BR0011273A - Heteroaryl and polycyclic aryl uracils substituted as anticoagulant agents - Google Patents
Heteroaryl and polycyclic aryl uracils substituted as anticoagulant agentsInfo
- Publication number
- BR0011273A BR0011273A BR0011273-9A BR0011273A BR0011273A BR 0011273 A BR0011273 A BR 0011273A BR 0011273 A BR0011273 A BR 0011273A BR 0011273 A BR0011273 A BR 0011273A
- Authority
- BR
- Brazil
- Prior art keywords
- heteroaryl
- polycyclic aryl
- anticoagulant agents
- substituted
- uracils substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"URACILAS HETEROARILA E ARILA POLICìCLICA SUBSTITUìDAS COMO AGENTES ANTI-COAGULANTES". A invenção refere-se a compostos de uracila heteroarila e arila policiclílica substituída úteis como inibidores de protease de serina dos compostos e cascata de coagulação, composições e métodos para terapia anticoagulante para o tratamento e prevenção de diversas condições trombóticas incluindo doenças da artéria coronariana e cerebrovasculares."HETEROARILLA URACILS AND POLYCLICALLY ARILA REPLACED AS ANTI-COAGULANT AGENTS". The invention relates to heteroaryl uracil and substituted polycyclic aryl compounds useful as compound serine protease inhibitors and coagulation cascade, compositions and methods for anticoagulant therapy for the treatment and prevention of various thrombotic conditions including coronary and cerebrovascular artery diseases .
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13495799P | 1999-05-19 | 1999-05-19 | |
PCT/US2000/008226 WO2000069833A1 (en) | 1999-05-19 | 2000-05-18 | Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0011273A true BR0011273A (en) | 2002-06-18 |
Family
ID=22465795
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0011273-9A BR0011273A (en) | 1999-05-19 | 2000-05-18 | Heteroaryl and polycyclic aryl uracils substituted as anticoagulant agents |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP1178971A1 (en) |
JP (1) | JP2002544263A (en) |
KR (1) | KR20010113969A (en) |
CN (1) | CN1152023C (en) |
AR (1) | AR043677A1 (en) |
AU (1) | AU771740B2 (en) |
BR (1) | BR0011273A (en) |
CA (1) | CA2373610A1 (en) |
MX (1) | MXPA01011806A (en) |
NZ (1) | NZ514877A (en) |
PE (1) | PE20010217A1 (en) |
UY (1) | UY26157A1 (en) |
WO (1) | WO2000069833A1 (en) |
ZA (2) | ZA200109338B (en) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6653316B1 (en) | 1999-05-19 | 2003-11-25 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
US6750342B1 (en) | 1999-05-19 | 2004-06-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
US7015230B1 (en) | 1999-05-19 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
US6716838B1 (en) | 1999-05-19 | 2004-04-06 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents |
US6664255B1 (en) | 1999-05-19 | 2003-12-16 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
US6867217B1 (en) | 1999-05-19 | 2005-03-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
US6458952B1 (en) | 1999-05-19 | 2002-10-01 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
WO2001055119A2 (en) | 2000-01-25 | 2001-08-02 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
AU2004200664B2 (en) * | 2000-01-25 | 2007-08-16 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
US6660885B2 (en) | 2000-03-13 | 2003-12-09 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade |
EP1268428A2 (en) | 2000-04-05 | 2003-01-02 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade |
DE60108948T2 (en) | 2000-04-05 | 2005-11-03 | Pharmacia Corp. | POLYCYCLIC ARYL AND HETEROARYL SUBSTITUTED 4-PYRONES USE AS SELECTIVE INHIBITION FROM THE COAGULATION PROCESS |
