BR0007749A - Vacinação não-invasiva através da pele - Google Patents
Vacinação não-invasiva através da peleInfo
- Publication number
- BR0007749A BR0007749A BR0007749-6A BR0007749A BR0007749A BR 0007749 A BR0007749 A BR 0007749A BR 0007749 A BR0007749 A BR 0007749A BR 0007749 A BR0007749 A BR 0007749A
- Authority
- BR
- Brazil
- Prior art keywords
- substance
- droplet
- substances
- times smaller
- diameter
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
Patente de Invenção: "VACINAçãO NãO-INVASIVA ATRAVéSDA PELE". A presente invenção refere-se a novas vacinas para aadministração transcutânea, não-invasiva de antígenosassociados com veículos ultradeformáveis, para o propósito devacinação profilática ou terapêutica. As vacinas compreendem (a)um veículo transdérmico que é um penetrante, suspenso oudisperso em um solvente aquoso na forma de uma gotículadiminuta de fluído circundada por um revestimento tipo membranade uma ou diversas camadas de pelo menos duas diferentessubstâncias ou duas formas diferentes de um substrato com atendência a agregar, as referidas substâncias ou formas de umasubstância diferindo pelo menos pelo fator de 10 em solubilidadeem um meio líquido, preferivelmente aquoso, tal que o diâmetromédio de homoagregados da substância ou forma mais solúvel dasubstância ou o diâmetro médio dos heteroagregados consistindoem ambas as referidas substâncias ou formas da referidasubstância é menor do que o diâmetro médio de homoagregadosda substância ou forma menos solúvel da substância, e/ou onde ocomponente mais solúvel tende a solubilizar a gotícula depenetração e onde o conteúdo de tais quantidades componentesde até 99 mol% da concentração requerida para solubilizar agotícula ou ainda corresponde a até 99 mol% da concentração desaturação na gotícula não-solubilizada, qualquer que seja é maior,e/ou onde a energia de deformação elástica da gotículacircundando o revestimento tipo membrana é pelo menos 5 vezesmenor, mais preferivelmente é pelo menos 10 vezes menor eidealmente é mais do que 10 vezes menor do que aquela dascélulas vermelhas do sangue ou das bicamadas fosfolipídicas comcadeias alifáticas fluídas, (b) um composto que especificamentelibera ou especificamente induz a atividade de citocina ouanticitocina ou exerce uma tal atividade em si, e (c) um antígeno,um alérgeno, uma mistura de antígenos e/ou uma mistura dealérgenos. A invenção ainda refere-se a métodos para a vacinaçãode mamíferos para obter uma resposta imune protetora outerapêutica.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99101479A EP1031346B1 (en) | 1999-01-27 | 1999-01-27 | Noninvasive vaccination through the skin |
PCT/EP2000/000597 WO2000044349A1 (en) | 1999-01-27 | 2000-01-26 | Non-invasive vaccination through the skin |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0007749A true BR0007749A (pt) | 2001-11-13 |
Family
ID=8237425
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0007749-6A BR0007749A (pt) | 1999-01-27 | 2000-01-26 | Vacinação não-invasiva através da pele |
Country Status (19)
Country | Link |
---|---|
US (1) | US7867480B1 (pt) |
EP (2) | EP1031346B1 (pt) |
JP (1) | JP2002535350A (pt) |
KR (2) | KR20010112252A (pt) |
