BR0008857A - Análogos de piridoxal para distúrbios da vitaminab-6 - Google Patents
Análogos de piridoxal para distúrbios da vitaminab-6Info
- Publication number
- BR0008857A BR0008857A BR0008857-9A BR0008857A BR0008857A BR 0008857 A BR0008857 A BR 0008857A BR 0008857 A BR0008857 A BR 0008857A BR 0008857 A BR0008857 A BR 0008857A
- Authority
- BR
- Brazil
- Prior art keywords
- sub
- alkanoyloxy
- alkoxy
- alkyl
- related diseases
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
- C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Abstract
"ANáLOGOS DE PIRIDOXAL PARA DISTúRBIOS DA VITAMINAB-6". Trata-se de análogos do piridoxal que podem ser úteis para otratamento da deficiência de vitamina B~ 6~ e doençasrelacionadas; doenças cardiovasculares e relacionadas; melanomae doenças relacionadas; e sintomas delas proveniente. Osanálogos possuem fórmula (V) ou (VI) ou um sal de adição ácidafarmaceuticamente aceitável deles proveniente, onde R~ 1~, éalquila, alquenila, onde a alquila ou a alquenila pode serinterrompida por nitrogênio, oxigênio, ou enxofre, e pode sersubstituída no carbono terminal por hidroxila, alcoxila, alcanoiloxila,alcanoiloxiarila, alcoxialcanoila, alcoxicarbonila, oudialquilcarbamoiloxila; alcoxila; dialquilamino; alcanoiloxila;alcanoiloxiarila; alcoxialcanoila; alcoxicarbonila;dialquilcarbamoiloxila; ou arila, ariloxila, ariltio, ou aralquila, ondearila pode ser substituída por alquila, alcoxila, amino, hidroxila, halo,nitro, ou alcanoiloxila. R~ 2~ é uma amina secundária. Essesanálogos podem ser administrados tanto sozinhos ouconcomitantemente com medicações conhecidas, para tratar asdoenças acima descritas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12369899P | 1999-03-08 | 1999-03-08 | |
US12588199P | 1999-03-24 | 1999-03-24 | |
PCT/IB2000/000255 WO2000053606A1 (en) | 1999-03-08 | 2000-03-07 | Pyridoxal analogues for vitamin b-6 disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0008857A true BR0008857A (pt) | 2001-12-18 |
Family
ID=26821806
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0008857-9A BR0008857A (pt) | 1999-03-08 | 2000-03-07 | Análogos de piridoxal para distúrbios da vitaminab-6 |
Country Status (13)
Country | Link |
---|---|
US (3) | US6339085B1 (pt) |
EP (1) | EP1169322B8 (pt) |
JP (1) | JP2002539127A (pt) |
AT (1) | ATE306489T1 (pt) |
AU (1) | AU763464B2 (pt) |
BR (1) | BR0008857A (pt) |
CA (1) | CA2366602A1 (pt) |
DE (1) | DE60023125T2 (pt) |
DK (1) | DK1169322T3 (pt) |
ES (1) | ES2250112T3 (pt) |
NZ (1) | NZ514567A (pt) |
PT (1) | PT1169322E (pt) |
WO (1) | WO2000053606A1 (pt) |
Families Citing this family (37)
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US6750209B1 (en) * | 1995-09-12 | 2004-06-15 | Kansas University Medical Center | Advanced glycation end-product intermediaries and post-amadori inhibition |
CA2366602A1 (en) * | 1999-03-08 | 2000-09-14 | Medicure Inc. | Pyridoxal analogues for vitamin b-6 disorders |
WO2001003682A2 (en) * | 1999-07-13 | 2001-01-18 | Medicure Inc. | Use of pyridoxin derivatives for the treatment of diabetes and related complications |
EP1210117A2 (en) * | 1999-08-24 | 2002-06-05 | Medicure International Inc. | Compositons for the treatment of cardiovascular diseases containing pyridoxal compounds and cardiovascular compounds |
US7442689B2 (en) * | 2000-02-29 | 2008-10-28 | Medicure International Inc. | Cardioprotective phosphonates and malonates |
AU2006220407B2 (en) * | 2000-03-28 | 2008-06-05 | Medicure International Inc. | Treatment of cerebrovascular disease |
EP1278526A2 (en) * | 2000-03-28 | 2003-01-29 | Medicure International Inc. | Treatment of cerebrovascular disease |
US6897228B2 (en) * | 2000-07-07 | 2005-05-24 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: new uses |
US20040121988A1 (en) * | 2001-03-28 | 2004-06-24 | Medicure International Inc. | Treatment of cerebrovascular disease |
US20040186077A1 (en) * | 2003-03-17 | 2004-09-23 | Medicure International Inc. | Novel heteroaryl phosphonates as cardioprotective agents |
WO2004084910A1 (en) * | 2003-03-27 | 2004-10-07 | Medicure Inc. | Compositions for treating angina |
WO2004084895A2 (en) * | 2003-03-27 | 2004-10-07 | Medicure, Inc. | Modulation of cell death |
WO2005060975A1 (en) * | 2003-12-23 | 2005-07-07 | Medicure International Inc. | Combination therapies employing a composition comprising a hmg coa reductase inhibitor and a vitamin b6 related compound |
