ATE651T1 - Mikrobiologische reduktion von 15-keto-prostaglandin-zwischenprodukten. - Google Patents

Mikrobiologische reduktion von 15-keto-prostaglandin-zwischenprodukten.

Info

Publication number
ATE651T1
ATE651T1 AT79730012T AT79730012T ATE651T1 AT E651 T1 ATE651 T1 AT E651T1 AT 79730012 T AT79730012 T AT 79730012T AT 79730012 T AT79730012 T AT 79730012T AT E651 T1 ATE651 T1 AT E651T1
Authority
AT
Austria
Prior art keywords
keto
intermediate products
microbiological reduction
prostaglandin intermediate
formula
Prior art date
Application number
AT79730012T
Other languages
English (en)
Inventor
Klaus Dr. Kieslich
Bernd Dr. Raduechel
Werner Dr. Skuballa
Helmut Prof. Vorbrueggen
Helmut Dr. Dahl
Original Assignee
Schering Aktiengesellschaft Berlin Und Bergkamen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Aktiengesellschaft Berlin Und Bergkamen filed Critical Schering Aktiengesellschaft Berlin Und Bergkamen
Application granted granted Critical
Publication of ATE651T1 publication Critical patent/ATE651T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/165—Yeast isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/18—Baker's yeast; Brewer's yeast
    • C12N1/185—Saccharomyces isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P31/00—Preparation of compounds containing a five-membered ring having two side-chains in ortho position to each other, and having at least one oxygen atom directly bound to the ring in ortho position to one of the side-chains, one side-chain containing, not directly bound to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having at least one oxygen atom bound in gamma-position to the ring, e.g. prostaglandins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/78—Hansenula
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/85—Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/85—Saccharomyces
    • C12R2001/86—Saccharomyces carlsbergensis ; Saccharomyces pastorianus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/93—Hansenula
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/94—Saccharomyces
    • Y10S435/941—Saccharomyces carlsbergensis

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Furan Compounds (AREA)
AT79730012T 1978-12-08 1979-12-06 Mikrobiologische reduktion von 15-keto-prostaglandin-zwischenprodukten. ATE651T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19782853637 DE2853637A1 (de) 1978-12-08 1978-12-08 Mikrobiologische reduktion von 15-keto-prostaglandin-zwischenprodukten
EP79730012A EP0012710B1 (de) 1978-12-08 1979-12-06 Mikrobiologische Reduktion von 15-Keto-prostaglandin-Zwischenprodukten

Publications (1)

Publication Number Publication Date
ATE651T1 true ATE651T1 (de) 1982-02-15

Family

ID=6056936

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79730012T ATE651T1 (de) 1978-12-08 1979-12-06 Mikrobiologische reduktion von 15-keto-prostaglandin-zwischenprodukten.

Country Status (5)

Country Link
US (1) US4247635A (de)
EP (1) EP0012710B1 (de)
JP (1) JPS5579384A (de)
AT (1) ATE651T1 (de)
DE (2) DE2853637A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0148612A3 (de) * 1984-01-10 1987-08-26 Ayerst, Mckenna And Harrison Inc. Stereospezifische mikrobische Reduktion
DE3519548A1 (de) * 1985-05-29 1986-12-04 Schering AG, 1000 Berlin und 4709 Bergkamen Mikrobiologische reduktion von prostacyclin-zwischenprodukten mit einer 15-ketogruppe
ITMI20132193A1 (it) * 2013-12-23 2015-06-24 Ind Chimica Srl Processo microbiologico per la preparazione di intermedi utili nella sintesi di prostaglandine
CN112481313B (zh) * 2020-11-23 2022-08-12 江苏阿尔法药业股份有限公司 一种贝美前列素中间体的酶催化合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3687811A (en) * 1970-12-18 1972-08-29 Searle & Co Microbiological reduction of 15-keto prostaglandin derivatives
US3799841A (en) * 1972-11-21 1974-03-26 Searle & Co Microbiological reduction of 11-hydroxy-15-keto prostaglandin intermediates
DE2401671A1 (de) * 1974-01-15 1975-07-24 Rueggeberg August Fa Verfahren zur herstellung einer feile aus einem duennwandigen rohr

Also Published As

Publication number Publication date
EP0012710A1 (de) 1980-06-25
JPS5579384A (en) 1980-06-14
DE2962072D1 (en) 1982-03-11
JPS6147517B2 (de) 1986-10-20
EP0012710B1 (de) 1982-02-03
US4247635A (en) 1981-01-27
DE2853637A1 (de) 1980-06-12

Similar Documents

Publication Publication Date Title
AU4251485A (en) Benzoxazole and benzthiazole derivatives
ATE239619T1 (de) Aufzeichnungsmaterial sowie bilddruckverfahren das dieses material verwendet
SE8003815L (sv) Alkyl-ketohexopyranosid-derivat
AU541413B2 (en) 2-(1,4-benzodioxan-2-ylalicyl)imidazoles
ES504702A0 (es) Procedimiento de fabricacion y de aplicacion de derivados iridoides reactivos
KR920008193A (ko) 카르바스틴의 제조방법
ATE651T1 (de) Mikrobiologische reduktion von 15-keto-prostaglandin-zwischenprodukten.
AU562515B2 (en) Pyridinecarbinols
KR920701455A (ko) 발효에 의한 2-(4-히드록시페녹시)프로피온산의 제조 방법
KR880011103A (ko) 5-아미노-4,6-디할로게노피리딘의 제조방법
KR830006302A (ko) 신규 피리미딘 유도체의 제조방법
KR830001948A (ko) 페니실린 설폭사이드의 제조방법
KR830001940A (ko) 알도즈 환원요소 억제성 퀴놀릴히단토인류
TR22546A (tr) Herbisit oezellikte yeni 2-alkoksi-aminosuelfonil-benzensuelfoniluereler
SE7904396L (sv) Sett att framstella arylettiksyraderivat
SE7904431L (sv) Nya acetylenderivat av androst-4-en
KR900701746A (ko) 2-할로-4-알킬술포닐벤조산의 제조방법
KR880006250A (ko) 3-치환된 세팔로스포린의 제조 방법
ES471267A1 (es) Procedimiento para la preparacion de alquilo inferior 2-tri-(inferior) alquilsililacetileno-n-carbetoxiglicinatos y ami-no acidos derivados de ellos
SE8104195L (sv) Sett att framstella 3-keto-cyklopenten-5-oxi-derivat
AU551839B2 (en) Imidazolylcarboxylic acids and derivative
DE3260314D1 (en) Derivatives of 4-methyl-3-formyl-pentanoic acid, their process of preparation and their application in the preparation of cyclic derivatives
KR900006295A (ko) 할로게노-4-메틸피라졸류 및 그의 제조방법
AU550155B2 (en) 3-oxabicyclo(3.1.0)hexan-2-ones
ATE17710T1 (de) Keten-0,0-acetale und verfahren zu ihrer herstellung.

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee