IT1296984B1 - Derivati ftalazinici inibitori della fosfodiesterasi 4 - Google Patents
Derivati ftalazinici inibitori della fosfodiesterasi 4Info
- Publication number
- IT1296984B1 IT1296984B1 IT97MI002806A ITMI972806A IT1296984B1 IT 1296984 B1 IT1296984 B1 IT 1296984B1 IT 97MI002806 A IT97MI002806 A IT 97MI002806A IT MI972806 A ITMI972806 A IT MI972806A IT 1296984 B1 IT1296984 B1 IT 1296984B1
- Authority
- IT
- Italy
- Prior art keywords
- phenyl
- alkyl
- group
- phosphodiesterase
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97MI002806A IT1296984B1 (it) | 1997-12-19 | 1997-12-19 | Derivati ftalazinici inibitori della fosfodiesterasi 4 |
| JP2000525393A JP2001526270A (ja) | 1997-12-19 | 1998-12-17 | フタラジン誘導体ホスホジエステラーゼ４阻害剤 |
| PCT/EP1998/008291 WO1999032456A1 (en) | 1997-12-19 | 1998-12-17 | Phthalazine derivatives phosphodiesterase 4 inhibitors |
| EP98966900A EP1042300B1 (en) | 1997-12-19 | 1998-12-17 | Phthalazine derivatives useful as phosphodiesterase 4 inhibitors |
| DE69821650T DE69821650T2 (de) | 1997-12-19 | 1998-12-17 | Phtalazin derivate wirksam als phosphodiesterase 4 inhibitoren |
| PT98966900T PT1042300E (pt) | 1997-12-19 | 1998-12-17 | Derivados ftalazina inibidores da fosfodiesterase 4 |
| ES98966900T ES2216354T3 (es) | 1997-12-19 | 1998-12-17 | Derivados de ftalazina utiles como inhibidores de fosfodiesterasa-4. |
| DK98966900T DK1042300T3 (da) | 1997-12-19 | 1998-12-17 | Phthalazinderivater, der kan anvendes som hæmmere af phosphodiesterase 4 |
| US09/581,506 US6589951B1 (en) | 1997-12-19 | 1998-12-17 | Phthalazine derivatives as phosphodiesterase 4 inhibitors |
| AU26132/99A AU2613299A (en) | 1997-12-19 | 1998-12-17 | Phthalazine derivatives phosphodiesterase 4 inhibitors |
| AT98966900T ATE259356T1 (de) | 1997-12-19 | 1998-12-17 | Phtalazin derivate wirksam als phosphodiesterase 4 inhibitoren |
| US10/441,177 US20040043999A1 (en) | 1997-12-19 | 2003-05-20 | Phthalazine derivatives as phosphodiesterase 4-inhibitors |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97MI002806A IT1296984B1 (it) | 1997-12-19 | 1997-12-19 | Derivati ftalazinici inibitori della fosfodiesterasi 4 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ITMI972806A1 ITMI972806A1 (it) | 1999-06-19 |
| IT1296984B1 true IT1296984B1 (it) | 1999-08-03 |
Family
ID=11378396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT97MI002806A IT1296984B1 (it) | 1997-12-19 | 1997-12-19 | Derivati ftalazinici inibitori della fosfodiesterasi 4 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6589951B1 (it) |
| EP (1) | EP1042300B1 (it) |
| JP (1) | JP2001526270A (it) |
| AT (1) | ATE259356T1 (it) |
| AU (1) | AU2613299A (it) |
| DE (1) | DE69821650T2 (it) |
| DK (1) | DK1042300T3 (it) |
| ES (1) | ES2216354T3 (it) |
| IT (1) | IT1296984B1 (it) |
| PT (1) | PT1042300E (it) |
| WO (1) | WO1999032456A1 (it) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1296984B1 (it) * | 1997-12-19 | 1999-08-03 | Zambon Spa | Derivati ftalazinici inibitori della fosfodiesterasi 4 |
| ITMI981671A1 (it) * | 1998-07-21 | 2000-01-21 | Zambon Spa | Derivati ftalazinici inibitori della fosfodisterasi 4 |
| ITMI981670A1 (it) | 1998-07-21 | 2000-01-21 | Zambon Spa | Derivati ftalazinici inibitori della fosfodiesterasi 4 |
| IT1303272B1 (it) | 1998-10-29 | 2000-11-06 | Zambon Spa | Derivati triciclici inibitori della fosfodiesterasi 4 |
| DE19963607B4 (de) * | 1999-12-23 | 2005-12-15 | Schering Ag | Verfahren zur Herstellung von 4-(Heteroaryl-methyl) halogen-1(2H)-phthalazinonen |
| ITMI20022739A1 (it) * | 2002-12-23 | 2004-06-24 | Zambon Spa | Derivati ftalazinici inibitori della fosfodiesterasi 4. |
| FR2868780B1 (fr) * | 2004-04-13 | 2008-10-17 | Sanofi Synthelabo | Derives de la 1-amino-phthalazine, leur preparation et leur application en therapeutique |
| WO2006074223A2 (en) * | 2005-01-03 | 2006-07-13 | Myriad Genetics, Inc. | Pharmaceutical compounds as activators of caspases and inducers of apoptosis and the use thereof |
