BR0016634A - Processo para preparação de 4-(heteroaril-metil)-halogênio-1(2h)-ftalazionas - Google Patents

Processo para preparação de 4-(heteroaril-metil)-halogênio-1(2h)-ftalazionas

Info

Publication number
BR0016634A
BR0016634A BR0016634-0A BR0016634A BR0016634A BR 0016634 A BR0016634 A BR 0016634A BR 0016634 A BR0016634 A BR 0016634A BR 0016634 A BR0016634 A BR 0016634A
Authority
BR
Brazil
Prior art keywords
heteroaryl
halogen
methyl
preparation
phthalaziones
Prior art date
Application number
BR0016634-0A
Other languages
English (en)
Inventor
Orlin Petrov
Tamas Heiner
Harribert Neh
Martin Krueger
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of BR0016634A publication Critical patent/BR0016634A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)

Abstract

"PROCESSO PARA PREPARAçãO DE 4-(HETEROARIL-METIL)-HALOGêNIO-1(2H) - FTALAZINONAS". é descrito um processo para preparação de 4-(heteroaril-metil)-halogênio-1(2H)-ftalazinonas, particularmente 4-(4-piridilmetil)-1(2H)-ftalazinona, que é caracterizado pela reação de sal de ftalidil-3-trifenilfosfónio com aldeído de 4-piridina na presença de um coadjuvante básico, reação subseq³ente com hidrato de hidrazina e subseq³ente tratamento com ácido, sendo que esse processo evita os problemas técnicos de segurança e ambientais dos processos conhecidos.
BR0016634-0A 1999-12-23 2000-12-20 Processo para preparação de 4-(heteroaril-metil)-halogênio-1(2h)-ftalazionas BR0016634A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19963607A DE19963607B4 (de) 1999-12-23 1999-12-23 Verfahren zur Herstellung von 4-(Heteroaryl-methyl) halogen-1(2H)-phthalazinonen
PCT/EP2000/013027 WO2001047912A1 (de) 1999-12-23 2000-12-20 Verfahren zur herstellung von 4-(heteroaryl-methyl)-halogen-1(2h)-phthalazinonen

Publications (1)

Publication Number Publication Date
BR0016634A true BR0016634A (pt) 2002-10-15

Family

ID=7934888

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0016634-0A BR0016634A (pt) 1999-12-23 2000-12-20 Processo para preparação de 4-(heteroaril-metil)-halogênio-1(2h)-ftalazionas

Country Status (32)

Country Link
US (1) US6891041B2 (pt)
EP (1) EP1242405B1 (pt)
JP (1) JP2003529555A (pt)
KR (1) KR100654265B1 (pt)
CN (1) CN1221545C (pt)
AT (1) ATE273972T1 (pt)
AU (1) AU772981B2 (pt)
BG (1) BG65387B1 (pt)
BR (1) BR0016634A (pt)
CA (1) CA2395407C (pt)
CZ (1) CZ20022146A3 (pt)
DE (2) DE19963607B4 (pt)
DK (1) DK1242405T3 (pt)
EE (1) EE04940B1 (pt)
ES (1) ES2223626T3 (pt)
HK (1) HK1055296A1 (pt)
HR (1) HRP20020605B1 (pt)
HU (1) HUP0300992A3 (pt)
IL (2) IL150017A0 (pt)
MX (1) MXPA02006224A (pt)
NO (1) NO321357B1 (pt)
NZ (1) NZ519285A (pt)
PL (1) PL200714B1 (pt)
PT (1) PT1242405E (pt)
RO (1) RO121211B1 (pt)
RS (1) RS50458B (pt)
RU (1) RU2250900C2 (pt)
SI (1) SI1242405T1 (pt)
SK (1) SK285522B6 (pt)
UA (1) UA72021C2 (pt)
WO (1) WO2001047912A1 (pt)
ZA (1) ZA200205853B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1296984B1 (it) * 1997-12-19 1999-08-03 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4
US7151102B2 (en) * 2000-10-30 2006-12-19 Kudos Pharmaceuticals Limited Phthalazinone derivatives
GB0419072D0 (en) * 2004-08-26 2004-09-29 Kudos Pharm Ltd Phthalazinone derivatives
TWI404716B (zh) * 2006-10-17 2013-08-11 Kudos Pharm Ltd 酞嗪酮（ｐｈｔｈａｌａｚｉｎｏｎｅ）衍生物
BRPI0817537B1 (pt) * 2007-10-17 2022-04-05 Kudos Pharmaceuticals Limited 4-[3-(4-ciclopropanocarbonil-piperazina-1-carbonil)-4-fluoro-benzil]-2h-ftalazin-1-ona, método para obtê-lo, composição farmacêutica compreendendo o mesmo, bem como usos terapêuticos do dito composto
WO2010041051A1 (en) 2008-10-07 2010-04-15 Astrazeneca Uk Limited Pharmaceutical formulation 514
CN105307655B (zh) 2013-03-13 2019-05-03 弗拉特利发现实验室有限责任公司 哒嗪酮化合物及其用于制备治疗囊肿状纤维化的药物的应用
CA2980028A1 (en) * 2015-03-19 2016-09-22 Clariant International Ltd Biodegradable sugar-amide-surfactants for enhanced oil recovery

