BR0109854A - Processo para produção de perciquinina e seu uso como produto farmacêutico - Google Patents
Processo para produção de perciquinina e seu uso como produto farmacêuticoInfo
- Publication number
- BR0109854A BR0109854A BR0109854-3A BR0109854A BR0109854A BR 0109854 A BR0109854 A BR 0109854A BR 0109854 A BR0109854 A BR 0109854A BR 0109854 A BR0109854 A BR 0109854A
- Authority
- BR
- Brazil
- Prior art keywords
- perciquinine
- production
- pharmaceutically acceptable
- pharmaceutical
- perciquinin
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 241000233866 Fungi Species 0.000 abstract 1
- 229940086609 Lipase inhibitor Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
Abstract
"PROCESSO PARA PRODUçãO DE PERCIQUININA E SEU USO COMO PRODUTO FARMACêUTICO". A presente invenção refere-se a um composto denominado Perciquinina, que é obtido mediante cultivo do fungo ST 001837 (DMS 13303) e a seus sais farmaceuticamente aceitáveis. A presente invenção refere-se ainda a um processo para produção de Perciquinina, ao microorganismo ST 001837 (DSM 13303), ao uso da Perciquinina e seus sais farmaceuticamente aceitáveis como produtos farmacêuticos, em particular ao seu uso como inibidor da lipase e a composições farmacêuticas compreendendo Perciquinina ou um sal farmaceuticamente aceitável da mesma.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00107536A EP1142886A1 (en) | 2000-04-07 | 2000-04-07 | Percyquinnin, a process for its production and its use as a pharmaceutical |
| PCT/EP2001/003392 WO2001077094A1 (en) | 2000-04-07 | 2001-03-24 | Percyquinnin, a process for its production and its use as a pharmaceutical |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0109854A true BR0109854A (pt) | 2003-06-03 |
Family
ID=8168397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0109854-3A BR0109854A (pt) | 2000-04-07 | 2001-03-24 | Processo para produção de perciquinina e seu uso como produto farmacêutico |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6596518B2 (pt) |
| EP (2) | EP1142886A1 (pt) |
| JP (1) | JP2003530391A (pt) |
| KR (1) | KR100791798B1 (pt) |
| CN (1) | CN1199959C (pt) |
| AT (1) | ATE269855T1 (pt) |
| AU (2) | AU784902B2 (pt) |
| BR (1) | BR0109854A (pt) |
| CA (1) | CA2405066A1 (pt) |
| CZ (1) | CZ20023310A3 (pt) |
| DE (1) | DE60103995T2 (pt) |
| DK (1) | DK1274698T3 (pt) |
| EE (1) | EE200200572A (pt) |
| ES (1) | ES2222992T3 (pt) |
| HK (1) | HK1052005A1 (pt) |
| HR (1) | HRP20020796A2 (pt) |
| HU (1) | HUP0300327A3 (pt) |
| IL (2) | IL152073A0 (pt) |
| MX (1) | MXPA02007895A (pt) |
| NO (1) | NO20024772D0 (pt) |
| NZ (1) | NZ521782A (pt) |
| PL (1) | PL357909A1 (pt) |
| PT (1) | PT1274698E (pt) |
| RS (1) | RS50140B (pt) |
| RU (1) | RU2266290C2 (pt) |
| SI (1) | SI1274698T1 (pt) |
| SK (1) | SK14322002A3 (pt) |
| TR (1) | TR200401739T4 (pt) |
| WO (1) | WO2001077094A1 (pt) |
| ZA (1) | ZA200207910B (pt) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1142886A1 (en) * | 2000-04-07 | 2001-10-10 | Aventis Pharma Deutschland GmbH | Percyquinnin, a process for its production and its use as a pharmaceutical |
| US7105526B2 (en) | 2002-06-28 | 2006-09-12 | Banyu Pharmaceuticals Co., Ltd. | Benzimidazole derivatives |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| WO2005028438A1 (ja) | 2003-09-22 | 2005-03-31 | Banyu Pharmaceutical Co., Ltd. | 新規ピペリジン誘導体 |
| EP2305352A1 (en) | 2004-04-02 | 2011-04-06 | Merck Sharp & Dohme Corp. | 5-alpha-reductase inhibitors for use in the treatment of men with metabolic and anthropometric disorders |
| CA2577060A1 (en) | 2004-08-13 | 2006-02-23 | Amgen Inc. | Substituted benzofused heterocycles |
| EP1916239A4 (en) | 2005-08-10 | 2009-10-21 | Banyu Pharma Co Ltd | PYRIDONE COMPOUND |
