BG66517B1 - Супресор на ендогенния човешки гама - интерферон - Google Patents
Супресор на ендогенния човешки гама - интерферонInfo
- Publication number
- BG66517B1 BG66517B1 BG110103A BG11010308A BG66517B1 BG 66517 B1 BG66517 B1 BG 66517B1 BG 110103 A BG110103 A BG 110103A BG 11010308 A BG11010308 A BG 11010308A BG 66517 B1 BG66517 B1 BG 66517B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- gamma
- inhibitor
- endogenous human
- human interferon
- hifn
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/57—IFN-gamma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Изобретението се отнася до cyпреcop на ендогенния човешки гама-интерферон (hIFN-гама), приложим при автоимунни заболявания и при използване на алотрансплантанти. По своята същност супресорът представлява генно-модифицирани варианти на hIFN-гама, при които в гена на IFN-гама са въведени точкови мутации, водещи до замяна на аминокиселините в позиции 86, 87 и 88 в областта, участваща в сигналната трансдукция.@
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BG110103A BG66517B1 (bg) | 2008-04-08 | 2008-04-08 | Супресор на ендогенния човешки гама - интерферон |
PCT/BG2008/000025 WO2009124362A1 (en) | 2008-04-08 | 2008-12-02 | Suppressor of the endogenous interferon- gamma |
US12/735,882 US20110135602A1 (en) | 2008-04-08 | 2008-12-02 | Supperssor of the endogenous interferon-gamma |
EP08873818.2A EP2274326B1 (en) | 2008-04-08 | 2008-12-02 | Suppressor of the endogenous interferon- gamma |
US14/243,861 US9359421B2 (en) | 2008-04-08 | 2014-04-02 | Suppressor of the endogenous interferon-gamma |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BG110103A BG66517B1 (bg) | 2008-04-08 | 2008-04-08 | Супресор на ендогенния човешки гама - интерферон |
Publications (2)
Publication Number | Publication Date |
---|---|
BG110103A BG110103A (bg) | 2009-10-30 |
BG66517B1 true BG66517B1 (bg) | 2016-02-29 |
Family
ID=41161478
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG110103A BG66517B1 (bg) | 2008-04-08 | 2008-04-08 | Супресор на ендогенния човешки гама - интерферон |
Country Status (4)
Country | Link |
---|---|
US (1) | US20110135602A1 (bg) |
EP (1) | EP2274326B1 (bg) |
BG (1) | BG66517B1 (bg) |
WO (1) | WO2009124362A1 (bg) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2211852A4 (en) * | 2007-10-18 | 2013-10-16 | Univ Yale | COMPOSITIONS AND METHODS FOR REDUCING HEPATOTOXICITY ASSOCIATED WITH DRUG ADMINISTRATION |
US20100016262A1 (en) * | 2007-10-18 | 2010-01-21 | Yale University | Compositions and methods for reducing hepatotoxicity associated with drug administration and treating non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and associated cirrhosis |
US9415046B2 (en) * | 2009-09-29 | 2016-08-16 | Yale University | Compositions and methods for inhibiting inflammation from and rejection of biomaterials and other methods |
BG67190B1 (bg) | 2017-03-29 | 2020-11-16 | Tigo Gmbh | Анти-гама мутантен протеин срещу ендогенния човешки гама интерферон |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3414831A1 (de) * | 1984-04-19 | 1985-10-31 | Hoechst Ag, 6230 Frankfurt | Herstellung von polypeptiden mit human-gammainterferon-aktivitaet |
AT393690B (de) | 1987-10-08 | 1991-11-25 | Hoffmann La Roche | Homogene, rekombinante immun-interferonfragmente |
US6372206B1 (en) | 1989-03-02 | 2002-04-16 | University Of Florida | Orally-administered interferon-TAU compositions and methods |
BG52073B2 (en) | 1990-01-24 | 1996-04-30 | Inst Molekuljarna Biolog | Method for the preparation of recombinant human noncystein -interferon, free of n-end methionine |
ZA952797B (en) | 1994-04-12 | 1996-10-07 | Res Dev Foundation | Method of treating auto-immune diseases using type one interferons |
WO1995030435A2 (en) | 1994-05-10 | 1995-11-16 | Immulogic Pharmaceutical Corporation | Compositions and treatment for multiple sclerosis |
RU2073522C1 (ru) | 1995-07-20 | 1997-02-20 | Олег Васильевич Рубальский | Лекарственный препарат противовирусного действия |
