ATE269855T1 - Perzychinin, verfahren zu seiner herstellung und seine verwendung als pharmazeutisches produkt - Google Patents

Perzychinin, verfahren zu seiner herstellung und seine verwendung als pharmazeutisches produkt

Info

Publication number
ATE269855T1
ATE269855T1 AT01929453T AT01929453T ATE269855T1 AT E269855 T1 ATE269855 T1 AT E269855T1 AT 01929453 T AT01929453 T AT 01929453T AT 01929453 T AT01929453 T AT 01929453T AT E269855 T1 ATE269855 T1 AT E269855T1
Authority
AT
Austria
Prior art keywords
percyquinnin
production
perzyquinine
pharmaceutical product
pharmaceutically acceptable
Prior art date
Application number
AT01929453T
Other languages
English (en)
Inventor
Cordula Hopmann
Michael Kurz
Guenter Mueller
Luigi Toti
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Application granted granted Critical
Publication of ATE269855T1 publication Critical patent/ATE269855T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
AT01929453T 2000-04-07 2001-03-24 Perzychinin, verfahren zu seiner herstellung und seine verwendung als pharmazeutisches produkt ATE269855T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00107536A EP1142886A1 (de) 2000-04-07 2000-04-07 Perzychinnin, Verfahren zu ihrer Herstellung und ihre Verwendung als pharmazeutisches Produkt
PCT/EP2001/003392 WO2001077094A1 (en) 2000-04-07 2001-03-24 Percyquinnin, a process for its production and its use as a pharmaceutical

Publications (1)

Publication Number Publication Date
ATE269855T1 true ATE269855T1 (de) 2004-07-15

Family

ID=8168397

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01929453T ATE269855T1 (de) 2000-04-07 2001-03-24 Perzychinin, verfahren zu seiner herstellung und seine verwendung als pharmazeutisches produkt

Country Status (30)

Country Link
US (1) US6596518B2 (de)
EP (2) EP1142886A1 (de)
JP (1) JP2003530391A (de)
KR (1) KR100791798B1 (de)
CN (1) CN1199959C (de)
AT (1) ATE269855T1 (de)
AU (2) AU784902B2 (de)
BR (1) BR0109854A (de)
CA (1) CA2405066A1 (de)
CZ (1) CZ20023310A3 (de)
DE (1) DE60103995T2 (de)
DK (1) DK1274698T3 (de)
EE (1) EE200200572A (de)
ES (1) ES2222992T3 (de)
HK (1) HK1052005A1 (de)
HR (1) HRP20020796A2 (de)
HU (1) HUP0300327A3 (de)
IL (2) IL152073A0 (de)
MX (1) MXPA02007895A (de)
NO (1) NO20024772D0 (de)
NZ (1) NZ521782A (de)
PL (1) PL357909A1 (de)
PT (1) PT1274698E (de)
RS (1) RS50140B (de)
RU (1) RU2266290C2 (de)
SI (1) SI1274698T1 (de)
SK (1) SK14322002A3 (de)
TR (1) TR200401739T4 (de)
WO (1) WO2001077094A1 (de)
ZA (1) ZA200207910B (de)