CA2405684A1 (en) | 2000-04-17 | 2001-10-25 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade |
US6710058B2 (en) | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
US7119094B1 (en) | 2000-11-20 | 2006-10-10 | Warner-Lambert Company | Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade |
JP2004517074A (en) | 2000-11-20 | 2004-06-10 | ファルマシア・コーポレーション | Substituted polycyclic aryl and heteroaryl pyridines useful for selectively inhibiting the coagulation cascade |
US7015223B1 (en) | 2000-11-20 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade |
EP1432687A2 (en) | 2001-10-03 | 2004-06-30 | Pharmacia Corporation | Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade |
EP1438292A1 (en) | 2001-10-03 | 2004-07-21 | Pharmacia Corporation | 6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade |
TW200307667A (en) | 2002-05-06 | 2003-12-16 | Bristol Myers Squibb Co | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors |
GB0622472D0 (en) * | 2006-11-10 | 2006-12-20 | Addex Pharmaceuticals Sa | Novel heterocyclic derivatives |
EA027603B1 (en) | 2011-11-29 | 2017-08-31 | Перосфере Инк. | Piperazine derivatives which reverse anticoagulant effects |
CN116410143A (en) * | 2021-12-29 | 2023-07-11 | 杭州奥默医药股份有限公司 | Polysubstituted uracil derivative, preparation method and application thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX9704439A (en) * | 1994-12-13 | 1997-10-31 | Corvas Int Inc | Aromatic heterocyclic derivatives as enzyme inhibitors. |
MXPA01011804A (en) * | 1999-05-19 | 2003-09-04 | Pharmacia Corp | Substituted polycyclic aryl and heteroaryl pyrymidinones useful as anticoagulants. |
-
2000
- 2000-05-18 AU AU49724/00A patent/AU771740B2/en not_active Ceased
- 2000-05-18 MX MXPA01011806A patent/MXPA01011806A/en unknown
- 2000-05-18 BR BR0011273-9A patent/BR0011273A/en not_active IP Right Cessation
- 2000-05-18 NZ NZ514877A patent/NZ514877A/en unknown
- 2000-05-18 KR KR1020017014750A patent/KR20010113969A/en not_active Application Discontinuation
- 2000-05-18 CN CNB008077533A patent/CN1152023C/en not_active Expired - Fee Related
- 2000-05-18 CA CA002373610A patent/CA2373610A1/en not_active Abandoned
- 2000-05-18 EP EP00931917A patent/EP1178971A1/en not_active Withdrawn
- 2000-05-18 WO PCT/US2000/008226 patent/WO2000069833A1/en not_active Application Discontinuation
- 2000-05-18 JP JP2000618250A patent/JP2002544263A/en active Pending
- 2000-05-19 UY UY26157A patent/UY26157A1/en unknown
- 2000-05-19 AR ARP000102449A patent/AR043677A1/en unknown
- 2000-06-02 PE PE2000000543A patent/PE20010217A1/en not_active Application Discontinuation
-
2001
- 2001-11-13 ZA ZA200109338A patent/ZA200109338B/en unknown
-
2004
- 2004-01-21 ZA ZA200400450A patent/ZA200400450B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN1152023C (en) | 2004-06-02 |
JP2002544263A (en) | 2002-12-24 |
AR043677A1 (en) | 2005-08-10 |
AU4972400A (en) | 2000-12-05 |
PE20010217A1 (en) | 2001-03-07 |
WO2000069833A1 (en) | 2000-11-23 |
AU771740B2 (en) | 2004-04-01 |
ZA200400450B (en) | 2004-09-29 |
KR20010113969A (en) | 2001-12-28 |
CA2373610A1 (en) | 2000-11-23 |
CN1351594A (en) | 2002-05-29 |
EP1178971A1 (en) | 2002-02-13 |
MXPA01011806A (en) | 2003-09-04 |
ZA200109338B (en) | 2004-05-26 |
UY26157A1 (en) | 2000-12-29 |
NZ514877A (en) | 2004-10-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 3A E 7A ANUIDADE |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1942 DE 25/03/2008. |