AU7126691A - Phosphorus-containing hmg-coa reductase inhibitors, new intermediates and method - Google Patents

Phosphorus-containing hmg-coa reductase inhibitors, new intermediates and method

Info

Publication number: AU7126691A
Authority: AU; Australia
Prior art keywords: phosphorus; coa reductase; reductase inhibitors; new intermediates; containing hmg
Prior art date: 1987-05-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

AU71266/91A

Other versions

AU643501B2 (en

Inventor

Michael Christopher Badia

Scott Adams Biller

Eric Michael Gordon

Donald Steven Karanewsky

Michael Joseph Sofia

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

ER Squibb and Sons LLC

Original Assignee

ER Squibb and Sons LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-05-22

Filing date

1991-02-21

Publication date

1991-05-02

1991-02-21 Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC

1991-05-02 Publication of AU7126691A publication Critical patent/AU7126691A/en

1993-11-18 Application granted granted Critical

1993-11-18 Publication of AU643501B2 publication Critical patent/AU643501B2/en

2008-05-20 Anticipated expiration legal-status Critical

Status Ceased legal-status Critical Current

Links

229940121710 HMGCoA reductase inhibitor Drugs 0.000 title 1
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 title 1
239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
229910052698 phosphorus Inorganic materials 0.000 title 1
239000011574 phosphorus Substances 0.000 title 1
229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/302—Acyclic unsaturated acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/303—Cycloaliphatic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/306—Arylalkanephosphinic acids, e.g. Ar-(CH2)n-P(=X)(R)(XH), (X = O,S, Se; n>=1)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3211—Esters of acyclic saturated acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3217—Esters of acyclic unsaturated acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3241—Esters of arylalkanephosphinic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AU71266/91A 1987-05-22 1991-02-21 Phosphorus-containing HMG-CoA reductase inhibitors, new intermediates and method Ceased AU643501B2 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US5323887A	1987-05-22	1987-05-22
US053238		1987-05-22
US10968187A	1987-10-19	1987-10-19
US109681		1987-10-19

Related Parent Applications (1)

Application Number	Title	Priority Date	Filing Date
AU16502/88A Division AU610174B2 (en)	1987-05-22	1988-05-20	Phosphorus-containing hmg-coa reductase inhibitors, new intermediates and method

Publications (2)

Publication Number	Publication Date
AU7126691A true AU7126691A (en)	1991-05-02
AU643501B2 AU643501B2 (en)	1993-11-18

Family

ID=26731613

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AU16502/88A Ceased AU610174B2 (en)	1987-05-22	1988-05-20	Phosphorus-containing hmg-coa reductase inhibitors, new intermediates and method
AU71266/91A Ceased AU643501B2 (en)	1987-05-22	1991-02-21	Phosphorus-containing HMG-CoA reductase inhibitors, new intermediates and method

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AU16502/88A Ceased AU610174B2 (en)	1987-05-22	1988-05-20	Phosphorus-containing hmg-coa reductase inhibitors, new intermediates and method

Country Status (24)