| US7759337B2 (en) * | 2005-03-03 | 2010-07-20 | Amgen Inc. | Phthalazine compounds and methods of use |
| EP1991531A1 (en) * | 2006-02-28 | 2008-11-19 | Amgen Inc. | Cinnoline and quinoxaline derivates as phosphodiesterase 10 inhibitors |
| US8044041B2 (en) * | 2006-11-15 | 2011-10-25 | Forest Laboratories Holdings Limited | Phthalazine derivatives as inhibitors of protein kinase |
| RU2009141592A (ru) * | 2007-04-11 | 2011-05-20 | Алькон Рисерч, Лтд. (Us) | ПРИМЕНЕНИЕ ИНГИБИТОРА TNFα В СОЧЕТАНИИ С АНТИГИСТАМИННЫМ СРЕДСТВОМ ДЛЯ ЛЕЧЕНИЯ АЛЛЕРГИЧЕСКОГО РИНИТА И АЛЛЕРГИЧЕСКОГО КОНЪЮНКТИВИТА |
| US20090182035A1 (en) * | 2007-04-11 | 2009-07-16 | Alcon Research, Ltd. | Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis |
| WO2010042649A2 (en) * | 2008-10-10 | 2010-04-15 | Amgen Inc. | PHTHALAZINE COMPOUNDS AS p38 MAP KINASE MODULATORS AND METHODS OF USE THEREOF |
| WO2010042646A1 (en) | 2008-10-10 | 2010-04-15 | Amgen Inc. | Aza- and diaza-phthalazine compounds as p38 map kinase modulators and methods of use thereof |
| EP2272831A1 (en) * | 2009-06-26 | 2011-01-12 | Prime European Therapeuticals S.p.A. | Process for the preparation of arylpyridinyl compounds |
| BR112012007091A2 (pt) * | 2009-10-01 | 2016-04-19 | Alcon Res Ltd | composições de olopatadina e seus usos |
| KR20160023854A (ko) * | 2013-06-24 | 2016-03-03 | 메르크 파텐트 게엠베하 | 프탈라진 유도체 |
| EP3080085B1 (en) * | 2013-12-09 | 2019-08-14 | UCB Biopharma SPRL | Fused bicyclic heteroaromatic derivatives as modulators of tnf activity |
| JP2022515838A (ja) | 2018-12-28 | 2022-02-22 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | アラキドン酸１５－リポキシゲナーゼ（ａｌｏｘ１５）阻害剤による呼吸器障害の治療 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2063249A (en) * | 1979-10-09 | 1981-06-03 | Mitsubishi Yuka Pharma | 4-Phenylphthalazine derivatives |
| EP0934307B1 (en) * | 1996-06-19 | 2011-04-27 | Aventis Pharma Limited | Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase |
| IT1296984B1 (it) * | 1997-12-19 | 1999-08-03 | Zambon Spa | Derivati ftalazinici inibitori della fosfodiesterasi 4 |
| ITMI981671A1 (it) * | 1998-07-21 | 2000-01-21 | Zambon Spa | Derivati ftalazinici inibitori della fosfodisterasi 4 |
| ITMI981670A1 (it) * | 1998-07-21 | 2000-01-21 | Zambon Spa | Derivati ftalazinici inibitori della fosfodiesterasi 4 |
| DE19963607B4 (de) * | 1999-12-23 | 2005-12-15 | Schering Ag | Verfahren zur Herstellung von 4-(Heteroaryl-methyl) halogen-1(2H)-phthalazinonen |
-
1997
- 1997-12-19 IT IT97MI002806A patent/IT1296984B1/it active IP Right Grant
-
1998
- 1998-12-17 JP JP2000525393A patent/JP2001526270A/ja active Pending
- 1998-12-17 AU AU26132/99A patent/AU2613299A/en not_active Abandoned
- 1998-12-17 ES ES98966900T patent/ES2216354T3/es not_active Expired - Lifetime
- 1998-12-17 PT PT98966900T patent/PT1042300E/pt unknown
- 1998-12-17 US US09/581,506 patent/US6589951B1/en not_active Expired - Fee Related
- 1998-12-17 AT AT98966900T patent/ATE259356T1/de not_active IP Right Cessation
- 1998-12-17 WO PCT/EP1998/008291 patent/WO1999032456A1/en active IP Right Grant
- 1998-12-17 DE DE69821650T patent/DE69821650T2/de not_active Expired - Fee Related
- 1998-12-17 EP EP98966900A patent/EP1042300B1/en not_active Expired - Lifetime
- 1998-12-17 DK DK98966900T patent/DK1042300T3/da active
-
2003
- 2003-05-20 US US10/441,177 patent/US20040043999A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20040043999A1 (en) | 2004-03-04 |
| EP1042300A1 (en) | 2000-10-11 |
| PT1042300E (pt) | 2004-06-30 |
| US6589951B1 (en) | 2003-07-08 |
| ITMI972806A1 (it) | 1999-06-19 |
| AU2613299A (en) | 1999-07-12 |
| ATE259356T1 (de) | 2004-02-15 |
| DE69821650D1 (de) | 2004-03-18 |
| ES2216354T3 (es) | 2004-10-16 |
| DE69821650T2 (de) | 2004-12-23 |
| JP2001526270A (ja) | 2001-12-18 |
| WO1999032456A1 (en) | 1999-07-01 |
| EP1042300B1 (en) | 2004-02-11 |
| DK1042300T3 (da) | 2004-06-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |