BR0107763A - âteres de dicarboxilato de cálcio, métodos para a sua fabricação, e tratamento de doenças vasculares e diabetes com os mesmos - Google Patents

âteres de dicarboxilato de cálcio, métodos para a sua fabricação, e tratamento de doenças vasculares e diabetes com os mesmos

Info

Publication number
BR0107763A
BR0107763A BR0107763-5A BR0107763A BR0107763A BR 0107763 A BR0107763 A BR 0107763A BR 0107763 A BR0107763 A BR 0107763A BR 0107763 A BR0107763 A BR 0107763A
Authority
BR
Brazil
Prior art keywords
treatment
diabetes
manufacture
methods
same
Prior art date
Application number
BR0107763-5A
Other languages
English (en)
Inventor
Howard Yoshihisa Ando
Donald Eugene Butler
Gary Jay Dozeman
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of BR0107763A publication Critical patent/BR0107763A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/125—Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/305—Saturated compounds containing more than one carboxyl group containing ether groups, groups, groups, or groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

"éTERES DE DICARBOXILATO DE CáLCIO, MéTODOS PARA A SUA FABRICAçãO, E TRATAMENTO DE DOENçAS VASCULARES E DIABETES COM OS MESMOS". Solvatos em álcool e em água do sal monocálcio do ácido 6-(5-carbóxi-5-metil-hexilóxi)-2,2-dimetilhexanóico são cristalinos e possuem a fórmula em que R~ 1~ é H ou uma alquila inferior, e x é um número de O a 10, e são úteis para o tratamento da dislipidemia.
BR0107763-5A 2000-01-25 2001-01-11 âteres de dicarboxilato de cálcio, métodos para a sua fabricação, e tratamento de doenças vasculares e diabetes com os mesmos BR0107763A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17782300P 2000-01-25 2000-01-25
PCT/IB2001/000026 WO2001055078A1 (en) 2000-01-25 2001-01-11 Calcium dicarboxylate ethers, methods of making same, and treatment of vascular disease and diabetes therewith

Publications (1)

Publication Number Publication Date
BR0107763A true BR0107763A (pt) 2002-11-12

Family

ID=22650106

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0107763-5A BR0107763A (pt) 2000-01-25 2001-01-11 âteres de dicarboxilato de cálcio, métodos para a sua fabricação, e tratamento de doenças vasculares e diabetes com os mesmos

Country Status (39)

