BR0017048A - Pró-drogas de bisamidato fosfonato - Google Patents

Pró-drogas de bisamidato fosfonato

Info

Publication number
BR0017048A
BR0017048A BR0017048-8A BR0017048A BR0017048A BR 0017048 A BR0017048 A BR 0017048A BR 0017048 A BR0017048 A BR 0017048A BR 0017048 A BR0017048 A BR 0017048A
Authority
BR
Brazil
Prior art keywords
phosphonate
bisamidate
prodrugs
drugs
pro
Prior art date
Application number
BR0017048-8A
Other languages
English (en)
Inventor
Tao Jiang
Srinivas Rao Kasibhatla
K Raja Reddy
Original Assignee
Metabasis Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabasis Therapeutics Inc filed Critical Metabasis Therapeutics Inc
Publication of BR0017048A publication Critical patent/BR0017048A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/44—Amides thereof
    • C07F9/4461—Amides thereof the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4465—Amides thereof the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"PRó-DROGAS DE BISAMIDATO FOSFONATO". Novas pró-drogas do tipo bisamidato fosfonato de inibidores de FBPase da fórmula (IA) e uso das mesmas no tratamento de diabetes e outras condições associadas com glicose sang³ínea elevada.
BR0017048-8A 1999-12-22 2000-12-22 Pró-drogas de bisamidato fosfonato BR0017048A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17186299P 1999-12-22 1999-12-22
PCT/IB2000/002071 WO2001047935A2 (en) 1999-12-22 2000-12-22 Novel bisamidate phosphonate prodrugs

Publications (1)

Publication Number Publication Date
BR0017048A true BR0017048A (pt) 2002-11-05

Family

ID=22625436

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0017048-8A BR0017048A (pt) 1999-12-22 2000-12-22 Pró-drogas de bisamidato fosfonato

Country Status (20)

Country Link
US (3) US6965033B2 (pt)
EP (1) EP1240174A2 (pt)
JP (1) JP2003519154A (pt)
KR (1) KR100875335B1 (pt)
CN (2) CN1740182A (pt)
AU (1) AU784370B2 (pt)
BR (1) BR0017048A (pt)
CA (1) CA2396713A1 (pt)
CZ (1) CZ301401B6 (pt)
HK (1) HK1049841A1 (pt)
HU (1) HUP0204092A3 (pt)
IL (1) IL149887A0 (pt)
MX (1) MXPA02006156A (pt)
NO (1) NO20022932L (pt)
NZ (1) NZ519219A (pt)
PL (1) PL356525A1 (pt)
RU (2) RU2273642C2 (pt)
SK (1) SK8892002A3 (pt)
WO (1) WO2001047935A2 (pt)
ZA (1) ZA200204399B (pt)

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JP2003519154A (ja) 2003-06-17
EP1240174A2 (en) 2002-09-18
US20020173490A1 (en) 2002-11-21
AU784370B2 (en) 2006-03-23
US6965033B2 (en) 2005-11-15
HUP0204092A2 (hu) 2003-03-28
KR20020063248A (ko) 2002-08-01
HK1049841A1 (zh) 2003-05-30
ZA200204399B (en) 2003-11-26
NO20022932L (no) 2002-08-22
CN100595204C (zh) 2010-03-24
NZ519219A (en) 2004-03-26
US20050004077A1 (en) 2005-01-06
KR100875335B1 (ko) 2008-12-22
RU2273642C2 (ru) 2006-04-10
NO20022932D0 (no) 2002-06-18
WO2001047935A2 (en) 2001-07-05
RU2005138719A (ru) 2007-06-20
SK8892002A3 (en) 2003-04-01
RU2002119708A (ru) 2004-03-20
IL149887A0 (en) 2002-11-10
MXPA02006156A (es) 2003-09-22
CN1740182A (zh) 2006-03-01
CZ301401B6 (cs) 2010-02-17
WO2001047935A3 (en) 2002-03-21
US20090192121A1 (en) 2009-07-30
CA2396713A1 (en) 2001-07-05
AU5244701A (en) 2001-07-09
HUP0204092A3 (en) 2005-02-28
PL356525A1 (en) 2004-06-28
CZ20022172A3 (cs) 2003-01-15
CN1434828A (zh) 2003-08-06

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