BG107852A - Метод за получаване на кристален n-формимидоил тиенамицин монохидрат (имипенем монохидрат) - Google Patents

Метод за получаване на кристален n-формимидоил тиенамицин монохидрат (имипенем монохидрат) Download PDF

Info

Publication number: BG107852A
Authority: BG; Bulgaria
Prior art keywords: formula; monohydrate; thienamycin; group; substituted
Prior art date: 2000-11-03

Application number

BG107852A

Other languages

Bulgarian (bg)

English (en)

Inventor

Yatendra Kumar

Neera Tewari

Ram C. Aryan

Bishwa P. Rai

Seema Ahuja

Original Assignee

Ranbaxy Laboratories Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-11-03

Filing date

2003-05-27

Publication date

2004-01-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11097114&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG107852(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-05-27 Application filed by Ranbaxy Laboratories Limited filed Critical Ranbaxy Laboratories Limited

2004-01-30 Publication of BG107852A publication Critical patent/BG107852A/bg

Links

238000000034 method Methods 0.000 title claims abstract description 20
GSOSVVULSKVSLQ-JJVRHELESA-N imipenem hydrate Chemical compound O.C1C(SCCNC=N)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 GSOSVVULSKVSLQ-JJVRHELESA-N 0.000 title claims abstract description 19
238000002360 preparation method Methods 0.000 title claims abstract description 9
-1 n-formimidoyl thienamycin monohydrate Chemical class 0.000 title claims description 22
WKDDRNSBRWANNC-UHFFFAOYSA-N Thienamycin Natural products C1C(SCCN)=C(C(O)=O)N2C(=O)C(C(O)C)C21 WKDDRNSBRWANNC-UHFFFAOYSA-N 0.000 claims description 20
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 17
UAOMVDZJSHZZME-UHFFFAOYSA-N diisopropylamine Chemical compound CC(C)NC(C)C UAOMVDZJSHZZME-UHFFFAOYSA-N 0.000 claims description 16
125000000217 alkyl group Chemical group 0.000 claims description 13
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 12
150000003951 lactams Chemical class 0.000 claims description 12
229960002182 imipenem Drugs 0.000 claims description 11
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical group C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 10
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 9
239000011541 reaction mixture Substances 0.000 claims description 9
150000001408 amides Chemical class 0.000 claims description 8
125000003118 aryl group Chemical group 0.000 claims description 8
150000003335 secondary amines Chemical class 0.000 claims description 8
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 7
229940043279 diisopropylamine Drugs 0.000 claims description 5
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 5
239000000203 mixture Substances 0.000 claims description 5
125000006239 protecting group Chemical group 0.000 claims description 5
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 5
FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 4
LINDOXZENKYESA-UHFFFAOYSA-N TMG Natural products CNC(N)=NC LINDOXZENKYESA-UHFFFAOYSA-N 0.000 claims description 4
238000002425 crystallisation Methods 0.000 claims description 4
230000008025 crystallization Effects 0.000 claims description 4
238000011065 in-situ storage Methods 0.000 claims description 4
150000002576 ketones Chemical class 0.000 claims description 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
239000002904 solvent Substances 0.000 claims description 4
WKDDRNSBRWANNC-ATRFCDNQSA-N Thienamycin Chemical compound C1C(SCCN)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 WKDDRNSBRWANNC-ATRFCDNQSA-N 0.000 claims description 3
LSNKBVFMXFAUOF-UHFFFAOYSA-N benzyl methanimidate;hydrochloride Chemical compound Cl.N=COCC1=CC=CC=C1 LSNKBVFMXFAUOF-UHFFFAOYSA-N 0.000 claims description 3
238000004587 chromatography analysis Methods 0.000 claims description 3
ZSKVGTPCRGIANV-ZXFLCMHBSA-N imipenem Chemical compound C1C(SCC\N=C\N)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 ZSKVGTPCRGIANV-ZXFLCMHBSA-N 0.000 claims description 3
239000003960 organic solvent Substances 0.000 claims description 3
125000006503 p-nitrobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])* 0.000 claims description 3
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 3
KYVBNYUBXIEUFW-UHFFFAOYSA-N 1,1,3,3-tetramethylguanidine Chemical compound CN(C)C(=N)N(C)C KYVBNYUBXIEUFW-UHFFFAOYSA-N 0.000 claims description 2
XWEHFBHUHPIKFI-UHFFFAOYSA-N 2,2-dimethyl-1-(2-methylpropyl)piperidine Chemical compound CC(C)CN1CCCCC1(C)C XWEHFBHUHPIKFI-UHFFFAOYSA-N 0.000 claims description 2
BZQAWHMCGZYKMH-UHFFFAOYSA-N 2-aminoethanethiol Chemical compound NCCS.NCCS BZQAWHMCGZYKMH-UHFFFAOYSA-N 0.000 claims description 2
XBPCUCUWBYBCDP-UHFFFAOYSA-N Dicyclohexylamine Chemical compound C1CCCCC1NC1CCCCC1 XBPCUCUWBYBCDP-UHFFFAOYSA-N 0.000 claims description 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
229930194542 Keto Natural products 0.000 claims description 2
NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 claims description 2
UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 claims description 2
230000003213 activating effect Effects 0.000 claims description 2
125000002877 alkyl aryl group Chemical group 0.000 claims description 2
150000001412 amines Chemical class 0.000 claims description 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
125000004122 cyclic group Chemical group 0.000 claims description 2
