ATE69602T1 - Hydroxy-ml-236b-derivate, deren herstellung und anwendung. - Google Patents

Hydroxy-ml-236b-derivate, deren herstellung und anwendung.

Info

Publication number
ATE69602T1
ATE69602T1 AT86307096T AT86307096T ATE69602T1 AT E69602 T1 ATE69602 T1 AT E69602T1 AT 86307096 T AT86307096 T AT 86307096T AT 86307096 T AT86307096 T AT 86307096T AT E69602 T1 ATE69602 T1 AT E69602T1
Authority
AT
Austria
Prior art keywords
sank
streptomyces
derivatives
nocardia
hydroxy
Prior art date
Application number
AT86307096T
Other languages
English (en)
Inventor
Kohei Furuya
Takao Okazaki
Yoshio Tsujita
Seigo Iwado
Kiyoshi Hamano
Masao Kuroda
Jun Yoshikawa
Toshiaki Iwai
Kunio Nakano
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Application granted granted Critical
Publication of ATE69602T1 publication Critical patent/ATE69602T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/365—Nocardia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
AT86307096T 1985-09-13 1986-09-15 Hydroxy-ml-236b-derivate, deren herstellung und anwendung. ATE69602T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP20261485 1985-09-13
JP22415385 1985-10-08

Publications (1)

Publication Number Publication Date
ATE69602T1 true ATE69602T1 (de) 1991-12-15

Family

ID=26513490

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86307096T ATE69602T1 (de) 1985-09-13 1986-09-15 Hydroxy-ml-236b-derivate, deren herstellung und anwendung.

Country Status (4)

Country Link
US (1) US5153124A (de)
EP (1) EP0215665B1 (de)
AT (1) ATE69602T1 (de)
DE (1) DE3682557D1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK175425B1 (da) * 1987-02-02 2004-10-18 Sankyo Co Cytochrom P-450-enzymer, Fremgangsmåde til fremstilling heraf samt Fremgangsmåde til hydroxylering af milbemycin eller ML-236-substrat
US5179013A (en) * 1987-02-02 1993-01-12 Sankyo Company, Limited Cytochrome P-450 enzymes
US4997848A (en) 1987-10-27 1991-03-05 Sankyo Company, Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
US5212296A (en) * 1989-09-11 1993-05-18 E. I. Du Pont De Nemours And Company Expression of herbicide metabolizing cytochromes
HU208997B (en) * 1992-06-17 1994-02-28 Gyogyszerkutato Intezet Microbiological method for producing mevinoline
KR100186758B1 (ko) 1996-08-09 1999-04-01 영진약품공업 주식회사 프라바스타틴(pravastatin)전구체의제조방법
KR100210482B1 (ko) * 1997-04-10 1999-07-15 김종인 스트렙토마이세스엑스포리아투스(streptomycesexfoliatus)yj-118과이를이용한프라바스타틴나트륨의제조방법
WO1999010499A1 (en) * 1997-08-22 1999-03-04 Dsm N.V. Statin production by fermentation
SI9800144A (sl) 1998-05-21 1999-12-31 LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. Nov biotehnološki postopek pridobivanja 3-hidroksi-ML-236B derivatov poznanih kot M-4 in M-4'
PT1265604E (pt) * 1999-11-30 2006-12-29 Teva Gyogyszergyar Zartkoeruen Processo para a recuperação de compostos de estatina de um caldo de fermentação
IL150187A0 (en) 1999-12-14 2002-12-01 Biogal Pharmaceutical Co Ltd Novel forms of pravastatin sodium
US20050215636A1 (en) * 2000-10-05 2005-09-29 Vilmos Keri Pravastatin sodium substantially free of pravastatin lactone and EPI-pravastatin, and compositions containing same
EP1452602A1 (de) * 2003-02-25 2004-09-01 Antibiotic Co., Fermentatives Verfahren zur Herstellung von Pravastatin
CN1244688C (zh) 2003-07-09 2006-03-08 上海天伟生物制药有限公司 生产普伐他汀钠的微生物和方法
ATE412409T1 (de) * 2003-11-24 2008-11-15 Teva Gyogyszergyar Zartkoeruee Verfahren zur reinigung von pravastatin
TW200640854A (en) * 2005-02-09 2006-12-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Methods of making pravastatin sodium

