BE895832A - Solutions stabilisees d'insuline et procede pour la preparation de celles-ci - Google Patents

Solutions stabilisees d'insuline et procede pour la preparation de celles-ci

Info

Publication number
BE895832A
BE895832A BE6/47775A BE6047775A BE895832A BE 895832 A BE895832 A BE 895832A BE 6/47775 A BE6/47775 A BE 6/47775A BE 6047775 A BE6047775 A BE 6047775A BE 895832 A BE895832 A BE 895832A
Authority
BE
Belgium
Prior art keywords
preparation
insulin solutions
stabilized insulin
stabilized
solutions
Prior art date
Application number
BE6/47775A
Other languages
English (en)
Inventor
J J V Brange
S Havelund
Original Assignee
Novo Industri As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Industri As filed Critical Novo Industri As
Publication of BE895832A publication Critical patent/BE895832A/fr

Links

Classifications

    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K13/00—Apparatus or processes specially adapted for manufacturing or adjusting assemblages of electric components
    • H05K13/06—Wiring by machine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacturing & Machinery (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
BE6/47775A 1982-02-05 1983-02-04 Solutions stabilisees d'insuline et procede pour la preparation de celles-ci BE895832A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK49182 1982-02-05

Publications (1)

Publication Number Publication Date
BE895832A true BE895832A (fr) 1983-08-04

Family

ID=8094159

Family Applications (1)

Application Number Title Priority Date Filing Date
BE6/47775A BE895832A (fr) 1982-02-05 1983-02-04 Solutions stabilisees d'insuline et procede pour la preparation de celles-ci

Country Status (22)