125000000753 cycloalkyl group Chemical group 0.000 claims description 2
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 2
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 2
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 2
125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims description 2
GUVUOGQBMYCBQP-UHFFFAOYSA-N dmpu Chemical compound CN1CCCN(C)C1=O GUVUOGQBMYCBQP-UHFFFAOYSA-N 0.000 claims description 2
150000002148 esters Chemical class 0.000 claims description 2
229910052736 halogen Inorganic materials 0.000 claims description 2
150000002367 halogens Chemical class 0.000 claims description 2
229910052739 hydrogen Inorganic materials 0.000 claims description 2
239000001257 hydrogen Substances 0.000 claims description 2
238000005984 hydrogenation reaction Methods 0.000 claims description 2
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
125000000468 ketone group Chemical group 0.000 claims description 2
125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims description 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
125000001624 naphthyl group Chemical group 0.000 claims description 2
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
VTGOHKSTWXHQJK-UHFFFAOYSA-N pyrimidin-2-ol Chemical compound OC1=NC=CC=N1 VTGOHKSTWXHQJK-UHFFFAOYSA-N 0.000 claims description 2
150000003839 salts Chemical class 0.000 claims description 2
125000001424 substituent group Chemical group 0.000 claims description 2
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 2
239000012442 inert solvent Substances 0.000 claims 2
YCIPQJTZJGUXND-UHFFFAOYSA-N Aglaia odorata Alkaloid Natural products C1=CC(OC)=CC=C1C1(C(C=2C(=O)N3CCCC3=NC=22)C=3C=CC=CC=3)C2(O)C2=C(OC)C=C(OC)C=C2O1 YCIPQJTZJGUXND-UHFFFAOYSA-N 0.000 claims 1
239000004922 lacquer Substances 0.000 claims 1
125000005010 perfluoroalkyl group Chemical group 0.000 claims 1
HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 1
239000000243 solution Substances 0.000 description 5
238000004108 freeze drying Methods 0.000 description 4
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
SJRJJKPEHAURKC-UHFFFAOYSA-N N-Methylmorpholine Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 description 3
150000004682 monohydrates Chemical class 0.000 description 3
229910052757 nitrogen Inorganic materials 0.000 description 3
239000000047 product Substances 0.000 description 3
ZFPGARUNNKGOBB-UHFFFAOYSA-N 1-Ethyl-2-pyrrolidinone Chemical compound CCN1CCCC1=O ZFPGARUNNKGOBB-UHFFFAOYSA-N 0.000 description 2
125000004066 1-hydroxyethyl group Chemical group [H]OC([H])([*])C([H])([H])[H] 0.000 description 2
HZAVSJRAODFHGF-UHFFFAOYSA-N 2-methyl-7-oxohept-2-enoic acid Chemical compound OC(=O)C(C)=CCCCC=O HZAVSJRAODFHGF-UHFFFAOYSA-N 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 2
125000000446 sulfanediyl group Chemical group *S* 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
XQQUKAGHLDAJGO-UHFFFAOYSA-N 1-(2,6-dihydroxy-4-methoxyphenyl)hexan-1-one Chemical compound CCCCCC(=O)C1=C(O)C=C(OC)C=C1O XQQUKAGHLDAJGO-UHFFFAOYSA-N 0.000 description 1
GGYVTHJIUNGKFZ-UHFFFAOYSA-N 1-methylpiperidin-2-one Chemical compound CN1CCCCC1=O GGYVTHJIUNGKFZ-UHFFFAOYSA-N 0.000 description 1
OGMADIBCHLQMIP-UHFFFAOYSA-N 2-aminoethanethiol;hydron;chloride Chemical compound Cl.NCCS OGMADIBCHLQMIP-UHFFFAOYSA-N 0.000 description 1
GFXKPZGNSSQMFN-UHFFFAOYSA-N 2-methyl-3,7-dioxoheptanoic acid Chemical compound OC(=O)C(C)C(=O)CCCC=O GFXKPZGNSSQMFN-UHFFFAOYSA-N 0.000 description 1
FYZUENZXIZCLAZ-UHFFFAOYSA-N 2-methylhept-2-enoic acid Chemical compound CCCCC=C(C)C(O)=O FYZUENZXIZCLAZ-UHFFFAOYSA-N 0.000 description 1
YHLVEHXOBBYATA-UHFFFAOYSA-N 5,5-dimethyl-1,3-diazinan-2-one Chemical compound CC1(C)CNC(=O)NC1 YHLVEHXOBBYATA-UHFFFAOYSA-N 0.000 description 1
108020004256 Beta-lactamase Proteins 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
238000002441 X-ray diffraction Methods 0.000 description 1
BHIIGRBMZRSDRI-UHFFFAOYSA-N [chloro(phenoxy)phosphoryl]oxybenzene Chemical compound C=1C=CC=CC=1OP(=O)(Cl)OC1=CC=CC=C1 BHIIGRBMZRSDRI-UHFFFAOYSA-N 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
102000006635 beta-lactamase Human genes 0.000 description 1
230000003115 biocidal effect Effects 0.000 description 1
YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical compound C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 description 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
150000007942 carboxylates Chemical class 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
UFULAYFCSOUIOV-UHFFFAOYSA-N cysteamine Chemical compound NCCS UFULAYFCSOUIOV-UHFFFAOYSA-N 0.000 description 1
238000004821 distillation Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000003480 eluent Substances 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
239000012467 final product Substances 0.000 description 1
238000007710 freezing Methods 0.000 description 1
230000008014 freezing Effects 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
238000002955 isolation Methods 0.000 description 1
229960003151 mercaptamine Drugs 0.000 description 1
125000000718 methaneimidamido group Chemical group C(=N)N* 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
238000001223 reverse osmosis Methods 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
150000003952 β-lactams Chemical class 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