CN (1) | CN1230151C (pt) |
AR (1) | AR037312A1 (pt) |
AT (1) | ATE216875T1 (pt) |
AU (1) | AU778972B2 (pt) |
BR (1) | BR0007749A (pt) |
CA (1) | CA2360692C (pt) |
DE (1) | DE69901377T2 (pt) |
DK (1) | DK1031346T3 (pt) |
ES (1) | ES2173678T3 (pt) |
HK (1) | HK1030363A1 (pt) |
HU (1) | HU225170B1 (pt) |
MX (1) | MXPA01007657A (pt) |
PT (1) | PT1031346E (pt) |
SI (1) | SI1031346T1 (pt) |
WO (1) | WO2000044349A1 (pt) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060002949A1 (en) | 1996-11-14 | 2006-01-05 | Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. | Transcutaneous immunization without heterologous adjuvant |
CN1560078B (zh) | 1998-07-31 | 2011-06-22 | 株式会社国际癌症免疫研究所 | 基于癌抑制基因wt1的产物的癌抗原 |
ES2173679T3 (es) | 1999-01-27 | 2002-10-16 | Idea Ag | Inmunizacion/transporte transnasal con vehiculos altamente adaptables. |
SI1031346T1 (en) | 1999-01-27 | 2002-08-31 | Idea Ag | Noninvasive vaccination through the skin |
FR2822049B1 (fr) | 2001-03-13 | 2003-08-01 | Dbv Medica 1 | Patch destine notamment a depister l'etat de sensibilisation d'un sujet a un allergene, procede de fabrication et utilisation |
US7635488B2 (en) | 2001-03-13 | 2009-12-22 | Dbv Technologies | Patches and uses thereof |
CA2440303C (en) | 2001-03-22 | 2013-03-19 | Haruo Sugiyama | Wt1 modified peptide |
US20020193729A1 (en) | 2001-04-20 | 2002-12-19 | Cormier Michel J.N. | Microprojection array immunization patch and method |
US8735357B2 (en) | 2001-09-28 | 2014-05-27 | International Institute Of Cancer Immunology, Inc. | Method of inducing antigen-specific T cells |
JPWO2003028758A1 (ja) * | 2001-09-28 | 2005-01-13 | 治夫 杉山 | 抗原特異的t細胞の誘導方法 |
CA2500911A1 (en) * | 2002-10-02 | 2004-04-15 | Nordic Vaccine Technology A/S | Composition for vaccination |
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US9132031B2 (en) | 2006-09-26 | 2015-09-15 | Zeltiq Aesthetics, Inc. | Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile |
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US8192474B2 (en) | 2006-09-26 | 2012-06-05 | Zeltiq Aesthetics, Inc. | Tissue treatment methods |
US20080287839A1 (en) | 2007-05-18 | 2008-11-20 | Juniper Medical, Inc. | Method of enhanced removal of heat from subcutaneous lipid-rich cells and treatment apparatus having an actuator |
US8523927B2 (en) | 2007-07-13 | 2013-09-03 | Zeltiq Aesthetics, Inc. | System for treating lipid-rich regions |
ES2693430T3 (es) | 2007-08-21 | 2018-12-11 | Zeltiq Aesthetics, Inc. | Monitorización del enfriamiento de células subcutáneas ricas en lípidos, como el enfriamiento de tejido adiposo |
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FR2924350B1 (fr) | 2007-12-03 | 2010-08-13 | Dbv Tech | Procede et compositions pour la vaccination par voie cutanee |
US8603073B2 (en) | 2008-12-17 | 2013-12-10 | Zeltiq Aesthetics, Inc. | Systems and methods with interrupt/resume capabilities for treating subcutaneous lipid-rich cells |
KR101701137B1 (ko) | 2009-04-30 | 2017-02-01 | 젤티크 애스세틱스, 인코포레이티드. | 피하 지질 과다 세포로부터 열을 제거하는 디바이스, 시스템 및 방법 |
WO2011000889A1 (en) * | 2009-06-30 | 2011-01-06 | William Henry | Topical vaccine formulations and methods of treating drug addiction using same |
JP2013502436A (ja) | 2009-08-21 | 2013-01-24 | ターゲッティド デリバリー テクノロジーズ リミテッド | 小胞状の製剤 |
