BR0009074A - Proteìna para bloquear adesão de plaqueta - Google Patents

Proteìna para bloquear adesão de plaqueta

Info

Publication number
BR0009074A
BR0009074A BR0009074-3A BR0009074A BR0009074A BR 0009074 A BR0009074 A BR 0009074A BR 0009074 A BR0009074 A BR 0009074A BR 0009074 A BR0009074 A BR 0009074A
Authority
BR
Brazil
Prior art keywords
protein
collagen
platelet adhesion
useful
naturally occurring
Prior art date
Application number
BR0009074-3A
Other languages
English (en)
Inventor
Wolfgang Strittmatter
Detlef Guessow
Uwe Hofmann
Juergen Hemberger
Zisi Fotev
Bernhard Scheuble
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR0009074A publication Critical patent/BR0009074A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43536—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Patente de Invenção: "PROTEìNA PARA BLOQUEAR ADESãO DE PLAQUETA". Uma proteína de ocorrência natural isolada da saliva da sanguessuga medicinal Hirudo medicinalis é descrita que fortemente liga-se a colágeno, desse modo atuando como um inibidor de adesão de plaqueta natural ao colágeno. A proteína tem um peso molecular de cerca de 12.000, um ponto isoelétrico acídico e contém seis cisteínas. A proteína foi seq³ênciada e o gene foi clonado de uma biblioteca de cDNA H. medicinalis. Os procedimentos para produzir tal polipeptídeo por técnicas recombinantes são divulgados. As proteínas recombinantes e as de ocorrência natural são inibidores potentes de adesão de plaqueta dependente de colágeno e portanto úteis para o tratamento terapêutico de várias condições relacionadas a doenças graves e doenças do sistema de circulação. Além disso a proteína é útil para revestir superfícies de colágeno natural ou artificial a fim de torná-las não adesivas às células e prevenir a ativação de células.
BR0009074-3A 1999-03-18 2000-03-10 Proteìna para bloquear adesão de plaqueta BR0009074A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99105530 1999-03-18
EP99109503 1999-05-12
PCT/EP2000/002117 WO2000056885A1 (en) 1999-03-18 2000-03-10 Protein for blocking platelet adhesion

Publications (1)

Publication Number Publication Date
BR0009074A true BR0009074A (pt) 2002-01-02

Family

ID=26152935

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0009074-3A BR0009074A (pt) 1999-03-18 2000-03-10 Proteìna para bloquear adesão de plaqueta

Country Status (27)

