BR0008857A - Análogos de piridoxal para distúrbios da vitaminab-6 - Google Patents

Análogos de piridoxal para distúrbios da vitaminab-6

Info

Publication number
BR0008857A
BR0008857A BR0008857-9A BR0008857A BR0008857A BR 0008857 A BR0008857 A BR 0008857A BR 0008857 A BR0008857 A BR 0008857A BR 0008857 A BR0008857 A BR 0008857A
Authority
BR
Brazil
Prior art keywords
sub
alkanoyloxy
alkoxy
alkyl
related diseases
Prior art date
Application number
BR0008857-9A
Other languages
English (en)
Inventor
Wasimul Haque
James L Charlton
Original Assignee
Medicure Inc
Univ Manitoba
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medicure Inc, Univ Manitoba filed Critical Medicure Inc
Publication of BR0008857A publication Critical patent/BR0008857A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

"ANáLOGOS DE PIRIDOXAL PARA DISTúRBIOS DA VITAMINAB-6". Trata-se de análogos do piridoxal que podem ser úteis para otratamento da deficiência de vitamina B~ 6~ e doençasrelacionadas; doenças cardiovasculares e relacionadas; melanomae doenças relacionadas; e sintomas delas proveniente. Osanálogos possuem fórmula (V) ou (VI) ou um sal de adição ácidafarmaceuticamente aceitável deles proveniente, onde R~ 1~, éalquila, alquenila, onde a alquila ou a alquenila pode serinterrompida por nitrogênio, oxigênio, ou enxofre, e pode sersubstituída no carbono terminal por hidroxila, alcoxila, alcanoiloxila,alcanoiloxiarila, alcoxialcanoila, alcoxicarbonila, oudialquilcarbamoiloxila; alcoxila; dialquilamino; alcanoiloxila;alcanoiloxiarila; alcoxialcanoila; alcoxicarbonila;dialquilcarbamoiloxila; ou arila, ariloxila, ariltio, ou aralquila, ondearila pode ser substituída por alquila, alcoxila, amino, hidroxila, halo,nitro, ou alcanoiloxila. R~ 2~ é uma amina secundária. Essesanálogos podem ser administrados tanto sozinhos ouconcomitantemente com medicações conhecidas, para tratar asdoenças acima descritas.
BR0008857-9A 1999-03-08 2000-03-07 Análogos de piridoxal para distúrbios da vitaminab-6 BR0008857A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12369899P 1999-03-08 1999-03-08
US12588199P 1999-03-24 1999-03-24
PCT/IB2000/000255 WO2000053606A1 (en) 1999-03-08 2000-03-07 Pyridoxal analogues for vitamin b-6 disorders

Publications (1)

Publication Number Publication Date
BR0008857A true BR0008857A (pt) 2001-12-18

Family

ID=26821806

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0008857-9A BR0008857A (pt) 1999-03-08 2000-03-07 Análogos de piridoxal para distúrbios da vitaminab-6

Country Status (13)

Country Link
US (3) US6339085B1 (pt)
EP (1) EP1169322B8 (pt)
JP (1) JP2002539127A (pt)
AT (1) ATE306489T1 (pt)
AU (1) AU763464B2 (pt)
BR (1) BR0008857A (pt)
CA (1) CA2366602A1 (pt)
DE (1) DE60023125T2 (pt)
DK (1) DK1169322T3 (pt)
ES (1) ES2250112T3 (pt)
NZ (1) NZ514567A (pt)
PT (1) PT1169322E (pt)
WO (1) WO2000053606A1 (pt)

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US6339085B1 (en) 2002-01-15
JP2002539127A (ja) 2002-11-19
EP1169322B8 (en) 2006-09-13
DE60023125D1 (de) 2006-02-23
PT1169322E (pt) 2007-04-30
US6890943B2 (en) 2005-05-10
US7230009B2 (en) 2007-06-12
CA2366602A1 (en) 2000-09-14
NZ514567A (en) 2002-11-26
DE60023125T2 (de) 2006-06-22
US20030195236A1 (en) 2003-10-16
AU3183400A (en) 2000-09-28
EP1169322A1 (en) 2002-01-09
AU763464B2 (en) 2003-07-24
US20010031770A1 (en) 2001-10-18
DK1169322T3 (da) 2006-03-06
WO2000053606A1 (en) 2000-09-14
ATE306489T1 (de) 2005-10-15
EP1169322B1 (en) 2005-10-12

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