BG60560B1 - Заместени n-(1-алкил-3-хидрокси-4-пиперидинил)бензамиди - Google Patents

Заместени n-(1-алкил-3-хидрокси-4-пиперидинил)бензамиди Download PDF

Info

Publication number: BG60560B1
Authority: BG; Bulgaria
Prior art keywords: formula; alkyl; compound; amino; hydrogen
Prior art date: 1987-09-25

Application number

BG85500A

Other languages

Bulgarian (bg)

English (en)

Other versions

BG85500A (bg

Inventor

Daele Georges Van

Freddy Vlaeminck

CLEYN Michel DE

Original Assignee

Janssen Pharmaceutica N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-09-25

Filing date

1988-09-23

Publication date

1995-08-28

1988-09-23 Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.

1993-12-24 Publication of BG85500A publication Critical patent/BG85500A/bg

1995-08-28 Publication of BG60560B1 publication Critical patent/BG60560B1/bg

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Nutrition Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)

BG85500A 1987-09-25 1988-09-23 Заместени n-(1-алкил-3-хидрокси-4-пиперидинил)бензамиди BG60560B1 (bg)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US10111587A	1987-09-25	1987-09-25

Publications (2)

Publication Number	Publication Date
BG85500A BG85500A (bg)	1993-12-24
BG60560B1 true BG60560B1 (bg)	1995-08-28

Family

ID=22283104

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG85500A BG60560B1 (bg)	1987-09-25	1988-09-23	Заместени n-(1-алкил-3-хидрокси-4-пиперидинил)бензамиди

Country Status (24)

Country	Link
EP (1)	EP0309043B1 (zh)
JP (1)	JP2830936B2 (zh)
KR (1)	KR0124054B1 (zh)
CN (2)	CN1021652C (zh)
AT (1)	ATE113936T1 (zh)
AU (1)	AU610241B2 (zh)
BG (1)	BG60560B1 (zh)
CA (1)	CA1317940C (zh)
DE (1)	DE3852085T2 (zh)
DK (1)	DK529888A (zh)
ES (1)	ES2066781T3 (zh)
FI (1)	FI94129C (zh)
GR (1)	GR3014972T3 (zh)
HU (1)	HU203724B (zh)
IE (1)	IE64980B1 (zh)
IL (1)	IL87847A0 (zh)
MA (1)	MA21381A1 (zh)
NO (1)	NO172580C (zh)
NZ (1)	NZ226125A (zh)
PH (1)	PH25504A (zh)
PT (1)	PT88577B (zh)
SU (1)	SU1625331A3 (zh)
TN (1)	TNSN88096A1 (zh)
ZA (1)	ZA887157B (zh)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ225152A (en) *	1987-07-17	1990-04-26	Janssen Pharmaceutica Nv	Heterocyclically substituted piperidinyl benzamides as pharmaceuticals
US5019583A (en) *	1989-02-15	1991-05-28	Glaxo Inc.	N-phenyl-N-(4-piperidinyl)amides useful as analgesics
US5374637A (en) *	1989-03-22	1994-12-20	Janssen Pharmaceutica N.V.	N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
GB9005014D0 (en)	1990-03-06	1990-05-02	Janssen Pharmaceutica Nv	N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
US5438064A (en) *	1991-12-23	1995-08-01	American Home Products Corporation	Derivatives of 4-anilinoquinoline-3-carboxamide as analgesic agents
TW294595B (zh) *	1992-11-20	1997-01-01	Janssen Pharmaceutica Nv
JP3719612B2 (ja) *	1993-06-14	2005-11-24	塩野義製薬株式会社	ヘテロ環を含有する尿素誘導体
JP3862750B2 (ja) *	1994-09-27	2006-12-27	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	フェニル−オキソ−アルキル−（４−ピペリジニル）ベンゾエート誘導体
BR9509036A (pt) *	1994-09-27	1997-10-14	Janssen Pharmaceutica Nv	Derivados biciclicos de benzoato de peperidinila n-substituída
US6096761A (en) *	1996-02-15	2000-08-01	Janssen Pharmaceutica N.V.	Esters of 3-hydroxy-piperidinemethanol derivatives
NZ330263A (en) *	1996-02-15	1999-06-29	Janssen Pharmaceutica Nv	Esters of 3-hydroxy-piperidinemethanol derivatives to improve gastric emptying
TW548103B (en)	1997-07-11	2003-08-21	Janssen Pharmaceutica Nv	Bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
CN1076173C (zh) *	1998-05-29	2001-12-19	孙国文	香身茶剂
TW570920B (en) *	1998-12-22	2004-01-11	Janssen Pharmaceutica Nv	4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders
CA2410939C (en) *	2000-06-07	2010-02-16	Aryx Therapeutics	Materials and methods for the treatment of gastroesophageal reflux disease
GB0211230D0 (en)	2002-05-16	2002-06-26	Medinnova Sf	Treatment of heart failure
US8138204B2 (en)	2004-01-07	2012-03-20	Aryx Therapeutics, Inc.	Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders
US8524736B2 (en)	2004-01-07	2013-09-03	Armetheon, Inc.	Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders
WO2005068461A1 (en) *	2004-01-07	2005-07-28	Aryx Therapeutics	Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders
MY150958A (en) *	2005-06-16	2014-03-31	Astrazeneca Ab	Compounds for the treatment of multi-drug resistant bacterial infections
WO2007028073A2 (en)	2005-08-31	2007-03-08	Aryx Therapeutics, Inc.	Synthetic methods and intermediates for stereoisomeric compounds useful for the treatment of gastrointestinal and central nervous system disorders
US20080085915A1 (en) *	2006-06-23	2008-04-10	Cyrus Becker	Compounds and methods for the treatment of gastrointestinal and central nervous system disorders
KR100976063B1 (ko) *	2007-03-16	2010-08-17	동아제약주식회사	신규한 벤즈아미드 유도체 화합물 및 그의 제조방법
TW201100427A (en)	2009-03-31	2011-01-01	Arqule Inc	Substituted heterocyclic compounds
AU2011298361B2 (en) *	2010-09-01	2014-03-13	Janssen Pharmaceutica Nv	5-HT2B receptor antagonists