Country Link
US (3) US6774107B1 (pt)
EP (1) EP1161530B1 (pt)
JP (1) JP4805461B2 (pt)
KR (1) KR100788219B1 (pt)
CN (1) CN1185344C (pt)
AR (1) AR023099A1 (pt)
AT (1) ATE295883T1 (pt)
AU (1) AU767172B2 (pt)
BR (1) BR0009074A (pt)
CA (1) CA2367457C (pt)
CO (1) CO5241328A1 (pt)
CZ (1) CZ301524B6 (pt)
DE (1) DE60020220T2 (pt)
DK (1) DK1161530T3 (pt)
ES (1) ES2240067T3 (pt)
HK (1) HK1045330B (pt)
HU (1) HU228068B1 (pt)
MX (1) MXPA01009363A (pt)
MY (1) MY123371A (pt)
NO (1) NO330769B1 (pt)
PL (1) PL200384B1 (pt)
PT (1) PT1161530E (pt)
RU (1) RU2292351C2 (pt)
SI (1) SI1161530T1 (pt)
SK (1) SK287496B6 (pt)
TR (1) TR200102729T2 (pt)
WO (1) WO2000056885A1 (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200102729T2 (tr) 1999-03-18 2002-04-22 Merck Patent Gmbh Platelet yapışmasını bloke etme amaçlı protein
MY128992A (en) * 2000-08-25 2007-03-30 Merck Patent Gmbh Saratin for inhibiting platelet adhesion to collagen
US7507412B2 (en) * 2001-07-18 2009-03-24 Merck Patent Gmbh Glycoprotein VI fusion proteins
US7053051B2 (en) 2003-10-28 2006-05-30 Medtronic, Inc. Methods of preparing crosslinked materials and bioprosthetic devices
US8017634B2 (en) 2003-12-29 2011-09-13 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
JP5762666B2 (ja) * 2004-10-12 2015-08-12 ボード、オブ、トラスティーズ、オブ、ミシガン、ステイト、ユニバーシティＢｏａｒｄ Ｏｆ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｍｉｃｈｉｇａｎ Ｓｔａｔｅ Ｕｎｉｖｅｒｓｉｔｙ フロログルシノールの生合成およびそれからの１，３−ジヒドロキシベンゼンの製造
US8999370B2 (en) * 2005-05-26 2015-04-07 Thomas Jefferson University Method to treat and prevent posterior capsule opacification
US7691839B2 (en) 2005-09-28 2010-04-06 Biovascular, Inc. Methods and compositions for blocking platelet and cell adhesion, cell migration and inflammation
US20110034396A1 (en) * 2005-09-28 2011-02-10 Biovascular, Inc. Methods and compositions for inhibiting cell migration and treatment of inflammatory conditions
US20080015145A1 (en) 2006-07-11 2008-01-17 Maria Gyongyossy-Issa Mimotope receptors and inhibitors for platelet-platelet and platelet-endothelium interactions
GB2462022B (en) 2008-06-16 2011-05-25 Biovascular Inc Controlled release compositions of agents that reduce circulating levels of platelets and methods thereof
HUE035888T2 (en) * 2008-10-15 2018-05-28 Ionis Pharmaceuticals Inc Modulation of Factor 11 Expression
WO2012003461A2 (en) 2010-07-02 2012-01-05 Draths Corporation Phloroglucinol synthases and methods of making and using the same
WO2012006244A1 (en) 2010-07-06 2012-01-12 Draths Corporation Method for producing phloroglucinol and dihydrophloroglucinol
WO2012006245A1 (en) 2010-07-06 2012-01-12 Draths Corporation Phloroglucinol reductase and methods of making and using the same
WO2012024650A2 (en) 2010-08-19 2012-02-23 Abbott Laboratories Anti-ngf antibodies and their use
US8790651B2 (en) 2011-07-21 2014-07-29 Zoetis Llc Interleukin-31 monoclonal antibody
DE202012012998U1 (de) 2011-08-31 2014-06-13 Daniel Elias Bioaktive, regenerative Mischung zur Herstellung eines Ergänzungsnahrungsmittels
CN104364264B (zh) 2012-06-06 2018-07-24 硕腾服务有限责任公司 犬源化抗ngf抗体和其方法
JP2015524268A (ja) 2012-07-19 2015-08-24 ゾエティス・エルエルシー ウシインフルエンザウイルス組成物
AU2013295770A1 (en) 2012-07-27 2015-01-29 Zoetis Services Llc Tick toxin compositions
CA3033759C (en) 2016-08-17 2022-06-14 Pharmaq As Sea lice vaccine
BR102017005783A2 (pt) * 2017-03-21 2018-10-02 Fund Butantan processo de obtenção de esculptina e seus fragmentos, esculptina recombinante e seus usos
RU2020129265A (ru) 2018-03-12 2022-04-12 ЗОИТИС СЕРВИСЕЗ ЭлЭлСи Антитела против ngf и связанные с ними способы
CA3093709C (en) 2018-03-16 2024-03-26 Zoetis Services Llc Peptide vaccines against interleukin-31
AU2019234220A1 (en) 2018-03-16 2020-09-10 Zoetis Services Llc Interleukin-31 monoclonal antibodies for veterinary use
AU2019266261A1 (en) 2018-05-09 2020-11-05 Ionis Pharmaceuticals, Inc. Compounds and methods for reducing FXI expression
CA3153379A1 (en) 2019-09-11 2021-03-18 Zoetis Services Llc Recombinant herpesvirus of turkey vectors expressing antigens of avian pathogens and uses thereof
US20220119513A1 (en) 2020-06-08 2022-04-21 Zoetis Services Llc Anti-tgfb antibodies and therapeutic uses thereof
US20210386854A1 (en) 2020-06-15 2021-12-16 Zoetis Services Llc Cell Line for Production of Marek's Disease Virus Vaccine and Methods of Making and Using the Same
MX2023004020A (es) 2020-10-07 2023-07-07 Zoetis Services Llc Anticuerpos anti-ngf y métodos para su uso.
TW202221039A (zh) 2020-10-19 2022-06-01 美商碩騰服務公司 犬及貓抑瘤素Ｍ受體β之抗體及其用途
AU2022349693A1 (en) 2021-09-27 2024-03-14 Zoetis Services Llc ANTI- TGFβ1,2,3 ANTIBODIES AND THERAPEUTIC USES THEREOF

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5705355A (en) * 1984-03-27 1998-01-06 Transgene, S.A. Hirudin, pharmaceutical compositions comprising it and their use
US4898734A (en) * 1988-02-29 1990-02-06 Massachusetts Institute Of Technology Polymer composite for controlled release or membrane formation
IL86857A (en) * 1988-06-24 1994-04-12 Yissum Res Dev Co Platelet-aggregating inhibitory agents from leech saliva and pharmaceutical preparations containing the same
US5182260A (en) * 1989-01-27 1993-01-26 Biogen, Inc. Dna sequences encoding snake venom inhibitors of platelet activation processes for producing those inhibitors and compositions using them
CA2052486A1 (en) * 1990-10-09 1992-04-10 Thomas M. Connolly Protein for inhibiting collagen-stimulated platelet aggregation
GB9022040D0 (en) * 1990-10-10 1990-11-21 Biopharm Ltd Platelet adhesion inhibitor
DE4136513A1 (de) * 1991-11-06 1993-05-13 Basf Ag Neues thrombininhibitorisches protein aus raubwanzen
ES2169080T3 (es) * 1993-07-01 2002-07-01 Merck Patent Gmbh Inhibidor de la agregacion de plaquetas estimulada por colageno.
DE69433381T3 (de) * 1993-07-29 2009-04-16 The Government of the United States of America, as represented by the Secretary National Institute of Health, Office of Technology Transfer Verfahren zur behandlung atherosklerose oder restenose mit hilfe eines mikrotubulusstabilisators
AU701643B2 (en) * 1994-09-12 1999-02-04 Schering Aktiengesellschaft Process for manufacture of a modified collagen-induced platelet aggregation inhibitor pallidipin
ATE211765T1 (de) * 1994-10-28 2002-01-15 Vitaleech Bioscience N V Neue familie von proteaseinhibitoren und andere biologisch aktive substanzen
TR200102729T2 (tr) * 1999-03-18 2002-04-22 Merck Patent Gmbh Platelet yapışmasını bloke etme amaçlı protein
MY128992A (en) * 2000-08-25 2007-03-30 Merck Patent Gmbh Saratin for inhibiting platelet adhesion to collagen

Also Published As

Publication number Publication date
KR100788219B1 (ko) 2007-12-26
CN1344318A (zh) 2002-04-10
HU228068B1 (en) 2012-09-28
PL200384B1 (pl) 2008-12-31
US6774107B1 (en) 2004-08-10
ES2240067T3 (es) 2005-10-16
US20050065084A1 (en) 2005-03-24
EP1161530B1 (en) 2005-05-18
AU767172B2 (en) 2003-11-06
CA2367457C (en) 2010-09-21
MXPA01009363A (es) 2002-06-04
DE60020220D1 (de) 2005-06-23
NO20014506L (no) 2001-11-16
NO330769B1 (no) 2011-07-11
JP4805461B2 (ja) 2011-11-02
US6962801B2 (en) 2005-11-08
TR200102729T2 (tr) 2002-04-22
MY123371A (en) 2006-05-31
PL350147A1 (en) 2002-11-04
SK12902001A3 (sk) 2002-03-05
HK1045330A1 (en) 2002-11-22
HUP0200353A3 (en) 2003-12-29
US7090986B2 (en) 2006-08-15
JP2002539788A (ja) 2002-11-26
DK1161530T3 (da) 2005-08-08
US20060094079A1 (en) 2006-05-04
AU3166200A (en) 2000-10-09
HUP0200353A2 (hu) 2002-05-29
CO5241328A1 (es) 2003-01-31
RU2292351C2 (ru) 2007-01-27
HK1045330B (zh) 2005-09-09
SI1161530T1 (en) 2005-10-31
KR20020008131A (ko) 2002-01-29
ATE295883T1 (de) 2005-06-15
CN1185344C (zh) 2005-01-19
CA2367457A1 (en) 2000-09-28
WO2000056885A1 (en) 2000-09-28
DE60020220T2 (de) 2006-05-24
NO20014506D0 (no) 2001-09-17
CZ20013341A3 (cs) 2002-01-16
SK287496B6 (sk) 2010-12-07
AR023099A1 (es) 2002-09-04
PT1161530E (pt) 2005-09-30
CZ301524B6 (cs) 2010-03-31
EP1161530A1 (en) 2001-12-12

Similar Documents

Publication Publication Date Title
BR0009074A (pt) Proteìna para bloquear adesão de plaqueta
BRPI0109494B8 (pt) muteína de fator viii, sequência de dna, vetor, processo para produção da muteína de fator viii, composição farmacêutica e uso da muteína do fator viii
JP2010155859A (ja) 生物活性ケラチンタンパク質
EP0255206B1 (en) Peptides that inhibit von Willebrand factor binding
BRPI0412799A (pt) imunógeno, composição, ácido nucleico, célula recombinante, métodos para preparar um polipeptìdeo, para induzir um a resposta imune protetora em um paciente e para induzir uma resposta anamnésica em um paciente, e, seqüência de ácido nucleico otimizada de levedura
Vogelmeier et al. Aerosolization of recombinant SLPI to augment antineutrophil elastase protection of pulmonary epithelium
Kurata et al. Structure and function of mannan-binding proteins isolated from human liver and serum
Castillo et al. Subunit structure of bovine ESF (extracellular-matrix stabilizing factor (s)): A chondroitin sulfate proteoglycan with homology to human Iαi (inter-α-trypsin inhibitors)
Tang et al. YY-39, a tick anti-thrombosis peptide containing RGD domain
JPH01250399A (ja) トリグラミン、血小板凝集抑制性ポリペプチド
BR9607628A (pt) Mólecula proteinácea biologicamente isolada, molécula recombinante, fragmento de peptìdeo, molécula de ácido nucleico, composição farmacêutica, e, processos para preparar uma molécula recombinante e para induzir a proliferação astroglial em um mamìfero
BR0207379A (pt) Uso de proteìnas de fusão cuja parte n-terminal é um derivado de hirudina para produção de proteìnas recombinantes via secreção por levedura
KR950702579A (ko) 트롬빈 억제제(thrombin inhibitors)
JP2703993B2 (ja) トロンビン阻害作用を有するアンブリオミン
JP4701355B2 (ja) プロトロンビン活性化タンパク質
Mayne et al. The structure of a small collagenous fragment isolated from chicken hyaline cartilage
Chow et al. Purification, Characterization, and Amino Acid Sequence Determination of Acanthins, Potent Inhibitors of Platelet Aggregation fromAcanthophis antarcticus (Common Death Adder) Venom
CZ195193A3 (en) Modified factor-4 of blood platelets, process of its preparation and pharmaceutical preparation in which it is comprised
PT655251E (pt) Composicao farmaceutica para a profilaxia e o tratamento de fracturas
ECSP003383A (es) Proteina para bloquear la adherencia plaquetaria
JP2696316B2 (ja) ヒルジンの発現のためのベクター、形質転換細胞及びヒルジンの製造方法
FR2900407B1 (fr) Nouveaux polypeptides induisant des cellules dendritiques ainsi que les medicaments et compositions pharmaceutiques contenant de tels polypeptides
WO2003075848A2 (en) Inhibitors for use in hemostasis
WO2005011584A2 (en) Decorin proteoglycan inhibitor of fibrinogen blood clotting
BR9510323A (pt) Variante de dnase i humana ácido nucleico isolado método para tratamento de um paciente tendo uma desordem ou doença pulmonar e composição farmacêutica

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 10 (IX), 18 (III), 24 E 25 DA LPI.

B09T Decision of refusal: decision cancelled [chapter 9.2.1 patent gazette]

Free format text: REF. A RPI NO 2070 DE 08/09/2010.

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07F Notification of approval that there is no relation to art. 229 of lpi (pipeline patents) [chapter 7.6 patent gazette]

Free format text: NOTIFICACAO DE NAO ANUENCIA RELACIONADA COM O ART. 229 DA LPI

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 15A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2342 DE 24-11-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.