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EP1142886A1 (de) * 2000-04-07 2001-10-10 Aventis Pharma Deutschland GmbH Perzychinnin, Verfahren zu ihrer Herstellung und ihre Verwendung als pharmazeutisches Produkt
US7105526B2 (en) 2002-06-28 2006-09-12 Banyu Pharmaceuticals Co., Ltd. Benzimidazole derivatives
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
WO2005028438A1 (ja) 2003-09-22 2005-03-31 Banyu Pharmaceutical Co., Ltd. 新規ピペリジン誘導体
EP2305352A1 (de) 2004-04-02 2011-04-06 Merck Sharp & Dohme Corp. 5-alpha-Reduktaseinhibitoren zur Behandlung von Stoffwechsel- und anthropometrischen Störungen
CA2577060A1 (en) 2004-08-13 2006-02-23 Amgen Inc. Substituted benzofused heterocycles
EP1916239A4 (de) 2005-08-10 2009-10-21 Banyu Pharma Co Ltd Pyridolverbindung
EP1921065B1 (de) 2005-08-24 2010-10-20 Banyu Pharmaceutical Co., Ltd. Phenylpyridonderivat
WO2007029847A1 (ja) 2005-09-07 2007-03-15 Banyu Pharmaceutical Co., Ltd. 二環性芳香族置換ピリドン誘導体
EP1940842B1 (de) 2005-09-29 2012-05-30 Merck Sharp & Dohme Corp. Acylierte spiropiperidinderivate als modulatoren des melanocortin-4-rezeptors
BRPI0617621A2 (pt) 2005-10-21 2011-08-02 Novartis Ag combinação de compostos orgánicos
AU2006307046A1 (en) 2005-10-27 2007-05-03 Msd K.K. Novel benzoxathiin derivative
MY146564A (en) 2005-11-10 2012-08-30 Msd Kk Aza-substituted spiro derivatives
CN100417650C (zh) * 2006-08-17 2008-09-10 中国科学院昆明植物研究所 韧革菌素及其制备方法和在药物上的应用
EP2698157B1 (de) 2006-09-22 2015-05-20 Merck Sharp & Dohme Corp. Verfahren zur Behandlung von Fettsäure-Synthese-Hemmern
WO2008038692A1 (fr) 2006-09-28 2008-04-03 Banyu Pharmaceutical Co., Ltd. dÉrivÉ de diarylcÉtimine
AU2008233662B2 (en) 2007-04-02 2012-08-23 Msd K.K. Indoledione derivative
US7879802B2 (en) 2007-06-04 2011-02-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2714617A1 (en) 2008-03-06 2009-09-11 Banyu Pharmaceutical Co., Ltd. Alkylaminopyridine derivative
US20110015198A1 (en) 2008-03-28 2011-01-20 Banyu Pharmaceutical Co., Inc. Diarylmethylamide derivative having melanin-concentrating hormone receptor antagonism
EP3239170B1 (de) 2008-06-04 2019-03-20 Synergy Pharmaceuticals Inc. Für die behandlung von gastrointestinalen erkrankungen, entzündungen, krebs und anderen erkrankungen geeignete agonisten von guanylatcyclase
EP2301936A1 (de) 2008-06-19 2011-03-30 Banyu Pharmaceutical Co., Ltd. Spirodiamin-diarylketoximid-derivat
EP3241839B1 (de) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Zur behandlung von erkrankungen des magen-darm-trakts, entzündlichen erkrankungen, krebs und anderen erkrankungen geeignete agonisten von guanylatcyclase
EP2319841A1 (de) 2008-07-30 2011-05-11 Msd K.K. (5-gliedriges)-(5-gliedriges) oder (5-gliedriges)-(6-gliedriges) kondensiertes ringcycloalkylaminderivat
CA2741125A1 (en) 2008-10-22 2010-04-29 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
CA2741644C (en) 2008-10-30 2013-05-07 Merck Sharp & Dohme Corp. Isonicotinamide orexin receptor antagonists
WO2010051206A1 (en) 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
US8895596B2 (en) 2010-02-25 2014-11-25 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EP2677869B1 (de) 2011-02-25 2017-11-08 Merck Sharp & Dohme Corp. Neue cyclische azabenzimidazolderivate als antidiabetika
AR088352A1 (es) 2011-10-19 2014-05-28 Merck Sharp & Dohme Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
AU2013296470B2 (en) 2012-08-02 2016-03-17 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
AU2014219020A1 (en) 2013-02-22 2015-07-23 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
WO2014139388A1 (en) 2013-03-14 2014-09-18 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
JP6769963B2 (ja) 2014-08-29 2020-10-14 ティエエッセ ファルマ ソチエタ レスポンサビリタ リミタータ α−アミノ−β−カルボキシムコン酸セミアルデヒド脱炭酸酵素の阻害剤
CN105906500B (zh) * 2016-04-22 2018-06-26 中国科学院昆明植物研究所 具有脂肪酶抑制作用的绵马次酸类化合物及其应用
AU2017342083A1 (en) 2016-10-14 2019-04-11 Tes Pharma S.R.L. Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
EP3551176A4 (de) 2016-12-06 2020-06-24 Merck Sharp & Dohme Corp. Antidiabetische heterocyclische verbindungen
EP3558298A4 (de) 2016-12-20 2020-08-05 Merck Sharp & Dohme Corp. Antidiabetische spirochromanverbindungen
CN109055231B (zh) * 2018-07-26 2021-04-27 云南大学 一种真菌发酵液及其应用
KR20210111248A (ko) 2018-11-20 2021-09-10 테스 파마 에스.알.엘. α-아미노-β-카르복시뮤콘산 세미알데하이드 데카르복실라제의 저해제
WO2020167706A1 (en) 2019-02-13 2020-08-20 Merck Sharp & Dohme Corp. 5-alkyl pyrrolidine orexin receptor agonists
WO2021026047A1 (en) 2019-08-08 2021-02-11 Merck Sharp & Dohme Corp. Heteroaryl pyrrolidine and piperidine orexin receptor agonists
CR20230089A (es) 2020-08-18 2023-04-11 Merck Sharp & Dohme Llc Agonistas de bicicloheptano pirrolidina de los receptores de orexina