Country Link
US (1) US4476118A (fr)
JP (1) JPS58192818A (fr)
AT (1) AT382780B (fr)
AU (1) AU549981B2 (fr)
BE (1) BE895832A (fr)
CA (1) CA1203476A (fr)
CH (1) CH657530A5 (fr)
DE (1) DE3303860A1 (fr)
ES (1) ES519533A0 (fr)
FI (1) FI78616C (fr)
FR (1) FR2521009B1 (fr)
GB (1) GB2114573B (fr)
GR (1) GR77388B (fr)
IE (1) IE54548B1 (fr)
IT (1) IT1178455B (fr)
LU (1) LU84632A1 (fr)
NL (1) NL187269C (fr)
NO (1) NO161204C (fr)
NZ (1) NZ203189A (fr)
PT (1) PT76195B (fr)
SE (1) SE460948B (fr)
ZA (1) ZA83742B (fr)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
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ATE50502T1 (de) * 1984-06-09 1990-03-15 Hoechst Ag Insulinzubereitungen, verfahren zu deren herstellung und deren verwendung.
JP2520262B2 (ja) * 1987-08-21 1996-07-31 春幸 川原 パツチテスト材料
US4789660A (en) * 1987-09-10 1988-12-06 American Home Products Corporation Insulin administration using methyl and propyl paraben
US5130298A (en) * 1989-05-16 1992-07-14 Ethicon, Inc. Stabilized compositions containing epidermal growth factor
US5534488A (en) * 1993-08-13 1996-07-09 Eli Lilly And Company Insulin formulation
US5474978A (en) * 1994-06-16 1995-12-12 Eli Lilly And Company Insulin analog formulations
YU18596A (sh) * 1995-03-31 1998-07-10 Eli Lilly And Company Analogne formulacije monomernog insulina
AU7678196A (en) * 1995-11-13 1997-06-05 Minimed, Inc. Methods and compositions for the delivery of monomeric proteins
CA2248142A1 (fr) * 1996-03-12 1997-09-18 Life Technologies, Inc. Additif pour milieu de culture nutritif pour cellules hematopoietiques
ES2218622T3 (es) * 1996-07-26 2004-11-16 Aventis Pharma Deutschland Gmbh Derivados de insulina con actividad de union al zinc incrementada.
EP1283051B1 (fr) * 1997-06-13 2006-06-14 Eli Lilly And Company Formulations stables à base de l'insuline
PE79099A1 (es) 1997-06-13 1999-08-24 Lilly Co Eli Formulaciones de insulina estables
EP1030688B1 (fr) * 1997-11-12 2004-09-29 Alza Corporation Procede d'administration dermale de polypeptides
DE19825447A1 (de) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
CN1210058C (zh) * 1998-10-16 2005-07-13 诺沃挪第克公司 用于肺送递的稳定的浓缩胰岛素制剂
DE19930676B4 (de) * 1999-07-02 2006-01-19 Sanofi-Aventis Deutschland Gmbh Verfahren zur Stabilisierung von Insulin, Insulinderivaten und/oder deren Vorläufer in komplexen Mischungen bei deren Lagerung in wäßrigen Lösungsmitteln
ES2266187T3 (es) * 2000-03-24 2007-03-01 Genentech, Inc. Uso de la insulina para el tratamiento de trastornos del cartilago.
JP4147234B2 (ja) * 2004-09-27 2008-09-10 キヤノン株式会社 吐出用液体、吐出方法、カートリッジ及び吐出装置
ATE496064T1 (de) 2002-05-07 2011-02-15 Novo Nordisk As Lösliche formulierungen, die monomeres insulin und acyliertes insulin enthalten
US20050065066A1 (en) * 2002-12-20 2005-03-24 Kaarsholm Niels Christian Stabilised insulin compositions
ATE378063T1 (de) * 2002-12-20 2007-11-15 Novo Nordisk As Pharmazeutische zusammensetzungen mit insulin und insulin-hexamer-liganden
WO2004096266A1 (fr) * 2003-05-02 2004-11-11 Novo Nordisk A/S Stabilite physique amelioree de preparations d'insuline
BRPI0413276B8 (pt) * 2003-08-05 2021-05-25 Novo Nordisk As derivado de insulina, complexo de zinco do mesmo, e, composição farmacêutica
EP2626368B1 (fr) 2004-07-19 2016-12-21 Biocon Limited Conjugués insuline-oligomère, formulations et utilisations de ceux-ci
ES2371361T3 (es) * 2005-12-28 2011-12-30 Novo Nordisk A/S Composiciones que comprenden una insulina acilada y zinc y método de producción de dichas composiciones.
US20090136538A1 (en) * 2006-05-22 2009-05-28 Jan Jezek Stable vaccine formulation
GB0700523D0 (en) * 2007-01-11 2007-02-21 Insense Ltd The Stabilisation Of Proteins
EP3050568B1 (fr) 2007-03-13 2020-12-02 JDS Therapeutics, LLC Procédés et compositions pour la libération prolongée de chrome
EP2167032B1 (fr) * 2007-06-13 2019-08-07 Novo Nordisk A/S Formule pharmaceutique contenant d'un dérivé de l'insuline
WO2009002867A2 (fr) 2007-06-26 2008-12-31 Nutrition 21, Inc. Forme posologique à unités multiples contenant un agent thérapeutique en combinaison avec un complément alimentaire
PT2597103T (pt) 2007-11-16 2017-02-08 Novo Nordisk As Composições farmacêuticas contendo insulina e um péptido insulinotrófico
EP2328607A1 (fr) * 2008-07-16 2011-06-08 Arecor Limited Formulation stable d'une protéine thérapeutique
EP2341940A1 (fr) * 2008-07-16 2011-07-13 Arecor Limited Stabilisation des proteines
BRPI0919946A2 (pt) * 2008-10-30 2016-02-16 Novo Nordisk As tratamento de diabetes melito usando injeções de insulina com frequência de injeção menor que diariamente
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
RU2013123515A (ru) 2010-10-27 2014-12-10 Ново Нордиск А/С Лечение сахарного диабета с помощью инъекций инсулина, вводимых с различными интервалами
US8933022B2 (en) 2011-03-01 2015-01-13 Jds Therapeutics, Llc Methods and compositions for the treatment and prevention Hypoglycemia and related disorders
CN104902922B (zh) 2012-11-13 2017-12-12 阿道恰公司 包含经取代阴离子化合物的速效胰岛素制剂
WO2014096985A2 (fr) 2012-12-19 2014-06-26 Wockhardt Limited Composition aqueuse stable comprenant de l'insuline humaine ou un analogue ou un dérivé de celle-ci
JP2016505601A (ja) 2012-12-26 2016-02-25 ウォックハート リミテッド 医薬組成物
TWI780236B (zh) * 2013-02-04 2022-10-11 法商賽諾菲公司 胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物
US10137172B2 (en) 2013-04-30 2018-11-27 Novo Nordisk A/S Administration regime
WO2015084694A2 (fr) * 2013-12-04 2015-06-11 Merck Sharp & Dohme Corp. Procédé de préparation d'insuline cristalline
AR102869A1 (es) 2014-12-16 2017-03-29 Lilly Co Eli Composiciones de insulina de rápida acción
JO3749B1 (ar) 2015-08-27 2021-01-31 Lilly Co Eli تركيبات إنسولين سريعة المفعول
MX2018009748A (es) 2016-02-11 2019-02-07 Nutrition 21 Llc Composiciones que contienen cromo para mejorar la salud y el estado físico.
EP3518893A1 (fr) * 2016-09-29 2019-08-07 Arecor Limited Nouvelles formulations
AU2018275545B2 (en) 2017-06-01 2021-02-04 Eli Lilly And Company Rapid-acting insulin compositions
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2882202A (en) * 1950-04-05 1959-04-14 Novo Terapeutisk Labor As Insulin crystal preparations and methods of producing them
US2787575A (en) * 1950-11-22 1957-04-02 Organon Zinc-glycine-insulin composition and production thereof
US2882203A (en) * 1951-06-26 1959-04-14 Novo Terapeutisk Labor As Injectable insulin preparation with protracted effect
DE1044360B (de) * 1953-08-19 1958-11-20 Roskilde Medical Company Ltd R Verfahren zur Herstellung von Zinkinsulin mit erhoehtem Zinkgehalt
DE956098C (de) * 1954-02-18 1957-01-10 Dr Dr Guenther Weitzel Verfahren zur Herstellung zinkreicher Insulin-Komplexverbindungen
US3058885A (en) * 1957-06-08 1962-10-16 Novo Terapeutisk Labor As Process for treatment of insulin crystals and for production of insulin preparationstherefrom
US3014842A (en) * 1957-08-10 1961-12-26 Novo Terapeutish Lab A S Injectable bovine insulin crystal suspensions and process of producing same
US3091573A (en) * 1958-05-12 1963-05-28 Novo Terapeutisk Labor As Quick acting insulin preparation
FR1263220A (fr) * 1958-08-01 1961-06-09 Novo Terapeutisk Labor As Procédé de production d'une préparation d'insuline à action rapide
DK116527B (da) * 1967-03-01 1970-01-19 Nordisk Insulinlab Fremgangsmåde til fremstilling af en hurtigtvirkende, holdbar, neutral opløsning af rent krystallinsk okseinsulin eller okseinsulin, der ved tilsætning af Zn er krystalliserbart i vand, eller blandinger af okseinsulin og insulin af anden oprindelse.
GB1285023A (en) * 1968-08-09 1972-08-09 Novo Terapeutisk Labor As Improvements in or relating to injectable insulin preparations
US3657425A (en) * 1969-03-12 1972-04-18 Burroughs Wellcome Co Beef insulin preparations
EP0018609B1 (fr) * 1979-04-30 1983-09-21 Hoechst Aktiengesellschaft Solutions aqueuses de protéines, stables à la dénaturation, procédé pour leur fabrication et leur utilisation
DK80781A (da) * 1980-02-29 1981-08-30 Hospital For Sick Children Oploesninger af polypeptider
WO1983003054A1 (fr) * 1982-03-03 1983-09-15 Johansen, Kristian, Betton Procede de production d'une preparation d'insuline

