AU7669794A - Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors - Google Patents
Hydroxyethylamino sulphonamides useful as retroviral protease inhibitorsInfo
- Publication number
- AU7669794A AU7669794A AU76697/94A AU7669794A AU7669794A AU 7669794 A AU7669794 A AU 7669794A AU 76697/94 A AU76697/94 A AU 76697/94A AU 7669794 A AU7669794 A AU 7669794A AU 7669794 A AU7669794 A AU 7669794A
- Authority
- AU
- Australia
- Prior art keywords
- hydroxyethylamino
- sulphonamides
- useful
- protease inhibitors
- retroviral protease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/05—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
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- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
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- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/41—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
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- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US110911 | 1993-08-24 | ||
US08/110,911 US5843946A (en) | 1992-08-25 | 1993-08-24 | α-and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
US08/204,827 US6060476A (en) | 1992-08-25 | 1994-03-02 | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
US204827 | 1994-03-02 | ||
PCT/US1994/009139 WO1995006030A1 (en) | 1993-08-24 | 1994-08-23 | Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
AU7669794A true AU7669794A (en) | 1995-03-21 |
Family
ID=26808496
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU76697/94A Abandoned AU7669794A (en) | 1993-08-24 | 1994-08-23 | Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0715618B1 (el) |
AT (1) | ATE174587T1 (el) |
AU (1) | AU7669794A (el) |
DE (1) | DE69415326T2 (el) |
DK (1) | DK0715618T3 (el) |
ES (1) | ES2127938T3 (el) |
GR (1) | GR3029378T3 (el) |
WO (1) | WO1995006030A1 (el) |
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AU2007203321C1 (en) * | 1998-06-23 | 2011-12-08 | The Board Of Trustees Of The University Of Illinois | Method of treating HIV infections |
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WO2003024932A1 (en) | 2001-09-18 | 2003-03-27 | Bristol-Myers Squibb Company | Bis-amino acid sulfonamides as hiv protease inhibitors |
TWI336621B (en) | 2001-12-21 | 2011-02-01 | Tibotec Pharm Ltd | Broad spectrum heterocyclic substituted phenyl containing sulfonamide hiv protease inhibitors |
US7157489B2 (en) | 2002-03-12 | 2007-01-02 | The Board Of Trustees Of The University Of Illinois | HIV protease inhibitors |
MY142238A (en) | 2002-03-12 | 2010-11-15 | Tibotec Pharm Ltd | Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors |
JP4864320B2 (ja) | 2002-05-16 | 2012-02-01 | テイボテク・フアーマシユーチカルズ・リミテツド | Hivプロテアーゼ阻害剤の疑似多形相 |
JP4674084B2 (ja) | 2002-05-17 | 2011-04-20 | テイボテク・フアーマシユーチカルズ・リミテツド | 広域スペクトルの置換ベンズイソキサゾールスルホンアミドhivプロテアーゼ阻害剤 |
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TWI383975B (zh) | 2004-03-31 | 2013-02-01 | Tibotec Pharm Ltd | 製備(3R,3aS,6aR)六氫-呋喃并〔2,3-b〕呋喃-3-醇之方法 |
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AR073248A1 (es) | 2008-09-01 | 2010-10-20 | Tibotec Pharm Ltd | Proceso para la preparacion de (1s, 2r)-3- ((4-aminofenil) sulfonil) ( isobutil) amino)-1- bencil-2- hidroxipropilcarbamato de (3r, 3as,6ar)- hexahidrofuro-(2,3-b) furan-3- ilo (darunavir) y compuestos intermediarios utiles en dicho proceso. |
US8921415B2 (en) | 2009-01-29 | 2014-12-30 | Mapi Pharma Ltd. | Polymorphs of darunavir |
PL2381786T3 (pl) | 2009-01-29 | 2015-06-30 | Mapi Pharma Ltd | Dimetylosulfotlenkowy solwat darunawiru |
WO2011061590A1 (en) | 2009-11-17 | 2011-05-26 | Hetero Research Foundation | Novel carboxamide derivatives as hiv inhibitors |
PT2513116E (pt) | 2009-12-16 | 2015-10-14 | Hetero Research Foundation | Polimorfos de darunavir |
WO2011083287A2 (en) | 2010-01-05 | 2011-07-14 | Cipla Limited | Darunavir polymorph and process for preparation thereof |
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RS56667B1 (sr) | 2011-07-07 | 2018-03-30 | Janssen Sciences Ireland Uc | Kombinovane formulacije darunavira |
DK2729128T3 (en) | 2011-07-07 | 2016-11-21 | Janssen Sciences Ireland Uc | Darunavir-FORMULATIONS |
CN104478830B (zh) * | 2014-12-31 | 2016-06-22 | 中国医学科学院医药生物技术研究所 | 一组叔胺类拟肽衍生物及其在抑制hiv-1蛋白酶中的应用 |
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Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3635907A1 (de) * | 1986-10-22 | 1988-04-28 | Merck Patent Gmbh | Hydroxy-aminosaeurederivate |
TW225540B (el) * | 1990-06-28 | 1994-06-21 | Shionogi & Co | |
DE69321845T2 (de) * | 1992-08-25 | 1999-04-29 | Monsanto Co | Hydroxyethylaminosulfonamide verwendbar als inhibitoren retroviraler proteasen |
-
1994
- 1994-08-23 ES ES94927162T patent/ES2127938T3/es not_active Expired - Lifetime
- 1994-08-23 EP EP94927162A patent/EP0715618B1/en not_active Expired - Lifetime
- 1994-08-23 DK DK94927162T patent/DK0715618T3/da active
- 1994-08-23 DE DE69415326T patent/DE69415326T2/de not_active Expired - Lifetime
- 1994-08-23 AT AT94927162T patent/ATE174587T1/de active
- 1994-08-23 AU AU76697/94A patent/AU7669794A/en not_active Abandoned
- 1994-08-23 WO PCT/US1994/009139 patent/WO1995006030A1/en active IP Right Grant
-
1999
- 1999-02-12 GR GR990400462T patent/GR3029378T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ES2127938T3 (es) | 1999-05-01 |
GR3029378T3 (en) | 1999-05-28 |
EP0715618B1 (en) | 1998-12-16 |
ATE174587T1 (de) | 1999-01-15 |
DK0715618T3 (da) | 1999-08-23 |
DE69415326T2 (de) | 1999-06-02 |
WO1995006030A1 (en) | 1995-03-02 |
EP0715618A1 (en) | 1996-06-12 |
DE69415326D1 (de) | 1999-01-28 |
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