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1183847A (en) *	1981-10-01	1985-03-12	Georges Van Daele	N-(3-hydroxy-4-piperidinyl)benzamide derivatives
US4634704A (en) *	1983-10-06	1987-01-06	Janssen Pharmaceutica, N.V.	Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
ZW12187A1 (en) *	1986-07-03	1989-02-01	Janssen Pharmaceutica Nv	4-(aroylamino)piperidinebutanamide derivatives
NZ225152A (en) *	1987-07-17	1990-04-26	Janssen Pharmaceutica Nv	Heterocyclically substituted piperidinyl benzamides as pharmaceuticals

1988
- 1988-09-06 CA CA000576546A patent/CA1317940C/en not_active Expired - Fee Related
- 1988-09-09 NZ NZ226125A patent/NZ226125A/xx unknown
- 1988-09-15 ES ES88202011T patent/ES2066781T3/es not_active Expired - Lifetime
- 1988-09-15 EP EP88202011A patent/EP0309043B1/en not_active Expired - Lifetime
- 1988-09-15 AT AT88202011T patent/ATE113936T1/de not_active IP Right Cessation
- 1988-09-15 DE DE3852085T patent/DE3852085T2/de not_active Expired - Fee Related
- 1988-09-19 AU AU22322/88A patent/AU610241B2/en not_active Ceased
- 1988-09-21 MA MA21626A patent/MA21381A1/fr unknown
- 1988-09-22 NO NO884208A patent/NO172580C/no unknown
- 1988-09-23 SU SU884356607A patent/SU1625331A3/ru active
- 1988-09-23 PH PH37582A patent/PH25504A/en unknown
- 1988-09-23 IL IL87847A patent/IL87847A0/xx not_active IP Right Cessation
- 1988-09-23 TN TNTNSN88096A patent/TNSN88096A1/fr unknown
- 1988-09-23 ZA ZA887157A patent/ZA887157B/xx unknown
- 1988-09-23 PT PT88577A patent/PT88577B/pt not_active IP Right Cessation
- 1988-09-23 DK DK529888A patent/DK529888A/da not_active Application Discontinuation
- 1988-09-23 IE IE288988A patent/IE64980B1/en not_active IP Right Cessation
- 1988-09-23 FI FI884375A patent/FI94129C/fi not_active IP Right Cessation
- 1988-09-23 BG BG85500A patent/BG60560B1/bg unknown
- 1988-09-23 HU HU884991A patent/HU203724B/hu not_active IP Right Cessation
- 1988-09-24 JP JP63237547A patent/JP2830936B2/ja not_active Expired - Lifetime
- 1988-09-24 CN CN88106959A patent/CN1021652C/zh not_active Expired - Fee Related
- 1988-09-27 KR KR1019880012475A patent/KR0124054B1/ko not_active IP Right Cessation
1992
- 1992-07-10 CN CN92105871A patent/CN1067889A/zh active Pending
1995
- 1995-02-08 GR GR940403606T patent/GR3014972T3/el unknown

