BR0008785A - Variantes de polipeptìdeo com capacidade aumentada de ligação com a heparina - Google Patents

Variantes de polipeptìdeo com capacidade aumentada de ligação com a heparina

Info

Publication number
BR0008785A
BR0008785A BR0008785-8A BR0008785A BR0008785A BR 0008785 A BR0008785 A BR 0008785A BR 0008785 A BR0008785 A BR 0008785A BR 0008785 A BR0008785 A BR 0008785A
Authority
BR
Brazil
Prior art keywords
sub
polypeptide variants
increased heparin
binding capacity
heparin binding
Prior art date
Application number
BR0008785-8A
Other languages
English (en)
Inventor
Walter Sebald
Original Assignee
Osteogenetics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osteogenetics Gmbh filed Critical Osteogenetics Gmbh
Publication of BR0008785A publication Critical patent/BR0008785A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

Patente de Invenção: "VARIANTES DE POLIPEPTìDEO COM CAPACIDADE AUMENTADA DE LIGAçãO COM A HEPARINA". A invenção refere-se a variantes de polipeptídeo com capacidade aumentada de ligação com a heparina. A capacidade aumentada de ligação com a heparina é obtida pela adição, inserção, e/ou substituição de uma seq³ência de aminoácido X~ 1~X~ 2X~ 3~X~ 4X~ 5~X~ 6~(SEQ ID NO.1 OU NO. 2). As variantes de polipeptídeo de acordo com a invenção são particularmente adequadas para estimulação de condrogênese, osteogênese, e cura de ferimento. A invenção também refere-se a moléculas de aminoácido as quais codificam as referidas variantes de polipeptídeo, células hospedeiras contendo as referidas moléculas de ácido nucléico, e processos para produção das variantes de polipeptídeo.
BR0008785-8A 1999-02-13 2000-01-27 Variantes de polipeptìdeo com capacidade aumentada de ligação com a heparina BR0008785A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19906096A DE19906096A1 (de) 1999-02-13 1999-02-13 Protein mit einem Heparin-bindenden Epitop
PCT/EP2000/000637 WO2000047736A1 (de) 1999-02-13 2000-01-27 Polypeptidvarianten mit erhöhter heparin-bindungsfähigkeit

Publications (1)

Publication Number Publication Date
BR0008785A true BR0008785A (pt) 2001-11-06

Family

ID=7897433

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0008785-8A BR0008785A (pt) 1999-02-13 2000-01-27 Variantes de polipeptìdeo com capacidade aumentada de ligação com a heparina

Country Status (11)

Country Link
US (1) US7253254B1 (pt)
EP (1) EP1151095B1 (pt)
JP (3) JP4155711B2 (pt)
CN (1) CN1169959C (pt)
AT (1) ATE470713T1 (pt)
AU (1) AU762387B2 (pt)
BR (1) BR0008785A (pt)
CA (1) CA2362496C (pt)
DE (2) DE19906096A1 (pt)
RU (1) RU2227743C2 (pt)
WO (1) WO2000047736A1 (pt)

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Also Published As

Publication number Publication date
RU2227743C2 (ru) 2004-04-27
EP1151095A1 (de) 2001-11-07
WO2000047736A1 (de) 2000-08-17
CA2362496C (en) 2011-04-19
CN1340102A (zh) 2002-03-13
DE19906096A1 (de) 2000-08-17
ATE470713T1 (de) 2010-06-15
AU2110600A (en) 2000-08-29
EP1151095B1 (de) 2010-06-09
US7253254B1 (en) 2007-08-07
JP2002536016A (ja) 2002-10-29
CN1169959C (zh) 2004-10-06
CA2362496A1 (en) 2000-08-17
AU762387B2 (en) 2003-06-26
JP2008086319A (ja) 2008-04-17
DE50015938D1 (de) 2010-07-22
JP2009011323A (ja) 2009-01-22
JP4155711B2 (ja) 2008-09-24

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