Country Link
EP (1) EP1259474B1 (pt)
JP (1) JP4750995B2 (pt)
KR (1) KR20020073182A (pt)
CN (1) CN1395555A (pt)
AP (1) AP2002002587A0 (pt)
AR (1) AR029436A1 (pt)
AT (1) ATE431326T1 (pt)
AU (1) AU2214001A (pt)
BG (1) BG106851A (pt)
BR (1) BR0107763A (pt)
CA (1) CA2397960C (pt)
CO (1) CO5261537A1 (pt)
CZ (1) CZ20022474A3 (pt)
DE (1) DE60138686D1 (pt)
DK (1) DK1259474T3 (pt)
DZ (1) DZ3239A1 (pt)
EA (1) EA004862B1 (pt)
EE (1) EE200200404A (pt)
ES (1) ES2324281T3 (pt)
GE (1) GEP20053428B (pt)
GT (1) GT200100015A (pt)
HN (1) HN2001000011A (pt)
HU (1) HUP0204422A3 (pt)
IL (1) IL150541A0 (pt)
IS (1) IS6442A (pt)
MA (1) MA26867A1 (pt)
MX (1) MXPA02007223A (pt)
NO (1) NO20023526L (pt)
NZ (1) NZ519550A (pt)
OA (1) OA12166A (pt)
PA (1) PA8510601A1 (pt)
PE (1) PE20011064A1 (pt)
PL (1) PL357076A1 (pt)
SK (1) SK10622002A3 (pt)
SV (1) SV2002000290A (pt)
TN (1) TNSN01013A1 (pt)
UY (1) UY26550A1 (pt)
WO (1) WO2001055078A1 (pt)
ZA (1) ZA200205880B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1481962A1 (en) * 1997-12-12 2004-12-01 Warner-Lambert Company LLC New cholesterolemia-lowering carboxyalkylether compound
PL375742A1 (en) * 2002-08-22 2005-12-12 Warner-Lambert Company Llc Method of treating osteoarthritis
US7816405B2 (en) 2005-04-19 2010-10-19 Eisai R&D Management Co., Ltd. Calcium bis [(2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl ]-2-isopropoxypropionate] and intermediate thereof
EP1873141A4 (en) * 2005-04-19 2010-09-22 Eisai R&D Man Co Ltd CALCIUM-BIS [2S] -3- [3- (2S) -3- (4-CHLORO-2-CYANOPHENOXY) -2-FLUORO-PROPOXYPHENYL] -2-ISOPROPOXYPROPIONATE] AND INTERMEDIATE PRODUCTS THEREOF
AU2015346037A1 (en) * 2014-11-14 2017-07-06 Gemphire Therapeutics Inc. Processes and intermediates for preparing alpha,omega-dicarboxylic acid-terminated dialkane ethers
CN110996928A (zh) * 2017-04-18 2020-04-10 燿石治疗公司 吉卡宾、其药学上可接受的盐、其组合物和其使用方法
US20200253877A1 (en) * 2018-10-18 2020-08-13 Neurobo Pharmaceuticals, Inc. Gemcabene, pharmaceutically acceptable salts thereof, compositions thereof and methods of use therefor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648387A (en) 1995-03-24 1997-07-15 Warner-Lambert Company Carboxyalkylethers, formulations, and treatment of vascular diseases
NZ503982A (en) 1997-12-12 2002-03-28 Warner Lambert Co Statin-carboxyalkylether combinations useful for treating vascular disorders and diabetes mellitus

Also Published As

Publication number Publication date
PE20011064A1 (es) 2001-10-22
IS6442A (is) 2002-06-25
NO20023526L (no) 2002-08-27
SK10622002A3 (sk) 2003-07-01
ZA200205880B (en) 2003-07-23
OA12166A (en) 2003-11-07
CA2397960A1 (en) 2001-08-02
DE60138686D1 (de) 2009-06-25
MA26867A1 (fr) 2004-12-20
KR20020073182A (ko) 2002-09-19
EA200200641A1 (ru) 2002-12-26
AP2002002587A0 (en) 2002-09-30
MXPA02007223A (es) 2002-11-29
CA2397960C (en) 2008-09-09
JP2003520835A (ja) 2003-07-08
CN1395555A (zh) 2003-02-05
AU2214001A (en) 2001-08-07
EA004862B1 (ru) 2004-08-26
NO20023526D0 (no) 2002-07-24
PA8510601A1 (es) 2002-08-26
EP1259474A1 (en) 2002-11-27
HUP0204422A2 (en) 2003-05-28
EE200200404A (et) 2003-10-15
DZ3239A1 (fr) 2001-08-02
BG106851A (en) 2003-01-31
CZ20022474A3 (cs) 2003-06-18
WO2001055078A1 (en) 2001-08-02
GT200100015A (es) 2001-10-19
AR029436A1 (es) 2003-06-25
HUP0204422A3 (en) 2003-08-28
JP4750995B2 (ja) 2011-08-17
NZ519550A (en) 2003-11-28
ATE431326T1 (de) 2009-05-15
UY26550A1 (es) 2001-08-27
EP1259474B1 (en) 2009-05-13
ES2324281T3 (es) 2009-08-04
IL150541A0 (en) 2003-02-12
DK1259474T3 (da) 2009-07-20
CO5261537A1 (es) 2003-03-31
TNSN01013A1 (fr) 2005-11-10
SV2002000290A (es) 2002-07-16
PL357076A1 (en) 2004-07-12
GEP20053428B (en) 2005-01-25
HN2001000011A (es) 2001-06-13

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A, 9A E 10A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2116 DE 26/07/2011.