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Publication number Priority date Publication date Assignee Title
FR2344285A1 (fr) * 1976-03-19 1977-10-14 Roussel Uclaf Nouvelles lactones derivees du cyclopentanol, leur procede de preparation et leur application comme medicaments
US5322779A (en) * 1992-04-16 1994-06-21 The Research And Development Institute, Inc. At Montana State University Taxol production by taxomyces andreanae
EP1142886A1 (de) * 2000-04-07 2001-10-10 Aventis Pharma Deutschland GmbH Perzychinnin, Verfahren zu ihrer Herstellung und ihre Verwendung als pharmazeutisches Produkt

Also Published As

Publication number Publication date
CZ20023310A3 (cs) 2003-01-15
CN1199959C (zh) 2005-05-04
TR200401739T4 (tr) 2004-08-23
NO20024772L (no) 2002-10-03
AU2006203704B8 (en) 2008-07-10
CN1418203A (zh) 2003-05-14
EP1274698B1 (de) 2004-06-23
HK1052005A1 (en) 2003-08-29
YU74002A (sh) 2005-11-28
AU5621901A (en) 2001-10-23
SK14322002A3 (sk) 2003-05-02
AU784902B2 (en) 2006-07-20
RU2002129890A (ru) 2004-03-27
US6596518B2 (en) 2003-07-22
CA2405066A1 (en) 2001-10-18
WO2001077094A1 (en) 2001-10-18
SI1274698T1 (en) 2004-12-31
EP1142886A1 (de) 2001-10-10
HUP0300327A3 (en) 2004-10-28
KR20020084299A (ko) 2002-11-04
AU2006203704A1 (en) 2006-09-21
NO20024772D0 (no) 2002-10-03
HRP20020796A2 (en) 2004-12-31
PT1274698E (pt) 2004-10-29
ES2222992T3 (es) 2005-02-16
IL152073A0 (en) 2003-05-29
JP2003530391A (ja) 2003-10-14
RU2266290C2 (ru) 2005-12-20
HUP0300327A2 (hu) 2003-06-28
US20020039768A1 (en) 2002-04-04
EP1274698A1 (de) 2003-01-15
PL357909A1 (en) 2004-08-09
DK1274698T3 (da) 2004-11-01
IL152073A (en) 2007-12-03
MXPA02007895A (es) 2002-11-29
EE200200572A (et) 2004-04-15
NZ521782A (en) 2004-05-28
DE60103995D1 (de) 2004-07-29
KR100791798B1 (ko) 2008-01-04
BR0109854A (pt) 2003-06-03
AU2006203704B2 (en) 2008-06-26
DE60103995T2 (de) 2005-01-05
ZA200207910B (en) 2003-07-21
RS50140B (sr) 2009-03-25

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