WO2011091431A1 (en) | 2010-01-25 | 2011-07-28 | Zeltiq Aesthetics, Inc. | Home-use applicators for non-invasively removing heat from subcutaneous lipid-rich cells via phase change coolants, and associated devices, systems and methods |
US8676338B2 (en) | 2010-07-20 | 2014-03-18 | Zeltiq Aesthetics, Inc. | Combined modality treatment systems, methods and apparatus for body contouring applications |
GB201205642D0 (en) | 2012-03-29 | 2012-05-16 | Sequessome Technology Holdings Ltd | Vesicular formulations |
GB201212010D0 (en) * | 2012-07-05 | 2012-08-22 | Sigmoid Pharma Ltd | Formulations |
US8652457B2 (en) | 2012-07-13 | 2014-02-18 | Wisconsin Alumni Research Foundation | Interleukin-10 peptides and antibodies thereof for inhibiting adverse effects of protozoan infection |
US9844460B2 (en) | 2013-03-14 | 2017-12-19 | Zeltiq Aesthetics, Inc. | Treatment systems with fluid mixing systems and fluid-cooled applicators and methods of using the same |
US9545523B2 (en) | 2013-03-14 | 2017-01-17 | Zeltiq Aesthetics, Inc. | Multi-modality treatment systems, methods and apparatus for altering subcutaneous lipid-rich tissue |
ES2542088B1 (es) * | 2014-01-29 | 2016-05-05 | Enoc Solutions, S.L. | Composición de azufre liposomado |
WO2015117001A1 (en) | 2014-01-31 | 2015-08-06 | Zeltiq Aesthetics, Inc. | Compositions, treatment systems and methods for improved cooling of lipid-rich tissue |
US10675176B1 (en) | 2014-03-19 | 2020-06-09 | Zeltiq Aesthetics, Inc. | Treatment systems, devices, and methods for cooling targeted tissue |
USD777338S1 (en) | 2014-03-20 | 2017-01-24 | Zeltiq Aesthetics, Inc. | Cryotherapy applicator for cooling tissue |
US10952891B1 (en) | 2014-05-13 | 2021-03-23 | Zeltiq Aesthetics, Inc. | Treatment systems with adjustable gap applicators and methods for cooling tissue |
US9821028B2 (en) * | 2014-07-11 | 2017-11-21 | Wisconsin Alumni Research Foundation | Methods of controlling parasitic worms in animals |
US10935174B2 (en) | 2014-08-19 | 2021-03-02 | Zeltiq Aesthetics, Inc. | Stress relief couplings for cryotherapy apparatuses |
US10568759B2 (en) | 2014-08-19 | 2020-02-25 | Zeltiq Aesthetics, Inc. | Treatment systems, small volume applicators, and methods for treating submental tissue |
EA038613B1 (ru) | 2015-06-30 | 2021-09-23 | Секвессом Текнолоджи Холдингс Лимитед | Смешанные составы |
US11154418B2 (en) | 2015-10-19 | 2021-10-26 | Zeltiq Aesthetics, Inc. | Vascular treatment systems, cooling devices, and methods for cooling vascular structures |
EP3399950A1 (en) | 2016-01-07 | 2018-11-14 | Zeltiq Aesthetics, Inc. | Temperature-dependent adhesion between applicator and skin during cooling of tissue |
US10765552B2 (en) | 2016-02-18 | 2020-09-08 | Zeltiq Aesthetics, Inc. | Cooling cup applicators with contoured heads and liner assemblies |
US11382790B2 (en) | 2016-05-10 | 2022-07-12 | Zeltiq Aesthetics, Inc. | Skin freezing systems for treating acne and skin conditions |
US10555831B2 (en) | 2016-05-10 | 2020-02-11 | Zeltiq Aesthetics, Inc. | Hydrogel substances and methods of cryotherapy |
US10682297B2 (en) | 2016-05-10 | 2020-06-16 | Zeltiq Aesthetics, Inc. | Liposomes, emulsions, and methods for cryotherapy |
