AU2001219236A1 - Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade - Google Patents

Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade

Info

Publication number
AU2001219236A1
AU2001219236A1 AU2001219236A AU1923601A AU2001219236A1 AU 2001219236 A1 AU2001219236 A1 AU 2001219236A1 AU 2001219236 A AU2001219236 A AU 2001219236A AU 1923601 A AU1923601 A AU 1923601A AU 2001219236 A1 AU2001219236 A1 AU 2001219236A1
Authority
AU
Australia
Prior art keywords
useful
coagulation cascade
selective inhibition
polycyclic aryl
substituted polycyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001219236A
Inventor
Darin E. Jones
Melvin L. Rueppel
Michael S. South
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia LLC
Original Assignee
Pharmacia LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia LLC filed Critical Pharmacia LLC
Publication of AU2001219236A1 publication Critical patent/AU2001219236A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2001219236A 2000-05-18 2000-11-20 Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade Abandoned AU2001219236A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09574207 2000-05-18
US09/574,207 US6458952B1 (en) 1999-05-19 2000-05-18 Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
PCT/US2000/031885 WO2001087852A1 (en) 2000-05-18 2000-11-20 Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade

Publications (1)

Publication Number Publication Date
AU2001219236A1 true AU2001219236A1 (en) 2001-11-26

Family

ID=24295129

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001219236A Abandoned AU2001219236A1 (en) 2000-05-18 2000-11-20 Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade

Country Status (3)

Country Link
US (2) US6458952B1 (en)
AU (1) AU2001219236A1 (en)
WO (1) WO2001087852A1 (en)

Families Citing this family (7)

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US7015230B1 (en) * 1999-05-19 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
PA8591801A1 (en) * 2002-12-31 2004-07-26 Pfizer Prod Inc BENZAMID INHIBITORS OF THE P2X7 RECEIVER.
MXPA06015273A (en) * 2004-06-29 2007-03-15 Pfizer Prod Inc Method for preparing 5-`4-(2-hydroxy -ethyl)-3, 5-dioxo-4, 5-dihydro-3h-`1, 2, 4!-triazin-2 -yl!benzamide derivatives with p2x7 inhibiting activity by reaction of the derivative unsubstituted in 4-position of the triazine with an oxiran in the presen
SI2724722T1 (en) * 2006-10-20 2017-07-31 Neurendo Pharma, Llc Method of restoring the incretin effect
UA112897C2 (en) 2012-05-09 2016-11-10 Байєр Фарма Акцієнгезелльшафт BICYCLIC SUBSTITUTED URATILES AND THEIR APPLICATIONS FOR THE TREATMENT AND / OR PREVENTION OF DISEASES
CN107405343A (en) 2014-11-07 2017-11-28 明尼苏达大学董事会 Salt and composition available for treatment disease
CN116410143A (en) * 2021-12-29 2023-07-11 杭州奥默医药股份有限公司 Polysubstituted uracil derivative, preparation method and application thereof

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US5304658A (en) * 1984-08-01 1994-04-19 Takeda Chemical Industries, Ltd. Quinone derivatives, their production and use
IL81264A (en) * 1986-01-30 1990-11-05 Takeda Chemical Industries Ltd Quinone derivatives,their production and pharmaceutical compositions containing them
US5008267A (en) * 1988-10-29 1991-04-16 Mitsui Toatsu Chemicals, Incorporated Pyrimidinedione compounds, method of producing the same and antiarrythmic agents containing the same
GB9216272D0 (en) 1991-08-15 1992-09-09 Ici Plc Substituted heterocycles
DE69314169T2 (en) 1992-04-16 1998-01-15 Zeneca Ltd PEPTIDES WITH AN ALPHAAMINOBORONAIRE GROUP AND THEIR USE AS AN ELASTASE INHIBITOR
US5441960A (en) 1992-04-16 1995-08-15 Zeneca Limited 1-pyrimidinylacetamide human leukocyte elastate inhibitors
US5618792A (en) 1994-11-21 1997-04-08 Cortech, Inc. Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase
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US5656645A (en) 1994-12-13 1997-08-12 Corvas International, Inc. Aromatic heterocyclic derivatives as enzyme inhibitors
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US5872138A (en) 1996-09-13 1999-02-16 Merck & Co., Inc. Thrombin inhibitors
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Also Published As

Publication number Publication date
US20030023086A1 (en) 2003-01-30
US6458952B1 (en) 2002-10-01
WO2001087852A1 (en) 2001-11-22

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