IL15298801A patent/IL152988A0/xx active IP Right Grant
- 2001-05-24 CN CNB018133401A patent/CN100423721C/zh not_active Expired - Lifetime
- 2001-05-24 SI SI200130790T patent/SI1294378T1/sl unknown
- 2001-05-24 JP JP2001585703A patent/JP3813875B2/ja not_active Expired - Lifetime
- 2001-05-24 BR BRPI0111116A patent/BRPI0111116B8/pt not_active IP Right Cessation
- 2001-05-24 EP EP01941599A patent/EP1294378B1/en not_active Expired - Lifetime
- 2001-05-24 NZ NZ533308A patent/NZ533308A/en not_active IP Right Cessation
-
2002
- 2002-11-20 IL IL152988A patent/IL152988A/en active Protection Beyond IP Right Term
- 2002-11-20 NO NO20025566A patent/NO324246B1/no active Protection Beyond IP Right Term
-
2003
- 2003-09-09 HK HK08103330.5A patent/HK1113057A1/xx not_active IP Right Cessation
- 2003-09-09 HK HK03106428A patent/HK1055561A1/xx not_active IP Right Cessation
- 2003-09-19 HK HK03106754.0A patent/HK1056114A1/zh unknown
-
2005
- 2005-12-07 JP JP2005353686A patent/JP4546919B2/ja not_active Expired - Fee Related
-
2006
- 2006-11-09 US US11/558,071 patent/US7335649B2/en not_active Expired - Fee Related
-
2007
- 2007-01-05 US US11/620,260 patent/US7332481B2/en not_active Expired - Lifetime
- 2007-01-08 US US11/650,651 patent/US7473686B2/en not_active Expired - Lifetime
- 2007-01-08 US US11/650,688 patent/US7439342B2/en not_active Expired - Fee Related
- 2007-01-08 US US11/650,838 patent/US7452874B2/en not_active Expired - Lifetime
- 2007-12-13 CY CY20071101583T patent/CY1107087T1/el unknown
-
2008
- 2008-04-10 HK HK08104080.5A patent/HK1117825A1/xx not_active IP Right Cessation
- 2008-05-02 AR ARP080101867A patent/AR066036A2/es active IP Right Grant
- 2008-06-18 US US12/141,397 patent/US7790704B2/en not_active Expired - Fee Related
- 2008-06-18 US US12/141,422 patent/US7648971B2/en not_active Expired - Fee Related
- 2008-06-18 US US12/141,379 patent/US7674887B2/en not_active Expired - Fee Related
- 2008-08-21 IL IL193617A patent/IL193617A/en not_active IP Right Cessation
- 2008-08-21 IL IL193618A patent/IL193618A0/en not_active IP Right Cessation
- 2008-08-21 IL IL193619A patent/IL193619A0/en unknown
-
2009
- 2009-08-13 CY CY20091100873T patent/CY1109435T1/el unknown
-
2010
- 2010-01-11 CY CY20101100027T patent/CY1109730T1/el unknown
- 2010-04-13 BE BE2010C018C patent/BE2010C018I2/fr unknown
- 2010-04-21 LU LU91681C patent/LU91681I2/fr unknown
- 2010-06-18 FR FR10C0034C patent/FR10C0034I2/fr active Active
- 2010-08-19 NO NO2010017C patent/NO2010017I2/no unknown
-
2020
- 2020-11-19 NO NO2020040C patent/NO2020040I1/no unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0111116A (pt) | Imitadores de trombopoietina | |
BR0014767A (pt) | Fibras de sementes de plantas e uso | |
PT91158A (pt) | Processo para a preparacao de novos estirenos e carboxamidas heterociclicos biciclicos e composicoes farmaceuticas que os contem | |
BR9915727A (pt) | ésteres derivados de compostos de fenil-ciclohexila substituìdos | |
MX9206851A (es) | Sales organicas de n,n'-diacetil cistina, proceso para su preparacion y composicion farmaceutica que las contiene. | |
BR0113776A (pt) | Composição de pirrolocarbazóis selecionados fundidos e método para tratar e prevenir várias doenças usando a citada composição | |
PT99400A (pt) | Processo para a preparacao de derivados de 3-amido- e 3-sulfamido-indolilo e de composicoes farmaceuticas que os contem | |
BR9609424A (pt) | Novos peptìdeos, compostos, composição farmacêutica, processo para tratar um tumor em um mamìfero, e, processo para preparar os compostos | |
PT93030A (pt) | Processo para a preparacao de novas acilaminobenzamidas com efeito fungicida e de composicoes fungicidas que as contem | |
PT89502A (pt) | Processo para a preparacao de derivados de 2-(2-hidroxi-3-fenoxi-metilo e de composicoes farmaceuticas que os contem | |
BR9509269A (pt) | Processo para tratar diabetes | |
BR9611790A (pt) | Composto derivados de anilidas processo de preparação e utilização dos mesmos e composições farmacêuticas | |
BR0211011A (pt) | Composição, método para fornecimento de estabilidade fìsica, método para tratamento de fibras queratìnicas e kit de múltiplos compartimentos | |
DE122011100046I1 (de) | In vitro kulturprozess fur verschiedene stadien von gewebeparasiten. | |
BR1100991A (pt) | Compostos, processo para preparação dos mesmos, medicamentos, e, compostos intermediários | |
BR0110184A (pt) | Derivado de piridina-1-óxido, e processo para a sua transformação em compostos farmaceuticamente eficazes | |
DE69405919D1 (de) | Zusammensetzungen zur Behandlung von Keratinfasern | |
BR8900834A (pt) | 1,2,4-triazinodionas substituidas e processo para sua preparacao;compostos intermediarios para as mesmas e processos para sua preparacao;composicoes contra protozoarios parasitarios;processo para o combate dos mesmos;e processo para preparacao de composicoes contra protozoarios parasitarios | |
PT99435A (pt) | Processo para a preparacao de derivados de amino-sulfonil-ureia e de composicoes farmaceuticas que os contem | |
BR0316400A (pt) | agentes branqueadores fluorescentes anfotéricos | |
MX9102518A (es) | Dicarbonatos y uretanos de acido 4,5,-dihidroxi y 4,5,8,-trihidroxi-9,10-dihidro-9,10-dioxi-2-1-antracencarboxilico que tiene actividad terapeutica. | |
PT94792A (pt) | Processo para a preparacao de novos compostos derivados de cromano e de composicoes farmaceuticas que os contem | |
BR9808923A (pt) | Composto, e, processo para fazer o mesmo | |
BR1100524A (pt) | Compostos, processo para sua preparação; compostos intermediários para os mesmos, e composições farmacêuticas | |
BR9705456A (pt) | Compostos heterocìclicos, processo de aminometila para sua preparação e composições farmacêuticas que os contêm. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25A | Requested transfer of rights approved |
Owner name: SMITHKLINE BEECHAM CORPORATION (US) Free format text: TRANSFERIDO DE: GLAXO GROUP LIMITED |
|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] |
Free format text: DE ACORDO COM ART. 34 " II " DA LPI ( LEI 9279, DE 14/05/96 ) , O EXAME FICA SUSPENSO PARA QUE O REQUERENTE APRESENTE DOCUMENTOS NECESSARIOS A REGULARIZACAO DO PROCESSO E EXAME DO PEDIDO. |
|
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B15G | Petition not considered as such [chapter 15.7 patent gazette] |
Free format text: DESCONHECO A PETICAO NO 020110029575 DE 28/03/2011, COM BASE NO DISPOSTO NO ART. 219, II DA LEI DA PROPRIEDADE INDUSTRIAL, UMA VEZ QUE O INTERESSADO NAO TEM LEGITIMIDADE PARA O ATO. |
|
B25D | Requested change of name of applicant approved |
Owner name: GLAXOSMITHKLINE LLC (US) Free format text: NOME ALTERADO DE: SMITHKLINE BEECHAM CORPORATION |
|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 08/10/2013, OBSERVADAS AS CONDICOES LEGAIS. |
|
B25A | Requested transfer of rights approved | ||
B25A | Requested transfer of rights approved | ||
B25A | Requested transfer of rights approved | ||
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/05/2001 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
|
B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 22A ANUIDADE. |
|
B21H | Decision of lapse of a patent or of a certificate of addition of invention cancelled [chapter 21.8 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 21.6 NA RPI NO 2724 DE 21/03/2023 POR TER SIDO INDEVIDA. |
|
B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 24/05/2021 |