JP7217700B2 (ja) | 2016-09-13 | 2023-02-03 | アラーガン、インコーポレイテッド | 安定化非タンパク質クロストリジウム毒素組成物 |
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BR112020004869A2 (pt) | 2017-09-12 | 2020-09-15 | Wisconsin Alumni Research Foundation | peptídeo do receptor-2 de interleucina-10, anticorpos, composições, e métodos de uso dos mesmos |
EP3829496A1 (en) | 2018-07-31 | 2021-06-09 | Zeltiq Aesthetics, Inc. | Methods, devices, and systems for improving skin characteristics |
CN114075551B (zh) * | 2021-06-11 | 2024-01-26 | 华中农业大学 | 沙林鼠种布鲁氏菌脂多糖的单克隆抗体及应用 |
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-
1999
- 1999-01-27 SI SI9930060T patent/SI1031346T1/xx unknown
- 1999-01-27 PT PT99101479T patent/PT1031346E/pt unknown
- 1999-01-27 DE DE69901377T patent/DE69901377T2/de not_active Expired - Lifetime
- 1999-01-27 DK DK99101479T patent/DK1031346T3/da active
- 1999-01-27 EP EP99101479A patent/EP1031346B1/en not_active Expired - Lifetime
- 1999-01-27 ES ES99101479T patent/ES2173678T3/es not_active Expired - Lifetime
- 1999-01-27 AT AT99101479T patent/ATE216875T1/de active
-
2000
- 2000-01-26 HU HU0200315A patent/HU225170B1/hu not_active IP Right Cessation
- 2000-01-26 CA CA2360692A patent/CA2360692C/en not_active Expired - Fee Related
- 2000-01-26 US US09/890,335 patent/US7867480B1/en not_active Expired - Fee Related
- 2000-01-26 BR BR0007749-6A patent/BR0007749A/pt not_active Application Discontinuation
- 2000-01-26 MX MXPA01007657A patent/MXPA01007657A/es not_active IP Right Cessation
- 2000-01-26 CN CNB008044538A patent/CN1230151C/zh not_active Expired - Fee Related
- 2000-01-26 AU AU27988/00A patent/AU778972B2/en not_active Ceased
- 2000-01-26 WO PCT/EP2000/000597 patent/WO2000044349A1/en active IP Right Grant
- 2000-01-26 JP JP2000595653A patent/JP2002535350A/ja active Pending
- 2000-01-26 KR KR1020017009479A patent/KR20010112252A/ko not_active Application Discontinuation
- 2000-01-26 KR KR1020077018740A patent/KR20070094662A/ko not_active Application Discontinuation
- 2000-01-26 EP EP00906231A patent/EP1146858A1/en not_active Withdrawn
- 2000-01-27 AR ARP000100372A patent/AR037312A1/es unknown
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2001
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Also Published As
Publication number | Publication date |
---|---|
HU225170B1 (en) | 2006-07-28 |
EP1031346B1 (en) | 2002-05-02 |
EP1146858A1 (en) | 2001-10-24 |
DE69901377T2 (de) | 2003-01-02 |
WO2000044349A1 (en) | 2000-08-03 |
AR037312A1 (es) | 2004-11-03 |
CA2360692C (en) | 2011-01-04 |
CN1230151C (zh) | 2005-12-07 |
HK1030363A1 (en) | 2003-05-06 |
KR20010112252A (ko) | 2001-12-20 |
ATE216875T1 (de) | 2002-05-15 |
US7867480B1 (en) | 2011-01-11 |
DK1031346T3 (da) | 2002-08-12 |
JP2002535350A (ja) | 2002-10-22 |
HUP0200315A2 (en) | 2002-05-29 |
AU2798800A (en) | 2000-08-18 |
MXPA01007657A (es) | 2003-06-24 |
EP1031346A1 (en) | 2000-08-30 |
CA2360692A1 (en) | 2000-08-03 |
KR20070094662A (ko) | 2007-09-20 |
DE69901377D1 (de) | 2002-06-06 |
PT1031346E (pt) | 2002-09-30 |
AU778972B2 (en) | 2004-12-23 |
SI1031346T1 (en) | 2002-08-31 |
CN1342066A (zh) | 2002-03-27 |
ES2173678T3 (es) | 2002-10-16 |
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