Country	Link
JP (1)	JPH01139589A (en)
KR (1)	KR880013959A (en)
CN (1)	CN1030761A (en)
AU (2)	AU610174B2 (en)
BE (1)	BE1002251A3 (en)
CH (3)	CH675582A5 (en)
DE (1)	DE3817298C2 (en)
DK (1)	DK277388A (en)
ES (1)	ES2009919A6 (en)
FI (1)	FI87927C (en)
FR (1)	FR2615516B1 (en)
GB (1)	GB2205838B (en)
GR (1)	GR880100332A (en)
HU (1)	HU201085B (en)
IE (1)	IE63715B1 (en)
IL (1)	IL86463A (en)
IT (1)	IT1217684B (en)
NL (1)	NL8801331A (en)
NO (1)	NO882219L (en)
NZ (1)	NZ224734A (en)
PH (2)	PH25581A (en)
PL (1)	PL157761B1 (en)
PT (1)	PT87540B (en)
SE (3)	SE501541C2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE503210C2 (en) *	1987-05-22	1996-04-22	Squibb & Sons Inc	Phosphorus-containing HMG-CoA-Reductase Inhibitor, New Intermediates and Methods
CA2027179A1 (en) *	1989-10-10	1991-04-11	Barry C. Ross	Chemical compounds
US5025000A (en) *	1990-03-02	1991-06-18	E. R. Squibb & Sons, Inc.	Phosphorus-containing HMG-CoA reductase inhibitor compounds
US5124453A (en) *	1990-03-02	1992-06-23	E. R. Squibb & Sons, Inc.	Process for preparing certain 5,6,7,8-tetrahydroindolizinyl (ethyl or ethynyl)-hydroxy or methoxy-phosphinyl-3-hydroxy-butanoates and derivatives thereof
CA2042526A1 (en) *	1990-06-11	1991-12-12	Adeoye Y. Olukotun	Method for preventing a second heart attack employing an hmg coa reductase inhibitor
CA2043525A1 (en) *	1990-06-24	1991-12-25	Donald S. Karanewsky	Phosphorus-containing hmg-coa reductase inhibitors, new intermediates and method
DE4023308A1 (en) *	1990-07-21	1992-01-23	Bayer Ag	SUBSTITUTED PYRIDO OXAZINE
DE4025818A1 (en) *	1990-08-16	1992-02-20	Bayer Ag	PHENYL SULPHONAMIDE SUBSTITUTED PYRIDINALKEN AND -AMINOOXYALKANCARBONE ACID DERIVATIVES
NZ241574A (en) *	1991-02-22	1993-08-26	Ishihara Sangyo Kaisha	Substituted phenyl derivatives of hydrazone and pesticidal compositions
US5202327A (en) *	1991-07-10	1993-04-13	E. R. Squibb & Sons, Inc.	Phosphorus-containing hmg-coa reductase inhibitors
US5256692A (en) *	1992-01-07	1993-10-26	E. R. Squibb & Sons, Inc.	Sulfur-containing HMG-COA reductase inhibitors
US20010006644A1 (en)	1997-07-31	2001-07-05	David J. Bova	Combinations of hmg-coa reductase inhibitors and nicotinic acid and methods for treating hyperlipidemia once a day at night
WO2003076409A1 (en) *	2002-03-14	2003-09-18	Syngenta Participations Ag	Derivatives of 1-phenyl-3-phenylpyrazole as herbicides
JP4407237B2 (en) *	2002-12-24	2010-02-03	三菱化学株式会社	Non-aqueous electrolyte and non-aqueous electrolyte secondary battery using the same
JP4485169B2 (en)	2003-05-16	2010-06-16	花王株式会社	Intestinal mineral absorption capacity improver
CN1760363B (en) *	2004-10-14	2010-04-28	蒋继宏	Coded sequence of reductase enzyme protein of eucommia 3-hydroxy-3-coenzyme of methyl glutaryl A
TW200736225A (en) *	2006-01-16	2007-10-01	Sankyo Agro Co Ltd	A (3-sulfur substituted phenyl) pyrazole derivative

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR339233A (en) *	1903-12-23	1905-01-26	Cyanidgesellschaft Mit Beschra	New process for obtaining explosives
DE803645C (en) *	1949-10-11	1951-04-05	Dynamit Act Ges Vormals Alfred	Firedamp proof detonator in connection with electric igniters
DE918196C (en) *	1952-12-23	1954-09-20	J G W Berckholtz Fa	Mass for producing colored smoke
US3274035A (en) *	1964-06-15	1966-09-20	Lohr A Burkardt	Metallic composition for production of hygroscopic smoke
US3862866A (en) *	1971-08-02	1975-01-28	Specialty Products Dev Corp	Gas generator composition and method
DE2841815C2 (en) *	1978-09-26	1985-02-21	Buck Chemisch-Technische Werke GmbH & Co, 7347 Bad Überkingen	Method for producing a floor filling
US4438700A (en) *	1982-07-19	1984-03-27	The United States Of America As Represented By The Secretary Of The Army	White smoke spotting composition for training ammunition
FR2596393B1 (en) *	1986-04-01	1988-06-03	Sanofi Sa	HYDROXY-3 DIHYDROXYOXOPHOSPHORIO-4 BUTANOIC ACID DERIVATIVES, THEIR PREPARATION PROCESS, THEIR USE AS MEDICAMENTS AND THE COMPOSITIONS CONTAINING THEM
SE503210C2 (en) *	1987-05-22	1996-04-22	Squibb & Sons Inc	Phosphorus-containing HMG-CoA-Reductase Inhibitor, New Intermediates and Methods