Also Published As

Publication number Publication date
AT382780B (de) 1987-04-10
GB2114573B (en) 1985-05-01
SE460948B (sv) 1989-12-11
AU549981B2 (en) 1986-02-20
IT1178455B (it) 1987-09-09
IT8319420A0 (it) 1983-02-04
IE54548B1 (en) 1989-11-08
GB8303133D0 (en) 1983-03-09
GR77388B (fr) 1984-09-11
US4476118A (en) 1984-10-09
PT76195B (en) 1986-01-27
DE3303860C2 (fr) 1989-12-28
FI830375L (fi) 1983-08-06
NO161204C (no) 1989-07-19
SE8300598L (sv) 1983-08-06
CH657530A5 (de) 1986-09-15
ZA83742B (en) 1983-11-30
ES8500060A1 (es) 1984-10-16
NO161204B (no) 1989-04-10
FR2521009B1 (fr) 1987-07-17
ATA38983A (de) 1986-09-15
NL8300440A (nl) 1983-09-01
GB2114573A (en) 1983-08-24
FI830375A0 (fi) 1983-02-03
NL187269B (nl) 1991-03-01
NL187269C (nl) 1991-08-01
NO830385L (no) 1983-08-08
SE8300598D0 (sv) 1983-02-04
AU1113683A (en) 1983-08-11
FI78616C (fi) 1989-09-11
PT76195A (en) 1983-03-01
NZ203189A (en) 1985-07-31
ES519533A0 (es) 1984-10-16
FR2521009A1 (fr) 1983-08-12
DE3303860A1 (de) 1983-08-18
FI78616B (fi) 1989-05-31
IE830220L (en) 1983-08-05
JPS58192818A (ja) 1983-11-10
JPH0367056B2 (fr) 1991-10-21
CA1203476A (fr) 1986-04-22
LU84632A1 (fr) 1983-09-08

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: *NOVO INDUSTRI A/S

Effective date: 20030204