BG107852A 2000-11-03 2003-05-27 Метод за получаване на кристален n-формимидоил тиенамицин монохидрат (имипенем монохидрат) BG107852A (bg)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IN983DE2000 IN191798B (de)	2000-11-03	2000-11-03
PCT/IB2001/002069 WO2002036594A1 (en)	2000-11-03	2001-11-05	Process for the preparation of crystalline n-formimidoyl thienamycin monohydrate (imipenem monohydrate)

Publications (1)

Publication Number	Publication Date
BG107852A true BG107852A (bg)	2004-01-30

Family

ID=11097114

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG107852A BG107852A (bg)	2000-11-03	2003-05-27	Метод за получаване на кристален n-формимидоил тиенамицин монохидрат (имипенем монохидрат)

Country Status (19)

Country	Link
US (1)	US7078534B2 (de)
EP (1)	EP1334105B1 (de)
JP (1)	JP2004525084A (de)
KR (1)	KR20030059812A (de)
CN (1)	CN100445284C (de)
AT (1)	ATE322495T1 (de)
AU (1)	AU2002212591A1 (de)
BG (1)	BG107852A (de)
CA (1)	CA2427762C (de)
DE (1)	DE60118593D1 (de)
DK (1)	DK1334105T3 (de)
EA (1)	EA006442B1 (de)
EE (1)	EE200300206A (de)
ES (1)	ES2261494T3 (de)
IN (1)	IN191798B (de)
MX (1)	MXPA03003916A (de)
PT (1)	PT1334105E (de)
WO (1)	WO2002036594A1 (de)
ZA (1)	ZA200303338B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2005514323A (ja) *	2001-05-18	2005-05-19	ランバクシーラボラトリーズリミテッド	結晶イミペネムの単離方法
ATE437879T1 (de) *	2001-05-18	2009-08-15	Ranbaxy Lab Ltd	Verfahren zur herstellung von imipenem
AP2003002912A0 (en) *	2001-05-18	2002-05-17	Ranbaxy Lab Ltd	Process for the preparation of amorphouse cilastatin sodium
EP1426376A4 (de) *	2001-08-13	2004-12-22	Eisai Co Ltd	Verfahren zur herstellung von carbapenem-antibiotika
MXPA04004604A (es)	2001-11-16	2004-09-10	Ranbaxy Lab Ltd	Proceso para la preparacion de imipenem cristalino.
US6537985B1 (en)	2001-11-30	2003-03-25	Phoenix Scientific, Inc.	Antibiotic formulation and a method of making this formulation
MXPA06001115A (es) *	2003-12-09	2006-04-11	Choongwae Pharm Co	Un proceso nuevo para la preparacion de imipenem.
KR100848751B1 (ko) *	2006-11-10	2008-07-25	제일약품주식회사	이미페넴의 제조방법
KR100848752B1 (ko) *	2006-11-10	2008-07-25	제일약품주식회사	티에나마이신 용매화합물 및 그의 제조방법
EP2209787A4 (de) *	2007-10-08	2011-08-03	Orchid Chemicals & Pharm Ltd	Verfahren zur herstellung eines carbapenem-antibiotikums
CN108623598A (zh) *	2018-05-21	2018-10-09	重庆天地药业有限责任公司	一种亚胺培南中间体及亚胺培南的制备方法
CN111413427A (zh) *	2020-04-08	2020-07-14	苏州和合医学检验有限公司	超滤前处理高效液相色谱测定血浆中亚胺培南含量的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4194047A (en) *	1975-11-21	1980-03-18	Merck & Co., Inc.	Substituted N-methylene derivatives of thienamycin
US4260543A (en) *	1978-07-03	1981-04-07	Merck & Co., Inc.	Crystalline N-formimidoyl thienamycin
JP3048196B2 (ja)	1991-06-20	2000-06-05	第一製薬株式会社	カルバペネム誘導体
DK0606336T3 (da)	1991-10-01	1997-04-14	Procter & Gamble Pharma	Fremgangsmåde til fremstilling af antimikrobielle quinolonyllactamer
CA2105746A1 (en)	1992-09-09	1994-03-10	Akira Yoshida	Process for preparing carbapenem and penem compounds and new compounds involved in that process
US5245069A (en) *	1992-10-27	1993-09-14	Merck & Co., Inc.	Process for the preparation of bis(aryl)-phosphorohalidates
US5872250A (en)	1997-07-30	1999-02-16	Merck & Co., Inc.	Process for synthesizing carbapenem antibiotics

2000
- 2000-11-03 IN IN983DE2000 patent/IN191798B/en unknown
2001
- 2001-11-05 PT PT01980805T patent/PT1334105E/pt unknown
- 2001-11-05 WO PCT/IB2001/002069 patent/WO2002036594A1/en active IP Right Grant
- 2001-11-05 EE EEP200300206A patent/EE200300206A/xx unknown
- 2001-11-05 MX MXPA03003916A patent/MXPA03003916A/es active IP Right Grant
- 2001-11-05 EP EP01980805A patent/EP1334105B1/de not_active Expired - Lifetime
- 2001-11-05 ES ES01980805T patent/ES2261494T3/es not_active Expired - Lifetime
- 2001-11-05 AT AT01980805T patent/ATE322495T1/de active
- 2001-11-05 KR KR10-2003-7006118A patent/KR20030059812A/ko not_active Application Discontinuation
- 2001-11-05 AU AU2002212591A patent/AU2002212591A1/en not_active Abandoned
- 2001-11-05 JP JP2002539352A patent/JP2004525084A/ja not_active Withdrawn
- 2001-11-05 CN CNB018207154A patent/CN100445284C/zh not_active Expired - Fee Related
- 2001-11-05 US US10/415,633 patent/US7078534B2/en not_active Expired - Fee Related
- 2001-11-05 EA EA200300520A patent/EA006442B1/ru not_active IP Right Cessation
- 2001-11-05 DE DE60118593T patent/DE60118593D1/de not_active Expired - Lifetime
- 2001-11-05 CA CA002427762A patent/CA2427762C/en not_active Expired - Fee Related
- 2001-11-05 DK DK01980805T patent/DK1334105T3/da active
2003
- 2003-04-30 ZA ZA200303338A patent/ZA200303338B/en unknown
- 2003-05-27 BG BG107852A patent/BG107852A/bg unknown

Also Published As

Publication number	Publication date
IN191798B (de)	2004-01-03
MXPA03003916A (es)	2004-01-29
DE60118593D1 (de)	2006-05-18
ES2261494T3 (es)	2006-11-16
WO2002036594A1 (en)	2002-05-10
EP1334105A1 (de)	2003-08-13
EA200300520A1 (ru)	2003-10-30
CA2427762A1 (en)	2002-05-10
PT1334105E (pt)	2006-08-31
DK1334105T3 (da)	2006-08-14
EE200300206A (et)	2003-10-15
AU2002212591A1 (en)	2002-05-15
ATE322495T1 (de)	2006-04-15
CN1481384A (zh)	2004-03-10
EA006442B1 (ru)	2005-12-29
KR20030059812A (ko)	2003-07-10
JP2004525084A (ja)	2004-08-19
CN100445284C (zh)	2008-12-24
ZA200303338B (en)	2004-03-09
US20040054167A1 (en)	2004-03-18
US7078534B2 (en)	2006-07-18
CA2427762C (en)	2009-10-20
EP1334105B1 (de)	2006-04-05

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