AU2009251863B2 - 2, 6-diamino-pyrimidin- 5-yl-carboxamides as syk or JAK kinases inhibitors - Google Patents
2, 6-diamino-pyrimidin- 5-yl-carboxamides as syk or JAK kinases inhibitors Download PDFInfo
- Publication number
- AU2009251863B2 AU2009251863B2 AU2009251863A AU2009251863A AU2009251863B2 AU 2009251863 B2 AU2009251863 B2 AU 2009251863B2 AU 2009251863 A AU2009251863 A AU 2009251863A AU 2009251863 A AU2009251863 A AU 2009251863A AU 2009251863 B2 AU2009251863 B2 AU 2009251863B2
- Authority
- AU
- Australia
- Prior art keywords
- carboxamide
- pyrimidine
- phenylamino
- cyclopropylamino
- ylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4540608P | 2008-04-16 | 2008-04-16 | |
| US4539908P | 2008-04-16 | 2008-04-16 | |
| US4541708P | 2008-04-16 | 2008-04-16 | |
| US61/045,406 | 2008-04-16 | ||
| US61/045,399 | 2008-04-16 | ||
| US61/045,417 | 2008-04-16 | ||
| US12034808P | 2008-12-05 | 2008-12-05 | |
| US12034408P | 2008-12-05 | 2008-12-05 | |
| US12034108P | 2008-12-05 | 2008-12-05 | |
| US61/120,344 | 2008-12-05 | ||
| US61/120,341 | 2008-12-05 | ||
| US61/120,348 | 2008-12-05 | ||
| PCT/US2009/002420 WO2009145856A1 (en) | 2008-04-16 | 2009-04-16 | 2, 6-diamino-pyrimidin- 5-yl-carboxamides as syk or jak kinases inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| AU2009251863A1 AU2009251863A1 (en) | 2009-12-03 |
| AU2009251863A2 AU2009251863A2 (en) | 2011-06-09 |
| AU2009251863B2 true AU2009251863B2 (en) | 2014-09-25 |
Family
ID=43570275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2009251863A Active AU2009251863B2 (en) | 2008-04-16 | 2009-04-16 | 2, 6-diamino-pyrimidin- 5-yl-carboxamides as syk or JAK kinases inhibitors |
Country Status (18)
| Country | Link |
|---|---|
| AU (1) | AU2009251863B2 (es) |
| BR (1) | BRPI0910560B8 (es) |
| CO (1) | CO6331433A2 (es) |
| CY (1) | CY1118559T1 (es) |
| DK (1) | DK2321283T3 (es) |
| ES (1) | ES2597441T3 (es) |
| GT (1) | GT201000298A (es) |
| HK (1) | HK1158179A1 (es) |
| HU (1) | HUE031638T2 (es) |
| IL (3) | IL208637A (es) |
| LT (1) | LT2321283T (es) |
| MX (1) | MX353206B (es) |
| NI (1) | NI201000176A (es) |
| NZ (1) | NZ589314A (es) |
| PL (1) | PL2321283T3 (es) |
| PT (1) | PT2321283T (es) |
| SI (1) | SI2321283T1 (es) |
| ZA (1) | ZA201007045B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| KR101892989B1 (ko) | 2008-06-27 | 2018-08-30 | 셀젠 카르 엘엘씨 | 헤테로아릴 화합물 및 이의 용도 |
| AU2013202496B2 (en) * | 2008-06-27 | 2016-08-04 | Celgene Car Llc | Heteroaryl compounds and uses thereof |
| JP6068340B2 (ja) | 2010-08-10 | 2017-01-25 | セルジーン アヴィロミクス リサーチ， インコーポレイテッド | Ｂｔｋ阻害剤のベシル酸塩 |
| TW201446745A (zh) | 2013-02-08 | 2014-12-16 | Celgene Avilomics Res Inc | Ｅｒｋ抑制劑及其用途 |
| WO2016025561A1 (en) | 2014-08-13 | 2016-02-18 | Celgene Avilomics Research, Inc. | Forms and compositions of an erk inhibitor |
| CN114196651B (zh) * | 2021-12-15 | 2023-06-30 | 中国林业科学研究院亚热带林业研究所 | D6蛋白激酶d6pkl2的新用途 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008009458A1 (en) * | 2006-07-21 | 2008-01-24 | Novartis Ag | 2, 4 -di (arylaminio) -pyrimidine-5-carboxamide compounds as jak kinases inhibitors |
| EP1054004B1 (en) * | 1997-12-15 | 2008-07-16 | Astellas Pharma Inc. | Novel pyrimidine-5-carboxamide derivatives |
| EP1518855B1 (en) * | 2002-06-28 | 2011-10-26 | Astellas Pharma Inc. | Diaminopyrimidinecarboxa mide derivative |
