BR0013792A - Derivados de amino-triazolopiridina - Google Patents

Derivados de amino-triazolopiridina

Info

Publication number
BR0013792A
BR0013792A BR0013792-8A BR0013792A BR0013792A BR 0013792 A BR0013792 A BR 0013792A BR 0013792 A BR0013792 A BR 0013792A BR 0013792 A BR0013792 A BR 0013792A
Authority
BR
Brazil
Prior art keywords
phenyl
lower alkyl
optionally substituted
halogen
lower alkoxy
Prior art date
Application number
BR0013792-8A
Other languages
English (en)
Inventor
Gerda Huber Trottmann
Walter Hunkeler
Roland Jakob-Roetne
Gavin John Kilpatrick
Matthias Heinrich Nettekoven
Claus Riemer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0013792A publication Critical patent/BR0013792A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Immunology (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Patente de Invenção: "DERIVADOS DE AMINO-TRIAZOLOPIRIDINA". A invenção refere-se a compostos de fórmula (I) em que R^ 1^ é um grupo de heteroarila de 5 ou 6 membros, contendo de 1 a 3 heteroátomos, selecionados de N, O ou S, e cujos grupos são opcionalmente substituídos por um ou dois substituintes, que são alquila inferior, -(CH~ 2~)~ n~OH, halogeno ou alcóxi inferior, e em que os grupos de heteroarila podem ser opcionalmente ligados ao anel de pirazol através de um grupo alquileno ou alquenila, ou é fenila, opcionalmente substituída por um ou dois substituintes sendo alquila inferior, alquila inferior de hidróxi, halogeno, hidróxi ou alcóxi inferior ou é -O(CH~ 2~)~ n~fenila, benzofurila, indolila ou benzotiofenila, ou é alquila S-inferior; R^ 2^ e R^ 4^ são independentemente um do outro hidrogênio, ciano ou S(O)~ 2~-fenila; R^ 3^ é hidrogênio, halogeno ou é um grupo heteroarila de 5 ou 6 membros, contendo de 1 a 3 heteroátomos, selecionados de N, O ou S, e cujos grupos são opcionalmente substituídos por um ou dois substituintes, que são alquila inferior, -(CH~ 2~)~ n~-arila, hidróxi, halogeno, alcóxi inferior, morfolinila, amino, alquilamino inferior ou -C(O)NR'~ 2~, e em que R' é alquila inferior ou hidrogênio, ou é fenila, opcionalmente substituída por um ou dois substituintes sendo halogeno, alquila inferior, alcóxi inferior, amino, di-alquil amino inferior, CF~ 3~, -OCF~ 3~, -NHC(O)alquila inferior, ciano, -C(O)-alquila inferior, -C(O)O-alquila inferior, -S-alquila inferior, -S(0)~ 2~NH-fenila, -S(0)~ 2~-metilpiperazinila; ou é -NR'R", em que R' e R" são independentemente um do outro hidrogênio, -(CH~ 2~)~ n~fenila, cujo anel de fenila é opcionalmente substituído por halogeno ou alcóxi inferior, -CH(alquila inferior)-fenila, indan-1-ila, 1,2,3,4-tetraidro-naftaleno, ou cicloalquila; ou é -O-fenila, cujo anel de fenila é opcionalmente substituído por halogeno, alquila inferior ou alcóxi inferior, -O-tetraidronaftalenila ou -O-CH~ 2~-6-metil-piridin-2-ila; ou é benzo[1,3]dioxolila, 1 H-indol-5-ila, naftila, benzofuran-2-ila, 1,3,4,9-tetraidrob-carbolin-2-ila, piperidin-1-ila, pirrolidin-1-ila, piperazin-4-il-metila ou morfolinila; R^ 5^ é -NR~ 2~, em que R pode ser o mesmo ou diferente e é hidrogênio, alquila inferior, fenila, benzila, alquila -CO-inferior, -CO-alcóxi inferior, alquenila inferior, -CO(CH~ 2~)~ n~-fenila ou -COO(CH~ 2~)~ n~-fenila, em que o anel de fenila é opcionalmente substituído por CF~ 3~, alcóxi inferior, halogeno ou alquila inferior, -CO(CH~ 2~)~ 3~-NHCO-alcóxi inferior, -(CH~ 2~)~ n~-fenila, em que o anel de fenila é opcionalmente substituído por alcóxi inferior, CF~ 3~ ou halogeno, ou é ácido 4,5-diidro-1H-imidazol-2-il-benzóico, ácido 1,4,5,6-tetraldro-pirimidin-2-il-benzóico ou ácido 4,5,6,7-tetraidro-1H-[1,3]diazepin-2-il-benzóico; n é de 0 a 4 e seus sais farmaceuticamente aceitáveis.
BR0013792-8A 1999-09-06 2000-08-28 Derivados de amino-triazolopiridina BR0013792A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99117578 1999-09-06
PCT/EP2000/008372 WO2001017999A2 (en) 1999-09-06 2000-08-28 Amino-triazolopyridine derivatives

Publications (1)

Publication Number Publication Date
BR0013792A true BR0013792A (pt) 2002-05-14

Family

ID=8238933

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0013792-8A BR0013792A (pt) 1999-09-06 2000-08-28 Derivados de amino-triazolopiridina

Country Status (22)

Country Link
US (1) US6355653B1 (pt)
EP (1) EP1214322A2 (pt)
JP (1) JP2003528811A (pt)
KR (1) KR20020027625A (pt)
CN (1) CN1379777A (pt)
AR (1) AR037484A1 (pt)
AU (1) AU7511000A (pt)
BR (1) BR0013792A (pt)
CA (1) CA2383998A1 (pt)
CZ (1) CZ20021220A3 (pt)
HR (1) HRP20020172A2 (pt)
HU (1) HUP0203316A3 (pt)
IL (1) IL148167A0 (pt)
MA (1) MA26816A1 (pt)
MX (1) MXPA02001748A (pt)
NO (1) NO20021077D0 (pt)
PE (1) PE20010629A1 (pt)
PL (1) PL354240A1 (pt)
TR (1) TR200200579T2 (pt)
WO (1) WO2001017999A2 (pt)
YU (1) YU13502A (pt)
ZA (1) ZA200201055B (pt)

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HUP0203316A3 (en) 2004-07-28
PE20010629A1 (es) 2001-05-30
IL148167A0 (en) 2002-09-12
ZA200201055B (en) 2003-07-30
AR037484A1 (es) 2004-11-17
EP1214322A2 (en) 2002-06-19
MXPA02001748A (es) 2002-08-06
US6355653B1 (en) 2002-03-12
MA26816A1 (fr) 2004-12-20
YU13502A (sh) 2004-11-25
CA2383998A1 (en) 2001-03-15
JP2003528811A (ja) 2003-09-30
CN1379777A (zh) 2002-11-13
CZ20021220A3 (cs) 2002-10-16
WO2001017999A3 (en) 2001-12-06
NO20021077L (no) 2002-03-05
HRP20020172A2 (en) 2003-10-31
TR200200579T2 (tr) 2002-12-23
KR20020027625A (ko) 2002-04-13
NO20021077D0 (no) 2002-03-05
HUP0203316A2 (hu) 2003-01-28
AU7511000A (en) 2001-04-10
WO2001017999A2 (en) 2001-03-15
PL354240A1 (en) 2003-12-29

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