AU2021428512A1 - Crystalline solids of mek inhibitor n-((r)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-benzamide and uses thereof - Google Patents
Crystalline solids of mek inhibitor n-((r)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-benzamide and uses thereof Download PDFInfo
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- AU2021428512A1 AU2021428512A1 AU2021428512A AU2021428512A AU2021428512A1 AU 2021428512 A1 AU2021428512 A1 AU 2021428512A1 AU 2021428512 A AU2021428512 A AU 2021428512A AU 2021428512 A AU2021428512 A AU 2021428512A AU 2021428512 A1 AU2021428512 A1 AU 2021428512A1
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- Prior art keywords
- crystalline form
- dihydroxypropoxy
- difluoro
- fluoro
- phenylamino
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2021/018381 WO2022177557A1 (en) | 2021-02-17 | 2021-02-17 | Crystalline solids of mek inhibitor n-((r)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-benzamide and uses thereof |
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| AU2021428512A1 true AU2021428512A1 (en) | 2023-09-21 |
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| Country | Link |
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| EP (1) | EP4294526A1 (zh) |
| JP (1) | JP2024509759A (zh) |
| KR (1) | KR20230147139A (zh) |
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| AR (1) | AR124911A1 (zh) |
| AU (1) | AU2021428512A1 (zh) |
| CA (1) | CA3207513A1 (zh) |
| IL (1) | IL305078A (zh) |
| TW (1) | TW202302526A (zh) |
| WO (1) | WO2022177557A1 (zh) |
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| WO2023223205A1 (en) | 2022-05-17 | 2023-11-23 | Teva Pharmaceuticals International Gmbh | Solid state forms of mirdametinib and process for preparation thereof |
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| CN1219753C (zh) | 2000-07-19 | 2005-09-21 | 沃尼尔·朗伯公司 | 4－碘苯氨基苯氧肟酸的氧合酯 |
| CA2542210A1 (en) | 2003-10-21 | 2005-05-06 | Warner-Lambert Company Llc | Polymorphic form of n-[(r)-2,3-dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-benzamide |
| WO2006134469A1 (en) | 2005-06-14 | 2006-12-21 | Warner-Lambert Company Llc | Methods of preparing mek inhibitor |
| US11066358B1 (en) * | 2021-02-17 | 2021-07-20 | Warner-Lambert Company Llc | Compositions of essentially pure form IV of N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide and uses thereof |
| US11084780B1 (en) * | 2021-02-17 | 2021-08-10 | Springworks Therapeutics, Inc. | Crystalline solids of MEK inhibitor N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide and uses thereof |
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2021
- 2021-02-17 KR KR1020237031522A patent/KR20230147139A/ko unknown
- 2021-02-17 JP JP2023549993A patent/JP2024509759A/ja active Pending
- 2021-02-17 EP EP21710829.9A patent/EP4294526A1/en active Pending
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- 2021-02-17 CA CA3207513A patent/CA3207513A1/en active Pending
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- 2022-02-17 AR ARP220100336A patent/AR124911A1/es unknown
- 2022-02-17 TW TW111105779A patent/TW202302526A/zh unknown
Also Published As
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|---|---|
| TW202302526A (zh) | 2023-01-16 |
| AR124911A1 (es) | 2023-05-17 |
| EP4294526A1 (en) | 2023-12-27 |
| KR20230147139A (ko) | 2023-10-20 |
| WO2022177557A1 (en) | 2022-08-25 |
| JP2024509759A (ja) | 2024-03-05 |
| CA3207513A1 (en) | 2022-08-25 |
| CN117083264A (zh) | 2023-11-17 |
| IL305078A (en) | 2023-10-01 |
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