1988
- 1988-05-20 GR GR880100332A patent/GR880100332A/en unknown
- 1988-05-20 DK DK277388A patent/DK277388A/en not_active Application Discontinuation
- 1988-05-20 DE DE3817298A patent/DE3817298C2/en not_active Expired - Fee Related
- 1988-05-20 NO NO882219A patent/NO882219L/en unknown
- 1988-05-20 SE SE8801904A patent/SE501541C2/en not_active IP Right Cessation
- 1988-05-20 FI FI882385A patent/FI87927C/en not_active IP Right Cessation
- 1988-05-20 IT IT20681/88A patent/IT1217684B/en active
- 1988-05-20 IE IE154488A patent/IE63715B1/en not_active IP Right Cessation
- 1988-05-20 IL IL8646388A patent/IL86463A/en not_active IP Right Cessation
- 1988-05-20 PT PT87540A patent/PT87540B/en not_active IP Right Cessation
- 1988-05-20 GB GB8811931A patent/GB2205838B/en not_active Expired - Fee Related
- 1988-05-20 HU HU882613A patent/HU201085B/en not_active IP Right Cessation
- 1988-05-20 NZ NZ224734A patent/NZ224734A/en unknown
- 1988-05-20 AU AU16502/88A patent/AU610174B2/en not_active Ceased
- 1988-05-20 PH PH36953A patent/PH25581A/en unknown
- 1988-05-20 ES ES8801611A patent/ES2009919A6/en not_active Expired
- 1988-05-21 PL PL1988286491A patent/PL157761B1/en unknown
- 1988-05-21 KR KR1019880006019A patent/KR880013959A/en not_active Application Discontinuation
- 1988-05-21 CN CN88103699A patent/CN1030761A/en active Pending
- 1988-05-23 JP JP63125630A patent/JPH01139589A/en active Pending
- 1988-05-24 FR FR888806884A patent/FR2615516B1/en not_active Expired - Fee Related
- 1988-05-24 CH CH1966/88A patent/CH675582A5/fr not_active IP Right Cessation
- 1988-05-24 NL NL8801331A patent/NL8801331A/en not_active Application Discontinuation
- 1988-05-24 BE BE8800565A patent/BE1002251A3/en not_active IP Right Cessation
- 1988-05-24 CH CH1462/90A patent/CH678625A5/fr not_active IP Right Cessation
- 1988-05-24 CH CH1463/90A patent/CH678626A5/fr not_active IP Right Cessation
1989
- 1989-05-19 PH PH38673A patent/PH26578A/en unknown
1991
- 1991-02-21 AU AU71266/91A patent/AU643501B2/en not_active Ceased
1992
- 1992-05-14 SE SE9201587A patent/SE9201587D0/en not_active Application Discontinuation
- 1992-05-20 SE SE9201588A patent/SE9201588A0/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
IE63715B1 (en)	1995-06-14
GB2205838A (en)	1988-12-21
FI87927B (en)	1992-11-30
PL157761B1 (en)	1992-06-30
PT87540B (en)	1992-09-30
DK277388D0 (en)	1988-05-20
FR2615516B1 (en)	1991-04-12
AU1650288A (en)	1988-11-24
PH25581A (en)	1991-08-08
FR2615516A1 (en)	1988-11-25
CH675582A5 (en)	1990-10-15
FI882385A0 (en)	1988-05-20
IL86463A (en)	1994-10-07
SE9201588D0 (en)	1992-05-20
CN1030761A (en)	1989-02-01
PH26578A (en)	1992-08-19
GB2205838B (en)	1991-12-11
GB8811931D0 (en)	1988-06-22
NO882219D0 (en)	1988-05-20
HUT47123A (en)	1989-01-30
NZ224734A (en)	1991-04-26
GR880100332A (en)	1989-02-23
DE3817298C2 (en)	1997-02-13
CH678625A5 (en)	1991-10-15
DK277388A (en)	1988-11-23
FI882385A (en)	1988-11-23
AU643501B2 (en)	1993-11-18
SE501541C2 (en)	1995-03-06
AU610174B2 (en)	1991-05-16
BE1002251A3 (en)	1990-11-06
IL86463A0 (en)	1988-11-15
CH678626A5 (en)	1991-10-15
SE8801904D0 (en)	1988-05-20
HU201085B (en)	1990-09-28
IE881544L (en)	1988-11-22
SE9201588A0 (en)	1992-05-20
PT87540A (en)	1989-05-31
SE8801904L (en)	1988-11-23
IT8820681A0 (en)	1988-05-20
ES2009919A6 (en)	1989-10-16
FI87927C (en)	1993-03-10
SE9201587D0 (en)	1992-05-20
KR880013959A (en)	1988-12-22
NO882219L (en)	1988-11-23
NL8801331A (en)	1988-12-16
DE3817298A1 (en)	1988-12-01
IT1217684B (en)	1990-03-30
SE9201587A0 (en)	1992-05-14
JPH01139589A (en)	1989-06-01