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE567431A (pt) * 1957-05-07
GB1293565A (en) * 1969-05-03 1972-10-18 Aspro Nicholas Ltd Aminophthalazines and pharmaceutical compositions thereof
IE47592B1 (en) * 1977-12-29 1984-05-02 Ici Ltd Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
EP0634404A1 (en) * 1993-07-13 1995-01-18 Rhone Poulenc Agriculture Ltd. Phtalazin derivatives and their use as pesticides
JP3919835B2 (ja) * 1994-08-09 2007-05-30 エーザイ・アール・アンド・ディー・マネジメント株式会社 縮合ピリダジン系化合物
NZ290952A (en) * 1994-08-09 1998-05-27 Eisai Co Ltd Phthalazine derivatives optionally substituted in position-1 by (generally benzyl) amino groups
EP0946520B1 (en) * 1996-12-18 2003-04-02 Neurogen Corporation Isoquinolinamine and phthalazinamine derivatives which interact with crf receptors
CO4950519A1 (es) * 1997-02-13 2000-09-01 Novartis Ag Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
IT1296984B1 (it) * 1997-12-19 1999-08-03 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4
ITMI981670A1 (it) * 1998-07-21 2000-01-21 Zambon Spa Derivati ftalazinici inibitori della fosfodiesterasi 4
ITMI981671A1 (it) * 1998-07-21 2000-01-21 Zambon Spa Derivati ftalazinici inibitori della fosfodisterasi 4
ITMI20000261A1 (it) * 2000-02-16 2001-08-16 Zambon Group Processo per la preparazione di piridiniliden-ftalidi

Also Published As

Publication number Publication date
RS50458B (sr) 2010-03-02
US20040192695A1 (en) 2004-09-30
MXPA02006224A (es) 2002-12-05
HRP20020605A2 (en) 2004-12-31
AU2012201A (en) 2001-07-09
JP2003529555A (ja) 2003-10-07
PT1242405E (pt) 2004-11-30
ATE273972T1 (de) 2004-09-15
HUP0300992A3 (en) 2005-11-28
WO2001047912A1 (de) 2001-07-05
NO20023014D0 (no) 2002-06-21
HRP20020605B1 (en) 2007-06-30
BG106843A (en) 2003-02-28
CN1221545C (zh) 2005-10-05
ES2223626T3 (es) 2005-03-01
HUP0300992A2 (hu) 2003-08-28
DK1242405T3 (da) 2004-11-01
NZ519285A (en) 2004-12-24
SK8922002A3 (en) 2002-11-06
DE19963607A1 (de) 2001-07-12
NO321357B1 (no) 2006-05-02
EE04940B1 (et) 2007-12-17
AU772981B2 (en) 2004-05-13
SI1242405T1 (en) 2005-02-28
RU2002119559A (ru) 2004-01-10
CZ20022146A3 (cs) 2002-09-11
CN1413203A (zh) 2003-04-23
BG65387B1 (bg) 2008-05-30
RO121211B1 (ro) 2007-01-30
CA2395407A1 (en) 2001-07-05
KR20020062363A (ko) 2002-07-25
SK285522B6 (sk) 2007-03-01
EP1242405B1 (de) 2004-08-18
HK1055296A1 (en) 2004-01-02
IL150017A0 (en) 2002-12-01
DE19963607B4 (de) 2005-12-15
EP1242405A1 (de) 2002-09-25
EE200200307A (et) 2003-06-16
KR100654265B1 (ko) 2006-12-07
YU47302A (sh) 2005-06-10
US6891041B2 (en) 2005-05-10
PL355525A1 (en) 2004-05-04
RU2250900C2 (ru) 2005-04-27
ZA200205853B (en) 2004-02-18
DE50007520D1 (de) 2004-09-23
IL150017A (en) 2006-12-31
NO20023014L (no) 2002-06-21
CA2395407C (en) 2009-04-28
PL200714B1 (pl) 2009-01-30
UA72021C2 (en) 2005-01-17

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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B09B Patent application refused [chapter 9.2 patent gazette]

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