| EP1921065B1 (en) | 2005-08-24 | 2010-10-20 | Banyu Pharmaceutical Co., Ltd. | Phenylpyridone derivative |
| WO2007029847A1 (ja) | 2005-09-07 | 2007-03-15 | Banyu Pharmaceutical Co., Ltd. | 二環性芳香族置換ピリドン誘導体 |
| EP1940842B1 (en) | 2005-09-29 | 2012-05-30 | Merck Sharp & Dohme Corp. | Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators |
| BRPI0617621A2 (pt) | 2005-10-21 | 2011-08-02 | Novartis Ag | combinação de compostos orgánicos |
| AU2006307046A1 (en) | 2005-10-27 | 2007-05-03 | Msd K.K. | Novel benzoxathiin derivative |
| MY146564A (en) | 2005-11-10 | 2012-08-30 | Msd Kk | Aza-substituted spiro derivatives |
| CN100417650C (zh) * | 2006-08-17 | 2008-09-10 | 中国科学院昆明植物研究所 | 韧革菌素及其制备方法和在药物上的应用 |
| EP2698157B1 (en) | 2006-09-22 | 2015-05-20 | Merck Sharp & Dohme Corp. | Method of treatment using fatty acid synthesis inhibitors |
| WO2008038692A1 (fr) | 2006-09-28 | 2008-04-03 | Banyu Pharmaceutical Co., Ltd. | dÉrivÉ de diarylcÉtimine |
| AU2008233662B2 (en) | 2007-04-02 | 2012-08-23 | Msd K.K. | Indoledione derivative |
| US7879802B2 (en) | 2007-06-04 | 2011-02-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| CA2714617A1 (en) | 2008-03-06 | 2009-09-11 | Banyu Pharmaceutical Co., Ltd. | Alkylaminopyridine derivative |
| US20110015198A1 (en) | 2008-03-28 | 2011-01-20 | Banyu Pharmaceutical Co., Inc. | Diarylmethylamide derivative having melanin-concentrating hormone receptor antagonism |
| EP3239170B1 (en) | 2008-06-04 | 2019-03-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| EP2301936A1 (en) | 2008-06-19 | 2011-03-30 | Banyu Pharmaceutical Co., Ltd. | Spirodiamine-diarylketoxime derivative |
| EP3241839B1 (en) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| EP2319841A1 (en) | 2008-07-30 | 2011-05-11 | Msd K.K. | (5-membered)-(5-membered) or (5-membered)-(6-membered) fused ring cycloalkylamine derivative |
| CA2741125A1 (en) | 2008-10-22 | 2010-04-29 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| CA2741644C (en) | 2008-10-30 | 2013-05-07 | Merck Sharp & Dohme Corp. | Isonicotinamide orexin receptor antagonists |
| WO2010051206A1 (en) | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| US8895596B2 (en) | 2010-02-25 | 2014-11-25 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| EP2677869B1 (en) | 2011-02-25 | 2017-11-08 | Merck Sharp & Dohme Corp. | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
| AR088352A1 (es) | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina |
| AU2013296470B2 (en) | 2012-08-02 | 2016-03-17 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| AU2014219020A1 (en) | 2013-02-22 | 2015-07-23 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
| WO2014139388A1 (en) | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
| CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
| JP6606491B2 (ja) | 2013-06-05 | 2019-11-13 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法 |
| WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| JP6769963B2 (ja) | 2014-08-29 | 2020-10-14 | ティエエッセ ファルマ ソチエタ レスポンサビリタ リミタータ | α−アミノ−β−カルボキシムコン酸セミアルデヒド脱炭酸酵素の阻害剤 |
| CN105906500B (zh) * | 2016-04-22 | 2018-06-26 | 中国科学院昆明植物研究所 | 具有脂肪酶抑制作用的绵马次酸类化合物及其应用 |
| AU2017342083A1 (en) | 2016-10-14 | 2019-04-11 | Tes Pharma S.R.L. | Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase |
| EP3551176A4 (en) | 2016-12-06 | 2020-06-24 | Merck Sharp & Dohme Corp. | ANTIDIABETIC HETEROCYCLIC COMPOUNDS |
| EP3558298A4 (en) | 2016-12-20 | 2020-08-05 | Merck Sharp & Dohme Corp. | ANTIDIABETIC SPIROCHROMAN COMPOUNDS |
| CN109055231B (zh) * | 2018-07-26 | 2021-04-27 | 云南大学 | 一种真菌发酵液及其应用 |
| KR20210111248A (ko) | 2018-11-20 | 2021-09-10 | 테스 파마 에스.알.엘. | α-아미노-β-카르복시뮤콘산 세미알데하이드 데카르복실라제의 저해제 |