Also Published As

Publication number	Publication date
NZ226125A (en)	1990-05-28
JPH01128968A (ja)	1989-05-22
GR3014972T3 (en)	1995-05-31
PH25504A (en)	1991-07-24
DK529888A (da)	1989-03-26
IL87847A0 (en)	1989-03-31
EP0309043B1 (en)	1994-11-09
BG85500A (bg)	1993-12-24
NO172580B (no)	1993-05-03
JP2830936B2 (ja)	1998-12-02
IE882889L (en)	1989-03-25
EP0309043A3 (en)	1990-08-08
KR0124054B1 (ko)	1997-11-27
MA21381A1 (fr)	1989-04-01
NO172580C (no)	1993-08-11
HU203724B (en)	1991-09-30
CN1021652C (zh)	1993-07-21
ES2066781T3 (es)	1995-03-16
NO884208D0 (no)	1988-09-22
FI94129C (fi)	1995-07-25
AU610241B2 (en)	1991-05-16
DE3852085D1 (de)	1994-12-15
DE3852085T2 (de)	1995-04-06
FI884375A (fi)	1989-03-26
NO884208L (no)	1989-03-28
CA1317940C (en)	1993-05-18
AU2232288A (en)	1989-04-06
CN1067889A (zh)	1993-01-13
CN1032438A (zh)	1989-04-19
EP0309043A2 (en)	1989-03-29
DK529888D0 (da)	1988-09-23
FI94129B (fi)	1995-04-13
PT88577A (pt)	1988-10-01
PT88577B (pt)	1992-11-30
ATE113936T1 (de)	1994-11-15
HUT48589A (en)	1989-06-28
IE64980B1 (en)	1995-09-20
SU1625331A3 (ru)	1991-01-30
KR890005053A (ko)	1989-05-11
ZA887157B (en)	1990-05-30
FI884375A0 (fi)	1988-09-23
TNSN88096A1 (fr)	1990-07-10

Publication	Publication Date	Title
BG60560B1 (bg)	1995-08-28	Заместени n-(1-алкил-3-хидрокси-4-пиперидинил)бензамиди
US5652246A (en)	1997-07-29	Piperidine compounds
EP1960347B1 (en)	2012-06-20	17-beta-hydroxysteroid dehydrogenase type 3 (17beta-hsd3) inhibitors
US6534522B2 (en)	2003-03-18	Subtype-selective NMDA receptor ligands and the use thereof
EA001323B1 (ru)	2001-02-26	4-замещенные аналоги пиперидина и их использование в качестве подтип-селективных антагонистов рецепторов nmda
SK15852000A3 (sk)	2001-06-11	Derivát 1-[(1-substituovaného-4-piperidinyl)metyl]-4-piperidínu, spôsob jeho prípravy, farmaceutický prípravok obsahujúci tento derivát a medziprodukt tohto derivátu
CA2420177C (en)	2008-07-08	Quinazoline derivatives as alpha-1 adrenergic antagonists
EP0187251A2 (en)	1986-07-16	1,4-Dihydropyridines; a process and intermediates for their preparation and their use as medicaments
EP0721941A1 (en)	1996-07-17	Novel compound having platelet aggregation inhibitor effect
EP2049514B1 (en)	2011-01-26	Nitrate esters of piperidines
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EP0029707B1 (en)	1984-02-01	Novel piperidine derivatives, method for the preparation thereof and pharmaceutical compositions containing them
US4975439A (en)	1990-12-04	Novel substituted N-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
AU704043B2 (en)	1999-04-15	Enterokinetic benzamide
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CZ342397A3 (cs)	1998-03-18	Piperazinové deriváty jako antagonisté neurokininu
DD149069A5 (de)	1981-06-24	Verfahren zur herstellung neuer piperidinopropylerivate
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US5041454A (en)	1991-08-20	Novel substituted N-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
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DE60112725T2 (de)	2006-06-01	Phenoxyalkylaminderivate als agonisten des opioid-delta rezeptors
JP2006513151A (ja)	2006-04-20	４−アミノピペリジン誘導体、その製造方法及び医薬品としての使用
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