BR0010216A - Derivados de tio-oxindol - Google Patents

Derivados de tio-oxindol

Info

Publication number
BR0010216A
BR0010216A BR0010216-4A BR0010216A BR0010216A BR 0010216 A BR0010216 A BR 0010216A BR 0010216 A BR0010216 A BR 0010216A BR 0010216 A BR0010216 A BR 0010216A
Authority
BR
Brazil
Prior art keywords
thio
oxindole derivatives
compounds
progesterone
derivatives
Prior art date
Application number
BR0010216-4A
Other languages
English (en)
Inventor
Andrew Fensome
Juwen Zhang
Jay E Wrobel
Lin Zhi
Todd K Jones
Christopher M Tegley
Marci C Koko
James P Edwards
Edward G Melenski
Original Assignee
American Home Prod
Ligand Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/552,033 external-priority patent/US6355648B1/en
Application filed by American Home Prod, Ligand Pharm Inc filed Critical American Home Prod
Publication of BR0010216A publication Critical patent/BR0010216A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

"DERIVADOS DE TIO-OXINDOL". Esta invenção relaciona-se a compostos que são agonistas do receptor de progesterona que possuem estruturas gerais (1) ou (2) em que os substituintes são conforme definidos; ou um sal dele farmaceuticamente aceitável, bem como métodos de utilizar esses compostos para induzir a contracepção ou tratar carcinomas e adenocarcinomas relacionados à progesterona.
BR0010216-4A 1999-05-04 2000-05-01 Derivados de tio-oxindol BR0010216A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17225999P 1999-05-04 1999-05-04
US09/552,033 US6355648B1 (en) 1999-05-04 2000-04-19 Thio-oxindole derivatives
PCT/US2000/011630 WO2000066555A1 (en) 1999-05-04 2000-05-01 Thio-oxindole derivatives

Publications (1)

Publication Number Publication Date
BR0010216A true BR0010216A (pt) 2002-03-19

Family

ID=26867898

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0010216-4A BR0010216A (pt) 1999-05-04 2000-05-01 Derivados de tio-oxindol

Country Status (18)

Country Link
EP (1) EP1181275A1 (pt)
JP (1) JP2002543182A (pt)
KR (1) KR20020000636A (pt)
CN (1) CN1143847C (pt)
AU (1) AU767762B2 (pt)
BG (1) BG106078A (pt)
BR (1) BR0010216A (pt)
CA (1) CA2371633A1 (pt)
CZ (1) CZ20013950A3 (pt)
EA (1) EA005034B1 (pt)
GE (1) GEP20043266B (pt)
HU (1) HUP0200993A3 (pt)
MX (1) MXPA01011285A (pt)
NO (1) NO320912B1 (pt)
NZ (1) NZ515351A (pt)
PL (1) PL351407A1 (pt)
SK (1) SK15902001A3 (pt)
TR (1) TR200103288T2 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4869221B2 (ja) * 2004-04-08 2012-02-08 ワイス・エルエルシー プロゲステロン受容体調節剤としてのチオアミド誘導体
JP4950027B2 (ja) * 2004-04-08 2012-06-13 ワイス・エルエルシー チオアミド不純物を最小限に抑えるための方法
GB201113538D0 (en) * 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
CN104995194B (zh) * 2012-10-12 2017-08-29 学校法人冲绳科学技术大学院大学学园 螺环吲哚衍生物及其制备方法
US10118890B2 (en) 2014-10-10 2018-11-06 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
CA3037587A1 (en) * 2016-09-30 2018-04-05 Epizyme, Inc. Substituted fused bi- or tri- heterocyclic compounds as ehmt2 inhibitors

