BE803955A - Substd hydroxy guanidines - as anti depressants - Google Patents

Substd hydroxy guanidines - as anti depressants

Info

Publication number
BE803955A
BE803955A BE134879A BE134879A BE803955A BE 803955 A BE803955 A BE 803955A BE 134879 A BE134879 A BE 134879A BE 134879 A BE134879 A BE 134879A BE 803955 A BE803955 A BE 803955A
Authority
BE
Belgium
Prior art keywords
substd
guanidines
hydroxy
anti depressants
contg
Prior art date
Application number
BE134879A
Other languages
French (fr)
Inventor
S C Cherkofsky
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of BE803955A publication Critical patent/BE803955A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Cpds of formula (I): where R4 is contg. 5-11C; contg. 6-12C; contg. 6-12C; or X is F, Cl, Br, CF3, NO2, 1-6C alkyl or alkoxy, -alkylthio or dialkylamino; k is 0-3; Y is F, Cl, Br, or 1-6C alkyl (II)p is 0-3; R5 is H, Me, Et, provided when R5 is Et and R4 is X is F, Cl, Br, NO2, 1-6C alkoxy, alkylthio or dialkylamino; R6 is H 1-6C alkyl or 2-6C alkenyl opt. substd. by one or two F, Cl, br, 1-6C alkoxy or dialkylamino provided that the unsaturated C in alkenyl is not adjacent to the N atom and provided >=1 of R5 and R6 is H and when R6 is not H, R4 is are used in antidepressant compsns.
BE134879A 1972-08-25 1973-08-23 Substd hydroxy guanidines - as anti depressants BE803955A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28377572A 1972-08-25 1972-08-25

Publications (1)

Publication Number Publication Date
BE803955A true BE803955A (en) 1973-12-17

Family

ID=23087495

Family Applications (2)

Application Number Title Priority Date Filing Date
BE134879A BE803955A (en) 1972-08-25 1973-08-23 Substd hydroxy guanidines - as anti depressants
BE134880A BE803956A (en) 1972-08-25 1973-08-23 HYDROXYGUANIDINE O-CARBAMATES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Family Applications After (1)

Application Number Title Priority Date Filing Date
BE134880A BE803956A (en) 1972-08-25 1973-08-23 HYDROXYGUANIDINE O-CARBAMATES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Country Status (2)

Country Link
BE (2) BE803955A (en)
ZA (2) ZA735808B (en)

Also Published As

Publication number Publication date
BE803956A (en) 1973-12-17
ZA735808B (en) 1974-08-28
ZA735807B (en) 1974-08-28

Similar Documents

Publication Publication Date Title
FR92974E (en) Oily colloidal composition and process for obtaining it.
BE759063A (en) TRANSFORMATION OF ALDOSES INTO CETOSES BY FERMENTATION.
FR2196813A1 (en) Substd hydroxy guanidines - as anti depressants
BE803955A (en) Substd hydroxy guanidines - as anti depressants
BE622943A (en) Therapeutic compositions, containing emetine derivatives.
FR1438698A (en) Gloves, especially for personal hygiene
BE811514R (en) DEVICE FOR THE TREATMENT OF TOBACCO SMOKE
FR1424052A (en) Hydrocarbon oxidation
BE797631A (en) DRAWER ACTUATION MECHANISM
FR2118932A1 (en) 2-oxo-1, 2, 3, 4-tetrahydroquinazoline derivs - sedatives antiinflammatories, analgesics, uricosurics and antimicrobials
FR1393576A (en) Realization of an objective for the medium infrared
FR1393397A (en) Removable double pocket for clothing
FR2078729A5 (en) Herbicidal 2,4-bis-trifluoromethyl-6-nitro-anilines
FR1603622A (en) Glucuronides of 3-indolyl-aliphatic carboxylic acids of general formula (I): R1 = H, lower alkyl, lower alkoxy, lower alkylthio or halogen; R2 and R3 = H,
FR2175564A1 (en) 2(4-alkyl-4-piperidyloxy)alkanols - inters for human and veterinary drugs
BE619267A (en) Depolymerized algin derivatives.
FR2208659A1 (en) 13-Alkyl, alkoxy or allyl berberrubin derivatives - anticancer agents, prepd by demethylation of a 13-subst berberine salt
FR2104832A1 (en) Cyclopropane carboxylate thienyl and furyl derivs - insecticides
IT949697B (en) URETHRAL SPRAYER
FR2086133A2 (en) N-bis (3-thienylpropyl) phenethylamines -with coronary vasodilator - activity
CA679939A (en) Process for the photochemical oxidation of no to no2"
FR2000702A1 (en) Substd pyrazolidines
JPS52119194A (en) Horizontally sliding vibration
BE783745A (en) Body deodorant compsn - contng hydroxyalkyl phenyl ether and 2-hydroxydiphenyl ether
FR2980M (en) New antibiotic substances referred to as anhydro-apo-mitomycins and -porfiromycins.