DE602005025755D1 (de) * | 2004-06-04 | 2011-02-17 | Teva Pharma | Irbesartan enthaltende pharmazeutische zusammensetzung |
CA2570048A1 (en) * | 2004-07-07 | 2006-01-12 | Medicure International Inc. | Combination therapies employing platelet aggregation drugs |
CA2572815A1 (en) * | 2004-07-09 | 2006-01-19 | Medicure International Inc. | Combination therapies employing nicotinic acid derivatives or fibric acid derivatives |
EP1786435A1 (en) * | 2004-08-10 | 2007-05-23 | Medicure International Inc. | Combination therapies employing vitamin b6 related compounds and ace inhibitors and uses thereof for the treatment of diabetic disorders |
US20070060549A1 (en) * | 2004-08-10 | 2007-03-15 | Friesen Albert D | Combination therapies employing ace inhibitors and uses thereof for the treatment of diabetic disorders |
US20060094749A1 (en) * | 2004-10-28 | 2006-05-04 | Medicure International Inc. | Substituted pyridoxines as anti-platelet agents |
WO2006050598A1 (en) * | 2004-10-28 | 2006-05-18 | Medicure International Inc. | Dual antiplatelet/anticoagulant pyridoxine analogs |
US7459468B2 (en) * | 2004-10-28 | 2008-12-02 | Medicure International, Inc. | Aryl sulfonic pyridoxines as antiplatelet agents |
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EP1853275A4 (en) * | 2004-11-26 | 2008-09-10 | Medicure Int Inc | PYRIDOXAL-5-PHOSPHATE FORMULATIONS AND MANUFACTURING METHOD |
JP2008526783A (ja) * | 2005-01-05 | 2008-07-24 | メディキュア・インターナショナル・インコーポレーテッド | トリグリセリドレベルを調節するための化合物及び方法 |
CA2503087A1 (en) * | 2005-03-30 | 2006-09-30 | Medicure International Inc. | Intravenous formulations of pyridoxal 5'-phosphate and method of preparation |
WO2007041643A1 (en) * | 2005-10-03 | 2007-04-12 | University Of Tennessee Research Foundation | Dietary calcium for reducing the production of reactive oxygen species |
AU2006317440A1 (en) * | 2005-11-28 | 2007-05-31 | Medicure International Inc. | Selected dosage for the treatment of cardiovascular and related pathologies |
DK1800675T3 (da) | 2005-12-23 | 2011-09-05 | Nutricia Nv | Sammensætninger omfattende polyumættede fedtsyrer, proteiner og mangan og/eller molybdæn og nucleosider/nucleotider til behandling af demens |
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US20070249562A1 (en) * | 2006-04-25 | 2007-10-25 | Friesen Albert D | Treatment of atrial fibrillation |
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-
2000
- 2000-03-07 CA CA002366602A patent/CA2366602A1/en not_active Abandoned
- 2000-03-07 WO PCT/IB2000/000255 patent/WO2000053606A1/en active IP Right Grant
- 2000-03-07 AU AU31834/00A patent/AU763464B2/en not_active Ceased
- 2000-03-07 PT PT00909553T patent/PT1169322E/pt unknown
- 2000-03-07 JP JP2000604042A patent/JP2002539127A/ja active Pending
- 2000-03-07 DE DE60023125T patent/DE60023125T2/de not_active Expired - Fee Related
- 2000-03-07 NZ NZ514567A patent/NZ514567A/xx unknown
- 2000-03-07 DK DK00909553T patent/DK1169322T3/da active
- 2000-03-07 AT AT00909553T patent/ATE306489T1/de not_active IP Right Cessation
- 2000-03-07 US US09/520,194 patent/US6339085B1/en not_active Expired - Fee Related
- 2000-03-07 EP EP00909553A patent/EP1169322B8/en not_active Expired - Lifetime
- 2000-03-07 BR BR0008857-9A patent/BR0008857A/pt not_active Application Discontinuation
- 2000-03-07 ES ES00909553T patent/ES2250112T3/es not_active Expired - Lifetime
-
2001
- 2001-05-22 US US09/863,093 patent/US6890943B2/en not_active Expired - Fee Related
-
2003
- 2003-06-03 US US10/453,414 patent/US7230009B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2250112T3 (es) | 2006-04-16 |
US6339085B1 (en) | 2002-01-15 |
JP2002539127A (ja) | 2002-11-19 |
EP1169322B8 (en) | 2006-09-13 |
DE60023125D1 (de) | 2006-02-23 |
PT1169322E (pt) | 2007-04-30 |
US6890943B2 (en) | 2005-05-10 |
US7230009B2 (en) | 2007-06-12 |
CA2366602A1 (en) | 2000-09-14 |
NZ514567A (en) | 2002-11-26 |
DE60023125T2 (de) | 2006-06-22 |
US20030195236A1 (en) | 2003-10-16 |
AU3183400A (en) | 2000-09-28 |
EP1169322A1 (en) | 2002-01-09 |
AU763464B2 (en) | 2003-07-24 |
US20010031770A1 (en) | 2001-10-18 |
DK1169322T3 (da) | 2006-03-06 |
WO2000053606A1 (en) | 2000-09-14 |
ATE306489T1 (de) | 2005-10-15 |
EP1169322B1 (en) | 2005-10-12 |
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B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
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