ES2181928T3 - Derivados de diester de acido fosfonico. - Google Patents

Derivados de diester de acido fosfonico.

Info

Publication number
ES2181928T3
ES2181928T3 ES96942639T ES96942639T ES2181928T3 ES 2181928 T3 ES2181928 T3 ES 2181928T3 ES 96942639 T ES96942639 T ES 96942639T ES 96942639 T ES96942639 T ES 96942639T ES 2181928 T3 ES2181928 T3 ES 2181928T3
Authority
ES
Spain
Prior art keywords
phosphonic acid
diester
derivatives
remedy
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96942639T
Other languages
English (en)
Inventor
Kazuyoshi Miyata
Yasuhiro Sakai
Yasuo Shoji
Yoshihiko Tsuda
Yasuhide Inoue
Keigo Sato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Otsuka Pharmaceutical Factory Inc
Original Assignee
Otsuka Pharmaceutical Co Ltd
Otsuka Pharmaceutical Factory Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd, Otsuka Pharmaceutical Factory Inc filed Critical Otsuka Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2181928T3 publication Critical patent/ES2181928T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
    • C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

DERIVADOS DIESTER DEL ACIDO FOSFONICO REPRESENTADOS POR LA FORMULA GENERAL (1), LOS CUALES SON UTILES COMO REMEDIO PARA LA HIPERLIPIDEMIA Y DIABETES, COMO AGENTE ANTITUMORAL Y COMO AGENTE PREVENTIVO O CURATIVO DE LAS CATARATAS, EN LA QUE R 1 REPRESENTA CICLOALQUILO, ETC.; R 2 REPRESENTA HIDROGENO, FENILO O ALQUILO INFERIOR; R 3 Y R 4 REPRESENTA C ADA UNO DE ELLOS ALQUILO INFERIOR; Y A REPRESENTA UN HETEROCICLO SELECCIONADO ENTRE PIRAZINA, TIOFENO Y ANILLOS DE TIAZOL SUSTITUIDOS CON FENILO.
ES96942639T 1995-12-27 1996-12-24 Derivados de diester de acido fosfonico. Expired - Lifetime ES2181928T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP34090995 1995-12-27

Publications (1)

Publication Number Publication Date
ES2181928T3 true ES2181928T3 (es) 2003-03-01

Family

ID=18341428

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96942639T Expired - Lifetime ES2181928T3 (es) 1995-12-27 1996-12-24 Derivados de diester de acido fosfonico.

Country Status (12)

Country Link
US (1) US5985858A (es)
EP (1) EP0882730B1 (es)
JP (1) JP3500468B2 (es)
KR (1) KR100324866B1 (es)
CN (1) CN1070863C (es)
AT (1) ATE225357T1 (es)
AU (1) AU702980B2 (es)
CA (1) CA2241679C (es)
DE (1) DE69624143T2 (es)
ES (1) ES2181928T3 (es)
TW (1) TW438806B (es)
WO (1) WO1997024360A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4032193B2 (ja) * 1998-04-24 2008-01-16 株式会社大塚製薬工場 ホスホン酸ジエステル誘導体
CA2343027A1 (en) * 1998-09-09 2000-03-16 Metabasis Therapeutics, Inc. Novel heteroaromatic inhibitors of fructose 1,6-bisphosphatase
JP2003519154A (ja) * 1999-12-22 2003-06-17 メタバシス・セラピューティクス・インコーポレイテッド 新規なビスアミダートホスホネートプロドラッグ
US7563774B2 (en) * 2000-06-29 2009-07-21 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
WO2006023515A2 (en) * 2004-08-18 2006-03-02 Metabasis Therapeutics, Inc. Novel thiazole inhibitors of fructose 1,6-bisphosphatase
US20060090132A1 (en) * 2004-10-26 2006-04-27 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Enhanced user assistance
US8762839B2 (en) * 2004-09-30 2014-06-24 The Invention Science Fund I, Llc Supply-chain side assistance
US20060206817A1 (en) * 2005-02-28 2006-09-14 Jung Edward K User assistance for a condition
US9098826B2 (en) * 2004-09-30 2015-08-04 The Invention Science Fund I, Llc Enhanced user assistance
US9307577B2 (en) * 2005-01-21 2016-04-05 The Invention Science Fund I, Llc User assistance
US9038899B2 (en) * 2004-09-30 2015-05-26 The Invention Science Fund I, Llc Obtaining user assistance
US20060075344A1 (en) * 2004-09-30 2006-04-06 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Providing assistance
US10687166B2 (en) * 2004-09-30 2020-06-16 Uber Technologies, Inc. Obtaining user assistance
US8704675B2 (en) * 2004-09-30 2014-04-22 The Invention Science Fund I, Llc Obtaining user assistance
US8341522B2 (en) * 2004-10-27 2012-12-25 The Invention Science Fund I, Llc Enhanced contextual user assistance
US10514816B2 (en) 2004-12-01 2019-12-24 Uber Technologies, Inc. Enhanced user assistance
US20100223162A1 (en) * 2004-09-30 2010-09-02 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Supply-chain side assistance
US9747579B2 (en) 2004-09-30 2017-08-29 The Invention Science Fund I, Llc Enhanced user assistance
US20100146390A1 (en) * 2004-09-30 2010-06-10 Searete Llc, A Limited Liability Corporation Obtaining user assestance
US10445799B2 (en) 2004-09-30 2019-10-15 Uber Technologies, Inc. Supply-chain side assistance
US8282003B2 (en) * 2004-09-30 2012-10-09 The Invention Science Fund I, Llc Supply-chain side assistance
US8358976B2 (en) 2006-03-24 2013-01-22 The Invention Science Fund I, Llc Wireless device with an aggregate user interface for controlling other devices
US11100434B2 (en) 2014-05-06 2021-08-24 Uber Technologies, Inc. Real-time carpooling coordinating system and methods
US9552559B2 (en) 2014-05-06 2017-01-24 Elwha Llc System and methods for verifying that one or more directives that direct transport of a second end user does not conflict with one or more obligations to transport a first end user
US10458801B2 (en) 2014-05-06 2019-10-29 Uber Technologies, Inc. Systems and methods for travel planning that calls for at least one transportation vehicle unit
US9483744B2 (en) 2014-05-06 2016-11-01 Elwha Llc Real-time carpooling coordinating systems and methods

