AU2002223603A1 - Process for the production of r(+)alpha-lipoic acid - Google Patents
Process for the production of r(+)alpha-lipoic acidInfo
- Publication number
- AU2002223603A1 AU2002223603A1 AU2002223603A AU2360302A AU2002223603A1 AU 2002223603 A1 AU2002223603 A1 AU 2002223603A1 AU 2002223603 A AU2002223603 A AU 2002223603A AU 2360302 A AU2360302 A AU 2360302A AU 2002223603 A1 AU2002223603 A1 AU 2002223603A1
- Authority
- AU
- Australia
- Prior art keywords
- alpha
- lipoic acid
- methylbenzylamine
- acid
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- AGBQKNBQESQNJD-UHFFFAOYSA-N alpha-Lipoic acid Natural products OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 title abstract 6
- AGBQKNBQESQNJD-SSDOTTSWSA-N (R)-lipoic acid Chemical compound OC(=O)CCCC[C@@H]1CCSS1 AGBQKNBQESQNJD-SSDOTTSWSA-N 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
- 238000001953 recrystallisation Methods 0.000 abstract 2
- 238000000926 separation method Methods 0.000 abstract 2
- RQEUFEKYXDPUSK-SSDOTTSWSA-N (1R)-1-phenylethanamine Chemical compound C[C@@H](N)C1=CC=CC=C1 RQEUFEKYXDPUSK-SSDOTTSWSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- -1 aliphatic hydroxy-carboxylic acids Chemical class 0.000 abstract 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 235000019136 lipoic acid Nutrition 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000012454 non-polar solvent Substances 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 229960002663 thioctic acid Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
- C07C319/06—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols from sulfides, hydropolysulfides or polysulfides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI2000A002187 | 2000-10-10 | ||
IT2000MI002187A IT1319195B1 (it) | 2000-10-10 | 2000-10-10 | Processo per la produzione dell'acido r(+)alfa-lipoico. |
PCT/EP2001/011575 WO2002030918A2 (en) | 2000-10-10 | 2001-10-08 | PROCESS FOR THE PRODUCTION OF R(+)α-LIPOIC ACID |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2002223603A1 true AU2002223603A1 (en) | 2002-04-22 |
Family
ID=11445936
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2002223603A Abandoned AU2002223603A1 (en) | 2000-10-10 | 2001-10-08 | Process for the production of r(+)alpha-lipoic acid |
Country Status (11)
Country | Link |
---|---|
US (1) | US6670484B2 (cs) |
EP (1) | EP1330450B1 (cs) |
JP (1) | JP4257573B2 (cs) |
KR (1) | KR100838922B1 (cs) |
AT (1) | ATE316082T1 (cs) |
AU (1) | AU2002223603A1 (cs) |
CZ (1) | CZ302932B6 (cs) |
DE (1) | DE60116796T2 (cs) |
ES (1) | ES2254522T3 (cs) |
IT (1) | IT1319195B1 (cs) |
WO (1) | WO2002030918A2 (cs) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1319196B1 (it) * | 2000-10-10 | 2003-09-26 | Laboratorio Chimico Int Spa | Sintesi dell'acido r(+)alfa-lipoico. |
DE10137381A1 (de) * | 2001-07-31 | 2003-02-13 | Viatris Gmbh | Neue Modifikationen des Trometamolsalzes der R-Thioctsäure sowie Verfahren zu ihrer Herstellung |
ITMI20030831A1 (it) | 2003-04-22 | 2004-10-23 | Laboratorio Chimico Int Spa | Sale basico dell'acido tiottico con la l-carnitina. |
ITMI20061024A1 (it) | 2006-05-25 | 2007-11-26 | Eurand Pharmaceuticals Ltd | Pellet a base di acido lipoico |
CA2741700A1 (en) * | 2008-10-24 | 2010-04-29 | Biolink Life Sciences, Inc. | Stable, water-insoluble r-(+)-.alpha.-lipoic acid salt useful for the treatment of diabetes mellitus and its co-morbidities |
