BR0010479A - Gene tipo prp - Google Patents

Gene tipo prp

Info

Publication number
BR0010479A
BR0010479A BR0010479-5A BR0010479A BR0010479A BR 0010479 A BR0010479 A BR 0010479A BR 0010479 A BR0010479 A BR 0010479A BR 0010479 A BR0010479 A BR 0010479A
Authority
BR
Brazil
Prior art keywords
dpl
polypeptide
nucleic acids
methods
human
Prior art date
Application number
BR0010479-5A
Other languages
English (en)
Inventor
Stanley B Prusiner
Patrick Tremblay
Richard Moore
David Westaway
Leroy E Hood
Inyoul Lee
Original Assignee
Univ California
Univ Toronto
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Univ Toronto, Univ Washington filed Critical Univ California
Publication of BR0010479A publication Critical patent/BR0010479A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

"GENE TIPO PrP". A presente invenção provê ácidos nucléicos que codificam a proteína Doppel ("Dpl"), os peptídios Dpl, e avalia a utilização dos ácidos nucléicos e/ou dos peptídios Dpl. Em aspectos relacionados, a invenção caracteriza vetores de expressão e células hospedeiras, que compreendem ácidos nucléicos que codificam um polipeptídio Dpl humano. A presente invenção também se refere a anticorpos que se ligam especificamente a um polipeptídio Dpl humano, a métodos para a produção de polipeptídios Dpl humanos, a métodos para a identificação de células que expressam Dpl, a métodos para uso do gene Dpl e do polipeptídio Dpl, para alterar a função celular e a infecciosidade com priónio, em cultura ou in vivo, e à identificação de indivíduos com risco de doenças de priónio, detectando a alteração na codificação de Dpl e seq³ências reguladoras e níveis de expressão de Dpl.
BR0010479-5A 1999-05-11 2000-05-11 Gene tipo prp BR0010479A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/309,317 US6277970B1 (en) 1999-05-11 1999-05-11 PRP-like gene
PCT/US2000/013099 WO2000068382A1 (en) 1999-05-11 2000-05-11 PrP-LIKE GENE

Publications (1)

Publication Number Publication Date
BR0010479A true BR0010479A (pt) 2003-04-29

Family

ID=23197693

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0010479-5A BR0010479A (pt) 1999-05-11 2000-05-11 Gene tipo prp

Country Status (10)

Country Link
US (2) US6277970B1 (pt)
EP (1) EP1181365A4 (pt)
JP (1) JP2003517812A (pt)
KR (1) KR20020026430A (pt)
CN (1) CN1355845A (pt)
AU (1) AU5132100A (pt)
BR (1) BR0010479A (pt)
CA (1) CA2373507A1 (pt)
IL (1) IL146332A0 (pt)
WO (1) WO2000068382A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7569660B1 (en) * 1999-06-09 2009-08-04 The University Of Chicago Recombinant prion-like proteins and materials comprising same
AU2001253129A1 (en) * 2000-04-03 2001-10-15 Biolink Partners, Inc. Reversible chemical modification of nucleic acids and improved method for nucleic acid hybridization
WO2003035843A2 (en) * 2001-10-25 2003-05-01 Buck Institute For Age Research Screening system for modulators of her2 mediated transcription and her2 modulators identifed thereby
WO2003085086A2 (en) 2002-04-09 2003-10-16 The Scripps Research Institute Motif-grafted hybrid polypeptides and uses thereof
MX2010003371A (es) 2007-09-28 2010-05-05 Intrexon Corp Constructos interruptores genicos terapeuticos y biorreactores para la expresion de moleculas bioterapeuticas y usos de los mismos.
FR2935711A1 (fr) * 2008-09-05 2010-03-12 Lfb Biotechnologies Clone cellulaire stable exprimant un prion
CA3004593A1 (en) * 2015-11-09 2017-05-18 The University Of British Columbia Systems and methods for predicting misfolded protein epitopes by collective coordinate biasing
CN108329392A (zh) * 2017-12-20 2018-07-27 中国人民解放军第四军医大学 特异性识别小鼠Doppel蛋白的单克隆抗体
CN112980935B (zh) * 2021-03-31 2023-10-13 西北农林科技大学 一种山羊prnt基因单核苷酸多态性标记在性状早期选择中的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8802667D0 (en) * 1988-02-05 1988-03-02 Chancellor Masters & Scholars Probe for pneumoxystis carinii

Also Published As

Publication number Publication date
WO2000068382A9 (en) 2002-08-29
EP1181365A1 (en) 2002-02-27
US6277970B1 (en) 2001-08-21
JP2003517812A (ja) 2003-06-03
CN1355845A (zh) 2002-06-26
WO2000068382A1 (en) 2000-11-16
EP1181365A4 (en) 2002-09-04
KR20020026430A (ko) 2002-04-10
IL146332A0 (en) 2002-07-25
US20010021771A1 (en) 2001-09-13
CA2373507A1 (en) 2000-11-16
AU5132100A (en) 2000-11-21

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]