Also Published As

Publication number Publication date
SK15902001A3 (sk) 2002-11-06
HUP0200993A2 (hu) 2002-07-29
CN1349499A (zh) 2002-05-15
AU4681400A (en) 2000-11-17
MXPA01011285A (es) 2003-09-04
NO320912B1 (no) 2006-02-13
NO20015380L (no) 2002-01-03
NZ515351A (en) 2004-01-30
EA005034B1 (ru) 2004-10-28
CZ20013950A3 (cs) 2002-06-12
JP2002543182A (ja) 2002-12-17
NO20015380D0 (no) 2001-11-02
KR20020000636A (ko) 2002-01-05
AU767762B2 (en) 2003-11-20
HUP0200993A3 (en) 2003-05-28
TR200103288T2 (tr) 2002-04-22
GEP20043266B (en) 2004-06-25
EA200101180A1 (ru) 2002-04-25
CN1143847C (zh) 2004-03-31
EP1181275A1 (en) 2002-02-27
BG106078A (en) 2002-05-31
CA2371633A1 (en) 2000-11-09
PL351407A1 (en) 2003-04-22

Similar Documents

Publication Publication Date Title
NO20022655D0 (no) <Beta>-2-adrenerge reseptoragonister
BR0206985A (pt) Anticorpos modificados e métodos de uso
CY1105144T1 (el) Χρηση μιας ουσιας που συνδεεται στον πepιφepειακο υποδοχεα των βενζοδιαζεπινων στη θepαπεια του δepματικου στρες
BR9910832A (pt) Agonistas de receptores "beta" 2-adrenérgicos
BR0009814A (pt) Processo para tratar de uma doença associada com o receptor-beta estrogênico
DE69732868D1 (de) Mittel gegen Juckreiz
CY1106424T1 (el) Παραγωγα ν-φαινυλ-πυρρολ γουανιδινης ως συνδετες υποδοχεις μελανοκορτινης
BR0116452A (pt) Composto, composição farmacêutica, uso de um composto
MEP35308A (en) COMPOUNDS SPECIFIC TO ADENOSINE A1, A2a, AND A3 RECEPTOR AND USES THEREOF
EE200100243A (et) 5HT1 retseptori agonistid ja metoklopramiid migreeni raviks
ID27820A (id) APLIKASI-APLIKASI PENGOBATAN POLIPEPTIDA MATURE FLINT (mFLINT) ATAU OPG3, BAGIAN KELOMPOK SUPER RESEPTOR TNF
DK1019426T3 (da) Hidtil ukendte A1-adenosinreceptoragonister og -antagonister
CY1106726T1 (el) Υποκατεστημενα βενζοπυρανια ως επιλεκτικοι συναγωνιστες οιστρογονικου υποδοχεα β
BR0107628A (pt) l,2-diarilbenzimidazóis para tratamento de doenças que estão associadas a uma ativação microglial
BR9809071A (pt) Agentes farmacológicos
NO20020574L (no) Substituerte 1,5-dihydropyrrol-2-on derivater som er virksomme som NMDA-reseptorantagonister for behandlingen avsmertetilstanden
NO20051663L (no) Fremgangsmater for behandling av neurodegenerasjon
BR0010216A (pt) Derivados de tio-oxindol
NO983177L (no) Anvendelse av 1-enantiomeren av centkroman til fremstilling av et farmasaytisk preparat for behandling eller profylakse av brystkreft
ECSP003590A (es) Compuestos calcioliticos
ES2189940T3 (es) Antagonista de receptor at1 para la estimulacion de la apoptosis.
BR0116600A (pt) Método para a preparação regiosseletiva de benzo(g)quinolina-3-carbonitrilas e benzo(g)quinazolinas substituìdas
BR9912153A (pt) Piperazinonas substituìdas e uso terapêuticos das mesmas
NO20020914L (no) Alkoksy-substituerte benzimidazolforbindelser, preparater inneholdende slike samt anvendelser derav
BR9910859A (pt) Derivados de cianoiminoquinoxalina

Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: LIGAND PHARMACEUTICALS, INC. (US) , WYETH (US)

Free format text: ALTERADO DE: AMERICAN HOME PRODUCTS CORPORATION

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A E 9A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 NA RPI2003 DE 26/05/2009.