| WO2020167706A1 (en) | 2019-02-13 | 2020-08-20 | Merck Sharp & Dohme Corp. | 5-alkyl pyrrolidine orexin receptor agonists |
| WO2021026047A1 (en) | 2019-08-08 | 2021-02-11 | Merck Sharp & Dohme Corp. | Heteroaryl pyrrolidine and piperidine orexin receptor agonists |
| CR20230089A (es) | 2020-08-18 | 2023-04-11 | Merck Sharp & Dohme Llc | Agonistas de bicicloheptano pirrolidina de los receptores de orexina |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2344285A1 (fr) * | 1976-03-19 | 1977-10-14 | Roussel Uclaf | Nouvelles lactones derivees du cyclopentanol, leur procede de preparation et leur application comme medicaments |
| US5322779A (en) * | 1992-04-16 | 1994-06-21 | The Research And Development Institute, Inc. At Montana State University | Taxol production by taxomyces andreanae |
| EP1142886A1 (en) * | 2000-04-07 | 2001-10-10 | Aventis Pharma Deutschland GmbH | Percyquinnin, a process for its production and its use as a pharmaceutical |
-
2000
- 2000-04-07 EP EP00107536A patent/EP1142886A1/en not_active Withdrawn
-
2001
- 2001-03-24 PT PT01929453T patent/PT1274698E/pt unknown
- 2001-03-24 BR BR0109854-3A patent/BR0109854A/pt not_active Application Discontinuation
- 2001-03-24 TR TR2004/01739T patent/TR200401739T4/xx unknown
- 2001-03-24 EP EP01929453A patent/EP1274698B1/en not_active Expired - Lifetime
- 2001-03-24 PL PL01357909A patent/PL357909A1/xx not_active IP Right Cessation
- 2001-03-24 KR KR1020027013443A patent/KR100791798B1/ko not_active IP Right Cessation
- 2001-03-24 SI SI200130168T patent/SI1274698T1/xx unknown
- 2001-03-24 JP JP2001575568A patent/JP2003530391A/ja active Pending
- 2001-03-24 IL IL15207301A patent/IL152073A0/xx active IP Right Grant
- 2001-03-24 WO PCT/EP2001/003392 patent/WO2001077094A1/en active IP Right Grant
- 2001-03-24 CN CNB018064981A patent/CN1199959C/zh not_active Expired - Fee Related
- 2001-03-24 RS YUP-740/02A patent/RS50140B/sr unknown
- 2001-03-24 DK DK01929453T patent/DK1274698T3/da active
- 2001-03-24 CA CA002405066A patent/CA2405066A1/en not_active Abandoned
- 2001-03-24 CZ CZ20023310A patent/CZ20023310A3/cs unknown
- 2001-03-24 HU HU0300327A patent/HUP0300327A3/hu unknown
- 2001-03-24 AT AT01929453T patent/ATE269855T1/de not_active IP Right Cessation
- 2001-03-24 MX MXPA02007895A patent/MXPA02007895A/es active IP Right Grant
- 2001-03-24 RU RU2002129890/04A patent/RU2266290C2/ru not_active IP Right Cessation
- 2001-03-24 DE DE60103995T patent/DE60103995T2/de not_active Expired - Lifetime
- 2001-03-24 NZ NZ521782A patent/NZ521782A/en unknown
- 2001-03-24 EE EEP200200572A patent/EE200200572A/xx unknown
- 2001-03-24 ES ES01929453T patent/ES2222992T3/es not_active Expired - Lifetime
- 2001-03-24 SK SK1432-2002A patent/SK14322002A3/sk unknown
- 2001-03-24 AU AU56219/01A patent/AU784902B2/en not_active Ceased
- 2001-04-06 US US09/826,866 patent/US6596518B2/en not_active Expired - Lifetime
-
2002
- 2002-10-02 ZA ZA200207910A patent/ZA200207910B/en unknown
- 2002-10-02 IL IL152073A patent/IL152073A/en not_active IP Right Cessation
- 2002-10-03 NO NO20024772A patent/NO20024772D0/no not_active Application Discontinuation
- 2002-10-04 HR HRP20020796 patent/HRP20020796A2/hr not_active Application Discontinuation
-
2003
- 2003-06-12 HK HK03104187A patent/HK1052005A1/xx not_active IP Right Cessation
-
2006
- 2006-08-25 AU AU2006203704A patent/AU2006203704B8/en not_active Ceased
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Legal Events
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| B25D | Requested change of name of applicant approved |
Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) Free format text: ALTERADO DE: AVENTIS PHARMA DEUTSCHLAND GMBH |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |