BR0008978A - Método para preparação de 5-cianoftalida - Google Patents

Método para preparação de 5-cianoftalida

Info

Publication number
BR0008978A
BR0008978A BR0008978-8A BR0008978A BR0008978A BR 0008978 A BR0008978 A BR 0008978A BR 0008978 A BR0008978 A BR 0008978A BR 0008978 A BR0008978 A BR 0008978A
Authority
BR
Brazil
Prior art keywords
cyanophthalide
preparing
preparation
sulfonamide
cyanophtalide
Prior art date
Application number
BR0008978-8A
Other languages
English (en)
Inventor
Beat Weber
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of BR0008978A publication Critical patent/BR0008978A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

"MéTODO PARA PREPARAçãO DE 5-CIANOFTALIDA".Provê-se um método para a preparação de 5-cianoftalida, no qual5-carboxiftalida é reagido com um agente de desidratação, talcomo tionilcloreto e sulfonamida, preferivelmente sulfonamida.Cianoftalida é preparado em rendimentos altos através de umprocedimento conveniente. 5-cianoftalida é um intermediárioutilizado na preparação do medicamento antidepressivo citalopram.
BR0008978-8A 1999-01-29 2000-01-26 Método para preparação de 5-cianoftalida BR0008978A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA199900128 1999-01-29
PCT/DK2000/000032 WO2000044738A1 (en) 1999-01-29 2000-01-26 Method for the preparation of 5-cyanophthalide

Publications (1)

Publication Number Publication Date
BR0008978A true BR0008978A (pt) 2001-11-27

Family

ID=8090069

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0008978-8A BR0008978A (pt) 1999-01-29 2000-01-26 Método para preparação de 5-cianoftalida

Country Status (31)

Country Link
US (1) US6441201B1 (pt)
EP (1) EP1150966B1 (pt)
JP (1) JP2002535397A (pt)
KR (1) KR100430327B1 (pt)
CN (1) CN1158271C (pt)
AR (1) AR022329A1 (pt)
AT (1) ATE222900T1 (pt)
AU (1) AU763666B2 (pt)
BG (1) BG64924B1 (pt)
BR (1) BR0008978A (pt)
CA (1) CA2361395C (pt)
CZ (1) CZ300257B6 (pt)
DE (1) DE60000364T2 (pt)
DK (1) DK1150966T3 (pt)
EA (1) EA003257B1 (pt)
ES (1) ES2180508T3 (pt)
HK (1) HK1044342B (pt)
HU (1) HUP0104976A3 (pt)
IL (2) IL144114A0 (pt)
IS (1) IS2223B (pt)
IT (1) IT1317741B1 (pt)
NO (1) NO326532B1 (pt)
NZ (1) NZ512775A (pt)
PL (1) PL198385B1 (pt)
PT (1) PT1150966E (pt)
SI (1) SI1150966T1 (pt)
SK (1) SK284367B6 (pt)
TR (1) TR200102135T2 (pt)
UA (1) UA70987C2 (pt)
WO (1) WO2000044738A1 (pt)
ZA (1) ZA200105549B (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000023431A1 (en) 1998-10-20 2000-04-27 H. Lundbeck A/S Method for the preparation of citalopram
EA003057B1 (ru) 1998-12-23 2002-12-26 Х.Лундбекк А/С Способ получения 5-цианофталида
CN1142926C (zh) 1999-04-14 2004-03-24 H·隆德贝克有限公司 制备西酞普兰的方法
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
EP1228056B1 (en) 1999-10-25 2004-09-22 H. Lundbeck A/S Method for the preparation of citalopram
PT1298124E (pt) 1999-10-25 2007-05-31 Lundbeck & Co As H Método para a preparação de citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
PT1246812E (pt) 1999-12-28 2004-08-31 Lundbeck & Co As H Metodo para a preparacao de citalopram
EP1246813B1 (en) 1999-12-30 2003-11-05 H. Lundbeck A/S Method for the preparation of citalopram
ATE252570T1 (de) 2000-01-14 2003-11-15 Lundbeck & Co As H Verfahren zur herstellung von 5-cyanophthalid
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
EP1265881A1 (en) 2000-03-13 2002-12-18 H. Lundbeck A/S Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
NZ521201A (en) 2000-03-13 2004-02-27 H Method for the preparation of citalopram
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
IL151488A0 (en) 2000-03-14 2003-04-10 Lundbeck & Co As H Method for the preparation of citalopram
EA200200982A1 (ru) * 2000-03-16 2003-02-27 Х.Лундбекк А/С Способ получения 5-циано-1-(4-фторфенил)-1,3-дигидроизобензофуранов
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
IL144816A (en) * 2000-08-18 2005-09-25 Lundbeck & Co As H Method for the preparation of citalopram
CA2360303C (en) 2000-12-22 2003-08-12 Marco Villa Process for the preparation of pure citalopram
PT1181272E (pt) 2000-12-28 2003-01-31 Lundbeck & Co As H Processo para a preparacao de citalopram puro
GR1004635B (el) * 2001-08-14 2004-07-14 H@Αlundbeckαa@Sαα Μεθοδοσαπαρασκευησατησασιταλοπραμης@αα
EP1321464A1 (en) * 2001-12-21 2003-06-25 ICROM S.p.A. Process for the preparation of 5-cyanophthalide and intermediates useful therein
PE20040991A1 (es) 2002-08-12 2004-12-27 Lundbeck & Co As H Separacion de intermediarios para la preparacion de escitalopram
US7687645B2 (en) 2003-03-21 2010-03-30 H. Lundbeck A/S Intermediates for the preparation of citalopram and escitalopram
TR200504022T1 (tr) * 2003-03-24 2006-08-21 Hetero Drugs Limited (S)-sitalopram oksalatın yeni sıvı kristal formları.
EP1777221A1 (en) * 2005-10-14 2007-04-25 Adorkem Technology SpA Process for the preparation of 5-cyanophthalide starting from 5-carboxyphthalide

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (pt) 1965-03-18
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
DE1015416T1 (de) 1997-07-08 2000-10-05 Lundbeck A S Kobenhavn Valby H Verfahren zur herstellung von citalopram
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
JP3813820B2 (ja) 1997-11-11 2006-08-23 ハー・ルンドベック・アクチエゼルスカベット シタロプラムの製造方法
WO2000023431A1 (en) 1998-10-20 2000-04-27 H. Lundbeck A/S Method for the preparation of citalopram
EA003057B1 (ru) * 1998-12-23 2002-12-26 Х.Лундбекк А/С Способ получения 5-цианофталида
CN1142926C (zh) 1999-04-14 2004-03-24 H·隆德贝克有限公司 制备西酞普兰的方法
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
EP1228056B1 (en) 1999-10-25 2004-09-22 H. Lundbeck A/S Method for the preparation of citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
IL144816A (en) 2000-08-18 2005-09-25 Lundbeck & Co As H Method for the preparation of citalopram
CA2360303C (en) 2000-12-22 2003-08-12 Marco Villa Process for the preparation of pure citalopram
PT1181272E (pt) 2000-12-28 2003-01-31 Lundbeck & Co As H Processo para a preparacao de citalopram puro

Also Published As

Publication number Publication date
TR200102135T2 (tr) 2002-01-21
EA200100834A1 (ru) 2001-12-24
CN1337957A (zh) 2002-02-27
ATE222900T1 (de) 2002-09-15
US6441201B1 (en) 2002-08-27
IS2223B (is) 2007-03-15
JP2002535397A (ja) 2002-10-22
AU2278200A (en) 2000-08-18
EP1150966A1 (en) 2001-11-07
ZA200105549B (en) 2002-07-05
IT1317741B1 (it) 2003-07-15
DE60000364D1 (de) 2002-10-02
HK1044342B (zh) 2005-04-22
SK284367B6 (sk) 2005-02-04
HUP0104976A3 (en) 2002-09-30
EA003257B1 (ru) 2003-02-27
US20020028956A1 (en) 2002-03-07
CZ300257B6 (cs) 2009-04-01
NZ512775A (en) 2003-11-28
BG105692A (en) 2002-02-28
NO326532B1 (no) 2008-12-29
CA2361395C (en) 2005-11-15
IL144114A (en) 2006-06-11
PL198385B1 (pl) 2008-06-30
SI1150966T1 (en) 2003-02-28
WO2000044738A1 (en) 2000-08-03
CZ20012734A3 (cs) 2002-01-16
NO20013667L (no) 2001-07-26
IS5982A (is) 2001-06-28
UA70987C2 (uk) 2004-11-15
HK1044342A1 (en) 2002-10-18
CA2361395A1 (en) 2000-08-03
DE60000364T2 (de) 2003-04-03
HUP0104976A2 (en) 2002-06-29
EP1150966B1 (en) 2002-08-28
KR20010101432A (ko) 2001-11-14
ES2180508T3 (es) 2003-02-16
AU763666B2 (en) 2003-07-31
ITMI20000112A0 (it) 2000-01-27
IL144114A0 (en) 2002-05-23
ITMI20000112A1 (it) 2001-07-27
SK10562001A3 (sk) 2002-01-07
KR100430327B1 (ko) 2004-05-03
BG64924B1 (bg) 2006-09-29
AR022329A1 (es) 2002-09-04
PT1150966E (pt) 2003-01-31
NO20013667D0 (no) 2001-07-26
DK1150966T3 (da) 2002-12-30
CN1158271C (zh) 2004-07-21
PL349908A1 (en) 2002-10-07

Similar Documents

Publication Publication Date Title
BR0008978A (pt) Método para preparação de 5-cianoftalida
BR0014652A (pt) Fabricação de conjugados de agente terapêutico-poliglutamato
CL2008002673A1 (es) Procedimiento se preparacion de citalopram que comprende hacer reaccionar un compuesto derivado de benzofurano con un agente eshidratante y una sulfonamida (div. sol. 2003-01).
BR0108058A (pt) Corpo maciço
FR2627696B1 (fr) Nouvelle forme galenique du fenofibrate
BRPI0111116B8 (pt) imitadores de trombopoietina
BR0102435A (pt) Artigo absorvente
MX9301053A (es) Guanidinas [(benzodioxan, benzofuran o benzopiran)-alquilamino]-alquil-substituidas.
BR9916955A (pt) Método para preparação de 5-cianoftalida
ES2189972T3 (es) Soporte ortopedico confortable y su procedimiento de fabricacion.
BR0215052A (pt) Composições acaricidas e métodos
ES2054649T3 (es) 2-aminotetralinas basicas substituidas.
ES2036199T3 (es) Procedimiento de obtencion de un preparado farmaceutico administrable a traves de una membrana corporal.
BR0112070A (pt) Combinações de substâncias ativas com propriedades inseticidas e acaricidas
BR0208797A (pt) Microcápsulas
ES2160534B1 (es) Nuevos esteres derivados de (rr,ss)-2-hidroxibenzoato de 3-(2-dimetilaminometil-1-hidroxiciclohexil) fenilo.
BR0107667A (pt) Composto de linezolida em forma de cristal que e farmaceuticamente útil como agente antibacteriano e método de preparação do mesmo
PT1158962E (pt) Processo para a preparacao de formas de dosagem solidas que contem ciclodextrina
BR0214706A (pt) Estrutura absorvente envolta
ATE249841T1 (de) Immunogene zubereitungen
BR9917604A (pt) Método para preparação de citalopram
DE50010978D1 (de) Kosmetische Stiftzubereitung
DE60137206D1 (de) Herstellung von fluoromethyl-2,2,2-trifluoro-1-(trifluoromethyl)ethylether
BR0110069A (pt) Combinações de substâncias ativas com propriedades inseticidas e acaricidas
AR004719A1 (es) Compuestos debisindolilmaleimidas con un punte n, n' y formulaciones farmaceuticas que los contienen, dichos compuestos son utiles comointermediarios para preparar otras bisindolilmaleimidas que poseen dicho puente n, n'

Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 12A ANUIDADE(S).

B11D Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time