BG61696B1 - Метод за диастереоселективна синтеза на нуклеозиди - Google Patents

Метод за диастереоселективна синтеза на нуклеозиди Download PDF

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Publication number: BG61696B1
Authority: BG; Bulgaria
Prior art keywords: formula; group; derivative; substituted; alkyl
Prior art date: 1991-05-21

Application number

BG98311A

Other languages

Bulgarian (bg)

English (en)

Other versions

BG98311A (bg

Inventor

Tarek Mansour

Allan H. Tse

Original Assignee

Biochem Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-21

Filing date

1993-12-20

Publication date

1998-03-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24825144&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG61696(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1993-12-20 Application filed by Biochem Pharma Inc filed Critical Biochem Pharma Inc

1994-08-30 Publication of BG98311A publication Critical patent/BG98311A/bg

1998-03-31 Publication of BG61696B1 publication Critical patent/BG61696B1/bg

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/04—Five-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
Virology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Veterinary Medicine (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Furan Compounds (AREA)
Catalysts (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Vehicle Step Arrangements And Article Storage (AREA)

BG98311A 1991-05-21 1993-12-20 Метод за диастереоселективна синтеза на нуклеозиди BG61696B1 (bg)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US70337991A	1991-05-21	1991-05-21
PCT/CA1992/000209 WO1992020696A1 (fr)	1991-05-21	1992-05-20	Procedes de synthese diastereoselective des nucleosides

Publications (2)

Publication Number	Publication Date
BG98311A BG98311A (bg)	1994-08-30
BG61696B1 true BG61696B1 (bg)	1998-03-31

Family

ID=24825144

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
BG98311A BG61696B1 (bg)	1991-05-21	1993-12-20	Метод за диастереоселективна синтеза на нуклеозиди
BG98310A BG61695B1 (bg)	1991-05-21	1993-12-20	Методи за диастереоселективен синтез на нуклеозиди

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
BG98310A BG61695B1 (bg)	1991-05-21	1993-12-20	Методи за диастереоселективен синтез на нуклеозиди

Country Status (34)

Country	Link
US (5)	US5756706A (fr)
EP (2)	EP0515156B1 (fr)
JP (3)	JP3229013B2 (fr)
KR (3)	KR100232012B1 (fr)
CN (6)	CN1035555C (fr)
AT (2)	ATE157662T1 (fr)
AU (4)	AU655973B2 (fr)
BG (2)	BG61696B1 (fr)
CA (2)	CA2069063C (fr)
CZ (3)	CZ284975B6 (fr)
DE (2)	DE69221936T2 (fr)
DK (2)	DK0515157T3 (fr)
EE (1)	EE03044B1 (fr)
ES (2)	ES2084937T3 (fr)
FI (3)	FI109025B (fr)
GR (2)	GR3018941T3 (fr)
GT (1)	GT199800047A (fr)
HK (2)	HK132196A (fr)
HU (2)	HU221850B1 (fr)
IE (2)	IE921618A1 (fr)
IL (6)	IL101932A (fr)
MD (1)	MD1155C2 (fr)
MX (2)	MX9202404A (fr)
NO (2)	NO301010B1 (fr)
NZ (2)	NZ242817A (fr)
OA (1)	OA10212A (fr)
PL (3)	PL176026B1 (fr)
RO (1)	RO116812B1 (fr)
RU (4)	RU2223960C2 (fr)
SG (1)	SG43863A1 (fr)
SK (2)	SK279438B6 (fr)
TW (4)	TWI245046B (fr)
WO (2)	WO1992020696A1 (fr)
ZA (2)	ZA923640B (fr)

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1992
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1995
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Also Published As