Publication	Publication Date	Title
AU610591B2 (en)	1991-05-23	Phosphorus-containing hmg-coa reductase inhibitors, new intermediates and method
AU6084686A (en)	1987-02-12	Novel hmg-coa reductase inhibitors
AU610174B2 (en)	1991-05-16	Phosphorus-containing hmg-coa reductase inhibitors, new intermediates and method
JPS6426535A (en)	1989-01-27	Novel hmg-coa reductase inhibitor
AU3106197A (en)	1998-01-07	Cytokine production inhibitors, triazepine compounds, and intermediates there of
AU5533094A (en)	1994-06-22	Enzyme inhibitors
AU2058992A (en)	1993-02-11	HMG-COA reductase inhibitors
EP0403487A4 (en)	1991-06-05	Novel hmg-coa reductase inhibitors
AU2175088A (en)	1989-03-16	Novel hmg-coa reductase inhibitors
EP0323866A3 (en)	1989-08-23	Novel hmg-coa reductase inhibitors
EP0415488A3 (en)	1991-09-11	7-substituted hmg-coa reductase inhibitors
GB2238545B (en)	1992-01-02	Phosphorus-containing hmg-coa reductase inhibitors,new intermediates and method
GB2235924B (en)	1991-11-20	Phosphorus-containing hmg-coa reductase inhibitors,new intermediates and method
EP0320052A3 (en)	1989-08-16	Intermediates and processes for 6-carboxy hmg-coa reductase inhibitors
ZA883621B (en)	1989-01-25	Phosphorus-containing hmg-coa reductase inhibitors,new intermediates and method
ZA883620B (en)	1989-01-25	Phosphorus-containing hmg-coa reductase inhibitors,new intermediates and methods
EP0283123A3 (en)	1990-06-13	Intermediates and process useful in the preparation of hmg-coa reductase inhibitors
EP0306263A3 (en)	1989-08-23	Novel hmg-coa reductase inhibitors
EP0468974A4 (en)	1992-03-25	Novel hmg-coa reductase inhibitors
ZA874487B (en)	1987-12-23	Novel hmg-coa reductase inhibitors
IE871654L (en)	1987-12-23	Novel hmg-coa reductase inhibitors
AU2459297A (en)	1997-11-07	Method of preparing phosphodiesterase iv inhibitors
JPS6485073A (en)	1989-03-30	Method for manufacturing protein similar to hmg-coa reductase
IE851368L (en)	1985-12-04	Preparing hmg-coa reductase inhibitors
IE861739L (en)	1987-01-05	Hmg-coa reductase inhibitors