CN106959348A (zh) * | 2017-05-12 | 2017-07-18 | 苏州富士莱医药股份有限公司 | 一种(r)‑硫辛酸的光学异构体含量的检测方法 |
CN108003134A (zh) * | 2018-01-19 | 2018-05-08 | 华东师范大学 | 一种r-(+)-硫辛酸的制备方法 |
CN112390779B (zh) * | 2019-08-16 | 2022-09-06 | 南京海润医药有限公司 | 一种右旋硫辛酸的制备方法 |
CN114163418A (zh) * | 2021-12-24 | 2022-03-11 | 山东龙辰药业有限公司 | 一种右旋硫辛酸的合成方法 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1374015A (en) * | 1920-08-17 | 1921-04-05 | Jerruss Joseph | Safety lock-bolt |
US1413024A (en) * | 1920-12-04 | 1922-04-18 | Annie L Harrell | Lock nut and bolt |
US2456234A (en) * | 1945-06-20 | 1948-12-14 | Panhandle Eastern Pipe Line Co | Bolt protector |
US2728895A (en) * | 1954-10-04 | 1955-12-27 | Whitney Blake Co | Self-locking coupling device |
US2966187A (en) * | 1958-10-14 | 1960-12-27 | Cock Chars Ter | Pawl and ratchet bolt and nut lock |
FR4630M (cs) * | 1965-06-09 | 1966-11-28 | ||
US3670795A (en) * | 1970-06-29 | 1972-06-20 | Wright Barry Corp | Self-locking fastener |
US3877672A (en) * | 1972-06-21 | 1975-04-15 | Trw Inc | Fastener |
US4784555A (en) * | 1985-09-09 | 1988-11-15 | Cantrell Roger M | Protective and ornamental cover for nuts and bolts |
US4875819A (en) * | 1988-10-11 | 1989-10-24 | Kevin Wilkinson | Wheel lock system apparatus |
US5042880A (en) * | 1990-04-10 | 1991-08-27 | Garuti Raymond R | Quick change wheel assembly |
DE4137773A1 (de) * | 1991-11-16 | 1993-05-19 | Degussa | Herstellung und verwendung von salzen der reinen enantiomere der (alpha)-liponsaeure |
US5360304A (en) * | 1993-05-11 | 1994-11-01 | Mcgard, Inc. | Fastener construction |
US5380070A (en) * | 1993-08-09 | 1995-01-10 | Wheel Masters, Inc. | Lug nut covers |
US5463093A (en) * | 1993-11-26 | 1995-10-31 | Garnett; Merrill | Palladium complexes and methods for using same in the treatment of tumors or Psoriasis |
DE4427079C2 (de) * | 1994-07-30 | 2002-12-19 | Viatris Gmbh | Verfahren zur Racemisierung von Enantiomeren der alpha-Liponsäure |
DE4433764A1 (de) * | 1994-09-22 | 1996-03-28 | Asta Medica Ag | Darreichungsformen enthaltend alpha-Liponsäure, feste Salze von R-Thioctsäure mit verbesserter Freisetzung und Bioverfügbarkeit |
IL123887A0 (en) * | 1997-04-02 | 1998-10-30 | Sankyo Co | Dithiolan derivatives their use and pharmaceutical compositions containing the same |
FR2768055A1 (fr) * | 1997-09-11 | 1999-03-12 | Synthelabo | Utilisation de derives de sulfonanilide pour obtenir un medicament destine au traitement de l'ejaculation retrograde ou de l'aspermie |
US5965618A (en) * | 1997-11-17 | 1999-10-12 | Perricone; Nicholas V. | Treatment of scar tissue using lipoic acid |
US6146070A (en) * | 1998-03-09 | 2000-11-14 | Mts Co. Ltd. | Bolt/nut unfastening preventing structure |
DE19834608A1 (de) * | 1998-07-31 | 2000-02-03 | Basf Ag | Kristallmodifikation der Liponsäure |
DE19938621A1 (de) * | 1999-08-14 | 2001-02-22 | Sueddeutsche Kalkstickstoff | Verfahren zur Herstellung von lösemittelfreier alpha-Liponsäure |
US6036420A (en) * | 1999-09-21 | 2000-03-14 | Horizon Technology, Llp | Capped wheel nut assembly |
-
2000
- 2000-10-10 IT IT2000MI002187A patent/IT1319195B1/it active
-
2001
- 2001-10-08 US US10/398,892 patent/US6670484B2/en not_active Expired - Lifetime
- 2001-10-08 CZ CZ20031006A patent/CZ302932B6/cs not_active IP Right Cessation
- 2001-10-08 EP EP01986685A patent/EP1330450B1/en not_active Expired - Lifetime