Publication number	Publication date
FI106377B (fi)	2001-01-31
KR0160144B1 (ko)	1998-11-16
SK281954B6 (sk)	2001-09-11
IL116176A0 (en)	1996-01-31
CN1229080A (zh)	1999-09-22
DK0515156T3 (da)	1996-06-17
KR920021575A (ko)	1992-12-18
BG98310A (bg)	1994-01-03
NO921989D0 (no)	1992-05-20
EE03044B1 (et)	1997-10-15
KR100242921B1 (ko)	2000-03-15
GT199800047A (es)	1999-08-26
AU655973B2 (en)	1995-01-19
SK279438B6 (sk)	1998-11-04
CA2069024A1 (fr)	1992-11-22
IL101932A0 (en)	1992-12-30
NO921988L (no)	1992-11-23
RU2223960C2 (ru)	2004-02-20
RU2140925C1 (ru)	1999-11-10
CN1067245A (zh)	1992-12-23
CN1229079A (zh)	1999-09-22
ES2104832T3 (es)	1997-10-16
CN1083450C (zh)	2002-04-24
DE69208144D1 (de)	1996-03-21
JP3330972B2 (ja)	2002-10-07
JP3704055B2 (ja)	2005-10-05
JP3229013B2 (ja)	2001-11-12
AU668086B2 (en)	1996-04-26
CZ249293A3 (en)	1994-03-16
KR100232012B1 (ko)	1999-12-01
DK0515157T3 (da)	1997-09-29
KR920021576A (ko)	1992-12-18
WO1992020669A1 (fr)	1992-11-26
IE76741B1 (en)	1997-11-05
IE921618A1 (en)	1992-12-02
FI20001900A (fi)	2000-08-29
TW366350B (en)	1999-08-11
CZ285220B6 (cs)	1999-06-16
RU2105009C1 (ru)	1998-02-20
JPH05186463A (ja)	1993-07-27
MD1155B2 (en)	1999-02-28
FI935151A0 (fi)	1993-11-19
NZ242818A (en)	1994-04-27
ES2084937T3 (es)	1996-05-16
FI935151A (fi)	1993-11-19
HU9303297D0 (en)	1994-03-28
CA2069063C (fr)	1997-07-15
OA10212A (en)	1997-10-07
CZ222496A3 (cs)	1999-04-14
WO1992020696A1 (fr)	1992-11-26
SK129393A3 (en)	1994-07-06
GR3024617T3 (en)	1997-12-31
US5663320A (en)	1997-09-02
NO921989L (no)	1992-11-23
NZ242817A (en)	1995-03-28
IL101932A (en)	1997-04-15
HK1002431A1 (en)	1998-08-21
HK132196A (en)	1996-07-26
MX9202395A (es)	1993-02-01
AU1639492A (en)	1992-11-26
CA2069024C (fr)	1997-09-23
TW467907B (en)	2001-12-11
AU1639592A (en)	1992-11-26
BG61695B1 (bg)	1998-03-31
CN1116204A (zh)	1996-02-07
TW366349B (en)	1999-08-11
US5696254A (en)	1997-12-09
NO921988D0 (no)	1992-05-20
BG98311A (bg)	1994-08-30
HUT67471A (en)	1995-04-28
IE921619A1 (en)	1992-12-02
CN1035555C (zh)	1997-08-06
CZ280857B6 (cs)	1996-04-17
IL116176A (en)	1998-02-08
TWI245046B (en)	2005-12-11
RO116812B1 (ro)	2001-06-29
CN1097049C (zh)	2002-12-25
ATE157662T1 (de)	1997-09-15
MX9202404A (es)	1993-08-31
CN1050603C (zh)	2000-03-22
DE69208144T2 (de)	1996-09-05
CN1067654A (zh)	1993-01-06
JPH05186465A (ja)	1993-07-27
IL116109A (en)	1998-12-27
EP0515156A1 (fr)	1992-11-25
SG43863A1 (en)	1997-11-14
US5756706A (en)	1998-05-26
CZ249393A3 (en)	1994-04-13
ZA923641B (en)	1993-02-24
HU223838B1 (hu)	2005-02-28
EP0515157B1 (fr)	1997-09-03
PL176026B1 (pl)	1999-03-31
AU1691392A (en)	1992-12-30
FI109025B (fi)	2002-05-15
CN1229078A (zh)	1999-09-22
PL170869B1 (pl)	1997-01-31
SK129493A3 (en)	1994-11-09
MD1155C2 (ro)	1999-10-31
PL168910B1 (pl)	1996-05-31
CZ284975B6 (cs)	1999-04-14
NO300593B1 (no)	1997-06-23
NO301010B1 (no)	1997-09-01
RU2163909C2 (ru)	2001-03-10
IL101931A0 (en)	1992-12-30
AU1690892A (en)	1992-12-30
DE69221936T2 (de)	1998-01-02
IL101931A (en)	1996-12-05
US5693787A (en)	1997-12-02
CA2069063A1 (fr)	1992-11-22
JP2001354667A (ja)	2001-12-25
ATE133958T1 (de)	1996-02-15
HU9303296D0 (en)	1994-03-28
CN1038591C (zh)	1998-06-03
DE69221936D1 (de)	1997-10-09
ZA923640B (en)	1993-02-24
US5744596A (en)	1998-04-28
FI935150A (fi)	1993-11-19
HU221850B1 (hu)	2003-02-28
EP0515156B1 (fr)	1996-02-07
IL116109A0 (en)	1996-01-31
EP0515157A1 (fr)	1992-11-25
GR3018941T3 (en)	1996-05-31
HUT67726A (en)	1995-04-28
CN1109030C (zh)	2003-05-21
MD950172A (en)	1996-08-30
FI935150A0 (fi)	1993-11-19

Publication	Publication Date	Title
BG61696B1 (bg)	1998-03-31	Метод за диастереоселективна синтеза на нуклеозиди
US6051709A (en)	2000-04-18	Process for the diastereoselective synthesis of nucleoside analogues
AU6966794A (en)	1995-01-03	Stereoselective synthesis of nucleoside analogues using bicyclic intermediate
MXPA96004880A (en)	1998-01-01	Procedure for the diasteros synthesiselectives of nucleus analogs