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0692381B2 (ja) * 1980-03-31 1994-11-16 三共株式会社 Ｍｂ−５３０ａ誘導体
JPS56150037A (en) * 1980-04-22 1981-11-20 Sankyo Co Ltd Hydronaphthalene compound
DK149080C (da) * 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
US4376838A (en) * 1981-03-18 1983-03-15 The Firestone Tire & Rubber Company Cured rubber skim stocks having improved metal adhesion and metal adhesion retention by use of organo-metal complexes and halogenated polymer
US4376863A (en) * 1981-08-21 1983-03-15 Merck & Co., Inc. Hypocholesterolemic fermentation products
JPS5889191A (ja) * 1981-11-20 1983-05-27 Sankyo Co Ltd ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
JPS60114199A (ja) * 1983-11-24 1985-06-20 Nippon Kayaku Co Ltd 新規モナコリン類
US4668699A (en) * 1985-08-05 1987-05-26 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors

Also Published As

Publication number Publication date
EP0215665A3 (en) 1988-10-05
EP0215665B1 (de) 1991-11-21
EP0215665A2 (de) 1987-03-25
US5153124A (en) 1992-10-06
DE3682557D1 (de) 1992-01-02

Similar Documents

Publication Publication Date Title
ATE69602T1 (de) Hydroxy-ml-236b-derivate, deren herstellung und anwendung.
KR840002451A (ko) 3-히드록시-ml-236b 유도체의 제조방법
ES466791A1 (es) Procedimiento para la produccion de esterastina.
ES8300353A1 (es) Procedimiento de preparar acidos hidroxicarboxilicos y sus derivados.
ATE12638T1 (de) Mb-530b derivate, deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
UA43366C2 (uk) Штам бактерій pseudomonas chlororaphis або його біологічно чисті культури, здатні продукувати активні антипатогенні метаболіти, композиція для профілактики захворювань рослин, спосіб профілактики захворювань рослин
JPS572689A (en) Preparation of l-glutamic acid
NO159608C (no) Fremgangsm te for fremstilling av 6-hydroksynikotin
JPS56102793A (en) Preparation of antibiotic c-15003 p-3
EP0922759A3 (de) Aldehyd-dehydrogenase
BR9806934A (pt) Método para produzir um óxido, meio de cultura e óxido
AU547968B2 (en) Ml-236b derivatives i.e. alactone and the corresponding free hydroxy-carboxylic acid
JPS57138382A (en) Preparation of microbial cell
KR930004467A (ko) α-히드록시 이소부틸아미드의 제조방법
NZ511728A (en) Substances WK-5344A and WK-5344B obtained from microorganisms of the genus Streptomyces
JPS56113294A (en) Microbial preparation of pristanol
Fitzgerald et al. Carbon and sulphur utilization during growth of Pseudomonas fluorescens on potassium D-glucose 6-O-sulphate as the sole sulphur source
ES2059532T3 (es) Procedimiento microbiologico para la preparacion de uk-61.689 y microorganismos utiles para el mismo.
JPS5635992A (en) Preparation of l-methionine by fermentation
Taylor et al. Aromatic ring cleavage by a Thiobacillus
JPS5585397A (en) Microbiological preparation of 9alpha-hydroxyandrostenedione
EP0071446A3 (de) Herstellung von Mikroorganismen
JPS572687A (en) Preparation of l-isoleucine by fermentation
JPS5615692A (en) Production of 9,10-secophenol by fermentation
KR890006822A (ko) D-(-)-타르타르산의 제조법

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time