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS636089A (ja) * 1986-06-27 1988-01-12 Nippon Shokubai Kagaku Kogyo Co Ltd 石炭−水スラリ−用分散剤
JPH0651625B2 (ja) * 1986-12-29 1994-07-06 株式会社大塚製薬工場 高脂質血症治療剤
JPH0745508B2 (ja) * 1988-06-29 1995-05-17 株式会社大塚製薬工場 カルボン酸アミド誘導体
AU606808B2 (en) * 1988-06-29 1991-02-14 Otsuka Pharmaceutical Factory, Inc. Arylcarboxamide substituted by alkylphosphonates, process for preparing the same and a pharmaceutical composition containing the same
KR0185225B1 (ko) * 1992-05-21 1999-05-15 오오쓰까 아끼히꼬 포스폰산 디에스테르 유도체
JP2787407B2 (ja) * 1992-06-19 1998-08-20 株式会社大塚製薬工場 ホスホン酸ジエステル誘導体
TW260664B (es) * 1993-02-15 1995-10-21 Otsuka Pharma Factory Inc
JP3156026B2 (ja) * 1993-12-27 2001-04-16 株式会社大塚製薬工場 ホスホン酸ジエステル誘導体
JP3109393B2 (ja) * 1994-09-30 2000-11-13 双葉電子工業株式会社 可変周波数発生器

Also Published As

Publication number Publication date
US5985858A (en) 1999-11-16
JP3500468B2 (ja) 2004-02-23
DE69624143T2 (de) 2003-06-12
EP0882730A1 (en) 1998-12-09
KR100324866B1 (ko) 2002-10-19
AU1173497A (en) 1997-07-28
WO1997024360A1 (fr) 1997-07-10
TW438806B (en) 2001-06-07
DE69624143D1 (de) 2002-11-07
AU702980B2 (en) 1999-03-11
CN1206419A (zh) 1999-01-27
CA2241679A1 (en) 1997-07-10
KR19990076819A (ko) 1999-10-15
EP0882730B1 (en) 2002-10-02
ATE225357T1 (de) 2002-10-15
EP0882730A4 (en) 1999-04-28
CN1070863C (zh) 2001-09-12
CA2241679C (en) 2002-02-12

Similar Documents

Publication Publication Date Title
ES2181928T3 (es) Derivados de diester de acido fosfonico.
AU680704B2 (en) Cyclic amide derivatives
DE69840755D1 (de) Pyridazinderivate und diese als aktiven bestandteil enthaltende medikamente
PT976748E (pt) Derivados de pirrolidina com actividade inibidora de fosfolipase a2
FI914187A0 (fi) Menetelmä valmistaa kaavan /I/ mukaista 1-metyylikarbapeneemijohdosta
CA2103590A1 (en) Benzamide derivative
PT916651E (pt) DERIVADOS DE áCIDO FENILALQUILCARBOXILICO
AU767923C (en) Novel 2-(N-cyanoimino)thiazolidin-4-one derivatives
AU755654C (en) Novel amide compounds and drugs containing the same
DE60223904D1 (de) Benzylaminanalogen
PT947504E (pt) Derivados de vitamina d 16-eno
ATE223411T1 (de) 1-methylcarbapenem-derivate
EP0807627A3 (en) Anilide compounds as ACAT inhibitors
EP0921122A4 (en) NEW EPOXYSUCCINAMIDE DERIVATIVES AND ASSOCIATED SALTS
DE60016384D1 (de) Chondrogonese promotoren und indolin-2-on derivate
WO2003075928A3 (en) Stable pharmaceutical compositions
GR3031390T3 (en) Fluoropropene compound, an insecticide containing the same and an intermediate for production thereof
EP1197211A4 (en) CANCER PREVENTION AND TREATMENT ACTIVE INGREDIENTS
ES2121036T3 (es) Derivados de alquilenodiamina.
SE9402596D0 (sv) Karboximetylidencykloheptimidazolderivat, förfarande för deras framställning och terapeutiska medel innehållande dessa