US6013253A (en) | 1997-08-15 | 2000-01-11 | Amgen, Inc. | Treatment of multiple sclerosis using consensus interferon and IL-1 receptor antagonist |
WO2001045747A1 (en) | 1998-11-27 | 2001-06-28 | Technion Research & Development Foundation Ltd. | Interferon gamma inducing factor based vaccine and use of same for protective immunity against multiple sclerosis |
AUPP823999A0 (en) | 1999-01-20 | 1999-02-11 | University Of Queensland, The | A treatment |
RU2268749C2 (ru) * | 1999-11-12 | 2006-01-27 | Максиджен Холдингз Лтд | КОНЪЮГАТЫ γ-ИНТЕРФЕРОНА |
RU2187332C1 (ru) | 2000-12-18 | 2002-08-20 | Гапонюк Петр Яковлевич | Лечебное средство |
HUP0303645A3 (en) | 2001-04-06 | 2005-12-28 | Maxygen Holdings Ltd Georgetow | Interferon gamma polypeptide variants |
CA2463935A1 (en) * | 2001-09-18 | 2003-03-27 | Chiron Corporation | Methods for treating multiple sclerosis |
BG66458B1 (bg) | 2005-03-21 | 2014-10-31 | Иван Иванов | Средство за конкурентно инхибиране на ендогенен гама интерферон |
KR20080019606A (ko) * | 2005-05-04 | 2008-03-04 | 나우틸루스 바이오텍 | 변형된 인터페론-감마 폴리펩티드 및 변형된 인터페론-감마폴리펩티드를 사용하는 방법 |
-
2008
- 2008-04-08 BG BG110103A patent/BG66517B1/bg unknown
- 2008-12-02 WO PCT/BG2008/000025 patent/WO2009124362A1/en active Application Filing
- 2008-12-02 US US12/735,882 patent/US20110135602A1/en not_active Abandoned
- 2008-12-02 EP EP08873818.2A patent/EP2274326B1/en not_active Not-in-force
Also Published As
Publication number | Publication date |
---|---|
BG110103A (bg) | 2009-10-30 |
WO2009124362A1 (en) | 2009-10-15 |
EP2274326A1 (en) | 2011-01-19 |
EP2274326B1 (en) | 2014-01-01 |
US20110135602A1 (en) | 2011-06-09 |
EP2274326A4 (en) | 2011-09-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NZ761434A (en) | Cytokine conjugates for the treatment of autoimmune diseases | |
NZ576467A (en) | Smoothened polypeptides and methods of use | |
TN2012000372A1 (en) | Fibronectin based scaffold domain proteins that bind il-23 | |
TW200613551A (en) | A polypeptide having a ω3 fatty acid desaturation activity, a polynucleotide for coding the same, and use thereof | |
MX2007009807A (es) | Agentes terapeuticos de aptameros utiles en el tratamiento de trastornos relacionados con el complemento. | |
GEP20146056B (en) | Acylated glucagon analogues | |
MX2009012650A (es) | Secuencias de aminoacido dirigidas contra rank-l y polipeptidos que comprenden lo mismo para el tratamiento de enfermedades y trastornos de huesos. | |
MX2010005783A (es) | Secuencias de aminoacidos dirigidas contra citoquinas heterodimericas y/o sus receptores y polipeptidos que comprenden las mismas. | |
ZA200900379B (en) | Human endogenous retrovirus polypeptide compositions and methods of use thereof | |
TN2012000303A1 (en) | Oxyntomodulin peptide analogue | |
UA94221C2 (en) | Lipocalin protein | |
NZ603813A (en) | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-trna synthetases | |
IN2014CN00414A (bg) | ||
TW200603798A (en) | Disalt inhibitors of il-12 production | |
MX2007004841A (es) | Triazoles utiles como inhibidores de proteinas cinasas. | |
UA115979C2 (uk) | Таблетований препарат (4'-трифторметилфеніл)аміду (z)-2-ціано-3-гідроксибут-2-еноєвої кислоти з поліпшеною стійкістю | |
TN2012000511A1 (en) | Compositions and methods of use for therapeutic low density lipoprotein -related protein 6 (lrp6) antibodies | |
NZ562436A (en) | Toll-like receptor 14 (TLR14) and use thereof | |
PL1890720T3 (pl) | Kompozycje farmaceutyczne zawierające peptydy pochodzące z kazeiny i sposoby ich stosowania | |
BG66517B1 (bg) | Супресор на ендогенния човешки гама - интерферон | |
EP2029754A4 (en) | MAGNETOSOME GENE EXPRESSION IN EUKARYONTIC CELLS | |
MX354302B (es) | Composicion farmaceutica para el tratamiento de la forma pulmonar de mal de montaña por falta de oxigeno y presion de aire reducida. | |
MY155568A (en) | Oral care methods and systems | |
TW200602062A (en) | Improved formulations of 6-mercaptopurine | |
UA95446C2 (ru) | Мутаци в генах oas1 |