BR0108990A - Processo para preparação de derivados de pirimidona com atividade antifungos - Google Patents

Processo para preparação de derivados de pirimidona com atividade antifungos

Info

Publication number
BR0108990A
BR0108990A BR0108990-0A BR0108990A BR0108990A BR 0108990 A BR0108990 A BR 0108990A BR 0108990 A BR0108990 A BR 0108990A BR 0108990 A BR0108990 A BR 0108990A
Authority
BR
Brazil
Prior art keywords
pyrimidone derivatives
antifungal activity
formula
preparing
preparing antifungal
Prior art date
Application number
BR0108990-0A
Other languages
English (en)
Other versions
BR0108990B1 (pt
BRPI0108990B8 (pt
Inventor
Javier Bartroli Orpi
Manuel Anguita Lopez
Original Assignee
Uriach & Cia Sa J
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uriach & Cia Sa J filed Critical Uriach & Cia Sa J
Publication of BR0108990A publication Critical patent/BR0108990A/pt
Publication of BR0108990B1 publication Critical patent/BR0108990B1/pt
Publication of BRPI0108990B8 publication Critical patent/BRPI0108990B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"PROCESSO PARA PREPARAçãO DE DERIVADOS DE PIRIMIDONA COM ATIVIDADE ANTIFUNGOS". A invenção refere-se a um processo para preparação de derivados de pirimidona da fórmula I, que compreende reação de um composto da fórmula II com um composto da fórmula III em presença de uma base. Os derivados de pirimidona da fórmula I são úteis como agentes antifungos.
BRPI0108990A 2000-03-07 2001-03-05 processo para preparação de derivados de pirimidona com atividade antifungos BRPI0108990B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES200000625A ES2159488B1 (es) 2000-03-07 2000-03-07 Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica.
ESP200000625 2000-03-07
PCT/ES2001/000081 WO2001066519A2 (es) 2000-03-07 2001-03-05 Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica

Publications (3)

Publication Number Publication Date
BR0108990A true BR0108990A (pt) 2003-12-30
BR0108990B1 BR0108990B1 (pt) 2014-03-25
BRPI0108990B8 BRPI0108990B8 (pt) 2021-05-25

Family

ID=8492714

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0108990A BRPI0108990B8 (pt) 2000-03-07 2001-03-05 processo para preparação de derivados de pirimidona com atividade antifungos

Country Status (17)

Country Link
US (1) US6653475B2 (pt)
EP (1) EP1282084B9 (pt)
JP (1) JP4772248B2 (pt)
KR (1) KR100735583B1 (pt)
AR (1) AR027607A1 (pt)
AT (1) ATE250256T1 (pt)
AU (1) AU2001237447A1 (pt)
BR (1) BRPI0108990B8 (pt)
CA (1) CA2402390C (pt)
DE (1) DE60100810T2 (pt)
DK (1) DK1282084T3 (pt)
ES (2) ES2159488B1 (pt)
HK (1) HK1052244B (pt)
MX (1) MXPA02008556A (pt)
NO (1) NO323314B1 (pt)
PT (1) PT1282084E (pt)
WO (1) WO2001066519A2 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6545004B1 (en) 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
EP1477481B1 (en) * 2002-01-28 2009-07-22 Ube Industries, Ltd. Process for producing quinazolin-4-one derivative
KR101048535B1 (ko) 2005-03-30 2011-07-11 주식회사 대웅제약 항진균성 트리아졸 유도체
EP1887004A1 (en) * 2006-08-07 2008-02-13 Palau Pharma, S.A. Crystalline forms of (1R,2R)-7-Chloro-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]quinazolin-4(3H)-one
CA2658843A1 (en) * 2006-08-07 2008-02-21 Stiefel Laboratories, Inc. Crystalline antifungal compounds
EP2009009A1 (en) * 2007-06-26 2008-12-31 Palau Pharma, S.A. Crystalline antifungal compounds
TWI395728B (zh) 2006-12-06 2013-05-11 Du Pont 製備２-胺基-５-氰基苯甲酸衍生物之方法
TWI415827B (zh) 2006-12-21 2013-11-21 Du Pont 製備２-胺基-５-氰基苯甲酸衍生物之方法
US8324227B2 (en) 2008-03-03 2012-12-04 Fdc Limited Thieno[2,3-D]-pyrimidin-4(3H)-one compounds with antifungal properties and process thereof
SE532624C2 (sv) * 2008-06-19 2010-03-09 Andritz Technology And Asset Management Gmbh Kylning av en cellulosamassabana
AU2011362281A1 (en) 2011-03-15 2013-09-05 Council Of Scientific & Industrial Research Enantiomers of fluconazole analogues containing thieno-[2,3-d]pyrimidin-4 (3H)-one moiety as antifungal agents
CN106588889B (zh) * 2016-11-25 2019-01-22 江苏恒盛药业有限公司 一种伏立康唑的制备方法
CN111018839B (zh) * 2019-12-02 2022-12-23 中国人民解放军第二军医大学 三氮唑醇类衍生物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8819308D0 (en) 1988-08-13 1988-09-14 Pfizer Ltd Triazole antifungal agents
TW218017B (pt) * 1992-04-28 1993-12-21 Takeda Pharm Industry Co Ltd
ATE198593T1 (de) * 1995-08-02 2001-01-15 Uriach & Cia Sa J Pyrimidonderivate mit antifungaler wirkung

Also Published As

Publication number Publication date
JP2004500391A (ja) 2004-01-08
DE60100810D1 (de) 2003-10-23
AU2001237447A1 (en) 2001-09-17
KR100735583B1 (ko) 2007-07-04
EP1282084A2 (en) 2003-02-05
ATE250256T1 (de) 2003-10-15
MXPA02008556A (es) 2003-02-24
PT1282084E (pt) 2004-02-27
WO2001066519A2 (es) 2001-09-13
CA2402390A1 (en) 2001-09-13
DK1282084T3 (da) 2004-02-02
HK1052244B (zh) 2003-12-19
AR027607A1 (es) 2003-04-02
ES2159488B1 (es) 2002-04-16
ES2159488A1 (es) 2001-10-01
EP1282084B9 (en) 2005-03-02
BR0108990B1 (pt) 2014-03-25
NO323314B1 (no) 2007-03-12
US6653475B2 (en) 2003-11-25
CA2402390C (en) 2009-09-15
NO20024256L (no) 2002-09-06
WO2001066519A3 (es) 2002-01-31
BRPI0108990B8 (pt) 2021-05-25
NO20024256D0 (no) 2002-09-06
JP4772248B2 (ja) 2011-09-14
EP1282084B1 (en) 2003-09-17
DE60100810T2 (de) 2004-07-01
ES2207605T3 (es) 2004-06-01
KR20020075809A (ko) 2002-10-05
HK1052244A1 (en) 2003-09-05
US20030064986A1 (en) 2003-04-03

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: PALAU PHARMA, S.A. (ES)

Free format text: TRANSFERIDO DE: J. URIACH AND CIA. S.A.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]

Free format text: DE ACORDO COM ART. 34 " II " DA LPI ( LEI 9279, DE 14/05/96 ) , O EXAME FICA SUSPENSO PARA QUE O REQUERENTE APRESENTE DOCUMENTOS NECESSARIOS A REGULARIZACAO DO PROCESSO E EXAME DO PEDIDO.

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 25/03/2014, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 05/03/2001 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 05/03/2021