- 2001-10-08 ES ES01986685T patent/ES2254522T3/es not_active Expired - Lifetime
- 2001-10-08 AT AT01986685T patent/ATE316082T1/de not_active IP Right Cessation
- 2001-10-08 KR KR1020037004733A patent/KR100838922B1/ko not_active IP Right Cessation
- 2001-10-08 DE DE60116796T patent/DE60116796T2/de not_active Expired - Lifetime
- 2001-10-08 AU AU2002223603A patent/AU2002223603A1/en not_active Abandoned
- 2001-10-08 WO PCT/EP2001/011575 patent/WO2002030918A2/en active IP Right Grant
- 2001-10-08 JP JP2002534304A patent/JP4257573B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CZ302932B6 (cs) | 2012-01-18 |
ITMI20002187A1 (it) | 2002-04-10 |
IT1319195B1 (it) | 2003-09-26 |
EP1330450B1 (en) | 2006-01-18 |
EP1330450A2 (en) | 2003-07-30 |
JP2004511476A (ja) | 2004-04-15 |
WO2002030918A3 (en) | 2002-08-01 |
DE60116796D1 (de) | 2006-04-06 |
WO2002030918A2 (en) | 2002-04-18 |
JP4257573B2 (ja) | 2009-04-22 |
KR20030070000A (ko) | 2003-08-27 |
ITMI20002187A0 (it) | 2000-10-10 |
KR100838922B1 (ko) | 2008-06-16 |
US6670484B2 (en) | 2003-12-30 |
ATE316082T1 (de) | 2006-02-15 |
ES2254522T3 (es) | 2006-06-16 |
DE60116796T2 (de) | 2006-11-30 |
US20030187279A1 (en) | 2003-10-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SI1474412T1 (sl) | Proizvodnja delta-9 tetrahidrokanabinola | |
IL166985A (en) | Method for the purification of lansoprazole | |
BRPI0410685A (pt) | processos de purificação de 1,3-propanodiol e composições | |
RS101403A (en) | Process for the preparation of racemic citalopram and/or s or r-citalopram by separation of a mixture of r-and s- citalopram | |
AU2002223603A1 (en) | Process for the production of r(+)alpha-lipoic acid | |
AU2002220596A1 (en) | Synthesis of r(+)alpha-lipoic acid | |
ES2187483T3 (es) | Procedimiento para la preparacion de acido a-lipoico esento de disolvente. | |
EP0983999A4 (en) | METHOD FOR PRODUCING AMIDE DERIVATIVES AND THEIR INTERMEDIATE COMPOUNDS | |
EP1460065A4 (en) | METHOD FOR THE PRODUCTION OF CYCLIC DIAMINO COMPOUNDS BZW. THE SALTS | |
CA2215251A1 (en) | Industrial preparation of high purity gallic acid | |
CA2146708A1 (en) | Process for producing glutamine derivative | |
WO2004039314A3 (en) | Process for synthesizing l-y-methylene glutamic acid and analogs | |
DE60039533D1 (de) | Verbessertes verfahren zur herstellung von 2s,3s-n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamid hydrochlorid und anderen derivaten von 2-hydroxy-1,3-diamin | |
US7091368B2 (en) | Method for the purification of liponic acid | |
HK1056870A1 (en) | Intermediate and process for producing fluorinatedcarboxylic acid derivative from the same. | |
EP1623975A4 (en) | PROCESS FOR PREPARING A PYRROLIDINE DERIVATIVE | |
EP0931069A1 (de) | Verfahren zur herstellung von amidinen | |
GB2418916A (en) | Process for purifying citalopram using polybasic acids | |
PT1462439E (pt) | Novos cristais estáveis de derivado do ácido fenilpropiónico substituído e processo para a sua produção | |
EP2325164A1 (en) | Methods for the production of l-carnitine | |
WO2004013071A3 (en) | Method for refining 2,6-naphthalene dicarboxylic acid | |
AR005903A1 (es) | Un proceso para la preparacion de clorhidrato en n(g)-monometil-l-arginina | |
JPH03190881A (ja) | ベンジルオキサゾピロロキノリン類 | |
AU2001266708A1 (en) | Improved purification of phenyl ester salts | |
MXPA00004698A (es) | Sintesis del 5,5'-diformil 2,2'-difurano y sus derivados. |