-
2009
- 2009-04-16 BR BRPI0910560A patent/BRPI0910560B8/pt active IP Right Grant
- 2009-04-16 HU HUE09755219A patent/HUE031638T2/en unknown
- 2009-04-16 NZ NZ589314A patent/NZ589314A/xx not_active IP Right Cessation
- 2009-04-16 ES ES09755219.4T patent/ES2597441T3/es active Active
- 2009-04-16 DK DK09755219.4T patent/DK2321283T3/en active
- 2009-04-16 LT LTEP09755219.4T patent/LT2321283T/lt unknown
- 2009-04-16 SI SI200931540A patent/SI2321283T1/sl unknown
- 2009-04-16 PL PL09755219T patent/PL2321283T3/pl unknown
- 2009-04-16 PT PT97552194T patent/PT2321283T/pt unknown
- 2009-04-16 AU AU2009251863A patent/AU2009251863B2/en active Active
- 2009-04-16 MX MX2010011464A patent/MX353206B/es active IP Right Grant
-
2010
- 2010-10-04 ZA ZA2010/07045A patent/ZA201007045B/en unknown
- 2010-10-11 IL IL208637A patent/IL208637A/en active IP Right Grant
- 2010-10-15 GT GT201000298A patent/GT201000298A/es unknown
- 2010-10-15 NI NI201000176A patent/NI201000176A/es unknown
- 2010-11-16 CO CO10143190A patent/CO6331433A2/es active IP Right Grant
-
2011
- 2011-11-16 HK HK11112350.6A patent/HK1158179A1/zh not_active IP Right Cessation
-
2016
- 2016-10-13 CY CY20161101026T patent/CY1118559T1/el unknown
-
2017
- 2017-04-09 IL IL251655A patent/IL251655B/en active IP Right Grant
-
2020
- 2020-05-07 IL IL274522A patent/IL274522A/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1054004B1 (en) * | 1997-12-15 | 2008-07-16 | Astellas Pharma Inc. | Novel pyrimidine-5-carboxamide derivatives |
| EP1518855B1 (en) * | 2002-06-28 | 2011-10-26 | Astellas Pharma Inc. | Diaminopyrimidinecarboxa mide derivative |
| WO2008009458A1 (en) * | 2006-07-21 | 2008-01-24 | Novartis Ag | 2, 4 -di (arylaminio) -pyrimidine-5-carboxamide compounds as jak kinases inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| CO6331433A2 (es) | 2011-10-20 |
| IL208637A (en) | 2017-04-30 |
| SI2321283T1 (sl) | 2017-01-31 |
| BRPI0910560B8 (pt) | 2023-03-21 |
| ZA201007045B (en) | 2012-08-29 |
| LT2321283T (lt) | 2016-12-12 |
| IL274522A (en) | 2020-06-30 |
| BRPI0910560A2 (pt) | 2021-04-27 |
| CY1118559T1 (el) | 2017-07-12 |
| IL251655B (en) | 2020-05-31 |
| BRPI0910560B1 (pt) | 2023-01-24 |
| IL251655A0 (en) | 2017-06-29 |
| PT2321283T (pt) | 2016-10-19 |
| DK2321283T3 (en) | 2016-10-31 |
| ES2597441T3 (es) | 2017-01-18 |
| AU2009251863A1 (en) | 2009-12-03 |
| NZ589314A (en) | 2012-10-26 |
| MX353206B (es) | 2018-01-08 |
| IL208637A0 (en) | 2010-12-30 |
| HUE031638T2 (en) | 2017-07-28 |
| GT201000298A (es) | 2014-05-07 |
| HK1158179A1 (zh) | 2012-07-13 |
| NI201000176A (es) | 2011-08-08 |
| PL2321283T3 (pl) | 2017-01-31 |
| MX2010011464A (es) | 2014-06-16 |
| AU2009251863A2 (en) | 2011-06-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DA3 | Amendments made section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE PRIORITY DETAILS TO READ 61/120,344 05 DEC 2008 US; 61/045,406 16 APR 2008 US; 61/120,341 05 DEC 2008 US; 61/045,399 16 APR 2008 US; 61/120,348 05 DEC 2008 US AND 61/045,417 16 APR 2008 US |
|
| DA3 | Amendments made section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 19 MAY 2011 |
|
| FGA | Letters patent sealed or granted (standard patent) | ||
| PC | Assignment registered |
Owner name: ALEXION PHARMACEUTICALS, INC. Free format text: FORMER OWNER(S): PORTOLA PHARMACEUTICALS, INC. |